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Article: Differential expression of apolipoprotein D and apolipoprotein E in the kainic acid-lesioned rat hippocampus.

Ong, W Y / He, Y / Suresh, S / Patel, S C

1997 Volume 79, Issue 2, Page(s) 359–367

Abstract: Expression of apolipoprotein D, a member of the lipocalin superfamily of transporter proteins, was ... investigated in the kainic acid-lesioned rat hippocampus. Using an anti-rat apolipoprotein D antibody and ... D expression, that was restricted mainly to scattered astrocytes. By contrast, kainic acid-injected ...

Abstract	Expression of apolipoprotein D, a member of the lipocalin superfamily of transporter proteins, was investigated in the kainic acid-lesioned rat hippocampus. Using an anti-rat apolipoprotein D antibody and biotin avidin-enhanced immunocytochemistry, in the normal rat hippocampus there was little apolipoprotein D expression, that was restricted mainly to scattered astrocytes. By contrast, kainic acid-injected rats showed apolipoprotein D immunoreactivity in the pyramidal neurons of the affected CA fields 24-48 h after injection of the excitotoxin, at a time when there was no histological evidence of cell death. Apolipoprotein D immunoreactivity peaked by day 3, coincident with neuronal cell death, and declined thereafter, reaching very low levels by day 7. Besides pyramidal neurons, apolipoprotein D immunoreactivity was also observed in a small number of reactive glial cells in the affected CA fields, but not in the vascular compartments at any time-point. In contrast to the neuronal expression of apolipoprotein D, apolipoprotein E immunoreactivity was observed predominantly in degenerating astrocytes. In conclusion, following excitotoxic injury with kainic acid, apolipoprotein D is expressed in hippocampal pyramidal neurons destined for subsequent cell death.
MeSH term(s)	Animals ; Apolipoproteins/metabolism ; Apolipoproteins D ; Apolipoproteins E/metabolism ; Hippocampus/metabolism ; Hippocampus/ultrastructure ; Kainic Acid/pharmacology ; Male ; Microscopy, Electron ; Rats ; Rats, Wistar
Chemical Substances	Apolipoproteins ; Apolipoproteins D ; Apolipoproteins E ; Kainic Acid (SIV03811UC)
Language	English
Publishing date	1997-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/s0306-4522(96)00608-2
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Article ; Online: Measurement of the form factors in the decay D+-->K-bar*0e+ nu e.

Anjos / Appel / Bean / Bracker / Browder / Cremaldi / Duboscq / Elliott / Escobar / Gibney / Hartner / Karchin / Kumar / Losty / Luste / Mantsch / Martin / McHugh / Menary /

Morrison / Nash / Ong / Pinfold / Punkar / Purohit / Santoro / Schmidt / Sidhu / Sliwa / Sokoloff / Souza / Spalding / Streetman / Stundia / Witherell

Physical review letters

1990 Volume 65, Issue 21, Page(s) 2630–2633

Language	English
Publishing date	1990-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.65.2630
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Article ; Online: Abdominal pain after a food crawl.

Ong, Danier / Yogendran, Rajiv / Fite, Emily

Journal of the American College of Emergency Physicians open

2024 Volume 5, Issue 1, Page(s) e13120

Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ISSN	2688-1152
ISSN (online)	2688-1152
DOI	10.1002/emp2.13120
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Article ; Online: Heart failure and the cost of dying: must the ferryman always be paid?

Sivanathan, Vithoosharan / Smallwood, Natasha / Ong, Jeffrey / Wee, Elin / Zentner, Dominica

Internal medicine journal

2024

Abstract: Background: Provision of palliative care in chronic heart failure (CHF) can support complex decision-making, significantly improve quality of life and may lower healthcare costs.: Aims: To examine whether healthcare costs differed in terminal ... ...

Abstract	Background: Provision of palliative care in chronic heart failure (CHF) can support complex decision-making, significantly improve quality of life and may lower healthcare costs. Aims: To examine whether healthcare costs differed in terminal admissions according to the adoption of a palliative approach. Design: Retrospective review of medical records and costing data for all admissions resulting in death from CHF (July 2011 to December 2019), analysed as two groups (2011-2016 and 2016-2019) because of background changes in costings. Setting: Admissions with CHF resulting in death in an Australian tertiary referral centre. Results: The cohort (n = 439) were elderly (median age 83.7 years, interquartile range (IQR) = 77.6-88.7 years) and mostly men (54.9%). Half (230, 52.4%) were referred to a specialist palliative care team, whereas over a third (172, 39.2%) received a palliative approach. Receiving a palliative approach was associated with a nonstatistically significant lower admission cost (AU$12 710 vs AU$15 978; P = 0.19) between 2011 and 2016 (n = 101, 38.8%) and a significantly lower cost (AU$11 319 vs AU$15 978; P < 0.01) between 2016 and 2019 (n = 71, 39.7%). Intensive care admission resulted in the single greatest additional cost at AU$14 624 (IQR = AU$4130-AU$44 197) (n = 48, 2011-2016). Median terminal admission cost was lower for patients with comfort goals of care (P < 0.01), without life-sustaining interventions (P < 0.01) or who received a palliative approach (P < 0.01). Referral to inpatient specialist palliative care or receiving a palliative approach resulted in comparable admission costings (AU$11 621 [IQR = AU$4705-AU$32 457] and AU$11 466 [IQR = AU$4973-AU$25 614]). Conclusion: A palliative approach in terminal CHF admission may improve quality at the end of life and decrease costs associated with care.
Language	English
Publishing date	2024-02-13
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.16338
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Zs.A 792: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 424: Show issues

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Article: Determining factors affecting Filipino consumers' behavioral intention to use cloud storage services: An extended technology acceptance model integrating valence framework.

Altes, Gerlyn C / Ong, Ardvin Kester S / German, Josephine D

Heliyon

2024 Volume 10, Issue 4, Page(s) e26447

Abstract: ... including education, e-commerce, healthcare, and more. ...

Abstract	Cloud Storage (CS) is a service that digitally stores, remotely manages, backs up, and renders internet-accessible data. However, despite its known benefits compared to traditional storage devices, this service is not widely used in developing nations such as the Philippines. This study integrated the Valence Theoretical Framework into the Extended Technology Acceptance Model (ETAM) to evaluate the influence of twelve variables on Filipino consumers' behavioral intention (BI) toward adopting CS services. The data is gathered through an online survey. Structural Equation Modeling was employed to examine the responses of 431 cloud users, mainly students and working professionals. Results showed that Perceived Benefit and Perceived Usefulness were the strongest determinants of BI. The Job Relevance was also found to be a significant factor. Therefore, CS providers should find additional ways to make their offerings more beneficial for the daily tasks of students and working individuals. Furthermore, considering the substantial influence of Perceived Risk and Subjective Norms on BI, CS providers must strengthen their security measures to boost users' trust in their services. Consumers who receive excellent service are likely to give positive reviews, which can be helpful to individuals who might also be considering purchasing CS for their data. Although the focus of this study is CS services, this can also serve as a reference when analyzing the BI of consumers concerning the adoption of other novel technologies applied in various sectors, including education, e-commerce, healthcare, and more.
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26447
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Article: Use of Botulinum Toxin A to Manage Hamstring-Induced Flexion Contracture Following Total Knee Arthroplasty: A Case Series.

Cheesman, Quincy T / Ponzio, Danielle Y / Thalody, Hope E / Lau, Vincent W / Post, Zachary D / Ong, Alvin

Cureus

2024 Volume 16, Issue 1, Page(s) e53113

Abstract: Introduction Flexion contractures following total knee arthroplasty (TKA) greatly affect patient function and satisfaction. Botulinum toxin A (BTX) has been described in the literature as a means of addressing post-operative flexion contractures due to ... ...

Abstract	Introduction Flexion contractures following total knee arthroplasty (TKA) greatly affect patient function and satisfaction. Botulinum toxin A (BTX) has been described in the literature as a means of addressing post-operative flexion contractures due to hamstring muscle rigidity. Methods We retrospectively report a case series of eight patients with range of motion (ROM) who developed a flexion contracture status post-TKA and were managed with the use of physical therapy, diagnostic hamstring lidocaine injections, and therapeutic hamstring BTX injections. Results All patients had an improvement in extension ROM following diagnostic lidocaine hamstring injections and were therefore considered candidates for therapeutic hamstring BTX injections. Prior to therapeutic hamstring BTX injections, patients had an average flexion contracture of 19° (range: 15°-22°). All patients had an improvement in extension ROM two to four weeks following the therapeutic hamstring BTX injection, with an average improvement in ROM of 7° (range: 2°-19°). At the final follow-up, all patients continued to sustain an improvement in extension ROM with an average deficit of 9° (range: 0°-17°). Conclusion Our case series highlights the use of diagnostic hamstring lidocaine injections to confirm hamstring rigidity as an etiology for flexion contracture following TKA. In addition, we showed a persistent improvement in flexion contracture for all patients after hamstring BTX injections. Therefore, when the appropriate patient is selected, BTX may provide an additional treatment option for a flexion contracture following TKA.
Language	English
Publishing date	2024-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.53113
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Article ; Online: Quantifying the Educational Value of a Student-Run Free Clinic.

Mazander, Megan / Rumenapp, Joseph / Lee, Derek / Ong, Charmine / Floramo, Emily / Benjamins, Maureen / Chen, Melissa

Family medicine

2024 Volume 56, Issue 3, Page(s) 176–179

Abstract: Background and objectives: Student-run free clinics (SRFCs) are settings in which students in health professions gain clinical experience, often while providing free or reduced-cost health care to the surrounding community. The current literature ... ...

Abstract	Background and objectives: Student-run free clinics (SRFCs) are settings in which students in health professions gain clinical experience, often while providing free or reduced-cost health care to the surrounding community. The current literature quantifies the many benefits these clinics provide to their patients and the impact they have on students' future careers; but few previous studies have assessed the financial impact of the education provided at an SRFC. We report on a net educational benefit, an educational benefit to educational cost ratio, and a net educational benefit to educational cost ratio of one SRFC from the perspective of the university. Methods: We calculated the value of education by multiplying all student hours worked in the clinic by the associated value of 1 hour in the typical tuition-based curriculum. Clinic educational costs and student hours were obtained from clinic records from August 1, 2021 through July 31, 2022. Results: We found the total educational value students received to be $73,571 over one academic year. The educational operating expenses of the clinic totaled $9,053, resulting in a benefit-cost ratio of 8.13. Conclusions: This analysis demonstrated a potential financial advantage of operating an SRFC when assessing clinic education expenses in relation to the value of university-generated education. Our research may serve as a starting point to showcase the economic benefit of SRFCs to their parent institutions and encourage further analysis of other benefits SRFCs may provide to institutions of higher education.
MeSH term(s)	Humans ; Student Run Clinic ; Ambulatory Care Facilities ; Students, Medical ; Curriculum ; Educational Status
Language	English
Publishing date	2024-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	639374-3
ISSN	1938-3800 ; 0742-3225
ISSN (online)	1938-3800
ISSN	0742-3225
DOI	10.22454/FamMed.2024.568265
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Zs.A 2327: Show issues

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Article ; Online: Creating a consumer-driven global community of practice to support action within environmental design with people living with dementia: assistive technology challenges and opportunities.

Ong, Emily / Frost, Dennis / Kuliga, Saskia / Layton, Natasha / Liddle, Jacki

Brain impairment : a multidisciplinary journal of the Australian Society for the Study of Brain Impairment

2023 Volume 24, Issue 2, Page(s) 219–228

Abstract: The environment, and assistive technologies as part of this, can play an important role in supporting the participation and wellbeing of people living with dementia. If not considered, environments can be overwhelming and disempowering. Disability ... ...

Abstract	The environment, and assistive technologies as part of this, can play an important role in supporting the participation and wellbeing of people living with dementia. If not considered, environments can be overwhelming and disempowering. Disability approaches including environmental considerations and assistive technology were often not offered routinely with people living with dementia. Concerned by this, dementia advocates aimed to create change in this area. The Environmental Design-Special Interest Group (ED-SiG) of Dementia Alliance International was developed as an international consumer-driven community of practice bringing together people with different relevant expertise including living experience (people living with dementia, care partners), architecture and design, occupational therapy, rehabilitation and care provision. This practice opinion piece provides an overview of dementia, the need for collaborative practices within practice with people living with dementia, and the considerations of assistive technology, environmental design and the global context. The reflection provides insights into this international community of practice, with personal reflections of members with living experience of dementia, and benefits and opportunities in considering environmental design and assistive technology from the perspectives of members. This work demonstrates and advocates collaborations that centre the perspectives and expertise of people living with dementia.
MeSH term(s)	Humans ; Community of Practice ; Dementia/rehabilitation ; Self-Help Devices ; Disabled Persons/rehabilitation ; Occupational Therapy
Language	English
Publishing date	2023-02-20
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2180113-7
ISSN	1839-5252 ; 1443-9646
ISSN (online)	1839-5252
ISSN	1443-9646
DOI	10.1017/BrImp.2023.4
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Book ; Online: Intermittent Safety Filters for Event-Triggered Safety Maneuvers with Application to Satellite Orbit Transfers

Ong, Pio / Ames, Aaron D.

2023

Abstract: In balancing safety with the nominal control objectives, e.g., stabilization, it is desirable ... by motivating this framework for impulsive control systems, e.g., a satellite orbiting an asteroid ...

Abstract	In balancing safety with the nominal control objectives, e.g., stabilization, it is desirable to reduce the time period when safety filters are in effect. Inspired by traditional spacecraft maneuvers, and with the ultimate goal of reducing the duration when safety is of concern, this paper proposes an event-triggered control framework with switching state-based triggers. Our first trigger in the scheme monitors safety constraints encoded by barrier functions, and thereby ensures safety without the need to alter the nominal controller--and when the boundary of the safety constraint is approached, the controller drives the system to the region where control actions are not needed. The second trigger condition determines if the safety constraint has improved enough for the success of the first trigger. We begin by motivating this framework for impulsive control systems, e.g., a satellite orbiting an asteroid. We then expand the approach to more general nonlinear system through the use of safety filtered controllers. Simulation results demonstrating satellite orbital maneuvers illustrate the utility of the proposed event-triggered framework. Comment: 8 pages, submitted to IEEE Conference on Decision and Control, 2023
Keywords	Electrical Engineering and Systems Science - Systems and Control ; Mathematics - Optimization and Control
Subject code	629
Publishing date	2023-04-17
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Interdisciplinary diagnosis and treatment planning for Class III malocclusion and determining the appropriate anterior tooth positions for individual patients.

Khan, Ambereen / Freer, Elissa / Ong, Desmond

Clinical case reports

2022 Volume 10, Issue 11, Page(s) e6468

Abstract: Patients presenting with Class III malocclusion often present significant challenges for the orthodontist and restorative clinician. The characteristic anterior crossbite is commonly associated with a maxillo-mandibular skeletal base discrepancy leading ... ...

Abstract	Patients presenting with Class III malocclusion often present significant challenges for the orthodontist and restorative clinician. The characteristic anterior crossbite is commonly associated with a maxillo-mandibular skeletal base discrepancy leading to both functional and esthetic issues. Three potential incisal tooth positions are discussed using clinical examples including implants.
Language	English
Publishing date	2022-11-16
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.6468
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