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Article: Dementia and functional decline in patients with Parkinson's disease.

Stella, Florindo / Banzato, Claudio Eduardo Muller / Quagliato, Elizabeth Maria Aparecida Barasnevicius / Viana, Maura Aparecida / Christofoletti, Gustavo

Dementia & neuropsychologia

2017 Volume 2, Issue 2, Page(s) 96–101

Abstract: Functional decline in Parkinson's disease (PD), characterized by reduced ability to carry out activities of daily living, usually results from typical motor impairment and may be aggravated by concomitant cognitive impairment.: Objective: To compare ... ...

Abstract	Functional decline in Parkinson's disease (PD), characterized by reduced ability to carry out activities of daily living, usually results from typical motor impairment and may be aggravated by concomitant cognitive impairment. Objective: To compare the functional decline in Parkinson's disease between patients with dementia and cognitively preserved patients. Methods: From an original sample composed of 50 patients with a clinical diagnosis of idiopathic PD seen in a consecutive series, 33 non-depressed patients were selected comprising 13 with dementia and 20 cognitively preserved individuals. All patients enrolled in this study were drawn from a public outpatient clinic, specialized in movement disorders. The clinical stage of PD was determined by the Hoehn & Yahr scale, and the functional capacity was verified using the Unified Parkinson's Disease Rating Scale UPDRS ADL (subscale II: activities of daily living) and the Schwab & England scale. The two last scales measure the functional degree of independence in activities of daily living. The neuropsychological assessment was performed using The Cambridge Examination for Mental Disorders of the Elderly - CAMCOG, Cognitive Section and the Stroop Color Word Test. Results: As expected, in comparison with cognitively preserved patients, the group with dementia presented significantly lower scores throughout the neuropsychological evaluation. The patients with dementia were found to have a longer period of disease, a more advanced clinical staging according to the Hoehn & Yahr, and greater functional decline according both to the UPDRS ADL and Schwab & England, with statistically significant difference between the groups. Conclusion: Patients with dementia were at a more advanced clinical stage of Parkinson's disease and evidenced greater functional decline in comparison with patients without dementia.
Language	English
Publishing date	2017-08-22
Publishing country	Brazil
Document type	Journal Article
ISSN	1980-5764
ISSN	1980-5764
DOI	10.1590/S1980-57642009DN20200004
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Article ; Online: Applications of visual evoked potentials and Fourier-domain optical coherence tomography in Parkinson's disease: a controlled study.

Quagliato, Lucas Barasnevicius / Domingues, Carolina / Quagliato, Elizabeth Maria Aparecida Barasnevicius / Abreu, Elvira Barbosa de / Kara-Junior, Newton

Arquivos brasileiros de oftalmologia

2014 Volume 77, Issue 4, Page(s) 238–242

Abstract: Purpose: The goal of this cross-sectional observational study was to quantify the pattern-shift visual evoked potentials (VEP) and the thickness as well as the volume of retinal layers using optical coherence tomography (OCT) across a cohort of ... ...

Abstract	Purpose: The goal of this cross-sectional observational study was to quantify the pattern-shift visual evoked potentials (VEP) and the thickness as well as the volume of retinal layers using optical coherence tomography (OCT) across a cohort of Parkinson's disease (PD) patients and age-matched controls. Methods: Forty-three PD patients and 38 controls were enrolled. All participants underwent a detailed neurological and ophthalmologic evaluation. Idiopathic PD cases were included. Cases with glaucoma or increased intra-ocular pressure were excluded. Patients were assessed by VEP and high-resolution Fourier-domain OCT, which quantified the inner and outer thicknesses of the retinal layers. VEP latencies and the thicknesses of the retinal layers were the main outcome measures. Results: The mean age, with standard deviation (SD), of the PD patients and controls were 63.1 (7.5) and 62.4 (7.2) years, respectively. The patients were predominantly in the initial Hoehn-Yahr (HY) disease stages (34.8% in stage 1 or 1.5, and 55.8 % in stage 2). The VEP latencies and the thicknesses as well as the volumes of the retinal inner and outer layers of the groups were similar. A negative correlation between the retinal thickness and the age was noted in both groups. The thickness of the retinal nerve fibre layer (RNFL) was 102.7 μm in PD patients vs. 104.2 μm in controls. Conclusions: The thicknesses of retinal layers, VEP, and RNFL of PD patients were similar to those of the controls. Despite the use of a representative cohort of PD patients and high-resolution OCT in this study, further studies are required to establish the validity of using OCT and VEP measurements as the anatomic and functional biomarkers for the evaluation of retinal and visual pathways in PD patients.
MeSH term(s)	Case-Control Studies ; Cross-Sectional Studies ; Evoked Potentials, Visual ; Female ; Fourier Analysis ; Humans ; Male ; Middle Aged ; Parkinson Disease/physiopathology ; Retina/anatomy & histology ; Tomography, Optical Coherence/methods
Language	English
Publishing date	2014-10-16
Publishing country	Brazil
Document type	Journal Article ; Observational Study
ZDB-ID	603915-7
ISSN	1678-2925 ; 0004-2749
ISSN (online)	1678-2925
ISSN	0004-2749
DOI	10.5935/0004-2749.20140061
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Article ; Online: Topiramate-associated acute, bilateral, angle-closure glaucoma: case report.

Quagliato, Lucas Barasnevicius / Barella, Kleyton / Abreu Neto, José Maria / Quagliato, Elizabeth Maria Aparecida Barasnevicius

Arquivos brasileiros de oftalmologia

2013 Volume 76, Issue 1, Page(s) 48–49

Abstract: This paper describes a topiramate induced acute bilateral angle-closure glaucoma. This rare adverse effect is an idiosyncratic reaction characterized by uveal effusion and lens forward displacement, leading to increased intraocular pressure and vision ... ...

Abstract	This paper describes a topiramate induced acute bilateral angle-closure glaucoma. This rare adverse effect is an idiosyncratic reaction characterized by uveal effusion and lens forward displacement, leading to increased intraocular pressure and vision loss. We describe a 55 year-old white woman with migraine, spasmodic torticollis and essential tremor, who developed bilateral acute angle-closure glaucoma, one week after starting topiramate 25 mg/day. She was seen at the Ophthalmology Emergency Department of the Fundação João Penido Burnier (Campinas, SP, Brazil) with a 4 hours history of blurry vision, ocular pain and bright flashes vision. Slit lamp examination revealed moderate conjunctival injection and corneal edema, and shallow anterior chambers. Intraocular pressure was 48 mmHg in both eyes. Fundoscopic examination findings were normal. She was treated with timolol, brimonidine, dorzolamide, pilocarpine, prednisone acetate eye drops and acetazolamide. One hour after those measures, as the intraocular pressure was 30 mmHg, she received a manitol intravenous injection and the intraocular pressure normalized. After 24 hours an iridotomy with Yag laser was performed. Topiramate was discontinued and she was totally recovered after one week.
MeSH term(s)	Female ; Fructose/adverse effects ; Fructose/analogs & derivatives ; Glaucoma, Angle-Closure/chemically induced ; Humans ; Middle Aged ; Migraine Disorders/prevention & control ; Neuroprotective Agents/adverse effects ; Topiramate
Chemical Substances	Neuroprotective Agents ; Topiramate (0H73WJJ391) ; Fructose (30237-26-4)
Language	English
Publishing date	2013-06-28
Publishing country	Brazil
Document type	Case Reports ; Journal Article
ZDB-ID	603915-7
ISSN	1678-2925 ; 0004-2749
ISSN (online)	1678-2925
ISSN	0004-2749
DOI	10.1590/s0004-27492013000100014
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Article ; Online: Topiramate-associated acute, bilateral, angle-closure glaucoma

Lucas Barasnevicius Quagliato / Kleyton Barella / José Maria Abreu Neto / Elizabeth Maria Aparecida Barasnevicius Quagliato

Arquivos Brasileiros de Oftalmologia, Vol 76, Iss 1, Pp 48-

case report

2013 Volume 49

Abstract	This paper describes a topiramate induced acute bilateral angle-closure glaucoma. This rare adverse effect is an idiosyncratic reaction characterized by uveal effusion and lens forward displacement, leading to increased intraocular pressure and vision loss. We describe a 55 year-old white woman with migraine, spasmodic torticollis and essential tremor, who developed bilateral acute angle-closure glaucoma, one week after starting topiramate 25 mg/day. She was seen at the Ophthalmology Emergency Department of the Fundação João Penido Burnier (Campinas, SP, Brazil) with a 4 hours history of blurry vision, ocular pain and bright flashes vision. Slit lamp examination revealed moderate conjunctival injection and corneal edema, and shallow anterior chambers. Intraocular pressure was 48 mmHg in both eyes. Fundoscopic examination findings were normal. She was treated with timolol, brimonidine, dorzolamide, pilocarpine, prednisone acetate eye drops and acetazolamide. One hour after those measures, as the intraocular pressure was 30 mmHg, she received a manitol intravenous injection and the intraocular pressure normalized. After 24 hours an iridotomy with Yag laser was performed. Topiramate was discontinued and she was totally recovered after one week.
Keywords	Glaucoma ; ângulo-fechado ; Anticonvulsivantes ; Pressão intraocular ; Doenças uveais ; Relato de caso ; Ophthalmology ; RE1-994 ; Medicine ; R
Language	English
Publishing date	2013-02-01T00:00:00Z
Publisher	Conselho Brasileiro de Oftalmologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Topiramate-associated acute, bilateral, angle-closure glaucoma

Lucas Barasnevicius Quagliato / Kleyton Barella / José Maria Abreu Neto / Elizabeth Maria Aparecida Barasnevicius Quagliato

Arquivos Brasileiros de Oftalmologia, Vol 76, Iss 1, Pp 48-

case report

2013 Volume 49

Abstract	This paper describes a topiramate induced acute bilateral angle-closure glaucoma. This rare adverse effect is an idiosyncratic reaction characterized by uveal effusion and lens forward displacement, leading to increased intraocular pressure and vision loss. We describe a 55 year-old white woman with migraine, spasmodic torticollis and essential tremor, who developed bilateral acute angle-closure glaucoma, one week after starting topiramate 25 mg/day. She was seen at the Ophthalmology Emergency Department of the Fundação João Penido Burnier (Campinas, SP, Brazil) with a 4 hours history of blurry vision, ocular pain and bright flashes vision. Slit lamp examination revealed moderate conjunctival injection and corneal edema, and shallow anterior chambers. Intraocular pressure was 48 mmHg in both eyes. Fundoscopic examination findings were normal. She was treated with timolol, brimonidine, dorzolamide, pilocarpine, prednisone acetate eye drops and acetazolamide. One hour after those measures, as the intraocular pressure was 30 mmHg, she received a manitol intravenous injection and the intraocular pressure normalized. After 24 hours an iridotomy with Yag laser was performed. Topiramate was discontinued and she was totally recovered after one week.
Keywords	Glaucoma ; ângulo-fechado ; Anticonvulsivantes ; Pressão intraocular ; Doenças uveais ; Relato de caso ; Ophthalmology ; RE1-994 ; Medicine ; R
Language	English
Publishing date	2013-02-01T00:00:00Z
Publisher	Conselho Brasileiro de Oftalmologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

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Article ; Online: Topiramate-associated acute, bilateral, angle-closure glaucoma

Lucas Barasnevicius Quagliato / Kleyton Barella / José Maria Abreu Neto / Elizabeth Maria Aparecida Barasnevicius Quagliato

Arquivos Brasileiros de Oftalmologia, Vol 76, Iss 1, Pp 48-

case report

2013 Volume 49

Abstract	This paper describes a topiramate induced acute bilateral angle-closure glaucoma. This rare adverse effect is an idiosyncratic reaction characterized by uveal effusion and lens forward displacement, leading to increased intraocular pressure and vision loss. We describe a 55 year-old white woman with migraine, spasmodic torticollis and essential tremor, who developed bilateral acute angle-closure glaucoma, one week after starting topiramate 25 mg/day. She was seen at the Ophthalmology Emergency Department of the Fundação João Penido Burnier (Campinas, SP, Brazil) with a 4 hours history of blurry vision, ocular pain and bright flashes vision. Slit lamp examination revealed moderate conjunctival injection and corneal edema, and shallow anterior chambers. Intraocular pressure was 48 mmHg in both eyes. Fundoscopic examination findings were normal. She was treated with timolol, brimonidine, dorzolamide, pilocarpine, prednisone acetate eye drops and acetazolamide. One hour after those measures, as the intraocular pressure was 30 mmHg, she received a manitol intravenous injection and the intraocular pressure normalized. After 24 hours an iridotomy with Yag laser was performed. Topiramate was discontinued and she was totally recovered after one week.
Keywords	Glaucoma ; ângulo-fechado ; Anticonvulsivantes ; Pressão intraocular ; Doenças uveais ; Relato de caso ; Ophthalmology ; RE1-994 ; Medicine ; R
Language	English
Publishing date	2013-02-01T00:00:00Z
Publisher	Conselho Brasileiro de Oftalmologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

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Article ; Online: Topiramate-associated acute, bilateral, angle-closure glaucoma

Lucas Barasnevicius Quagliato / Kleyton Barella / José Maria Abreu Neto / Elizabeth Maria Aparecida Barasnevicius Quagliato

Arquivos Brasileiros de Oftalmologia, Vol 76, Iss 1, Pp 48-

case report

2013 Volume 49

Abstract	This paper describes a topiramate induced acute bilateral angle-closure glaucoma. This rare adverse effect is an idiosyncratic reaction characterized by uveal effusion and lens forward displacement, leading to increased intraocular pressure and vision loss. We describe a 55 year-old white woman with migraine, spasmodic torticollis and essential tremor, who developed bilateral acute angle-closure glaucoma, one week after starting topiramate 25 mg/day. She was seen at the Ophthalmology Emergency Department of the Fundação João Penido Burnier (Campinas, SP, Brazil) with a 4 hours history of blurry vision, ocular pain and bright flashes vision. Slit lamp examination revealed moderate conjunctival injection and corneal edema, and shallow anterior chambers. Intraocular pressure was 48 mmHg in both eyes. Fundoscopic examination findings were normal. She was treated with timolol, brimonidine, dorzolamide, pilocarpine, prednisone acetate eye drops and acetazolamide. One hour after those measures, as the intraocular pressure was 30 mmHg, she received a manitol intravenous injection and the intraocular pressure normalized. After 24 hours an iridotomy with Yag laser was performed. Topiramate was discontinued and she was totally recovered after one week.
Keywords	Glaucoma ; ângulo-fechado ; Anticonvulsivantes ; Pressão intraocular ; Doenças uveais ; Relato de caso ; Ophthalmology ; RE1-994 ; Medicine ; R
Language	English
Publishing date	2013-02-01T00:00:00Z
Publisher	Conselho Brasileiro de Oftalmologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

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Article ; Online: Topiramate-associated acute, bilateral, angle-closure glaucoma

Lucas Barasnevicius Quagliato / Kleyton Barella / José Maria Abreu Neto / Elizabeth Maria Aparecida Barasnevicius Quagliato

Arquivos Brasileiros de Oftalmologia, Vol 76, Iss 1, Pp 48-

case report

2013 Volume 49

Abstract	This paper describes a topiramate induced acute bilateral angle-closure glaucoma. This rare adverse effect is an idiosyncratic reaction characterized by uveal effusion and lens forward displacement, leading to increased intraocular pressure and vision loss. We describe a 55 year-old white woman with migraine, spasmodic torticollis and essential tremor, who developed bilateral acute angle-closure glaucoma, one week after starting topiramate 25 mg/day. She was seen at the Ophthalmology Emergency Department of the Fundação João Penido Burnier (Campinas, SP, Brazil) with a 4 hours history of blurry vision, ocular pain and bright flashes vision. Slit lamp examination revealed moderate conjunctival injection and corneal edema, and shallow anterior chambers. Intraocular pressure was 48 mmHg in both eyes. Fundoscopic examination findings were normal. She was treated with timolol, brimonidine, dorzolamide, pilocarpine, prednisone acetate eye drops and acetazolamide. One hour after those measures, as the intraocular pressure was 30 mmHg, she received a manitol intravenous injection and the intraocular pressure normalized. After 24 hours an iridotomy with Yag laser was performed. Topiramate was discontinued and she was totally recovered after one week.
Keywords	Glaucoma ; ângulo-fechado ; Anticonvulsivantes ; Pressão intraocular ; Doenças uveais ; Relato de caso ; Ophthalmology ; RE1-994 ; Medicine ; R
Language	English
Publishing date	2013-02-01T00:00:00Z
Publisher	Conselho Brasileiro de Oftalmologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Applications of visual evoked potentials and Fourier-domain optical coherence tomography in Parkinson's disease

Lucas Barasnevicius Quagliato / Carolina Domingues / Elizabeth Maria Aparecida Barasnevicius Quagliato / Elvira Barbosa de Abreu / Newton Kara-Junior

Arquivos Brasileiros de Oftalmologia, Vol 77, Iss 4, Pp 238-

a controlled study

2014 Volume 242

Abstract	Purpose: The goal of this cross-sectional observational study was to quantify the pattern-shift visual evoked potentials (VEP) and the thickness as well as the volume of retinal layers using optical coherence tomography (OCT) across a cohort of Parkinson's disease (PD) patients and age-matched controls. Methods: Forty-three PD patients and 38 controls were enrolled. All participants underwent a detailed neurological and ophthalmologic evaluation. Idiopathic PD cases were included. Cases with glaucoma or increased intra-ocular pressure were excluded. Patients were assessed by VEP and high-resolution Fourier-domain OCT, which quantified the inner and outer thicknesses of the retinal layers. VEP latencies and the thicknesses of the retinal layers were the main outcome measures. Results: The mean age, with standard deviation (SD), of the PD patients and controls were 63.1 (7.5) and 62.4 (7.2) years, respectively. The patients were predominantly in the initial Hoehn-Yahr (HY) disease stages (34.8% in stage 1 or 1.5, and 55.8 % in stage 2). The VEP latencies and the thicknesses as well as the volumes of the retinal inner and outer layers of the groups were similar. A negative correlation between the retinal thickness and the age was noted in both groups. The thickness of the retinal nerve fibre layer (RNFL) was 102.7 μm in PD patients vs. 104.2 μm in controls. Conclusions: The thicknesses of retinal layers, VEP, and RNFL of PD patients were similar to those of the controls. Despite the use of a representative cohort of PD patients and high-resolution OCT in this study, further studies are required to establish the validity of using OCT and VEP measurements as the anatomic and functional biomarkers for the evaluation of retinal and visual pathways in PD patients.
Keywords	Potenciais evocados visuais ; Tomografia de coerência óptica/métodos ; Ophthalmology ; RE1-994 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2014-08-01T00:00:00Z
Publisher	Conselho Brasileiro de Oftalmologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

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Article ; Online: Applications of visual evoked potentials and Fourier-domain optical coherence tomography in Parkinson's disease

Lucas Barasnevicius Quagliato / Carolina Domingues / Elizabeth Maria Aparecida Barasnevicius Quagliato / Elvira Barbosa de Abreu / Newton Kara-Junior

Arquivos Brasileiros de Oftalmologia, Vol 77, Iss 4, Pp 238-

a controlled study

2014 Volume 242

Abstract	Purpose: The goal of this cross-sectional observational study was to quantify the pattern-shift visual evoked potentials (VEP) and the thickness as well as the volume of retinal layers using optical coherence tomography (OCT) across a cohort of Parkinson's disease (PD) patients and age-matched controls. Methods: Forty-three PD patients and 38 controls were enrolled. All participants underwent a detailed neurological and ophthalmologic evaluation. Idiopathic PD cases were included. Cases with glaucoma or increased intra-ocular pressure were excluded. Patients were assessed by VEP and high-resolution Fourier-domain OCT, which quantified the inner and outer thicknesses of the retinal layers. VEP latencies and the thicknesses of the retinal layers were the main outcome measures. Results: The mean age, with standard deviation (SD), of the PD patients and controls were 63.1 (7.5) and 62.4 (7.2) years, respectively. The patients were predominantly in the initial Hoehn-Yahr (HY) disease stages (34.8% in stage 1 or 1.5, and 55.8 % in stage 2). The VEP latencies and the thicknesses as well as the volumes of the retinal inner and outer layers of the groups were similar. A negative correlation between the retinal thickness and the age was noted in both groups. The thickness of the retinal nerve fibre layer (RNFL) was 102.7 μm in PD patients vs. 104.2 μm in controls. Conclusions: The thicknesses of retinal layers, VEP, and RNFL of PD patients were similar to those of the controls. Despite the use of a representative cohort of PD patients and high-resolution OCT in this study, further studies are required to establish the validity of using OCT and VEP measurements as the anatomic and functional biomarkers for the evaluation of retinal and visual pathways in PD patients.
Keywords	Potenciais evocados visuais ; Tomografia de coerência óptica/métodos ; Ophthalmology ; RE1-994 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2014-08-01T00:00:00Z
Publisher	Conselho Brasileiro de Oftalmologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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