Article ; Online: Autophagic degradation of the endoplasmic reticulum.
Proceedings of the Japan Academy. Series B, Physical and biological sciences
2020 Volume 96, Issue 1, Page(s) 1–9
Abstract: Autophagy is an intracellular degradation system that is present in most eukaryotes. In the process of autophagy, double membrane vesicles called autophagosomes sequester a wide variety of cellular constituents and deliver them to lytic organelles: ... ...
Abstract | Autophagy is an intracellular degradation system that is present in most eukaryotes. In the process of autophagy, double membrane vesicles called autophagosomes sequester a wide variety of cellular constituents and deliver them to lytic organelles: lysosomes in mammals and vacuoles in yeast and plants. Although autophagy used to be considered a non-selective process in its target sequestration into autophagosomes, recent studies have revealed that autophagosomes can also selectively sequester certain proteins and organelles that have become unnecessary or harmful for the cell. We recently discovered that the endoplasmic reticulum (ER) is degraded by autophagy in a selective manner in the budding yeast Saccharomyces cerevisiae, and identified "receptor proteins" that play pivotal roles in this "ER-phagy" pathway. Moreover, several ER-phagy receptors in mammalian cells have also been reported. This report provides an overview of our current knowledge on ER-phagy and discuss their mechanisms, physiological roles, and possible links to human diseases. |
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MeSH term(s) | Animals ; Autophagosomes/metabolism ; Autophagy ; Endoplasmic Reticulum/metabolism ; Endoplasmic Reticulum Stress ; Humans ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism |
Chemical Substances | Saccharomyces cerevisiae Proteins |
Language | English |
Publishing date | 2020-01-13 |
Publishing country | Japan |
Document type | Journal Article ; Review |
ZDB-ID | 161781-3 |
ISSN | 1349-2896 ; 0386-2208 |
ISSN (online) | 1349-2896 |
ISSN | 0386-2208 |
DOI | 10.2183/pjab.96.001 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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