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Article ; Online: High-performance solutions of geographically weighted regression in R

Binbin Lu / Yigong Hu / Daisuke Murakami / Chris Brunsdon / Alexis Comber / Martin Charlton / Paul Harris

Geo-spatial Information Science, Pp 1-

2022 Volume 14

Abstract: ... which are increasingly prevalent in today’s digital world. In this study, we propose two high-performance R ... performance R solutions to existing ones, where for certain data-rich GWR studies, they should be preferred. ...

Abstract	As an established spatial analytical tool, Geographically Weighted Regression (GWR) has been applied across a variety of disciplines. However, its usage can be challenging for large datasets, which are increasingly prevalent in today’s digital world. In this study, we propose two high-performance R solutions for GWR via Multi-core Parallel (MP) and Compute Unified Device Architecture (CUDA) techniques, respectively GWR-MP and GWR-CUDA. We compared GWR-MP and GWR-CUDA with three existing solutions available in Geographically Weighted Models (GWmodel), Multi-scale GWR (MGWR) and Fast GWR (FastGWR). Results showed that all five solutions perform differently across varying sample sizes, with no single solution a clear winner in terms of computational efficiency. Specifically, solutions given in GWmodel and MGWR provided acceptable computational costs for GWR studies with a relatively small sample size. For a large sample size, GWR-MP and FastGWR provided coherent solutions on a Personal Computer (PC) with a common multi-core configuration, GWR-MP provided more efficient computing capacity for each core or thread than FastGWR. For cases when the sample size was very large, and for these cases only, GWR-CUDA provided the most efficient solution, but should note its I/O cost with small samples. In summary, GWR-MP and GWR-CUDA provided complementary high-performance R solutions to existing ones, where for certain data-rich GWR studies, they should be preferred.
Keywords	Non-stationarity ; big data ; parallel computing ; Compute Unified Device Architecture (CUDA) ; Geographically Weighted models (GWmodel) ; Mathematical geography. Cartography ; GA1-1776 ; Geodesy ; QB275-343
Subject code	518 ; 519
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Characterization of RNF43 frameshift mutations that drive Wnt ligand- and R-spondin-dependent colon cancer.

Yamamoto, Daisuke / Oshima, Hiroko / Wang, Dong / Takeda, Haruna / Kita, Kenji / Lei, Xuelian / Nakayama, Mizuho / Murakami, Kazuhiro / Ohama, Takashi / Takemura, Hirofumi / Toyota, Mutsumi / Suzuki, Hiromu / Inaki, Noriyuki / Oshima, Masanobu

The Journal of pathology

2022 Volume 257, Issue 1, Page(s) 39–52

Abstract: Loss-of-function mutations in RNF43 induce activation of Wnt ligand-dependent Wnt/β-catenin signaling through stabilization of the Frizzled receptor, which is often found in microsatellite instability (MSI)-type colorectal cancer (CRC) that develops from ...

Abstract	Loss-of-function mutations in RNF43 induce activation of Wnt ligand-dependent Wnt/β-catenin signaling through stabilization of the Frizzled receptor, which is often found in microsatellite instability (MSI)-type colorectal cancer (CRC) that develops from sessile serrated adenomas. However, the mechanism underlying how RNF43 mutations promote tumorigenesis remains poorly understood. In this study, we established nine human CRC-derived organoids and found that three organoid lines carried RNF43 frameshift mutations associated with MSI-high and BRAF
MeSH term(s)	Carcinogenesis/genetics ; Cell Transformation, Neoplastic ; Colonic Neoplasms/genetics ; Frameshift Mutation ; Humans ; Ligands ; Microsatellite Instability ; Mutation ; Thrombospondins/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Wnt Signaling Pathway/genetics ; beta Catenin/metabolism
Chemical Substances	Ligands ; Thrombospondins ; beta Catenin ; RNF43 protein, human (EC 2.3.2.27) ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2022-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	3119-7
ISSN	1096-9896 ; 0022-3417
ISSN (online)	1096-9896
ISSN	0022-3417
DOI	10.1002/path.5868
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Article ; Online: Tumor-Targeting Salmonella typhimurium A1-R Promotes Tumoricidal CD8

Murakami, Takashi / Hiroshima, Yukihiko / Zhang, Yong / Zhao, Ming / Kiyuna, Tasuku / Hwang, Ho Kyoung / Miyake, Kentaro / Homma, Yuki / Mori, Ryutaro / Matsuyama, Ryusei / Chishima, Takashi / Ichikawa, Yasushi / Tanaka, Kuniya / Bouvet, Michael / Endo, Itaru / Hoffman, Robert M

Journal of cellular biochemistry

2017

Abstract: The present study determined the effect of the tumor-targeting strain Salmonella typhimurium A1-R ... S. typhimurium A1-R) on CD8 ...

Abstract	The present study determined the effect of the tumor-targeting strain Salmonella typhimurium A1-R (S. typhimurium A1-R) on CD8
Language	English
Publishing date	2017-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.26224
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Article ; Online: Immunostimulatory effect of kumquat (Fortunella crassifolia) and its constituents, β-cryptoxanthin and R-limonene.

Terao, Rina / Murata, Akira / Sugamoto, Kazuhiro / Watanabe, Tomoko / Nagahama, Kiyoko / Nakahara, Keiko / Kondo, Tomomi / Murakami, Noboru / Fukui, Keiichi / Hattori, Hidemi / Eto, Nozomu

Food & function

2018 Volume 10, Issue 1, Page(s) 38–48

Abstract: ... as an active kumquat component with a NK cell-activating effect, and R-limonene as an active component ... BCX, R-limonene, and R-limonene metabolites were found to enhance IFN-γ production in KHYG-1 cells ...

Abstract	Natural killer (NK) cells play an important role in the innate immune system by eliminating cancer cells and virally infected cells. Aging and stress attenuate the activity of NK cells, thereby increasing the risk of various diseases. In this study, we demonstrated that the consumption of a small number of kumquats in an in vivo model could suppress elevated plasma corticosterone levels and reverse the decline in splenocyte cytotoxicity caused by restraint stress. Our results identified β-cryptoxanthin (BCX) as an active kumquat component with a NK cell-activating effect, and R-limonene as an active component that mediates not only the anti-stress effect but also NK cell activation by oral administration. In addition, BCX, R-limonene, and R-limonene metabolites were found to enhance IFN-γ production in KHYG-1 cells, a human NK cell line. Collectively, our findings suggest that the ingestion of a few kumquats on a daily basis can help to combat stress and enhance NK cell activity.
MeSH term(s)	Adjuvants, Immunologic/chemistry ; Adjuvants, Immunologic/metabolism ; Animals ; Beta-Cryptoxanthin/chemistry ; Beta-Cryptoxanthin/metabolism ; Cell Line ; Corticosterone/blood ; Humans ; Interferon-gamma/immunology ; Killer Cells, Natural/immunology ; Limonene/chemistry ; Limonene/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Plant Extracts/chemistry ; Plant Extracts/metabolism ; Rutaceae/chemistry ; Rutaceae/metabolism ; Stress, Physiological
Chemical Substances	Adjuvants, Immunologic ; Beta-Cryptoxanthin ; Plant Extracts ; Interferon-gamma (82115-62-6) ; Limonene (9MC3I34447) ; Corticosterone (W980KJ009P)
Language	English
Publishing date	2018-12-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/c8fo01971a
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Article ; Online: Tumor-targeting Salmonella typhimurium A1-R overcomes partial carboplatinum-resistance of a cancer of unknown primary (CUP).

Tissue & cell

2018 Volume 54, Page(s) 144–149

Abstract: ... of Salmonella typhimurium A1-R (S. typhimurium A1-R) alone and carboplatinum alone (CAR) on a CUP patient tumor ... typhimurium A1-R combined with CAR on the CUP PDOX model. The CUP tumors were implanted orthotopically ...

Abstract	Cancer of unknown primary (CUP) is metastatic disease without a known primary and therefore very difficult to identify effective therapy. Previously, we demonstrated partial efficacy of Salmonella typhimurium A1-R (S. typhimurium A1-R) alone and carboplatinum alone (CAR) on a CUP patient tumor in the patient-derived xenograft (PDOX) model. The aim of the present study was to investigate the efficacy of S. typhimurium A1-R combined with CAR on the CUP PDOX model. The CUP tumors were implanted orthotopically into the left supraclavicular fossa of nude mice to match the site from which they were resected from the patient. CUP PDOX models were divided randomly into the following 4 groups after the tumor volume reached 100 mm
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Carboplatin/pharmacology ; Drug Resistance, Neoplasm/drug effects ; Humans ; Mice ; Mice, Nude ; Neoplasms, Unknown Primary/pathology ; Salmonella typhimurium/physiology ; Xenograft Model Antitumor Assays
Chemical Substances	Antineoplastic Agents ; Carboplatin (BG3F62OND5)
Language	English
Publishing date	2018-09-14
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2018.09.001
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Book ; Online: Data and R-code from 'Mode of death and mortality risk factors in Amazon trees'. Nature communications. 2020

Esquivel-Muelbert, Adriane / Phillips, Oliver L. / Brienen, Roel J.W. / Fauset, Sophie / Sullivan, Martin J.P. / Baker, Timothy R. / Chao, Kuo Jung / Feldpausch, Ted R. / Gloor, Emanuel / Higuchi, Niro / Houwing-Duistermaat, Jeanne / Lloyd, Jon / Liu, Haiyan / Malhi, Yadvinder / Marimon, Beatriz / Marimon Junior, Ben Hur / Monteagudo-Mendoza, Abel / Poorter, Lourens / Silveira, Marcos /

Torre, Emilio Vilanova / Dávila, Esteban Alvarez / del Aguila Pasquel, Jhon / Almeida, Everton / Loayza, Patricia Alvarez / Andrade, Ana / Aragão, Luiz E.O.C. / Araujo-Murakami, Alejandro / Arets, Eric / Arroyo, Luzmila / Aymard C, Gerardo A. / Baisie, Michel / Baraloto, Christopher / Camargo, Plínio Barbosa / Barroso, Jorcely / Blanc, Lilian / Bonal, Damien / Bongers, Frans / Boot, René / Brown, Foster / Burban, Benoit / Camargo, José Luís / Castro, Wendeson / Moscoso, Victor Chama / Chave, Jerome / Comiskey, James / Valverde, Fernando Cornejo / da Costa, Antonio Lola / Cardozo, Nallaret Davila / Di Fiore, Anthony / Dourdain, Aurélie / Erwin, Terry / Llampazo, Gerardo Flores / Vieira, Ima Célia Guimarães / Herrera, Rafael / Honorio Coronado, Eurídice / Huamantupa-Chuquimaco, Isau / Jimenez-Rojas, Eliana / Killeen, Timothy / Laurance, Susan / Laurance, William / Levesley, Aurora / Lewis, Simon L. / Ladvocat, Karina Liana Lisboa Melgaço / Lopez-Gonzalez, Gabriela / Lovejoy, Thomas / Meir, Patrick / Mendoza, Casimiro / Morandi, Paulo / Neill, David / Nogueira Lima, Adriano José / Vargas, Percy Nuñez / de Oliveira, Edmar Almeida / Camacho, Nadir Pallqui / Pardo, Guido / Peacock, Julie / Peña-Claros, Marielos / Peñuela-Mora, Maria Cristina / Pickavance, Georgia / Pipoly, John / Pitman, Nigel / Prieto, Adriana / Pugh, Thomas A.M. / Quesada, Carlos / Ramirez-Angulo, Hirma / de Almeida Reis, Simone Matias / Rejou-Machain, Maxime / Correa, Zorayda Restrepo / Bayona, Lily Rodriguez / Rudas, Agustín / Salomão, Rafael / Serrano, Julio / Espejo, Javier Silva / Silva, Natalino / Singh, James / Stahl, Clement / Stropp, Juliana / Swamy, Varun / Talbot, Joey / ter Steege, Hans / Terborgh, John / Thomas, Raquel / Toledo, Marisol / Torres-Lezama, Armando / Gamarra, Luis Valenzuela / van der Heijden, Geertje / van der Meer, Peter / van der Hout, Peter / Martinez, Rodolfo Vasquez / Vieira, Simone Aparecida / Cayo, Jeanneth Villalobos / Vos, Vincent / Zagt, Roderick / Zuidema, Pieter / Galbraith, David

2020

Abstract: The carbon sink capacity of tropical forests is substantially affected by tree mortality. However, the main drivers of tropical tree death remain largely unknown. Here we present a pan-Amazonian assessment of how and why trees die, analysing over 120,000 ...

Abstract	The carbon sink capacity of tropical forests is substantially affected by tree mortality. However, the main drivers of tropical tree death remain largely unknown. Here we present a pan-Amazonian assessment of how and why trees die, analysing over 120,000 trees representing > 3800 species from 189 long-term RAINFOR forest plots. While tree mortality rates vary greatly Amazon-wide, on average trees are as likely to die standing as they are broken or uprooted—modes of death with different ecological consequences. Species-level growth rate is the single most important predictor of tree death in Amazonia, with faster-growing species being at higher risk. Within species, however, the slowest-growing trees are at greatest risk while the effect of tree size varies across the basin. In the driest Amazonian region species-level bioclimatic distributional patterns also predict the risk of death, suggesting that these forests are experiencing climatic conditions beyond their adaptative limits. These results provide not only a holistic pan-Amazonian picture of tree death but large-scale evidence for the overarching importance of the growth–survival trade-off in driving tropical tree mortality.
Keywords	Life Science
Subject code	580
Publisher	University of Birmingham
Publishing country	nl
Document type	Book ; Online
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Article ; Online: Tumor-targeting Salmonella typhimurium A1-R regresses an osteosarcoma in a patient-derived xenograft model resistant to a molecular-targeting drug.

Oncotarget

2017 Volume 8, Issue 5, Page(s) 8035–8042

Abstract: ... A1-R (S. typhimurium A1-R, p<0.001 compared to untreated control). The osteosarcoma was only ... typhimurium A1-R was significantly more effective than sorafenib (P <0.001). S. typhimurium grew ... in the treated tumors and caused extensive necrosis of the tumor tissue. These data show that S. typhimurium A1-R ...

Abstract	Osteosarcoma occurs mostly in children and young adults, who are treated with multiple agents in combination with limb-salvage surgery. However, the overall 5-year survival rate for patients with recurrent or metastatic osteosarcoma is 20-30% which has not improved significantly over 30 years. Refractory patients would benefit from precise individualized therapy. We report here that a patient-derived osteosarcoma growing in a subcutaneous nude-mouse model was regressed by tumor-targeting Salmonella typhimurium A1-R (S. typhimurium A1-R, p<0.001 compared to untreated control). The osteosarcoma was only partially sensitive to the molecular-targeting drug sorafenib, which did not arrest its growth. S. typhimurium A1-R was significantly more effective than sorafenib (P <0.001). S. typhimurium grew in the treated tumors and caused extensive necrosis of the tumor tissue. These data show that S. typhimurium A1-R is powerful therapy for an osteosarcoma patient-derived xenograft model.
MeSH term(s)	Adolescent ; Animals ; Antineoplastic Agents/pharmacology ; Biological Therapy/methods ; Bone Neoplasms/microbiology ; Bone Neoplasms/pathology ; Bone Neoplasms/therapy ; Drug Resistance, Neoplasm ; Humans ; Male ; Mice, Nude ; Molecular Targeted Therapy ; Necrosis ; Niacinamide/analogs & derivatives ; Niacinamide/pharmacology ; Osteosarcoma/microbiology ; Osteosarcoma/pathology ; Osteosarcoma/therapy ; Phenylurea Compounds/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Salmonella typhimurium/pathogenicity ; Sorafenib ; Time Factors ; Tumor Burden ; Xenograft Model Antitumor Assays
Chemical Substances	Antineoplastic Agents ; Phenylurea Compounds ; Protein Kinase Inhibitors ; Niacinamide (25X51I8RD4) ; Sorafenib (9ZOQ3TZI87)
Language	English
Publishing date	2017-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.14040
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Article: Immunostimulatory effect of kumquat (Fortunella crassifolia) and its constituents, β-cryptoxanthin and R-limonene

Terao, Rina / Akira Murata / Hidemi Hattori / Kazuhiro Sugamoto / Keiichi Fukui / Keiko Nakahara / Kiyoko Nagahama / Noboru Murakami / Nozomu Eto / Tomoko Watanabe / Tomomi Kondo

Food & function. 2019 Jan. 22, v. 10, no. 1

2019

Abstract	Natural killer (NK) cells play an important role in the innate immune system by eliminating cancer cells and virally infected cells. Aging and stress attenuate the activity of NK cells, thereby increasing the risk of various diseases. In this study, we demonstrated that the consumption of a small number of kumquats in an in vivo model could suppress elevated plasma corticosterone levels and reverse the decline in splenocyte cytotoxicity caused by restraint stress. Our results identified β-cryptoxanthin (BCX) as an active kumquat component with a NK cell-activating effect, and R-limonene as an active component that mediates not only the anti-stress effect but also NK cell activation by oral administration. In addition, BCX, R-limonene, and R-limonene metabolites were found to enhance IFN-γ production in KHYG-1 cells, a human NK cell line. Collectively, our findings suggest that the ingestion of a few kumquats on a daily basis can help to combat stress and enhance NK cell activity.
Keywords	beta-cryptoxanthin ; corticosterone ; cytotoxicity ; Fortunella crassifolia ; human cell lines ; immunostimulants ; innate immunity ; interferon-gamma ; kumquats ; metabolites ; models ; natural killer cells ; neoplasm cells ; neoplasms ; oral administration ; splenocytes
Language	English
Dates of publication	2019-0122
Size	p. 38-48.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/c8fo01971a
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Combining Tumor-Selective Bacterial Therapy with Salmonella typhimurium A1-R and Cancer Metabolism Targeting with Oral Recombinant Methioninase Regressed an Ewing's Sarcoma in a Patient-Derived Orthotopic Xenograft Model.

Miyake, Kentaro / Kiyuna, Tasuku / Li, Shukuan / Han, Qinghong / Tan, Yuying / Zhao, Ming / Oshiro, Hiromichi / Kawaguchi, Kei / Higuchi, Takashi / Zhang, Zhiying / Razmjooei, Sahar / Barangi, Maryam / Wangsiricharoen, Sintawat / Murakami, Takashi / Singh, Arun S / Li, Yunfeng / Nelson, Scott D / Eilber, Fritz C / Bouvet, Michael /

Hiroshima, Yukihiko / Chishima, Takashi / Matsuyama, Ryusei / Singh, Shree Ram / Endo, Itaru / Hoffman, Robert M

Chemotherapy

2019 Volume 63, Issue 5, Page(s) 278–283

Abstract: ... A1-R combined with tumor metabolism targeting with oral administration of recombinant methioninase (o ... when the tumor volume reached 80 mm3: G1: untreated control; G2: doxorubicin; G3: S. typhimurium A1-R; G4: o-rMETase; G5 ... S. typhimurium A1-R combined with o-rMETase. All mice were sacrificed on day 15. Body weight and ...

Abstract	Background: Ewing's sarcoma (ES) is a recalcitrant disease in need of transformative therapeutics. Objectives: The aim of this study was to investigate the efficacy of tumor-selective Salmonella typhimurium A1-R combined with tumor metabolism targeting with oral administration of recombinant methioninase (o-rMETase), on an ES patient-derived orthotopic xenograft (PDOX) model. Methods: The ES PDOX models were previously established in the right chest wall. The ES PDOX models were randomized into 5 groups when the tumor volume reached 80 mm3: G1: untreated control; G2: doxorubicin; G3: S. typhimurium A1-R; G4: o-rMETase; G5: S. typhimurium A1-R combined with o-rMETase. All mice were sacrificed on day 15. Body weight and tumor volume were assessed twice a week. Results: S. typhimurium A1-R and o-rMETase respectively suppressed tumor growth as monotherapies (p = 0.050 and p = 0.032). S. typhimurium A1-R combined with o-rMETase regressed tumor growth significantly compared to untreated group on day 15 (p < 0.032). S. typhimurium A1-R combined with o-rMETase group was significantly more effective than S. typhimurium A1-R or o-rMETase monotherapy (p = 0.032, p = 0.032). Conclusions: The present results suggest that the combination of S. typhimurium A1-R and o-rMETase has promise to be a transformative therapy for ES.
MeSH term(s)	Administration, Oral ; Animals ; Antibiotics, Antineoplastic/therapeutic use ; Body Weight ; Bone Neoplasms/drug therapy ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Carbon-Sulfur Lyases/genetics ; Carbon-Sulfur Lyases/metabolism ; Carbon-Sulfur Lyases/therapeutic use ; Disease Models, Animal ; Doxorubicin/therapeutic use ; Female ; Humans ; Mice ; Mice, Nude ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/therapeutic use ; Salmonella typhimurium/pathogenicity ; Sarcoma, Ewing/drug therapy ; Sarcoma, Ewing/metabolism ; Sarcoma, Ewing/pathology ; Transplantation, Heterologous
Chemical Substances	Antibiotics, Antineoplastic ; Recombinant Proteins ; Doxorubicin (80168379AG) ; Carbon-Sulfur Lyases (EC 4.4.-) ; L-methionine gamma-lyase (EC 4.4.1.11)
Language	English
Publishing date	2019-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	6708-8
ISSN	1421-9794 ; 0009-3157
ISSN (online)	1421-9794
ISSN	0009-3157
DOI	10.1159/000495574
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Article ; Online: Tumor-targeting Salmonella typhimurium A1-R overcomes nab-paclitaxel resistance in a cervical cancer PDOX mouse model.

Miyake, Kentaro / Murata, Takuya / Murakami, Takashi / Zhao, Ming / Kiyuna, Tasuku / Kawaguchi, Kei / Igarashi, Kentaro / Miyake, Masuyo / Lwin, Thinzar M / Hozumi, Chihiro / Komatsu, Shin / Kikuchi, Takashi / Bouvet, Michael / Shimoya, Koichiro / Singh, Shree Ram / Endo, Itaru / Hoffman, Robert M

Archives of gynecology and obstetrics

2019 Volume 299, Issue 6, Page(s) 1683–1690

Abstract: ... targeting bacteria Salmonella typhimurium A1-R (S. typhimurium A1-R). The aim of the present study was ... to investigate the efficacy of S. typhimurium A1-R to overcome nab-PTX resistance in the cervical cancer PDOX ... the tumor volume reached 60 mm: Results: Nab-PTX and Salmonella typhimurium A1-R did not show significant ...

Abstract	Purpose: Cervical cancer is a recalcitrant disease. To help overcome this problem, we previously established a patient-derived orthotopic xenograft (PDOX) model of cervical cancer. In the previous study, we found the tumor to be resistant to nab-paclitaxal (nab-PTX). We also previously developed the tumor-targeting bacteria Salmonella typhimurium A1-R (S. typhimurium A1-R). The aim of the present study was to investigate the efficacy of S. typhimurium A1-R to overcome nab-PTX resistance in the cervical cancer PDOX model. Methods: Cervical-cancer tumor fragments were implanted orthotopically into the neck of the uterus of nude mice. The cervical-cancer PDOX models were randomized into the following four groups after the tumor volume reached 60 mm Results: Nab-PTX and Salmonella typhimurium A1-R did not show significant efficacy as monotherapy compared to the control group (P = 0.564 and P = 0.120, respectively). In contrast, nab-PTX combined with Salmonella typhimurium A1-R significantly suppressed tumor growth compared to the untreated control group and nab-PTX group (P < 0.001 and P = 0.026, respectively). Conclusions: Salmonella typhimurium A1-R has potential future clinical application to overcome drug resistance in cervical cancer.
MeSH term(s)	Albumins/pharmacology ; Albumins/therapeutic use ; Animals ; Disease Models, Animal ; Doxorubicin/analogs & derivatives ; Doxorubicin/metabolism ; Female ; Humans ; Mice ; Mice, Nude ; Oligopeptides/metabolism ; Paclitaxel/pharmacology ; Paclitaxel/therapeutic use ; Salmonella typhimurium/drug effects ; Uterine Cervical Neoplasms/drug therapy ; Xenograft Model Antitumor Assays
Chemical Substances	130-nm albumin-bound paclitaxel ; Albumins ; Oligopeptides ; acetyl-phenylalanyl-lysyl-para-aminobenzyloxycarbonyl-adriamycin ; Doxorubicin (80168379AG) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2019-04-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	896455-5
ISSN	1432-0711 ; 0932-0067
ISSN (online)	1432-0711
ISSN	0932-0067
DOI	10.1007/s00404-019-05147-3
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