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Article ; Online: Endonasal endoscopic nasolacrimal duct dissection for primary nasolacrimal duct obstruction.

Chang, Ko-Fang / Shen, Yun-Dun

Taiwan journal of ophthalmology

2019 Volume 10, Issue 2, Page(s) 116–120

Abstract: ... Hospital by a single surgeon (YD, Shen).: Results: The mean follow-up time for the 39 patients (43 eyes ...

Abstract	Purpose: The purpose of this study is to describe the results of endonasal endoscopic nasolacrimal duct dissection (EE-NLDD); a surgical technique used for the treatment of primary nasolacrimal duct obstruction (NLDO). Materials and methods: Before the operation, the patency of the nasolacrimal duct (NLD) was evaluated through irrigation and probing. The EE-NLDD surgical procedure involved the removal of the bony structure covering the NLD. The NLD mucosa was dissected and marsupialized with nasal mucosa, creating a mucosa-covered ostium. The bone surrounding the lacrimal fossa and lacrimal sac mucosa was preserved throughout procedure. The postoperative anatomical and functional outcomes were evaluated through irrigation, endonasal endoscopic fluorescein dye test, and subjective descriptions of the patients. Study design: This is a retrospective chart review study which included all patients with primary NLDO treated with EE-NLDD surgical technique from February 2012 to July 2016 in Taipei Medical University Shuang Ho Hospital by a single surgeon (YD, Shen). Results: The mean follow-up time for the 39 patients (43 eyes) was 14.7 months (range: 0.5-46 months). Anatomical patency was achieved in all patients. Under endonasal endoscopy, fluorescein dye was observed at the internal orifice after the dye was instilled into the conjunctival sac in all patients. The complete resolution of the epiphora was reported in 36 patients (39 eyes) and two patients (2 eyes) exhibited an improvement of the epiphora after surgery. However, one patient (2 eyes) reported persistent bilateral epiphora without improvement even under solid evidence of anatomical patency. No major complications were noted intraoperatively or postoperatively. Conclusions: The results suggested that the EE-NLDD is a safe and effective procedure and has a success rate comparable with that of conventional endonasal dacryocystorhinostomy.
Language	English
Publishing date	2019-06-04
Publishing country	India
Document type	Journal Article
ISSN	2211-5072
ISSN (online)	2211-5072
DOI	10.4103/tjo.tjo_111_18
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Article ; Online: Correction to: Refractive outcomes of femtosecond laser-assisted cataract surgery with arcuate keratotomy and standard phacoemulsification with toric intraocular lens implantation.

Lin, Meng-Yin / Shen, Yun-Dun / Tan, Hsin-Yuan / Wang, I-Jong / Lin, I-Chan

International ophthalmology

2022 Volume 42, Issue 9, Page(s) 2643

Language	English
Publishing date	2022-08-26
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-022-02358-7
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Article ; Online: Easy and Safe Simultaneous Zygoma Reduction and Facelift by Single Incision Through Subcutaneous Approach.

Hsiao, Cheng-Wei / Hsiao, Kae-Yi / Shen, Yun-Dun / Zavala, Abraham / Hsiao, Ya-Wen

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2022 Volume 75, Issue 9, Page(s) 3513–3520

Abstract: Background: The surgery for facelift or zygoma reduction usually has a long operative time, swelling, and blood loss consideration; and therefore, these two procedures are often performed separately. In recent years, an increasing demand for ... ...

Abstract	Background: The surgery for facelift or zygoma reduction usually has a long operative time, swelling, and blood loss consideration; and therefore, these two procedures are often performed separately. In recent years, an increasing demand for simultaneous zygoma reduction and facelift has been observed; however, few studies have examined safe and effective of simultaneous zygoma reduction and facelift. Objective: The aim of this study was to present a safe, easy, and flexible method for combining facelift and zygoma reduction through single facelift incision with minimal blood loss. Methods: From 2015 to 2020, the senior author performed zygoma reduction with facelift by using a subcutaneous approach through single facelift incision in patients with wide zygoma and an aging face. Operative time, intraoperative blood loss, postoperative course, and complications were recorded. Results: In total, 56 patients met the inclusion criteria and were included in the study. The combined surgery was successfully performed in all cases, and no serious complications were reported. The follow-up period ranged from 6.5 to 60 months. The average operating time was 187 minutes, and the mean intraoperative blood loss was minimal (30 mL). All patients were satisfied with the outcome, different scores were assessed with Global Aesthetic Improvement Scale (GAIS). Conclusions: Facelift and zygoma reduction using a subcutaneous approach through single facelift incision provides complete visualization of the zygoma, superior hemostasis control, resulting in an easy and safe surgery that does not require additional intraoral incisions.
MeSH term(s)	Humans ; Osteotomy/methods ; Reconstructive Surgical Procedures/methods ; Rhytidoplasty/methods ; Surgical Wound/surgery ; Zygoma/surgery
Language	English
Publishing date	2022-06-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2022.05.002
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Article ; Online: Baseline characteristics and treatment response predictive of nAMD outcomes with ranibizumab therapy in treatment-naive patients: the RACER subgroup analysis.

Tsai, Ching-Yao / Wu, Chien-Liang / Cheng, Cheng-Kuo / Shen, Yun-Dun / Wu, Wen-Chuan / Wu, Pei-Chang / Tsai, Arslan / Chen, Jiann-Torng

BMC ophthalmology

2023 Volume 23, Issue 1, Page(s) 39

Abstract: Background: The Ranibizumab AMD Clinical Efficacy Study (RACER) conducted in treatment-naive adult Taiwanese patients with neovascular age-related macular degeneration (nAMD) suggested the importance of early and intensive dosing of ranibizumab for ... ...

Abstract	Background: The Ranibizumab AMD Clinical Efficacy Study (RACER) conducted in treatment-naive adult Taiwanese patients with neovascular age-related macular degeneration (nAMD) suggested the importance of early and intensive dosing of ranibizumab for optimal treatment outcomes. This subgroup analysis aims to provide clinical information on treatment response that can potentially guide on maintaining the treatment or switching anti-VEGF agents in the real-world setting. Methods: Visual acuity (VA) and central retinal thickness (CRT) were assessed in the RACER subgroup population. Subgroup analysis sets were categorised based on: (1) baseline best-corrected VA (BCVA; ≤ 48 and > 48 letters); (2) baseline CRT (≤ 325 or > 325 μm); and (3) treatment response after three monthly initial injections: < or ≥ 5-letter gain in BCVA and reduction of < or ≥ 50 μm in CRT. Results: Patient age, sex, nAMD duration and number of ranibizumab injections did not differ significantly between the treatment subgroups. Poor baseline BCVA (≤ 48 letters) and baseline CRT severity (> 325 µm) were predictors of maximum BCVA gains (9.6 ± 12.9 letters [95%CI: 6.3 to 12.9] and 5.1 ± 18.3 letters [95%CI: - 0.5 to 10.8] at Months 3 and 12, respectively) and better CRT reductions (- 127.6 ± 104.2 µm and - 104.2 ± 107.4 µm at Months 3 and 12, respectively; both P < 0.001). For the subgroup showing favourable treatment improvement with BCVA gains ≥ 5 letters after three monthly initial injections, 75.6% of patients maintained follow-up at Month 12 with a mean of 6.5 ± 14.3 letter gains (95% CI: 1.2 to 11.7). The BCVA gains < 5-letter subgroup nevertheless had stable BCVA (0.4 ± 12.1 letter gains) and CRT (- 41.9 ± 61.2 µm) at Month 12, respectively. In the subgroup with ≥ 50 µm CRT reduction after three monthly initial injections, there are significantly higher BCVA improvements vs. the < 50 µm CRT reduction subgroup at Month 3 (5.0 ± 8.6 letter gains vs. 1.5 ± 11.6 letter gains, respectively; intergroup P = 0.005). Conclusion: Lower baseline BCVA and higher baseline CRT were associated with BCVA gains and CRT reductions throughout the 12-month study period. Early CRT improvements after three monthly initial injections were associated with BCVA gains as early as Month 3.
MeSH term(s)	Adult ; Humans ; Angiogenesis Inhibitors/therapeutic use ; Intravitreal Injections ; Ranibizumab/therapeutic use ; Tomography, Optical Coherence ; Treatment Outcome ; Vascular Endothelial Growth Factor A
Chemical Substances	Angiogenesis Inhibitors ; Ranibizumab (ZL1R02VT79) ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2023-01-27
Publishing country	England
Document type	Clinical Study ; Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-023-02780-0
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Article ; Online: Refractive outcomes of femtosecond laser-assisted cataract surgery with arcuate keratotomy and standard phacoemulsification with toric intraocular lens implantation.

Lin, Meng-Yin / Shen, Yun-Dun / Tan, Hsin-Yuan / Wang, I-Jong / Lin, I-Chan

International ophthalmology

2021 Volume 42, Issue 9, Page(s) 2633–2642

Abstract: Purpose: Femtosecond laser arcuate keratotomy (FS-AK) and toric intraocular lens (IOL) implantation are effective for the correction of eyes with corneal astigmatism. In this study, the postoperative refractive outcomes of patients receiving femtosecond ...

Abstract	Purpose: Femtosecond laser arcuate keratotomy (FS-AK) and toric intraocular lens (IOL) implantation are effective for the correction of eyes with corneal astigmatism. In this study, the postoperative refractive outcomes of patients receiving femtosecond laser-assisted cataract surgery (FLACS) with FS-AK and patients receiving standard phacoemulsification with toric IOL implantation were evaluated. Methods: This retrospective study reviewed the postoperative outcomes of patients undergoing FLACS with FS-AK (the FS-AK group) and patients undergoing standard phacoemulsification with toric IOL implantation (the toric IOL group). The main outcome measures were uncorrected and corrected visual acuities, keratometric and refractive astigmatism, and vector analysis. Results: The FS-AK group included 41 eyes with preoperative keratometric astigmatism of - 1.64 ± 0.42 diopters (D), and the toric IOL group included 53 eyes with preoperative keratometric astigmatism of - 2.29 ± 0.91 D (P < 0.001). Postoperative refractive astigmatism was comparable between the two groups. Compared with the FS-AK group, postoperative uncorrected visual acuity was significantly better (P = 0.005) and corrected visual acuity was marginally better in the toric IOL group (P = 0.051). The absolute angles of error were 9.95° ± 9.57° and 5.08° ± 4.94° (P = 0.02) in the FS-AK and the toric IOL groups, respectively. Conclusion: Both FLACS with FS-AK and standard phacoemulsification with toric IOL implantation are safe and effective methods for astigmatism correction during cataract surgery. Standard phacoemulsification with toric IOL implantation achieves better visual acuity than FLACS with FS-AK at the 6-month follow-up.
MeSH term(s)	Astigmatism ; Cataract ; Humans ; Lasers ; Lens Implantation, Intraocular ; Lenses, Intraocular ; Phacoemulsification ; Refraction, Ocular ; Retrospective Studies
Language	English
Publishing date	2021-11-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-021-02090-8
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Article ; Online: A 12-month, prospective, observational study of ranibizumab in treatment-naïve Taiwanese patients with neovascular age-related macular degeneration: the RACER study.

Wu, Wen-Chuan / Chen, Jiann-Torng / Tsai, Ching-Yao / Wu, Chien-Liang / Cheng, Cheng-Kuo / Shen, Yun-Dun / Tsai, Arslan / Wu, Pei-Chang

BMC ophthalmology

2020 Volume 20, Issue 1, Page(s) 462

Abstract: Background: The current National Health Insurance scheme in Taiwan reimburses 3 initial plus 4 additional injections of ranibizumab 0.5 mg for eligible patients with neovascular age-related macular degeneration (nAMD). The Ranibizumab AMD Clinical ... ...

Abstract	Background: The current National Health Insurance scheme in Taiwan reimburses 3 initial plus 4 additional injections of ranibizumab 0.5 mg for eligible patients with neovascular age-related macular degeneration (nAMD). The Ranibizumab AMD Clinical Efficacy in Real-world practice (RACER) study aimed to observe the effectiveness of ranibizumab injections under this reimbursement system. Methods: RACER was a 12-month, prospective, observational study conducted in treatment-naïve, adult Taiwanese patients with nAMD. Patients received intravitreal ranibizumab 0.5 mg injections in adherence with local prescribing information. Results: Of 161 patients enrolled, 114 (70.8%) completed the 12-month study. Overall, patients received a mean (standard deviation [SD]) of 4.3 (1.7) ranibizumab injections. The mean (SD, [95% confidence interval], P value) gain in best-corrected visual acuity (BCVA) from baseline at Month 3 was 5.2 (12.2, [3.1, 7.3] letters, P < 0.0001) and at Month 12 was 3.4 (15.4, [0.2-6.6] letters, P = 0.0352). Mean central retinal thickness also decreased from baseline at Months 3 and 12 (both P < 0.001). In subgroup analyses, better treatment outcomes at Months 3 and 12 were observed among patients who received a loading dose and those who had a shorter duration of nAMD at baseline. Adverse events were reported in 58.4% of patients; most (94.4%) were mild-to-moderate in severity and 98.8% were deemed unrelated to study treatment. Conclusions: Treatment with ranibizumab 0.5 mg resulted in significant improvements in visual outcomes among treatment-naïve Taiwanese patients with nAMD. Early treatment and frequent dosing in the real-world setting may be the key to achieving better outcomes.
MeSH term(s)	Adult ; Angiogenesis Inhibitors/therapeutic use ; Humans ; Intravitreal Injections ; Macular Degeneration/drug therapy ; Prospective Studies ; Ranibizumab/therapeutic use ; Taiwan/epidemiology ; Tomography, Optical Coherence ; Treatment Outcome ; Vascular Endothelial Growth Factor A ; Visual Acuity
Chemical Substances	Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Ranibizumab (ZL1R02VT79)
Language	English
Publishing date	2020-11-25
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-020-01715-3
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Article ; Online: Preparation of an electrochemical sensor utilizing graphene-like biochar for the detection of tetracycline.

Chou, Chih-Ming / Dai, Yung-Dun / Yuan, Ching / Shen, Yun-Hwei

Environmental research

2023 Volume 236, Issue Pt 2, Page(s) 116785

Abstract: Tetracycline (TC), which is ubiquitous in the aquatic environment, can cause ecological imbalance and adversely affect human health. Therefore, a quick, inexpensive, and easy method for the detection of TC in water systems is highly desirable. This study ...

Abstract	Tetracycline (TC), which is ubiquitous in the aquatic environment, can cause ecological imbalance and adversely affect human health. Therefore, a quick, inexpensive, and easy method for the detection of TC in water systems is highly desirable. This study reports the development of a novel electrochemical sensor from waste peanut shell for the quick detection of TC in water. Raman and TEM lattice mapping analyses confirmed the successful preparation of graphene -like biochar from waste peanut shells (PSs) via hydrothermal and pyrolysis processes. An electrochemical sensor, PS@glassy carbon electrode (PS@GCE), was then developed by coating the prepared graphene-like biochar on the surface of a glass electrode to enhance its conductivity. The feasibility of using this sensor for the detection of TC in the aqueous system was investigated. The PS@GCE sensor exhibited excellent sensitivity with a low detection limit of 3.6 × 10
Language	English
Publishing date	2023-07-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.116785
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Article ; Online: Ophthalmic plastic and orbital surgery in Taiwan.

Hsu, Chi-Hsin / Lin, I-Chan / Shen, Yun-Dun / Hsu, Wen-Ming

Journal of the Chinese Medical Association : JCMA

2014 Volume 77, Issue 6, Page(s) 333–336

Abstract: We describe in this paper the current status of ophthalmic plastic and orbital surgery in Taiwan. Data were collected from the Bureau of National Health Insurance of Taiwan, the Bulletin of the Taiwan Ophthalmic Plastic and Reconstructive Society, and ... ...

Abstract	We describe in this paper the current status of ophthalmic plastic and orbital surgery in Taiwan. Data were collected from the Bureau of National Health Insurance of Taiwan, the Bulletin of the Taiwan Ophthalmic Plastic and Reconstructive Society, and the Statistics Yearbook of Practicing Physicians and Health Care Organizations in Taiwan by the Taiwan Medical Association. We ascertained that 94 ophthalmologists were oculoplastic surgeons and accounted for 5.8% of 1621 ophthalmologists in Taiwan. They had their fellowship training abroad (most ophthalmologists trained in the United States of America) or in Taiwan. All ophthalmologists were well trained and capable of performing major oculoplastic surgeries. The payment rates by our National Health Insurance for oculoplastic and orbital surgeries are relatively low, compared to Medicare payments in the United States. Ophthalmologists should promote the concept that oculoplastic surgeons specialize in periorbital plastic and aesthetic surgeries. However, general ophthalmologists should receive more educational courses on oculoplastic and cosmetic surgery.
MeSH term(s)	Humans ; Ophthalmology/standards ; Ophthalmology/statistics & numerical data ; Orbit/surgery ; Surgery, Plastic/standards ; Surgery, Plastic/statistics & numerical data ; Taiwan
Language	English
Publishing date	2014-06-02
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1016/j.jcma.2013.05.014
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Article: Retrocaruncular approach for the repair of medial orbital wall fractures: an anatomical and clinical study.

Shen, Yun-Dun / Paskowitz, Daniel / Merbs, Shannath L / Grant, Michael P

Craniomaxillofacial trauma & reconstruction

2014 Volume 8, Issue 2, Page(s) 100–104

Abstract: The aim of this article is to investigate a retrocaruncular approach for repairing medial orbital wall fractures. A total of 10 fresh cadaver orbits were dissected to investigate a transconjunctival approach to the orbit posterior to the caruncle. ... ...

Abstract	The aim of this article is to investigate a retrocaruncular approach for repairing medial orbital wall fractures. A total of 10 fresh cadaver orbits were dissected to investigate a transconjunctival approach to the orbit posterior to the caruncle. Medical records of consecutive patients with medial orbital wall fractures repaired via a retrocaruncular incision at Wilmer Eye Institute over a 10-year period were retrospectively reviewed. The study was approved by the Johns Hopkins Medical Institution's Institutional Review Board. Feasibility of this approach was clearly demonstrated on all cadavers. Horner muscle was observed to be directly attached to the caruncle and remained undisturbed throughout the retrocaruncular approach. For each of the 174 patients reviewed, this approach allowed successful access to the fracture and proper implant placement. The origin of the inferior oblique muscle was divided in only 19 patients. Sutures were not used for conjunctival incision closure in any patient. For 120 patients who underwent acute repair, the percentage with enophthalmos (≥ 2 mm) decreased from 34% preoperatively to 4% postoperatively; extraocular motility deficit decreased from 41 to 11%. Postoperative complications included recurrence of the preexisting retrobulbar hemorrhage, conjunctival granuloma, and temporary torsional diplopia, each in one patient. The retrocaruncular transconjunctival incision is an effective and safe approach for repairing medial orbital wall fractures with minimal complications. The retrocaruncular incision offers advantages over dividing the caruncle because Horner muscle is left undisturbed, and the incision heals well without suturing.
Language	English
Publishing date	2014-06-02
Publishing country	United States
Document type	Journal Article
ISSN	1943-3875
ISSN	1943-3875
DOI	10.1055/s-0034-1375168
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Article ; Online: Comparison of treatment for congenital nasolacrimal duct obstruction: a systematic review and meta-analysis.

Lin, Allen E / Chang, Yu-Chieh / Lin, Meng-Ying / Tam, Ka-Wai / Shen, Yun-Dun

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2016 Volume 51, Issue 1, Page(s) 34–40

Abstract: Objective: To conduct a systematic review and meta-analysis of randomized controlled trials comparing the success and complication rates among various congenital nasolacrimal duct obstruction (CNLDO) procedures, intervention times, and tubes types.: ... ...

Abstract	Objective: To conduct a systematic review and meta-analysis of randomized controlled trials comparing the success and complication rates among various congenital nasolacrimal duct obstruction (CNLDO) procedures, intervention times, and tubes types. Design: Systematic review with quantitative meta-analysis. Methods: Studies were identified by searching the PubMed, EMBASE, SCOPUS, and Cochrane databases. The comparisons between categorical variables were analyzed using the χ(2) test, and the dichotomous outcomes were reported as risk ratios. The precision of the effect size was based on the 95% confidence interval. Results: Seven studies published between 2007 and 2013 were included. Immediate versus observation/deferred probing had similar rates of success (82.7% vs 81.8%). Balloon dacryocystoplasty and silicone intubation had similar rates of success (79.8% vs 77.8%). Monocanalicular and bicanalicular intubation had similar rates of success (88.3% vs 88.0%). The dislocation rates for monocanalicular versus bicanalicular intubation were 8.5% and 9.8%, respectively. Conclusions: Immediate and deferred probing do not differ in their success rates. No difference in success rates was observed between balloon dilation and intubation. Monocanalicular and bicanalicular intubation were similar in their success and dislocation rates. Therefore, the preference of surgeons on the treatment of CNLDO should be discussed with parents to ensure the best possible outcome.
MeSH term(s)	Balloon Occlusion ; Dacryocystorhinostomy ; Humans ; Intubation ; Lacrimal Duct Obstruction/congenital ; Lacrimal Duct Obstruction/therapy ; Nasolacrimal Duct ; Stents
Language	English
Publishing date	2016-02
Publishing country	England
Document type	Comparative Study ; Journal Article ; Meta-Analysis ; Review
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2015.10.002
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