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  1. Article ; Online: NaN(SiMe

    Meng, Xiang-He / Xu, Xue-Cen / Wang, Zhuo / Liang, Yong-Xin / Zhao, Yu-Long

    The Journal of organic chemistry

    2022  Volume 87, Issue 5, Page(s) 3156–3166

    Abstract: A NaN(SiMe ...

    Abstract A NaN(SiMe
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.1c02890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: SulfoxFluor-enabled deoxyazidation of alcohols with NaN

    Guo, Junkai / Wang, Xiu / Ni, Chuanfa / Wan, Xiaolong / Hu, Jinbo

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2752

    Abstract: Direct deoxyazidation of alcohols with NaN ...

    Abstract Direct deoxyazidation of alcohols with NaN
    Language English
    Publishing date 2022-05-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30132-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Two new sesquiterpenes in Qi-nan Aquilariae Lignum Resinatum].

    Chen, De-Li / Ma, Guo-Xu / Liu, Hui-Mei / Wang, Can-Hong / Liu, Yang-Yang / Yang, Yun / Wei, Jian-He

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2024  Volume 48, Issue 23, Page(s) 6403–6407

    Abstract: This study aimed to investigate the chemical constituents of supercritical extract from Qi-nan ...

    Abstract This study aimed to investigate the chemical constituents of supercritical extract from Qi-nan Aquilariae Lignum Resinatum by silica gel column chromatography, thin-layer chromatography, and semi-preparative high-performance liquid chromatography. One new elemane-type and one new eudesmane-type sesquiterpene compounds were isolated from the extract, and their structures were identified by MS, UV, IR, NMR, and ECD spectroscopic techniques, and named aquqinanol C(1) and aquqinanol D(2). Both compounds are novel compounds. The neuroprotective effect of the compounds on CORT-induced PC12 cell damage was determined in vitro. The results showed that compounds 1 and 2 exhibited a certain protective effect against CORT-induced damage in PC12 cells.
    MeSH term(s) Rats ; Animals ; Qi ; Sesquiterpenes/pharmacology ; Molecular Structure
    Chemical Substances Sesquiterpenes
    Language Chinese
    Publishing date 2024-01-09
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20230618.203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3056: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: "Qi Nan" agarwood restores podocyte autophagy in diabetic kidney disease by targeting EGFR signaling pathway.

    Li, Ning / Liu, Xuenan / Wang, Hao / Duan, Yingling / Zhang, Yu / Zhou, Ping / Dai, Haofu / Lan, Tian

    Chinese medicine

    2024  Volume 19, Issue 1, Page(s) 63

    Abstract: Background: Diabetic kidney disease (DKD) is a microvascular complication of diabetes mellitus, contributing to end-stage renal disease with limited treatment options. The development of DKD is attributed to podocyte injury resulting from abnormal ... ...

    Abstract Background: Diabetic kidney disease (DKD) is a microvascular complication of diabetes mellitus, contributing to end-stage renal disease with limited treatment options. The development of DKD is attributed to podocyte injury resulting from abnormal podocyte autophagy. Consequently, the restoration of podocyte autophagy is deemed a practicable approach in the treatment of DKD.
    Methods: Diabetic mice were induced by streptozotocin and high-fat diet feeding. Following 8 weeks of "QN" agarwood treatment, metrics such as albuminuria, serum creatinine (Scr), and blood urea nitrogen (BUN) were evaluated. Renal histological lesions were evaluated by H&E, PAS, Masson, and Sirius red staining. Evaluation of the effects of "QN" agarwood on renal inflammation and fibrosis in DKD mice through WB, q-PCR, and IHC staining analysis. Cytoscape 3.7.1 was used to construct a PPI network. With the DAVID server, the gene ontology (GO) functional annotation and the Kyoto encyclopedia of genes and genomes (KEGG) signaling pathways of the target enrichment were performed. Molecular docking and binding affinity calculations were conducted using AutoDock, while PyMOL software was employed for visualizing the docking results of active compounds and protein targets.
    Results: The results of this study show that "QN" agarwood reduced albuminuria, Scr, and BUN in DKD mice, and improved the renal pathological process. Additionally, "QN" agarwood was observed to downregulate the mRNA and protein expression levels of pro-inflammatory and pro-fibrotic factors in the kidneys of DKD mice. Network pharmacology predicts that "QN" agarwood modulates the epidermal growth factor receptor (EGFR) signaling pathway. "QN" agarwood can increase the expression of LC3B and Nphs1 in DKD mice while reducing the expression of EGFR.
    Conclusion: The present study demonstrated that "QN" agarwood ameliorated renal injury in DKD by targeting EGFR and restoring podocyte autophagy.
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-024-00923-z
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  5. Article ; Online: Gas Emergence Characteristics of the Upper Corner on the 215101 Mining Working Face of the Yue Nan Coal Mine.

    Chen, Xiangjun / Dong, Xiaozhen / Wang, Lin / Huang, Zhen / Cui, Pengfei

    ACS omega

    2022  Volume 7, Issue 29, Page(s) 25663–25674

    Abstract: To prevent the gas over limit in the upper corner of the 215101 working face of the Yue Nan coal ...

    Abstract To prevent the gas over limit in the upper corner of the 215101 working face of the Yue Nan coal mine, a numerical simulation method was used to analyze the gas concentration in the upper corner of the working face at different air intake volumes and mining velocities. The research results show that the gas concentration in the upper corner is 0.78, 0.52, 0.39, and 0.32% when the wind speed of the intake airflow roadway is 1, 1.5, 2, and 2.5 m/s, respectively, and an optimal wind speed of the intake airflow roadway is selected as 2 m/s. When the wind speed of the intake airflow roadway is 2 m/s, the working face mining velocity is 1, 2, 3, and 4 m/d, and the gas concentration in the upper corner is 0.27, 0.39, 0.58, and 0.83%, respectively, and an optimal working face mining velocity of 3 m/d is selected. Under the optimal mining conditions, the working face wind leakage area is divided, with 0∼30 m of the working face as the main leakage area and 150-180 m as the wind flow compensation area. According to the wind speed in the gob, the wind flow disturbance area is divided, the gob 0-50 m is the wind flow intense disturbance area, which is the main area of the upper corner gas source; the gob 50-62 m is the wind flow medium disturbance area, which is the secondary area of the upper corner gas source; the gob 62-75 m is the slight disturbance area, which has less influence on the upper corner gas concentration; the gob after 75 m is the wind flow undisturbed area, and the upper corner gas concentration is almost unaffected by it.
    Language English
    Publishing date 2022-07-14
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c02898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Palladium-Catalyzed Cascade Carbonylative Synthesis of 1,2,4-Triazol-3-ones from Hydrazonoyl Chlorides and NaN

    Du, Shiying / Wang, Wei-Feng / Song, Yufei / Chen, Zhengkai / Wu, Xiao-Feng

    Organic letters

    2021  Volume 23, Issue 3, Page(s) 974–978

    Abstract: A palladium-catalyzed three-component carbonylative reaction for the synthesis of ... ...

    Abstract A palladium-catalyzed three-component carbonylative reaction for the synthesis of 3
    Language English
    Publishing date 2021-01-12
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.0c04167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Chi-Nan Hu-Pioneer of Chinese neuroscience and cognitive science.

    Wang, Yunjin / Qian, Yanyan

    Protein & cell

    2019  Volume 11, Issue 7, Page(s) 465–468

    MeSH term(s) China ; Cognitive Science/history ; History, 20th Century ; Humans ; Neurosciences/history ; United States
    Language English
    Publishing date 2019-10-08
    Publishing country Germany
    Document type Biography ; Historical Article ; Journal Article ; Portrait ; Research Support, Non-U.S. Gov't
    ZDB-ID 2543451-2
    ISSN 1674-8018 ; 1674-800X
    ISSN (online) 1674-8018
    ISSN 1674-800X
    DOI 10.1007/s13238-019-00658-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Characteristic Fragrant Sesquiterpenes and 2-(2-Phenylethyl)chromones in Wild and Cultivated "Qi-Nan" Agarwood.

    Yang, Li / Yang, Jin-Ling / Dong, Wen-Hua / Wang, Ya-Li / Zeng, Jun / Yuan, Jing-Zhe / Wang, Hao / Mei, Wen-Li / Dai, Hao-Fu

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 2

    Abstract: Recently, cultivated "Qi-Nan" (CQN) agarwood has emerged as a new high-quality agarwood ...

    Abstract Recently, cultivated "Qi-Nan" (CQN) agarwood has emerged as a new high-quality agarwood in the agarwood market owing to its similar characteristics, such as high content of resin and richness in two 2-(2-phenylethyl)chromone derivatives, 2-(2-phenylethyl)chromone (
    MeSH term(s) Flavonoids/analysis ; Flavonoids/chemistry ; Molecular Structure ; Odorants/analysis ; Perfume/analysis ; Perfume/chemistry ; Sesquiterpenes/analysis ; Sesquiterpenes/chemistry ; Thymelaeaceae/chemistry ; Wood/chemistry
    Chemical Substances Flavonoids ; Perfume ; Sesquiterpenes ; 2-(2-phenylethyl)chromone (61828-53-3)
    Language English
    Publishing date 2021-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26020436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  9. Article: Apatinib plus vinorelbine versus vinorelbine for metastatic triple-negative breast cancer who failed first/second-line treatment: the NAN trial.

    Li, Dou-Dou / Tao, Zhong-Hua / Wang, Bi-Yun / Wang, Lei-Ping / Cao, Jun / Hu, Xi-Chun / Zhang, Jian

    NPJ breast cancer

    2022  Volume 8, Issue 1, Page(s) 110

    Abstract: While therapies such as chemotherapy combined with immunotherapy, sacituzumab govitecan, and PARP inhibitors are available for metastatic TNBC, on disease progression after these therapies, the mainstay of therapy is chemotherapy. Apatinib is a small- ... ...

    Abstract While therapies such as chemotherapy combined with immunotherapy, sacituzumab govitecan, and PARP inhibitors are available for metastatic TNBC, on disease progression after these therapies, the mainstay of therapy is chemotherapy. Apatinib is a small-molecule tyrosine kinase inhibitor that has promising anti-angiogenesis and antitumor activity for TNBC. We aimed to evaluate the safety and efficacy of adding apatinib to chemotherapy in patients with advanced TNBC with failed first/second-line treatment. A total of 66 patients were randomly assigned, in a 1:1 ratio, to receive vinorelbine or vinorelbine with apatinib in 28-day cycles. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), overall response rate (ORR) and safety. 33 received apatinib plus vinorelbine and 32 received vinorelbine (1 was withdrawal). Median PFS was significantly longer in the apatinib plus vinorelbine group than in the vinorelbine group (3.9 months vs. 2.0 months; hazard ratio, 1.82; 95% confidence interval [CI], 1.06 to 3.11; P = 0.026). Median OS was 11.5 months with apatinib plus vinorelbine and 9.9 months with vinorelbine (HR,1.01; 95% CI, 0.51 to 1.97; P = 0.985). The ORR was 9.1% in the apatinib plus vinorelbine group and 6.3% in the vinorelbine group (P = 0.667). The most common treatment-related hematologic grade 3-4 adverse events in apatinib plus vinorelbine group, were leukopenia, granulocytopenia, anemia, and thrombocytopenia. no treatment-related nonhematologic grade 4 adverse events or treatment-related deaths were observed. Collectively, adding apatinib to vinorelbine shows a promising benefit in PFS compared to vinorelbine monotherapy, with an excellent toxicity profile, warranting further exploration.
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Journal Article
    ISSN 2374-4677
    ISSN 2374-4677
    DOI 10.1038/s41523-022-00462-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Transcriptome-Wide m6A Analysis Provides Novel Insights Into Testicular Development and Spermatogenesis in Xia-Nan Cattle.

    Liu, Shen-He / Ma, Xiao-Ya / Yue, Ting-Ting / Wang, Zi-Chen / Qi, Kun-Long / Li, Ji-Chao / Lin, Feng / Rushdi, Hossam E / Gao, Yu-Yang / Fu, Tong / Li, Ming / Gao, Teng-Yun / Yang, Li-Guo / Han, Xue-Lei / Deng, Ting-Xian

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 791221

    Abstract: Testis is the primary organ of the male reproductive tract in mammals that plays a substantial role in spermatogenesis. Improvement of our knowledge regarding the molecular mechanisms in testicular development and spermatogenesis will be reflected in ... ...

    Abstract Testis is the primary organ of the male reproductive tract in mammals that plays a substantial role in spermatogenesis. Improvement of our knowledge regarding the molecular mechanisms in testicular development and spermatogenesis will be reflected in producing spermatozoa of superior fertility. Evidence showed that N6-Methyladenosine (m6A) plays a dynamic role in post-transcription gene expression regulation and is strongly associated with production traits. However, the role of m6A in bovine testis has not been investigated yet. In this study, we conducted MeRIP-Seq analysis to explore the expression profiles of the m6A and its potential mechanism underlying spermatogenesis in nine bovine testes at three developmental stages (prepuberty, puberty and postpuberty). The experimental animals with triplicate in each stage were chosen based on their semen volume and sperm motility except for the prepuberty bulls and used for testes collection. By applying MeRIP-Seq analysis, a total of 8,774 m6A peaks and 6,206 m6A genes among the studied groups were identified. All the detected peaks were found to be mainly enriched in the coding region and 3'- untranslated regions. The cross-analysis of m6A and mRNA expression exhibited 502 genes with concomitant changes in the mRNA expression and m6A modification. Notably, 30 candidate genes were located in the largest network of protein-protein interactions. Interestingly, four key node genes (
    Language English
    Publishing date 2021-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.791221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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