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  1. Article ; Online: Effects of dispersant-treated oil upon behavioural and metabolic parameters of the anti-predator response in juvenile European sea bass (Dicentrarchus labrax).

    Aimon, C / Lebigre, C / Le Floch, S / Claireaux, G

    The Science of the total environment

    2022  Volume 834, Page(s) 155430

    Abstract: ... of such pattern in E fish suggest altered capacity to habituate over time to the surrounding environment and ...

    Abstract Acute exposure to oil and oil dispersants can cause a wide range of physiological dysfunctions in marine fish species and evidences for consequences on behaviour are also increasing. In response to the presence of predators or to food availability, the modulation of locomotor activity and schools' behaviour enable fish to maximize their survival rates. However, the degree to which this regulatory process is affected by exposure to oil and/or dispersants is yet unknown. Here we investigated the effect of a 62-h experimental exposure to dispersant-treated oil on the behavioural (shoal cohesion, spontaneous activity) and metabolic (oxygen consumption) responses to simulated predation in juvenile European sea bass, Dicentrarchus labrax L. Our results suggest that exposure to petroleum hydrocarbons may affect negatively individual fitness through impaired ability to respond to predation. Shoal cohesion was not affected, but fish swimming activity was higher than control individuals under predation pressure and the amplitude of their metabolic response was significantly reduced. Fish recovered from alteration of their metabolic response 7 days post-exposure. Additionally, a strong habituation component was observed in C fish and the absence of such pattern in E fish suggest altered capacity to habituate over time to the surrounding environment and possible impairments of the related cognitive performances. Altogether, our data show that juvenile sea bass exposed to oil exhibit transient physiological dysfunctions and impairments of complex behaviours that may have major population-level consequences.
    MeSH term(s) Animals ; Bass/physiology ; Hydrocarbons ; Petroleum/toxicity ; Petroleum Pollution ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/toxicity
    Chemical Substances Hydrocarbons ; Petroleum ; Water Pollutants, Chemical
    Language English
    Publishing date 2022-04-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.155430
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    Zs.A 949: Show issues Location:
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  2. Article ; Online: Systematic evaluation of B-cell clonal family inference approaches.

    Balashova, Daria / van Schaik, Barbera D C / Stratigopoulou, Maria / Guikema, Jeroen E J / Caniels, Tom G / Claireaux, Mathieu / van Gils, Marit J / Musters, Anne / Anang, Dornatien C / de Vries, Niek / Greiff, Victor / van Kampen, Antoine H C

    BMC immunology

    2024  Volume 25, Issue 1, Page(s) 13

    Abstract: The reconstruction of clonal families (CFs) in B-cell receptor (BCR) repertoire analysis is a crucial step to understand the adaptive immune system and how it responds to antigens. The BCR repertoire of an individual is formed throughout life and is ... ...

    Abstract The reconstruction of clonal families (CFs) in B-cell receptor (BCR) repertoire analysis is a crucial step to understand the adaptive immune system and how it responds to antigens. The BCR repertoire of an individual is formed throughout life and is diverse due to several factors such as gene recombination and somatic hypermutation. The use of Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) using next generation sequencing enabled the generation of full BCR repertoires that also include rare CFs. The reconstruction of CFs from AIRR-seq data is challenging and several approaches have been developed to solve this problem. Currently, most methods use the heavy chain (HC) only, as it is more variable than the light chain (LC). CF reconstruction options include the definition of appropriate sequence similarity measures, the use of shared mutations among sequences, and the possibility of reconstruction without preliminary clustering based on V- and J-gene annotation. In this study, we aimed to systematically evaluate different approaches for CF reconstruction and to determine their impact on various outcome measures such as the number of CFs derived, the size of the CFs, and the accuracy of the reconstruction. The methods were compared to each other and to a method that groups sequences based on identical junction sequences and another method that only determines subclones. We found that after accounting for data set variability, in particular sequencing depth and mutation load, the reconstruction approach has an impact on part of the outcome measures, including the number of CFs. Simulations indicate that unique junctions and subclones should not be used as substitutes for CF and that more complex methods do not outperform simpler methods. Also, we conclude that different approaches differ in their ability to correctly reconstruct CFs when not considering the LC and to identify shared CFs. The results showed the effect of different approaches on the reconstruction of CFs and highlighted the importance of choosing an appropriate method.
    MeSH term(s) Humans ; B-Lymphocytes ; Mutation ; Receptors, Antigen, B-Cell/genetics ; High-Throughput Nucleotide Sequencing
    Chemical Substances Receptors, Antigen, B-Cell
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041500-X
    ISSN 1471-2172 ; 1471-2172
    ISSN (online) 1471-2172
    ISSN 1471-2172
    DOI 10.1186/s12865-024-00600-8
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  3. Article ; Online: Responses by fishes to environmental hypoxia: integration through Fry's concept of aerobic metabolic scope.

    Claireaux, G / Chabot, D

    Journal of fish biology

    2016  Volume 88, Issue 1, Page(s) 232–251

    Abstract: ... using as a background the conceptual scheme initially proposed by F. E. J. Fry. They revisited ...

    Abstract The problem of understanding the effect of the environment on fish activities and performance, in any generalized way, remains intractable. Solving this issue is, however, a key to addressing contemporary environmental concerns. As suggested 20 years ago by W. H. Neill, the authors returned to the drawing board, using as a background the conceptual scheme initially proposed by F. E. J. Fry. They revisited the effect of ambient oxygen availability upon fish metabolism and clarified the definitions of limiting, critical and incipient lethal oxygen (ILO) levels. The concepts of oxy-conformer and oxy-regulator are revisited, and P. W. Hochachka's idea of scope for survival is explored. Finally, how the cardiovascular system contributes to the capacity of fishes to respond to the reduced oxygen availability is considered. Various hands-on recommendations and software (R scripts) are provided for researchers interested in investigating these concepts.
    MeSH term(s) Animals ; Environment ; Fishes/physiology ; Hypoxia ; Oxygen/metabolism ; Oxygen Consumption
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 410564-3
    ISSN 1095-8649 ; 0022-1112
    ISSN (online) 1095-8649
    ISSN 0022-1112
    DOI 10.1111/jfb.12833
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  4. Article: An intrapericardial teratoma in a newborn infant.

    CLAIREAUX, A E

    The Journal of pathology and bacteriology

    2004  Volume 63, Issue 4, Page(s) 743–745

    MeSH term(s) Heart Neoplasms ; Humans ; Infant ; Infant, Newborn ; Neoplasms ; Pericardium ; Teratoma ; Thymus Neoplasms
    Language English
    Publishing date 2004-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 3101-x
    ISSN 1555-2039 ; 0368-3494
    ISSN (online) 1555-2039
    ISSN 0368-3494
    DOI 10.1002/path.1700630421
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    Ud II Zs.12: Show issues Location:
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  5. Article: Effects of dispersant-treated oil upon behavioural and metabolic parameters of the anti-predator response in juvenile European sea bass (Dicentrarchus labrax)

    Aimon, C. / Lebigre, C. / Le Floch, S. / Claireaux, G.

    Science of the total environment. 2022 Apr. 18,

    2022  

    Abstract: ... of such pattern in E fish suggest altered capacity to habituate over time to the surrounding environment and ...

    Abstract Acute exposure to oil and oil dispersants can cause a wide range of physiological dysfunctions in marine fish species and evidences for consequences on behaviour are also increasing. In response to the presence of predators or to food availability, the modulation of locomotor activity and schools' behaviour enable fish to maximize their survival rates. However, the degree to which this regulatory process is affected by exposure to oil and/or dispersants is yet unknown. Here we investigated the effect of a 62-h experimental exposure to dispersant-treated oil on the behavioural (shoal cohesion, spontaneous activity) and metabolic (oxygen consumption) responses to simulated predation in juvenile European sea bass, Dicentrarchus labrax L. Our results suggest that exposure to petroleum hydrocarbons may affect negatively individual fitness through impaired ability to respond to predation. Shoal cohesion was not affected, but fish swimming activity was higher than control individuals under predation pressure and the amplitude of their metabolic response was significantly reduced. Fish recovered from alteration of their metabolic response 7 days post-exposure. Additionally, a strong habituation component was observed in C fish and the absence of such pattern in E fish suggest altered capacity to habituate over time to the surrounding environment and possible impairments of the related cognitive performances. Altogether, our data show that juvenile sea bass exposed to oil exhibit transient physiological dysfunctions and impairments of complex behaviours that may have major population-level consequences.
    Keywords Dicentrarchus labrax ; acute exposure ; biochemical pathways ; cognition ; cohesion ; dispersants ; environment ; food availability ; habituation ; juveniles ; locomotion ; marine fish ; oils ; oxygen consumption ; petroleum ; predation
    Language English
    Dates of publication 2022-0418
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.155430
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 74/341: Show issues

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  6. Article: Respiratory hazards in the premature infant.

    CLAIREAUX, A E

    Postgraduate medical journal

    2003  Volume 30, Issue 345, Page(s) 338–348

    MeSH term(s) Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Respiration
    Language English
    Publishing date 2003-07-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 80325-x
    ISSN 1469-0756 ; 0032-5473
    ISSN (online) 1469-0756
    ISSN 0032-5473
    DOI 10.1136/pgmj.30.345.338
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.340: Show issues Location:
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  7. Article ; Online: Understanding repertoire sequencing data through a multiscale computational model of the germinal center.

    García-Valiente, Rodrigo / Merino Tejero, Elena / Stratigopoulou, Maria / Balashova, Daria / Jongejan, Aldo / Lashgari, Danial / Pélissier, Aurélien / Caniels, Tom G / Claireaux, Mathieu A F / Musters, Anne / van Gils, Marit J / Rodríguez Martínez, María / de Vries, Niek / Meyer-Hermann, Michael / Guikema, Jeroen E J / Hoefsloot, Huub / van Kampen, Antoine H C

    NPJ systems biology and applications

    2023  Volume 9, Issue 1, Page(s) 8

    Abstract: Sequencing of B-cell and T-cell immune receptor repertoires helps us to understand the adaptive immune response, although it only provides information about the clonotypes (lineages) and their frequencies and not about, for example, their affinity or ... ...

    Abstract Sequencing of B-cell and T-cell immune receptor repertoires helps us to understand the adaptive immune response, although it only provides information about the clonotypes (lineages) and their frequencies and not about, for example, their affinity or antigen (Ag) specificity. To further characterize the identified clones, usually with special attention to the particularly abundant ones (dominant), additional time-consuming or expensive experiments are generally required. Here, we present an extension of a multiscale model of the germinal center (GC) that we previously developed to gain more insight in B-cell repertoires. We compare the extent that these simulated repertoires deviate from experimental repertoires established from single GCs, blood, or tissue. Our simulations show that there is a limited correlation between clonal abundance and affinity and that there is large affinity variability among same-ancestor (same-clone) subclones. Our simulations suggest that low-abundance clones and subclones, might also be of interest since they may have high affinity for the Ag. We show that the fraction of plasma cells (PCs) with high B-cell receptor (BcR) mRNA content in the GC does not significantly affect the number of dominant clones derived from single GCs by sequencing BcR mRNAs. Results from these simulations guide data interpretation and the design of follow-up experiments.
    MeSH term(s) Germinal Center ; B-Lymphocytes ; Receptors, Antigen, B-Cell/genetics
    Chemical Substances Receptors, Antigen, B-Cell
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2056-7189
    ISSN (online) 2056-7189
    DOI 10.1038/s41540-023-00271-y
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  8. Article: INTRACRANIAL HAEMORRHAGE IN THE PREMATURE INFANT.

    CLAIREAUX, A E

    Developmental medicine and child neurology

    2003  Volume 6, Page(s) 518–519

    MeSH term(s) Cerebral Hemorrhage ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases ; Intracranial Hemorrhages
    Language English
    Publishing date 2003-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 80369-8
    ISSN 1469-8749 ; 0012-1622
    ISSN (online) 1469-8749
    ISSN 0012-1622
    DOI 10.1111/j.1469-8749.1964.tb10820.x
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  9. Article: Renal osteodystrophy.

    CLAIREAUX, A E

    The Journal of pathology and bacteriology

    2003  Volume 65, Issue 2, Page(s) 291–306

    MeSH term(s) Chronic Kidney Disease-Mineral and Bone Disorder ; Humans ; Kidney ; Rickets
    Language English
    Publishing date 2003-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 3101-x
    ISSN 1555-2039 ; 0368-3494
    ISSN (online) 1555-2039
    ISSN 0368-3494
    DOI 10.1002/path.1700650203
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  10. Article: Perinatal mortality in toxaemia of pregnancy.

    CLAIREAUX, A E

    Pathologia et microbiologia

    2003  Volume 24, Page(s) 607–621

    MeSH term(s) Female ; Humans ; Infant Mortality ; Perinatal Death ; Perinatal Mortality ; Pre-Eclampsia/complications ; Pregnancy ; Pregnancy Complications ; Toxemia
    Language English
    Publishing date 2003-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 200190-1
    ISSN 0031-2959
    ISSN 0031-2959
    DOI 10.1159/000161170
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    Ud II Zs.101: Show issues Location:
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