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  1. Article ; Online: New Dimension to Study on Platelet Bioenergetics.

    Dash, Debabrata

    Arteriosclerosis, thrombosis, and vascular biology

    2023  Volume 44, Issue 2, Page(s) 417–418

    MeSH term(s) Blood Platelets ; Platelet Activation ; Energy Metabolism ; Leukocytes
    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.123.320355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1705: Show issues Location:
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  2. Article: Iteration of Reverse Controlled Antegrade and Retrograde Tracking for Coronary Chronic Total Occlusion Intervention: a Current Appraisal.

    Dash, Debabrata

    Korean circulation journal

    2020  Volume 50, Issue 10, Page(s) 867–879

    Abstract: Coronary chronic total occlusion (CTO) remains one of the most challenging subsets for percutaneous coronary intervention (PCI). The retrograde recanalization is one of the most significant amendments of the technique that remains critical to improved ... ...

    Abstract Coronary chronic total occlusion (CTO) remains one of the most challenging subsets for percutaneous coronary intervention (PCI). The retrograde recanalization is one of the most significant amendments of the technique that remains critical to improved success of CTO PCI. Currently the reverse controlled antegrade and retrograde tracking (CART) is the most dominant retrograde technique. With emergence of new equipment and important iterations, this approach has become safer, faster and more successful. In this review, the author proposes the iteration and standardization of this technique which would further facilitates its adoption with more efficacy and safety.
    Language English
    Publishing date 2020-07-10
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2557464-4
    ISSN 1738-5520
    ISSN 1738-5520
    DOI 10.4070/kcj.2020.0156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Demystifying the conundrum of COVID-19 and cardiovascular system

    Debabrata Dash

    Iberoamerican Journal of Medicine 2(4) 297-305

    2020  

    Abstract: The outbreak of novel Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic and a public health crisis. COVID-19 is the clinical manifestation of infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Although it is ... ...

    Abstract The outbreak of novel Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic and a public health crisis. COVID-19 is the clinical manifestation of infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Although it is predominantly a respiratory illness, there is growing awareness of the cardiovascular manifestations of COVID-19 disease. Patients with pre-existing cardiovascular co-morbidities appear to be at highest risk for mortality from this disease along with the elderly. COVID-19 also contributes to cardiovascular complications, including myocardtits, acute coronary syndromes, arrhythmias, acute heart failure, and, in the most severe cases, cardiogenic shock and death. Several medications proposed in the treatment of this infection have cardiac-specific adverse effects that warrant cardiac monitoring. This review summarizes the rapidly emerging data on the cardiovascular implications of COVID-19.
    Keywords COVID-19 ; SARS-CoV-2 ; Myocarditis ; Heart failure ; Arrhythmia ; covid19
    Subject code 610
    Language English
    Publishing date 2020-06-01
    Publishing country eu
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Demystifying the conundrum of COVID-19 and cardiovascular system

    Debabrata Dash

    Iberoamerican Journal of Medicine, Vol 2, Iss 4, Pp 297-

    2020  Volume 305

    Abstract: The outbreak of novel Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic and a public health crisis. COVID-19 is the clinical manifestation of infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Although it is ... ...

    Abstract The outbreak of novel Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic and a public health crisis. COVID-19 is the clinical manifestation of infection with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Although it is predominantly a respiratory illness, there is growing awareness of the cardiovascular manifestations of COVID-19 disease. Patients with pre-existing cardiovascular co-morbidities appear to be at highest risk for mortality from this disease along with the elderly. COVID-19 also contributes to cardiovascular complications, including myocardtits, acute coronary syndromes, arrhythmias, acute heart failure, and, in the most severe cases, cardiogenic shock and death. Several medications proposed in the treatment of this infection have cardiac-specific adverse effects that warrant cardiac monitoring. This review summarizes the rapidly emerging data on the cardiovascular implications of COVID-19.
    Keywords covid-19 ; sars-cov-2 ; myocarditis ; heart failure ; arrhythmia ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Emergency Department of Hospital San Pedro (Logroño, Spain)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Non-canonical non-genomic morphogen signaling in anucleate platelets: a critical determinant of prothrombotic function in circulation.

    Kulkarni, Paresh P / Ekhlak, Mohammad / Dash, Debabrata

    Cell communication and signaling : CCS

    2024  Volume 22, Issue 1, Page(s) 13

    Abstract: Circulating platelets derived from bone marrow megakaryocytes play a central role in thrombosis and hemostasis. Despite being anucleate, platelets express several proteins known to have nuclear niche. These include transcription factors and steroid ... ...

    Abstract Circulating platelets derived from bone marrow megakaryocytes play a central role in thrombosis and hemostasis. Despite being anucleate, platelets express several proteins known to have nuclear niche. These include transcription factors and steroid receptors whose non-genomic functions are being elucidated in platelets. Quite remarkably, components of some of the best-studied morphogen pathways, namely Notch, Sonic Hedgehog (Shh), and Wnt have also been described in recent years in platelets, which regulate platelet function in the context of thrombosis as well as influence their survival. Shh and Notch pathways in stimulated platelets establish feed-forward loops of autocrine/juxtacrine/paracrine non-canonical signaling that helps perpetuate thrombosis. On the other hand, non-canonical Wnt signaling is part of a negative feedback loop for restricting platelet activation and possibly limiting thrombus growth. The present review will provide an overview of these signaling pathways in general. We will then briefly discuss the non-genomic roles of transcription factors and steroid receptors in platelet activation. This will be followed by an elaborate description of morphogen signaling in platelets with a focus on their bearing on platelet activation leading to hemostasis and thrombosis as well as their potential for therapeutic targeting in thrombotic disorders.
    MeSH term(s) Humans ; Hedgehog Proteins/metabolism ; Blood Platelets/metabolism ; Platelet Activation ; Thrombosis/metabolism ; Receptors, Steroid/metabolism
    Chemical Substances Hedgehog Proteins ; Receptors, Steroid
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01448-y
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  6. Article ; Online: Non-canonical non-genomic morphogen signaling in anucleate platelets

    Paresh P. Kulkarni / Mohammad Ekhlak / Debabrata Dash

    Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-

    a critical determinant of prothrombotic function in circulation

    2024  Volume 20

    Abstract: Abstract Circulating platelets derived from bone marrow megakaryocytes play a central role in thrombosis and hemostasis. Despite being anucleate, platelets express several proteins known to have nuclear niche. These include transcription factors and ... ...

    Abstract Abstract Circulating platelets derived from bone marrow megakaryocytes play a central role in thrombosis and hemostasis. Despite being anucleate, platelets express several proteins known to have nuclear niche. These include transcription factors and steroid receptors whose non-genomic functions are being elucidated in platelets. Quite remarkably, components of some of the best-studied morphogen pathways, namely Notch, Sonic Hedgehog (Shh), and Wnt have also been described in recent years in platelets, which regulate platelet function in the context of thrombosis as well as influence their survival. Shh and Notch pathways in stimulated platelets establish feed-forward loops of autocrine/juxtacrine/paracrine non-canonical signaling that helps perpetuate thrombosis. On the other hand, non-canonical Wnt signaling is part of a negative feedback loop for restricting platelet activation and possibly limiting thrombus growth. The present review will provide an overview of these signaling pathways in general. We will then briefly discuss the non-genomic roles of transcription factors and steroid receptors in platelet activation. This will be followed by an elaborate description of morphogen signaling in platelets with a focus on their bearing on platelet activation leading to hemostasis and thrombosis as well as their potential for therapeutic targeting in thrombotic disorders.
    Keywords Platelet activation ; Notch ; Sonic Hedgehog (Shh) ; Wnt ; Non-canonical signaling ; Vismodegib ; Medicine ; R ; Cytology ; QH573-671
    Subject code 570
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Clinical implications of revised piperacillin-tazobactam breakpoints in CLSI M-100 S32.

    Dash, Debabrata / Rai, Sumit

    Indian journal of medical microbiology

    2022  Volume 42, Page(s) 108–109

    MeSH term(s) Humans ; Piperacillin, Tazobactam Drug Combination ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Piperacillin/pharmacology ; Piperacillin/therapeutic use ; Penicillanic Acid/pharmacology ; Penicillanic Acid/therapeutic use ; Microbial Sensitivity Tests
    Chemical Substances Piperacillin, Tazobactam Drug Combination (157044-21-8) ; Anti-Bacterial Agents ; Piperacillin (X00B0D5O0E) ; Penicillanic Acid (87-53-6)
    Language English
    Publishing date 2022-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1038798-5
    ISSN 1998-3646 ; 0255-0857
    ISSN (online) 1998-3646
    ISSN 0255-0857
    DOI 10.1016/j.ijmmb.2022.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2639: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Double kissing crush in left main coronary bifurcation lesions: A crushing blow to the rival stenting techniques!

    Dash, Debabrata

    Indian heart journal

    2018  Volume 70, Issue 5, Page(s) 758–761

    MeSH term(s) Coronary Angiography ; Coronary Artery Bypass/methods ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/surgery ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Decision Making ; Drug-Eluting Stents ; Humans ; Percutaneous Coronary Intervention/methods ; Postoperative Complications/prevention & control
    Language English
    Publishing date 2018-06-30
    Publishing country India
    Document type Letter
    ZDB-ID 604366-5
    ISSN 2213-3763 ; 0019-4832
    ISSN (online) 2213-3763
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2018.06.005
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    Zs.A 616: Show issues Location:
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  9. Article ; Online: A step-by-step guide to mastering retrograde coronary chronic total occlusion intervention in 2018: The author's perspective.

    Dash, Debabrata

    Indian heart journal

    2018  Volume 70 Suppl 3, Page(s) S446–S455

    Abstract: Chronic total occlusion remains one of the most challenging subsets and represents the "last frontier" of percutaneous coronary intervention. Retrograde recanalization is one of the most significant amendments of the technique and has become an important ...

    Abstract Chronic total occlusion remains one of the most challenging subsets and represents the "last frontier" of percutaneous coronary intervention. Retrograde recanalization is one of the most significant amendments of the technique and has become an important complement to the classical antegrade approach. It yields a high success rate even in most complex patients. With emergence of important iterations, this approach has become safer, faster, and more successful. The author proposes a step-by-step guide to the retrograde approach with alternatives to various steps for operators wishing to embark on this strategy.
    MeSH term(s) Chronic Disease ; Coronary Angiography ; Coronary Occlusion/diagnosis ; Coronary Occlusion/surgery ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery ; Humans ; Percutaneous Coronary Intervention/methods
    Language English
    Publishing date 2018-08-18
    Publishing country India
    Document type Journal Article ; Review
    ZDB-ID 604366-5
    ISSN 2213-3763 ; 0019-4832
    ISSN (online) 2213-3763
    ISSN 0019-4832
    DOI 10.1016/j.ihj.2018.08.011
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    Zs.A 616: Show issues Location:
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  10. Article ; Online: Effects of Nanoceria on Human Platelet Functions and Blood Coagulation.

    Kailashiya, Jyotsna / Dash, Debabrata

    International journal of nanomedicine

    2022  Volume 17, Page(s) 273–284

    Abstract: Purpose: Cerium oxide nanoparticles (nanoceria) exist in either 3+ or 4+ oxidation state with interesting redox properties and exhibit both oxidant and antioxidant attributes based on concentration, environment and pH. Thanks to their wide spread use in ...

    Abstract Purpose: Cerium oxide nanoparticles (nanoceria) exist in either 3+ or 4+ oxidation state with interesting redox properties and exhibit both oxidant and antioxidant attributes based on concentration, environment and pH. Thanks to their wide spread use in fuel, cosmetics and other industries as well as in biomedical field, nanoceria particles get released into environment with risk of significant human exposure, and thus necessitate careful examination and optimization of their biomedical applications.
    Methods: This research was planned to explore effects of nanoceria on human platelet functions and whole blood coagulation. Platelets and whole blood from volunteer healthy donors were treated with different doses of nanoceria and various platelet functions, fibrin polymerization and blood coagulation were tested.
    Results: Nanoceria particles were found to reduce platelet aggregation and secretion of granule contents in a dose-dependent manner, impaired fibrin polymerization and retraction of fibrin-rich thrombi, associated with reduced cytosolic filamentous actin. Remarkably, nanoceria instigated early clot formation in whole blood attributable to putative activation of coagulation cascade.
    Conclusion: Above observations provide cautionary framework to critically re-evaluate and accordingly plan biomedical applications of nanoceria.
    MeSH term(s) Blood Coagulation ; Blood Platelets ; Cerium ; Humans ; Nanoparticles
    Chemical Substances Cerium (30K4522N6T) ; ceric oxide (619G5K328Y)
    Language English
    Publishing date 2022-01-20
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2364941-0
    ISSN 1178-2013 ; 1176-9114
    ISSN (online) 1178-2013
    ISSN 1176-9114
    DOI 10.2147/IJN.S332909
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