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  1. Article ; Online: Effects of COVID-19 pandemic period on neonatal mortality and morbidity.

    Hekimoğlu, Berna / Aktürk Acar, Filiz

    Pediatrics and neonatology

    2021  Volume 63, Issue 1, Page(s) 78–83

    Abstract: Background: Corona Virus Disease 2019 (COVID-19) in pregnant women has important impacts on perinatal and neonatal outcomes. However, there are a limited number of studies investigating the effect of the pandemic period on newborns. With this study, we ... ...

    Abstract Background: Corona Virus Disease 2019 (COVID-19) in pregnant women has important impacts on perinatal and neonatal outcomes. However, there are a limited number of studies investigating the effect of the pandemic period on newborns. With this study, we aimed to determine the impact of the 2020 COVID-19 outbreak on prenatal care, obstetric outcomes, neonatal mortality and morbidity.
    Methods: The retrospective results of patients hospitalized to the Tertiary Neonatal Intensive Care Unit between 1 March and 30 May 2020, the first peak period of the pandemic in our country, were compared with the data of the same period of the previous year.
    Results: A total of 307 cases were included in our study. The mean gestational weeks of the neonates hospitalized in the Neonatal Intensive Care Unit during the COVID-19 period were higher than those in the control group (p: 0.003). During the pandemic period, an increase was found in the frequency of pregnant women presenting to obstetric emergency services in emergencies requiring acute intervention (p: 0.01). Compared to the control group, there was an increase in the number of infants with small for gestational age (SGA) diagnosis, 5th-minute Apgar score of <7, and newborns with a diagnosis of hypoxic-ischemic encephalopathy who were treated with hypothermia in the study group (p < 0.05). No difference was found in terms of maternal and neonatal mortality (p > 0.05).
    Conclusions: During the COVID-19 pandemic, it was shown that pregnant women disrupted their regular antenatal care, and more pregnant women were admitted to the obstetric emergency department with emergencies requiring acute intervention. This led to an increase in the number of cases diagnosed with SGA and hypoxic-ischemic encephalopathy in newborns. Our results will be useful for better management of current and future pandemic periods.
    MeSH term(s) COVID-19 ; Female ; Humans ; Infant ; Infant Mortality ; Infant, Newborn ; Morbidity ; Pandemics ; Pregnancy ; Pregnancy Outcome ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-10-27
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2441816-X
    ISSN 2212-1692 ; 1875-9572
    ISSN (online) 2212-1692
    ISSN 1875-9572
    DOI 10.1016/j.pedneo.2021.08.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Retinal Findings of Hospitalized Neonates Recovered from COVID-19 Infection: A Prospective, Observational, Descriptive Study.

    Aktürk Acar, Filiz / Esenülkü, Mahmut Cenap / Hekimoğlu, Berna

    Journal of tropical pediatrics

    2022  Volume 68, Issue 3

    Abstract: Purpose: Coronavirus disease 2019 (COVID-19) that is caused by severe acute respiratory syndrome coronavirus 2 can cause microvascular alterations that can lead to irreversible complications in multiple tissues and organs. Detrimental effects of COVID- ... ...

    Abstract Purpose: Coronavirus disease 2019 (COVID-19) that is caused by severe acute respiratory syndrome coronavirus 2 can cause microvascular alterations that can lead to irreversible complications in multiple tissues and organs. Detrimental effects of COVID-19 on retinal structure have recently been reported in adult population. However, literature data about neonatal population is very scarce. Thus, we aimed to assess possible retinal changes of neonates recovered from COVID-19 infection in this prospective, observational, descriptive study.
    Methods: The neonates recovered from COVID-19 infection were included to the study between 01 September 2020 and 30 April 2021. Their initial ophthalmological examination was made after a negative real-time reverse transcription-polymerase chain reaction obtained and all patients were re-examined 1 month later. All examinations were performed by same retina specialist using a binocular indirect ophthalmoscopy.
    Results: A total of 15 neonates [9 (60%) male, 6 (40%) female, mean gestational age of 38.9 ± 0.9 weeks (ranging from 37 to 40 week)] were evaluated in the study. The mean age at the time of hospitalization was 17.5 ± 8.7 days (ranging from 2 to 29 days), and the mean duration of hospitalization was 12.5 ± 6.2 days (ranging from 4 to 27 days). Except for one patient with bilateral avascular area in Zone-III, no further retinal manifestation related to COVID-19 was found in the study.
    Conclusion: COVID-19 infection can cause retinal damage in neonates. Therefore, these patients should be closely monitored for signs of ocular involvement.
    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/diagnosis ; Female ; Hospitalization ; Humans ; Infant ; Infant, Newborn ; Male ; Prospective Studies ; Retina ; SARS-CoV-2
    Language English
    Publishing date 2022-05-18
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 800065-7
    ISSN 1465-3664 ; 0449-3281 ; 0142-6338
    ISSN (online) 1465-3664
    ISSN 0449-3281 ; 0142-6338
    DOI 10.1093/tropej/fmac036
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  3. Article ; Online: Risk Factors and Clinical Characteristics of Metabolic Bone Disease of Prematurity.

    Mutlu, Mehmet / Aktürk-Acar, Filiz / Kader, Şebnem / Aslan, Yakup / Karagüzel, Gülay

    American journal of perinatology

    2021  Volume 40, Issue 5, Page(s) 519–524

    Abstract: Objective: The study aimed to analyze the risk factors and clinical features of metabolic bone disease of prematurity (MBDP) in premature infants compared with infants of similar gestational age and birth weight without MBDP.: Study design: This ... ...

    Abstract Objective: The study aimed to analyze the risk factors and clinical features of metabolic bone disease of prematurity (MBDP) in premature infants compared with infants of similar gestational age and birth weight without MBDP.
    Study design: This retrospective case-control study was performed by comparing 81 cases of MBDP with 63 controls to identify potential risk factors. Premature infants with a gestational age ≤33 weeks and birth weight <1,500 g were included. Medical records were examined in terms of maternal conditions, potential risk factors, and clinical characteristics.
    Results: Bone fractures and invasive ventilator dependence were the most common clinical features of MBDP. Duration of invasive ventilation and total mechanical ventilation days, necrotizing enterocolitis, corticosteroid use, anticonvulsive drug use, duration of dexamethasone and caffeine use, total parenteral nutrition, and length of hospitalization were significantly higher in neonates with MBDP (
    Conclusion: Our results show that anticonvulsive drug use is a significant risk factor for the development of MBDP. If long-term use is not required, anticonvulsive drugs should be stopped as soon as possible. Further studies involving patients with MBDP are required to determine the risk factors and clinical features.
    Key points: · MBDP is a multifactorial disorder.. · Anticonvulsive drug use is an important risk factor for the development of MBDP.. · Bone fractures and invasive ventilator dependence are the most common clinical features of MBDP..
    MeSH term(s) Infant ; Female ; Infant, Newborn ; Humans ; Birth Weight ; Retrospective Studies ; Case-Control Studies ; Anticonvulsants ; Infant, Premature ; Bone Diseases, Metabolic/epidemiology ; Risk Factors ; Infant, Newborn, Diseases ; Fractures, Bone ; Enterocolitis, Necrotizing/epidemiology ; Infant, Very Low Birth Weight
    Chemical Substances Anticonvulsants
    Language English
    Publishing date 2021-05-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0041-1729559
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Preventive Effects of Probiotic Supplementation on Neonatal Hyperbilirubinemia Caused by Isoimmunization.

    Mutlu, Mehmet / Aslan, Yakup / Kader, Şebnem / Aktürk Acar, Filiz

    American journal of perinatology

    2019  Volume 37, Issue 11, Page(s) 1173–1176

    Abstract: Objective: Probiotic supplementation can help to improve recovery from jaundice by reducing enterohepatic circulation through the regulation of intestinal microbial flora. The aim of our study was to investigate the effect of probiotic supplementation ... ...

    Abstract Objective: Probiotic supplementation can help to improve recovery from jaundice by reducing enterohepatic circulation through the regulation of intestinal microbial flora. The aim of our study was to investigate the effect of probiotic supplementation on neonatal hyperbilirubinemia caused by isoimmunization alone.
    Study design: Sixty neonates were randomly divided into a placebo group and a probiotic group (
    Results: STB and rebound STB levels at 36 hours were lower in the probiotic group than in the placebo group (
    Conclusion: Probiotics do not affect STB levels in the first 24 hours of life or duration of phototherapy in neonates with jaundice caused by blood group incompatibility. The effect of probiotic supplementation by reducing enterohepatic circulation occurs at 36 hours of life in newborns with isoimmunization.
    MeSH term(s) Bilirubin/blood ; Female ; Humans ; Hyperbilirubinemia, Neonatal/blood ; Hyperbilirubinemia, Neonatal/microbiology ; Hyperbilirubinemia, Neonatal/therapy ; Infant, Newborn ; Lactobacillus rhamnosus ; Male ; Meconium/physiology ; Phototherapy ; Probiotics/therapeutic use ; Prospective Studies ; Turkey
    Chemical Substances Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2019-06-26
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0039-1692690
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Clinical signs and symptoms of toxic serum digoxin levels in neonates.

    Mutlu, Mehmet / Aslan, Yakup / Kader, Şebnem / Aktürk-Acar, Filiz / Dilber, Embiya

    The Turkish journal of pediatrics

    2020  Volume 61, Issue 2, Page(s) 244–249

    Abstract: Mutlu M, Aslan Y, Kader Ş, Aktürk-Acar F, Dilber E. Clinical signs and symptoms of toxic serum ...

    Abstract Mutlu M, Aslan Y, Kader Ş, Aktürk-Acar F, Dilber E. Clinical signs and symptoms of toxic serum digoxin levels in neonates. Turk J Pediatr 2019; 61: 244-249. Digoxin is widely used in the treatment of congestive heart failure and some arrhythmias. Digoxin toxicity may occur easily because digoxin has a narrow therapeutic index. This retrospective study was conducted to evaluate the clinical signs and symptoms of toxic serum digoxin levels in neonates. Medical reports of the neonates who had serum digoxin concentrations > 2 nanogram/milliliter (ng/ml) were reviewed in terms of patient demographics, serum digoxin concentrations, signs and symptoms of digoxin toxicity, serum digoxin and electrolyte levels, renal function tests, electrocardiograms, echocardiography, and treatments applied. Digoxin toxic levels were identified in the 13 neonates. Of the 13 neonates with digoxin toxic level, 9 (69%) were term and 8 (62%) were female. Twenty-three percent (3/13) of newborn infants were symptomatic. Symptomatic patients had statistically significantly higher serum digoxin levels, at 7.76±2.76 (5.4-10.8) ng/ml, than asymptomatic patients, at 3.31±1.09 (2.02-4.95) (p=0.036). Symptoms related to toxic digoxin levels were observed in the three neonates with plasma digoxin levels > 5 ng/ml. Gastrointestinal and central nervous system symptoms were the major clinic findings. Despite high digoxin levels, no digoxin-related arrhythmia was observed on electrocardiography, other than sinus bradycardia. Two premature neonates were treated with digoxin-specific antibody Fab fragments (DigiFab®) and hypokalemia developed in both of them. Our data suggests that symptoms related with digoxin toxic levels were observed in neonates with plasma digoxin levels > 5 ng/ml. Serum digoxin levels should be measured in case of signs and symptoms of digoxin toxicity or risk factors for such toxicity.
    MeSH term(s) Arrhythmias, Cardiac/blood ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/drug therapy ; Cardiotonic Agents/adverse effects ; Cardiotonic Agents/pharmacokinetics ; Digoxin/adverse effects ; Digoxin/pharmacokinetics ; Disease Progression ; Drug-Related Side Effects and Adverse Reactions/blood ; Echocardiography ; Electrocardiography/drug effects ; Female ; Heart Failure/blood ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Humans ; Immunoassay ; Infant, Newborn ; Male ; Retrospective Studies ; Risk Factors
    Chemical Substances Cardiotonic Agents ; Digoxin (73K4184T59)
    Language English
    Publishing date 2020-01-24
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 123487-0
    ISSN 0041-4301
    ISSN 0041-4301
    DOI 10.24953/turkjped.2019.02.013
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  6. Article ; Online: Changing trend of microbiologic profile and antibiotic susceptibility of the microorganisms isolated in the neonatal nosocomial sepsis: a 14 years analysis.

    Mutlu, Mehmet / Aslan, Yakup / Aktürk Acar, Filiz / Kader, Şebnem / Bayramoğlu, Gülçin / Yılmaz, Gürdal

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2019  Volume 33, Issue 21, Page(s) 3658–3665

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Drug Resistance, Microbial ; Humans ; Infant, Newborn ; Microbial Sensitivity Tests ; Neonatal Sepsis/drug therapy ; Sepsis/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2019-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2019.1582633
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  7. Article: Risk Factors and Clinical Characteristics of Metabolic Bone Disease of Prematurity

    Mutlu, Mehmet / Aktürk-Acar, Filiz / Kader, Şebnem / Aslan, Yakup / Karagüzel, Gülay

    American Journal of Perinatology

    2021  Volume 40, Issue 05, Page(s) 519–524

    Abstract: Objective: The study aimed to analyze the risk factors and clinical features of metabolic bone disease of prematurity (MBDP) in premature infants compared with infants of similar gestational age and birth weight without MBDP.: Study Design: This ... ...

    Abstract Objective: The study aimed to analyze the risk factors and clinical features of metabolic bone disease of prematurity (MBDP) in premature infants compared with infants of similar gestational age and birth weight without MBDP.
    Study Design: This retrospective case–control study was performed by comparing 81 cases of MBDP with 63 controls to identify potential risk factors. Premature infants with a gestational age ≤33 weeks and birth weight <1,500 g were included. Medical records were examined in terms of maternal conditions, potential risk factors, and clinical characteristics.
    Results: Bone fractures and invasive ventilator dependence were the most common clinical features of MBDP. Duration of invasive ventilation and total mechanical ventilation days, necrotizing enterocolitis, corticosteroid use, anticonvulsive drug use, duration of dexamethasone and caffeine use, total parenteral nutrition, and length of hospitalization were significantly higher in neonates with MBDP ( p  < 0.05). Breastfed neonates and those receiving human milk fortifier had a lower incidence of MBDP than those premature formula or mixed feeding ( p  < 0.05). Anticonvulsive drug use (odds ratio: 2.935; 95% confidence interval: 1.265–6.810) was identified as a risk factor for MBDP at multiple regression analysis.
    Conclusion: Our results show that anticonvulsive drug use is a significant risk factor for the development of MBDP. If long-term use is not required, anticonvulsive drugs should be stopped as soon as possible. Further studies involving patients with MBDP are required to determine the risk factors and clinical features.
    Key Points: MBDP is a multifactorial disorder. Anticonvulsive drug use is an important risk factor for the development of MBDP. Bone fractures and invasive ventilator dependence are the most common clinical features of MBDP.
    Keywords metabolic bone disease ; prematurity ; risk factor
    Language English
    Publishing date 2021-05-11
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0041-1729559
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  8. Article: Antenatal Bartter Syndrome Caused by a Novel Homozygous Mutation in

    Acar, Filiz Aktürk / Işik, Güneş / Mutlu, Mehmet / Kader, Şebnem / Aslan, Yakup / Kalyoncu, Mukaddes

    Indian journal of nephrology

    2018  Volume 29, Issue 5, Page(s) 360–363

    Abstract: Antenatal Bartter syndrome (BS) is an autosomal recessive hereditary renal tubular disorder caused by mutation in ... ...

    Abstract Antenatal Bartter syndrome (BS) is an autosomal recessive hereditary renal tubular disorder caused by mutation in the
    Language English
    Publishing date 2018-09-19
    Publishing country India
    Document type Case Reports
    ZDB-ID 2134388-3
    ISSN 1998-3662 ; 0971-4065
    ISSN (online) 1998-3662
    ISSN 0971-4065
    DOI 10.4103/ijn.IJN_175_18
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  9. Article: ARC syndrome.

    Mutlu, Mehmet / Aslan, Yakup / Aktürk-Acar, Filiz / Çakır, Murat / Erduran, Erol / Kalyoncu, Mukaddes

    The Turkish journal of pediatrics

    2018  Volume 59, Issue 4, Page(s) 487–490

    Abstract: Mutlu M, Aslan Y, Aktürk-Acar F, Çakır M, Erduran E, Kalyoncu M. ARC syndrome. Turk J Pediatr 2017 ...

    Abstract Mutlu M, Aslan Y, Aktürk-Acar F, Çakır M, Erduran E, Kalyoncu M. ARC syndrome. Turk J Pediatr 2017; 59: 487-490. Arthrogryposis-renal dysfunction-cholestasis (ARC) is an autosomal recessive multisystem disorder characterized by arthrogryposis, renal tubular dysfunction and neonatal cholestasis with low gamma glutamyl transpeptidase activity. Most of the mutations in ARC syndrome are associated with the vacuolar protein sorting 33B (VPS33B) gene on chromosome 15q26.1. Herein, we report a female newborn with ARC syndrome caused by homozygous mutations in VPS33B [IVS1-2A > C (c.97-2A > C)].
    MeSH term(s) Arthrogryposis/diagnosis ; Arthrogryposis/genetics ; Cholestasis/diagnosis ; Cholestasis/genetics ; Fatal Outcome ; Female ; Homozygote ; Humans ; Infant, Newborn ; Mutation ; Renal Insufficiency/diagnosis ; Renal Insufficiency/genetics ; Vesicular Transport Proteins/genetics
    Chemical Substances VPS33B protein, human ; Vesicular Transport Proteins
    Language English
    Publishing date 2018-05-09
    Publishing country Turkey
    Document type Case Reports ; Journal Article
    ZDB-ID 123487-0
    ISSN 0041-4301
    ISSN 0041-4301
    DOI 10.24953/turkjped.2017.04.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Nuclear Projections in Neutrophils for Supporting the Diagnosis of Trisomy 13.

    Kader, Şebnem / Mutlu, Mehmet / Aktürk Acar, Filiz / Aslan, Yakup / Erduran, Erol

    Turkish journal of haematology : official journal of Turkish Society of Haematology

    2017  Volume 35, Issue 2, Page(s) 144

    Title translation Trisomi 13 Tanısını Desteklemede Nötrofillerdeki Nükleer Çıkıntılar.
    MeSH term(s) Cell Nucleus/pathology ; Humans ; Infant, Newborn ; Karyotyping ; Neutrophils/pathology ; Trisomy 13 Syndrome/blood ; Trisomy 13 Syndrome/diagnosis ; Trisomy 13 Syndrome/genetics ; Trisomy 13 Syndrome/pathology
    Language English
    Publishing date 2017-07-27
    Publishing country Turkey
    Document type Case Reports ; Letter
    ZDB-ID 2185903-6
    ISSN 1308-5263 ; 1300-7777
    ISSN (online) 1308-5263
    ISSN 1300-7777
    DOI 10.4274/tjh.2017.0227
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