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Article: Response to "Comments on 'Sarcopenia Is an Independent Risk Factor for Proximal Junctional Disease Following Adult Spinal Deformity Surgery' by Eleswarapu et al".

Klineberg, Eric

2021 Volume 11, Issue 5, Page(s) 816

Language	English
Publishing date	2021-05-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2648287-3
ISSN	2192-5690 ; 2192-5682
ISSN (online)	2192-5690
ISSN	2192-5682
DOI	10.1177/2192568220972729
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Article ; Online: Dysphagia After Anterior Cervical Spine Surgery: Pathophysiology, Diagnosis, and Management.

Le, Hai V / Javidan, Yashar / Khan, Safdar N / Klineberg, Eric O

The Journal of the American Academy of Orthopaedic Surgeons

2024

Abstract: Anterior cervical spine surgery (ACSS) is a surgical intervention widely used for a myriad of indications including degenerative, oncologic, inflammatory, traumatic, and congenital spinal conditions. A primary concern for surgeons performing ACSS is the ... ...

Abstract	Anterior cervical spine surgery (ACSS) is a surgical intervention widely used for a myriad of indications including degenerative, oncologic, inflammatory, traumatic, and congenital spinal conditions. A primary concern for surgeons performing ACSS is the postoperative development of oropharyngeal dysphagia. Current literature reports a wide incidence of this complication ranging from 1 to 79%. Dysphagia after ACSS is multifactorial, with common risk factors being prolonged duration of operation, revision surgeries, multilevel surgeries, and use of recombinant human bone morphogenetic protein-2. Many technical strategies have been developed to reduce the risk of postoperative dysphagia, including the development of low-profile implants and retropharyngeal local steroid application. In this article, we review the most recent literature regarding the epidemiology and pathophysiology, diagnostic criteria, risk factors, and management of dysphagia after ACSS.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-23-00778
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Zs.A 4048: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 274: Show issues

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Article ; Online: Assessing Alignment Using GAP Score and Complications for Pedicle Subtraction Osteotomy Revision Surgeries for Sagittal Deformity in Previously Fused Spines Using a Satellite Rod Technique.

Yahanda, Alexander T / Wegner, Adam M / Klineberg, Eric O / Gupta, Munish C

World neurosurgery

2023 Volume 179, Page(s) e262–e268

Abstract: Objective: Pedicle subtraction osteotomy (PSO) is a surgical technique to restore lumbar lordosis in patients with rigid sagittal deformity. Herein, we report on outcomes of a surgical technique utilizing a 4-rod PSO with satellite rods.: Methods: A ... ...

Abstract	Objective: Pedicle subtraction osteotomy (PSO) is a surgical technique to restore lumbar lordosis in patients with rigid sagittal deformity. Herein, we report on outcomes of a surgical technique utilizing a 4-rod PSO with satellite rods. Methods: A retrospective study was performed for a cohort of patients who underwent 4-rod PSO revision surgery for sagittal deformity. Procedures were performed by one surgeon at 2 different academic centers between 2004-2018. Alignment outcomes and complications specifically for revision surgeries in previously fused spines were assessed. Results: 40 patients underwent PSO with the satellite rod technique (n = 29 at L3, 72.5%; n = 7 at L4, 17.5%). Mean PSO angle was 28.7 ± 7.6°. Two patients (5%) had rod fracture necessitating revision surgery at 32 and 34 months. Three patients (7.5%) developed proximal junctional kyphosis (PJK), but none required revision. No patients developed pseudoarthrosis. Mean preoperative sagittal vertical axis (SVA) was 13.5 ± 7.3 cm, which decreased to 4.8 ± 7.3 cm (P = 0.002) postoperatively. Mean preoperative pelvic incidence-lumbar lordosis (PI-LL) mismatch improved from 35.9 ± 16.6° preoperatively to 11.8 ± 14.6° postoperatively (P < 0.001). Mean preoperative pelvic tilt (PT) improved from 34.7 ± 9.8° preoperatively to 30.1 ± 9.0° (P = 0.026) postoperatively. Mean global alignment and proportion (GAP) score improved from 10 ± 2 preoperatively to 8 ± 2 postoperatively (P < 0.001), which was still considered severely disproportioned. Conclusions: Rod failure rate after PSO with the 4-rod satellite configuration was low. SVA, PI-LL mismatch, and PT significantly improved for these previously-fused patients. Mean GAP score also improved, but was still considered severely disproportioned, likely due to the inability of PSO to correct low LL or PT in previously-fused spines.
MeSH term(s)	Humans ; Lordosis/diagnostic imaging ; Lordosis/surgery ; Reoperation ; Retrospective Studies ; Osteotomy/methods ; Kyphosis/diagnostic imaging ; Kyphosis/surgery ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Spinal Fusion/adverse effects ; Spinal Fusion/methods ; Treatment Outcome ; Thoracic Vertebrae/surgery
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2023.08.070
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Zs.A 1159: Show issues

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Article ; Online: Ossification of the Posterior Longitudinal Ligament: Pathophysiology, Diagnosis, and Management.

Le, Hai V / Wick, Joseph B / Van, Benjamin W / Klineberg, Eric O

The Journal of the American Academy of Orthopaedic Surgeons

2022 Volume 30, Issue 17, Page(s) 820–830

Abstract: Ossification of the posterior longitudinal ligament (OPLL) occurs as heterotopic bone forms in the posterior longitudinal ligament, resulting in neural compression, myelopathy, and radiculopathy. OPLL is most commonly observed in East Asian populations, ... ...

Abstract	Ossification of the posterior longitudinal ligament (OPLL) occurs as heterotopic bone forms in the posterior longitudinal ligament, resulting in neural compression, myelopathy, and radiculopathy. OPLL is most commonly observed in East Asian populations, with prevalence rates of 1.9% to 4.3% reported in Japan. OPLL rates are lower in North American and European patients, with reported prevalence of 0.1% to 1.7%. Patients typically develop symptoms due to OPLL in their cervical spines. The etiology of OPLL is multifactorial, including genetic, metabolic, and anatomic factors. Asymptomatic or symptomatic patients with OPLL can be managed nonsurgically, whereas patients with neurologic symptoms may require surgical decompression from an anterior, posterior, or combined approach. Surgical treatment can provide notable improvement in neurologic function. Surgical decision making accounts for multiple factors, including patient comorbidities, neurologic status, disease morphology, radiographic findings, and procedure complication profiles. In this study, we review OPLL epidemiology and pathophysiology, clinical features, radiographic evaluation, management, and complications.
MeSH term(s)	Cervical Vertebrae/surgery ; Decompression, Surgical/methods ; Humans ; Longitudinal Ligaments/surgery ; Ossification of Posterior Longitudinal Ligament/surgery ; Ossification of Posterior Longitudinal Ligament/therapy ; Osteogenesis ; Spinal Fusion/methods ; Treatment Outcome
Language	English
Publishing date	2022-05-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-22-00049
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Zs.A 4048: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 274: Show issues

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Article ; Online: Intervertebral Disc Mechanics With Nucleotomy: Differences Between Simple and Dual Loading.

Yang, Bo / Klineberg, Eric / O'Connell, Grace D

Journal of biomechanical engineering

2021 Volume 143, Issue 8

Abstract: Painful herniated discs are treated surgically by removing extruded nucleus pulposus (NP) material (nucleotomy). NP removal through enzymatic digestion is also commonly performed to initiate degenerative changes to study potential biological repair ... ...

Abstract	Painful herniated discs are treated surgically by removing extruded nucleus pulposus (NP) material (nucleotomy). NP removal through enzymatic digestion is also commonly performed to initiate degenerative changes to study potential biological repair strategies. Experimental and computational studies have shown a decrease in disc stiffness with nucleotomy under single loading modalities, such as compression-only or bending-only loading. However, studies that apply more physiologically relevant loading conditions, such as compression in combination with bending or torsion, have shown contradicting results. We used a previously validated bone-disc-bone finite element model (Control) to create a Nucleotomy model to evaluate the effect of dual loading conditions (compression with torsion or bending) on intradiscal deformations. While disc joint stiffness decreased with nucleotomy under single loading conditions, as commonly reported in the literature, dual loading resulted in an increase in bending stiffness. More specifically, dual loading resulted in a 40% increase in bending stiffness under flexion and extension and a 25% increase in stiffness under lateral bending. The increase in bending stiffness was due to an increase and shift in compressive stress, where peak stresses migrated from the NP-annulus interface to the outer annulus. In contrast, the decrease in torsional stiffness was due to greater fiber reorientation during compression. In general, large radial strains were observed with nucleotomy, suggesting an increased risk for delamination or degenerative remodeling. In conclusion, the effect of nucleotomy on disc mechanics depends on the type and complexity of applied loads.
MeSH term(s)	Intervertebral Disc
Language	English
Publishing date	2021-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	243094-0
ISSN	1528-8951 ; 0148-0731
ISSN (online)	1528-8951
ISSN	0148-0731
DOI	10.1115/1.4050538
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Zs.B 2672: Show issues

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Article ; Online: Letter to the Editor for state of the art: proximal junctional kyphosis; diagnosis, management and prevention.

Sardar, Zeeshan M / Kim, Yongjung / Lafage, Virginie / Rand, Frank / Lenke, Lawrence / Klineberg, Eric

Spine deformity

2022 Volume 10, Issue 4, Page(s) 971–972

MeSH term(s)	Humans ; Kyphosis/diagnosis ; Kyphosis/prevention & control ; Thoracic Vertebrae
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2717704-X
ISSN	2212-1358 ; 2212-134X ; 2212-1358
ISSN (online)	2212-1358 ; 2212-134X
ISSN	2212-1358
DOI	10.1007/s43390-022-00513-9
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Article ; Online: The evidence-based approach for surgical complications in the treatment of lumbar disc herniation.

Harper, Robert / Klineberg, Eric

International orthopaedics

2018 Volume 43, Issue 4, Page(s) 975–980

Abstract: Purpose: The purpose of this article is to review the evidence-based approach for surgical complications following disc herniation.: Methods: A search of the primary English literature was conducted for research examining the outcomes and ... ...

Abstract	Purpose: The purpose of this article is to review the evidence-based approach for surgical complications following disc herniation. Methods: A search of the primary English literature was conducted for research examining the outcomes and complications of surgical discectomy. Special regard was given to high-quality prospective randomized studies. Results: The most commonly reported complications of surgical treatment of disc herniation are included in this review. Medical complications, and surgical complications including infection, durotomy, neurological injury, symptomatic re-herniation, and revision surgery are defined and systematically reviewed in detail for incidence, evaluation, and management. Conclusion: This article provides the clinician and surgeon with a review of the evidence-based evaluation and management of surgical complications following disc herniation, offering best practice guidelines for informed discussions with patients in shared decision-making.
MeSH term(s)	Diskectomy ; Humans ; Incidence ; Intervertebral Disc Degeneration/surgery ; Intervertebral Disc Displacement/surgery ; Lumbar Vertebrae/surgery ; Prospective Studies ; Reoperation ; Treatment Outcome
Language	English
Publishing date	2018-12-12
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-018-4255-6
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Zs.A 1324: Show issues

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Article ; Online: Diffuse Idiopathic Skeletal Hyperostosis of the Spine: Pathophysiology, Diagnosis, and Management.

Le, Hai V / Wick, Joseph B / Van, Benjamin W / Klineberg, Eric O

The Journal of the American Academy of Orthopaedic Surgeons

2021 Volume 29, Issue 24, Page(s) 1044–1051

Abstract: Diffuse idiopathic skeletal hyperostosis (DISH) is an ankylosing condition affecting up to 32.5% of the general cohort. Although often asymptomatic, affected individuals may present with back pain, stiffness, dysphagia, functional decline, and neurologic ...

Abstract	Diffuse idiopathic skeletal hyperostosis (DISH) is an ankylosing condition affecting up to 32.5% of the general cohort. Although often asymptomatic, affected individuals may present with back pain, stiffness, dysphagia, functional decline, and neurologic deficits. Radiographically, DISH is characterized by flowing ossifications along the anterior spine spanning ≥4 vertebral bodies. Although the etiology of DISH remains unknown, diabetes mellitus and other metabolic derangements are strongly associated with DISH. Importantly, spinal ankylosis in DISH predisposes patients to unstable spine fractures from low-energy trauma, and careful consideration must be taken in managing these patients. This article reviews the epidemiology and pathophysiology of DISH, and its clinical findings, diagnostic criteria, and management.
MeSH term(s)	Back Pain ; Deglutition Disorders ; Humans ; Hyperostosis, Diffuse Idiopathic Skeletal/diagnosis ; Hyperostosis, Diffuse Idiopathic Skeletal/diagnostic imaging ; Osteogenesis ; Spine
Language	English
Publishing date	2021-08-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-20-01344
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Zs.A 4048: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Paediatric syndromic scoliosis: proceedings of the half-day course at the 57th annual meeting of the Scoliosis Research Society.

Mehta, Jwalant S / Pahys, Joshua M / Saad, Ahmed / Sponseller, Paul / Andras, Lindsay / Marks, David / Poon, Selina / Klineberg, Eric / White, Klane K / Helenius, Ilkka / Welborn, Michelle / Redding, Greg

Spine deformity

2024 Volume 12, Issue 3, Page(s) 523–543

Abstract: There are some syndromes that present with unique manifestations pertaining to the spinal column. A good working understanding of these common syndromes is useful for the spinal deformity surgeons and related healthcare providers. This review attempts to ...

Abstract	There are some syndromes that present with unique manifestations pertaining to the spinal column. A good working understanding of these common syndromes is useful for the spinal deformity surgeons and related healthcare providers. This review attempts to encompass these unique features and discuss them in three broad groups: hypermobility syndromes, muscle pathology-related syndromes, and syndromes related to poor bone quality. This review explores the features of these syndromes underpinning the aspects of surgical and medical management. This review represents the proceedings of the Paediatric Half-Day Course at the 57th Annual Meeting of the Scoliosis Research Society.
MeSH term(s)	Humans ; Scoliosis ; Child ; Syndrome ; Spine ; Congresses as Topic
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2717704-X
ISSN	2212-1358 ; 2212-134X ; 2212-1358
ISSN (online)	2212-1358 ; 2212-134X
ISSN	2212-1358
DOI	10.1007/s43390-024-00822-1
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Article ; Online: Cervical spondylotic myelopathy: a review of the evidence.

Klineberg, Eric

The Orthopedic clinics of North America

2010 Volume 41, Issue 2, Page(s) 193–202

Abstract: Cervical spondylotic myelopathy (CSM) is the most common progressive spinal cord disorder in patients more than 55 years old. This disease is also the most common cause of acquired spasticity in later life and may lead to progressive spasticity and ... ...

Abstract	Cervical spondylotic myelopathy (CSM) is the most common progressive spinal cord disorder in patients more than 55 years old. This disease is also the most common cause of acquired spasticity in later life and may lead to progressive spasticity and neurologic decline. This article explores some of the controversies about CSM and reviews pertinent articles, specifically prospective and randomized clinical trials when possible, to obtain the cleanest and least biased data. The 4 current controversial topics that surround CSM are: (1) natural history of mild CSM; (2) surgical approach: anterior versus posterior; (3) laminoplasty or laminectomy; and (4) cervical arthroplasty for CSM.
MeSH term(s)	Arthroplasty ; Cervical Vertebrae ; Decompression, Surgical ; Gait Disorders, Neurologic/etiology ; Humans ; Randomized Controlled Trials as Topic ; Spinal Cord Diseases/diagnosis ; Spinal Cord Diseases/surgery ; Spinal Cord Diseases/therapy ; Spinal Fusion ; Treatment Outcome
Language	English
Publishing date	2010-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	417389-2
ISSN	1558-1373 ; 0030-5898
ISSN (online)	1558-1373
ISSN	0030-5898
DOI	10.1016/j.ocl.2009.12.010
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