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  1. Article ; Online: The Role of Optical Coherence Tomography and Optical Coherence Tomography Angiography in the Differential Diagnosis of Posterior Uveitis.

    Agarwal, Aniruddha / Invernizzi, Alessandro

    Ocular immunology and inflammation

    2022  Volume 30, Issue 3, Page(s) 682–689

    Abstract: Purpose: Modalities such as optical coherence tomography (OCT) and OCT angiography (OCTA) have improved the diagnostic utility of fundus imaging in management of uveitis. The purpose of this study is to review role of OCT and OCTA in differential ... ...

    Abstract Purpose: Modalities such as optical coherence tomography (OCT) and OCT angiography (OCTA) have improved the diagnostic utility of fundus imaging in management of uveitis. The purpose of this study is to review role of OCT and OCTA in differential diagnosis of certain posterior uveitic entities.
    Methods: Narrative review.
    Results: In this review, we have comprehensively summarized the utility of OCT and OCTA in helping the clinician diagnose common but challenging inflammatory conditions including ocular toxoplasmosis, viral retinitis, and vitreoretinal lymphoma, among others. OCT and OCTA can also be used to assess the choriocapillaris involvement in conditions such as multiple evanescent white dot syndrome, and choroidal granulomas in tubercular and sarcoid uveitis.
    Conclusions: Fundus imaging with OCT and OCTA has assumed a significant role in establishing the diagnosis in uveitis apart from microbiological and other laboratory analysis. Advantages such as rapidity and non-invasiveness make these imaging modalities very useful and convenient.
    MeSH term(s) Diagnosis, Differential ; Fluorescein Angiography/methods ; Humans ; Retinal Neoplasms/diagnosis ; Tomography, Optical Coherence/methods ; Uveitis/diagnosis ; Vitreous Body ; White Dot Syndromes
    Language English
    Publishing date 2022-05-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2022.2071743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Algorithm-Based Risk Identification in Patients with Breast Cancer-Related Lymphedema: A Cross-Sectional Study.

    Nascimben, Mauro / Lippi, Lorenzo / de Sire, Alessandro / Invernizzi, Marco / Rimondini, Lia

    Cancers

    2023  Volume 15, Issue 2

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15020336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of MASLD and MetALD on clinical outcomes: A meta-analysis of preliminary evidence.

    Ciardullo, Stefano / Mantovani, Alessandro / Morieri, Mario Luca / Muraca, Emanuele / Invernizzi, Pietro / Perseghin, Gianluca

    Liver international : official journal of the International Association for the Study of the Liver

    2024  

    Abstract: A recent Delphi consensus proposed a new definition for metabolic dysfunction associated steatotic liver disease (MASLD) and introduced a disease entity called MetALD, a condition in which steatotic liver disease (SLD), metabolic dysfunction and moderate ...

    Abstract A recent Delphi consensus proposed a new definition for metabolic dysfunction associated steatotic liver disease (MASLD) and introduced a disease entity called MetALD, a condition in which steatotic liver disease (SLD), metabolic dysfunction and moderate alcohol intake coexist. Given the limited available data on the prognostic implications of these disease entities, we performed a systematic review and meta-analysis of available cohort studies to evaluate the association of MASLD and MetALD with hard clinical outcomes. We included 5 studies for a total of 9 824 047 participants. Compared with participants without SLD, increased rates of all-cause mortality and incident cardiovascular disease were present for both MASLD and MetALD. Moreover, MetALD was also associated with significantly higher risks of cancer-related mortality (n = 2 studies, random-effects HR 2.10, 95% CI 1.35-3.28) and cardiovascular mortality (n = 3 studies, random-effects HR 1.17, 95% CI 1.12-1.22). Although preliminary, available evidence indicates a more unfavourable prognosis for patients with MetALD compared with those with MASLD.
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Anterior Segment Optical Coherence Tomography (AS-OCT) Visualization of Anterior Vitritis.

    Zicarelli, Federico / Staurenghi, Giovanni / Invernizzi, Alessandro

    Ocular immunology and inflammation

    2022  Volume 31, Issue 5, Page(s) 1101–1102

    Abstract: The clinical grading of vitreous haze presents some limitations such as subjectivity and intra-grader variability. On the other hand the proposed OCT-based methods only explore the posterior part of the vitreous. Here we describe the inflammatory changes ...

    Abstract The clinical grading of vitreous haze presents some limitations such as subjectivity and intra-grader variability. On the other hand the proposed OCT-based methods only explore the posterior part of the vitreous. Here we describe the inflammatory changes affecting the anterior vitreous imaged by Anterior Segment Optical Coherence, Tomography (AS-OCT) from patients affected by uveitis. The AS-OCT (Anterion, Heidelberg Engineering, Heidelberg, Germany) detected vitreous sheets, vitreous lacunae, and formations resembling inflammatory cells, providing an objective characterization of the inflammatory changes in the anterior vitreous as well as their relationships with the other ocular structures.
    MeSH term(s) Humans ; Tomography, Optical Coherence/methods ; Uveitis/diagnosis ; Endophthalmitis ; Orbital Diseases ; Eye
    Language English
    Publishing date 2022-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2022.2079535
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  5. Article ; Online: OCT Angiography Reveals Bilateral Macular Neovascularization Encircling Macular Atrophy.

    Cozzi, Mariano / Airaldi, Matteo / Invernizzi, Alessandro

    Ophthalmology

    2021  Volume 128, Issue 9, Page(s) 1275

    MeSH term(s) Aged ; Atrophy ; Fluorescein Angiography ; Humans ; Macula Lutea/pathology ; Male ; Retinal Neovascularization/diagnosis ; Tomography, Optical Coherence
    Language English
    Publishing date 2021-06-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2021.02.023
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  6. Article ; Online: Oxygen-ozone therapy for pain relief in patients with trapeziometacarpal osteoarthritis: a proof-of-concept study.

    de Sire, Alessandro / Marotta, Nicola / Sconza, Cristiano / Lippi, Lorenzo / Drago Ferrante, Vera / Respizzi, Stefano / Invernizzi, Marco / Ammendolia, Antonio

    Disability and rehabilitation

    2024  , Page(s) 1–7

    Abstract: Purpose: Trapeziometacarpal osteoarthritis (TMC-OA) is a prevalent hand disorder affecting a growing number of people worldwide. While a multidisciplinary approach might provide additional advantages, the analgesic and anti-inflammatory role of intra- ... ...

    Abstract Purpose: Trapeziometacarpal osteoarthritis (TMC-OA) is a prevalent hand disorder affecting a growing number of people worldwide. While a multidisciplinary approach might provide additional advantages, the analgesic and anti-inflammatory role of intra-articular oxygen-ozone (O
    Materials and methods: A prospective open-label study conducted in the Physical and Rehabilitation Medicine Unit of the "Renato Dulbecco" University Hospital of Catanzaro. We assessed patients with TMC-OA who had not responded to standard medical therapy. Participants received O
    Results: Seventeen patients with a mean age of 67.1 ± 6.1 years were included in the study. Short-term improvements in pain intensity were observed (T0: 6.221 ± 1.514; T1: 3.172 ± 1.1451;
    Conclusions: A combination of O
    Language English
    Publishing date 2024-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1104775-6
    ISSN 1464-5165 ; 0963-8288
    ISSN (online) 1464-5165
    ISSN 0963-8288
    DOI 10.1080/09638288.2024.2342491
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  7. Article ; Online: Photodynamic Therapy for the Treatment of Vascularized Intraretinal Tuberculoma.

    Parrulli, Salvatore / Zicarelli, Federico / Torre, Alessandro / Pellegrini, Marco / Invernizzi, Alessandro

    Ocular immunology and inflammation

    2021  Volume 30, Issue 5, Page(s) 1203–1206

    Abstract: Purpose: To report a case of intraretinal tubercular granuloma successfully treated with photodynamic therapy (PDT).: Methods: Retrospective case report. Multimodal imaging was performed at each follow-up visit.: Results: The tuberculoma did not ... ...

    Abstract Purpose: To report a case of intraretinal tubercular granuloma successfully treated with photodynamic therapy (PDT).
    Methods: Retrospective case report. Multimodal imaging was performed at each follow-up visit.
    Results: The tuberculoma did not regress and did not significantly reduce its exudation after anti-tubercular therapy (ATT), systemic steroid therapy and intravitreal anti-VEGF. Second line treatment with PDT was attempted. The lesion showed a regression with reduced sub-retinal fluid and intra-retinal exudates. A second PDT was performed for reactivation of the lesion 5 months after the first treatment. Further regression of the lesion was observed.
    Conclusion: PDT may be a valuable second-line therapeutic approach for vascularized intraretinal granulomas.
    MeSH term(s) Angiogenesis Inhibitors ; Fluorescein Angiography ; Humans ; Intravitreal Injections ; Photochemotherapy/methods ; Photosensitizing Agents/therapeutic use ; Retrospective Studies ; Steroids/therapeutic use ; Tomography, Optical Coherence ; Tuberculoma/diagnosis ; Tuberculoma/drug therapy
    Chemical Substances Angiogenesis Inhibitors ; Photosensitizing Agents ; Steroids
    Language English
    Publishing date 2021-01-21
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2020.1869788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Optical Coherence Tomography Angiography Findings of Iris Ischemia and Reperfusion in Cytomegalovirus Panuveitis.

    Zicarelli, Federico / Parrulli, Salvatore / Torre, Alessandro / Oldani, Marta / Invernizzi, Alessandro

    Ocular immunology and inflammation

    2021  Volume 30, Issue 7-8, Page(s) 1595–1598

    Abstract: Purpose: To report a case of iris ischemia in an eye affected by Cytomegalovirus (CMV)-related Chronic Retinal Necrosis (CRN) with partial reperfusion after antiviral therapy demonstrated by optical coherence tomography angiography (OCTA).: Methods: ... ...

    Abstract Purpose: To report a case of iris ischemia in an eye affected by Cytomegalovirus (CMV)-related Chronic Retinal Necrosis (CRN) with partial reperfusion after antiviral therapy demonstrated by optical coherence tomography angiography (OCTA).
    Methods: Retrospective case report. Multimodal imaging was performed at each follow-up visits.
    Results: At baseline, the clinical findings and PCR on aqueous confirmed the diagnosis of CMV-induced CRN, while OCTA and Fluorescein Angiography showed multi-sectoral retinal and iris non-perfusion. After three weekly intravitreal injections of Foscarnet and retinal photocoagulation, the clinical and angiographic picture improved, with partial reperfusion of both retinal and iris vasculature.
    Conclusion: Retinal and iris non-perfusion in CRN can be partially reversible, if prompt treatment is administered. OCTA of the anterior segment allowed an accurate follow-up of the iris vasculature and its perfusion.
    MeSH term(s) Humans ; Tomography, Optical Coherence ; Cytomegalovirus/genetics ; Retrospective Studies ; Iris/diagnostic imaging ; Ischemia/diagnosis
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2021.1916041
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  9. Article ; Online: Diagnostic and Therapeutic Challenges.

    Menean, Matteo / Querques, Lea / Sacconi, Riccardo / Invernizzi, Alessandro / Boon, Camiel J F / Jampol, Lee M / Bandello, Francesco / Querques, Giuseppe / Kim, Stephen J

    Retina (Philadelphia, Pa.)

    2023  Volume 43, Issue 7, Page(s) 1213–1218

    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003630
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  10. Article ; Online: Utility of Anterior Segment OCT in the Management of Uveitic Cataract Surgery: A Fibrinoid Syndrome Case Treated with rtPA.

    Muñoz-Solano, Javier / Tondini, Giovanni / Zicarelli, Federico / Staurenghi, Giovanni / Oldani, Marta / Invernizzi, Alessandro

    Ocular immunology and inflammation

    2023  , Page(s) 1–4

    Abstract: Purpose: To highlight the importance of swept-source anterior segment optical coherence tomography (SS-ASOCT) in the peri-surgical management of cataract in uveitis. To describe a case of fibrinoid syndrome in uveitis treated with recombinant tissue ... ...

    Abstract Purpose: To highlight the importance of swept-source anterior segment optical coherence tomography (SS-ASOCT) in the peri-surgical management of cataract in uveitis. To describe a case of fibrinoid syndrome in uveitis treated with recombinant tissue plasminogen activator (rtPA).
    Methods: SS-ASOCT was performed at each follow-up before and after cataract surgery to assess anterior chamber inflammation and assist the clinical management of the patient.
    Results: A patient with idiopathic autoimmune uveitis was scheduled for cataract surgery. SS-ASOCT allowed to correctly plan the surgery timing. The patient developed a severe fibrinoid syndrome. Postsurgical SS-ASOCT allowed to distinguish between anterior chamber cells and fibrin thus guiding the timing for rtPA intracameral injection. Visual acuity improved from 20/400 the day after the surgery to 20/40.
    Conclusion: SS-ASOCT allowed a precise assessment of the inflammatory components (cellular vs fibrinoid) after cataract surgery. Intracameral rtPA was safe and effective in the treatment fibrinoid syndrome in uveitis.
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2023.2203232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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