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  1. Article: Évaluation de la pratique pharmaceutique en établissement de santé : une étude exploratoire comparant les processus en France et au Québec.

    Marc, Manon / Rambourg, Patrick / Bussières, Jean-François

    Annales pharmaceutiques francaises

    2024  Volume 82, Issue 3, Page(s) 560–574

    Abstract: ... the methods of evaluating pharmaceutical practice in hospitals in France and Quebec.: Results: In order ... to identify and compare the methods of evaluating pharmaceutical practice in hospitals in France and Quebec ... our approach allowed us to identify more organizations in France (i.e., High Authority of Health, Regional ...

    Title translation Evaluation of pharmaceutical practice in hospitals: An exploratory study comparing processes in France and Quebec.
    Abstract Context: To ensure compliance with the legal and normative framework, the professional orders, which supervise the practice of pharmacy have established a professional inspection process. In addition to this process, other external organizations also require an accreditation, authorization, certification or validation process for professional practices.
    Objective: The main objective is to identify and compare the methods of evaluating pharmaceutical practice in hospitals in France and Quebec.
    Results: In order to identify and compare the methods of evaluating pharmaceutical practice in hospitals in France and Quebec, our approach allowed us to identify more organizations in France (i.e., High Authority of Health, Regional Health Agencies, the National Order of Pharmacists, the Nuclear Safety Agency, the Biomedicine Agency and the National Agency for the Safety of Medicines and Health Products) than in Quebec (i.e., Accreditation Canada, Ordre des pharmaciens du Québec and Health Canada). The study highlights the legal framework and applicable standards, the surveyors, the evaluation methods and the particularities for the evaluation of the hospital, the pharmacy department and the members of the department.
    Conclusions: This study highlights the evaluation processes of pharmaceutical practice in hospitals. In France, as in Quebec, we recognize the importance of the drug circuit in the hospital, the development and operation of a pharmacy department and the practice of pharmacy. While there are more similarities for the assessment of the drug circuit in hospitals and pharmacy department, important differences are observed for the assessment of individuals. We believe that the publication of a comparative analysis can contribute to discussions and exchanges to benefit from the best practices of each country.
    MeSH term(s) Humans ; Quebec ; Pharmacy Service, Hospital ; Hospitals ; Pharmacy ; Pharmacists ; France ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations
    Language French
    Publishing date 2024-02-15
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 307-4
    ISSN 0003-4509
    ISSN 0003-4509
    DOI 10.1016/j.pharma.2024.02.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 223: Show issues Location:
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  2. Article ; Online: Two-year audit of compliance in the preparation and administration of medications by nursing staff in a mother-and-child university hospital center.

    Jacolin, Charlotte / Monnier, Amélie / Farcy, Élisabeth / Atkinson, Suzanne / Pelchat, Véronique / Duval, Stéphanie / Bussières, Jean-François

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

    2024  Volume 31, Issue 2, Page(s) 100–105

    Abstract: Objective: Audits are essential for reviewing and improving the medication-use process. Identifying areas for improvement can limit the risk of errors when preparing and administering drugs. Pediatric centers face specific challenges in ensuring the ... ...

    Abstract Objective: Audits are essential for reviewing and improving the medication-use process. Identifying areas for improvement can limit the risk of errors when preparing and administering drugs. Pediatric centers face specific challenges in ensuring the safety of the medication-use process. The objective of this study was to observe and compare compliance with criteria for the preparation and administration of medications by nurses in a mother-and-child university hospital center over two consecutive years.
    Methods: This observational cross-sectional study was conducted in a Canadian mother-and-child university hospital center. Audits were conducted over a 1-month period in 16 and 18 nursing care sectors in 2021 and 2022, respectively. The standardized audit evaluated compliance with prespecified criteria related to the preparation and administration of medication by nursing staff (77 criteria for 2021 and 82 criteria for 2022). The auditors comprised nurses and a pharmacist trained by the research team. Compliance was compared between years and assessed through a chi-square test.
    Results: The audit consisted of 522 observations in 2021 and 448 observations in 2022. Overall compliance was 76% in 2021 and 66% in 2022. The compliance rate by criterion ranged from 16% to 100%. In 2021 and 2022, 51 (84%) and 52 (87%) of the criteria, respectively, had compliance rates of more than 75%, and 12 (20%) and eight (13%), respectively, had 100% compliance. There were statistically significant decreases in compliance for nine of the 39 criteria for preparation of medications, notably prior hand hygiene (91%% vs. 84%, p = 0.002), and for six of the 17 criteria for administration of medications, including mentioning possible adverse effects to the patient (41% vs- 30%, p = 0.008).
    Conclusion: In this study, compliance was over 75% for most of the criteria. However, for a few criteria, we observed a decrease in compliance from 2021 to 2022. Various hypotheses are proposed to explain these decreases, such as the COVID-19 pandemic.
    MeSH term(s) Female ; Humans ; Mothers ; Pandemics ; Canada ; Pharmaceutical Preparations ; Nursing Staff ; Hospitals, University ; Nursing Staff, Hospital
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2024-01-22
    Publishing country France
    Document type Observational Study ; Journal Article
    ZDB-ID 1181947-9
    ISSN 1769-664X ; 0929-693X
    ISSN (online) 1769-664X
    ISSN 0929-693X
    DOI 10.1016/j.arcped.2023.09.011
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  3. Article ; Online: [No title information]

    Maurin, Charlotte / Atkinson, Suzanne / Hamouche, Linda / Bussières, Jean-François

    The Canadian journal of hospital pharmacy

    2024  Volume 77, Issue 2, Page(s) e3497

    Abstract: Background: Since 2022, it has been mandatory in Québec to report all incidents and accidents (I&As) occurring in health-care facilities. Since 2011, a summary report of these I&As has been published each year. However, it is difficult to compare health ...

    Title translation Ratios d’incidents et d’accidents totaux et médicamenteux par 1000 jours-présence en établissement de santé au Québec: une étude exploratoire.
    Abstract Background: Since 2022, it has been mandatory in Québec to report all incidents and accidents (I&As) occurring in health-care facilities. Since 2011, a summary report of these I&As has been published each year. However, it is difficult to compare health facilities given that no denominator is specified and ratios are not calculated.
    Objective: The primary objective was to calculate the ratios of total I&As and medication-related I&As per 1000 inpatient-days per type of facility for all health-care facilities in Québec.
    Methods: This retrospective descriptive study was based on data from the period of April 1, 2016, to March 31, 2021. Data were extracted from the National Register of Incidents and Accidents Occurring during the Provision of Health Care and Social Services in Québec
    Results: A total of 85 health-care facilities had usable data, specifically 33 acute-care facilities, 45 long-term care facilities, and 7 rehabilitation facilities. The mean ratio for total I&As/1000 inpatient-days varied from 33 ± 19 to 38 ± 22 in acute-care facilities, from 14 ± 5 to 16 ± 7 in long-term care facilities, and from 99 ± 39 to 147 ± 55 in rehabilitation facilities. The mean ratio for medication-related I&As/1000 inpatient-days varied from 11 ± 7 to 12 ± 7 in acute care facilities, from 3 ± 2 to 4 ± 3 in long-term care facilities, and from 24 ± 10 to 40 ± 21 in rehabilitation facilities.
    Conclusions: This exploratory study demonstrated the feasibility of calculating I&A ratios from the National Register of Incidents and Accidents Occurring during the Provision of Health Care and Social Services in Québec. These ratios facilitate discussion of the reporting culture of I&As within the health-care system. It is hoped that these ratios will be added to future annual reports from the Québec I&A register.
    Language French
    Publishing date 2024-04-10
    Publishing country Canada
    Document type English Abstract ; Journal Article
    ZDB-ID 413450-3
    ISSN 1920-2903 ; 0008-4123
    ISSN (online) 1920-2903
    ISSN 0008-4123
    DOI 10.4212/cjhp.3497
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    Zs.B 1844: Show issues Location:
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  4. Article ; Online: [No title information]

    Maurin, Charlotte / Atkinson, Suzanne / Hamouche, Linda / Bussières, Jean-François

    The Canadian journal of hospital pharmacy

    2024  Volume 77, Issue 2, Page(s) e3528

    Abstract: Background: The safety of care provided is based on an analysis of medication incidents and accidents.: Objective: The primary objective was to describe medication-related incidents and accidents (I&A) within a university-affiliated hospital.: ... ...

    Title translation Incidents et accidents médicamenteux en établissement de santé : une analyse descriptive au sein d’un CHU mère-enfant de 2018 à 2022.
    Abstract Background: The safety of care provided is based on an analysis of medication incidents and accidents.
    Objective: The primary objective was to describe medication-related incidents and accidents (I&A) within a university-affiliated hospital.
    Methods: This retrospective descriptive study was based on data from a 500-bed mother-child university-affiliated hospital. All I&As declared between April 1, 2018, and March 31, 2022, were considered. The analysis included all medication-related I&As that occurred during an admission or in an outpatient setting. Some variables were recoded manually. Descriptive statistical analyses were performed.
    Results: A total of 23 284 I&As were considered, including 7578 medication-related I&As. Daily averages of 15.9 ± 14.0 I&As and 5.2 ± 0.3 medication-related I&As were reported. There were 22.4 medication-related I&As/1000 inpatient days. The majority of medication-related I&As occurred in surgery (20%, 1530/7578), oncology (19%, 1405/7578), and pediatrics (16%, 1200/7578). Most were associated with incorrect dosing (21%, 1575/7578); infiltration, extravasation, or removed lines (19%, 1405/7578); and omissions (16%, 1205/7578). Physical consequences were reported in 15% (1158/7578) of the medication-related I&As. Conversely, psychological consequences were reported in less than 1% (44/7578) of medication-related I&As.
    Conclusions: This study provides a comprehensive descriptive profile over a 4-year period. Most of the reported I&As did not lead to consequences for patients. The sharing of ratios promotes comparative analysis with other facilities and can contribute to discussions about risk reduction. A culture of reporting events is present within this health care facility.
    Language French
    Publishing date 2024-04-10
    Publishing country Canada
    Document type English Abstract ; Journal Article
    ZDB-ID 413450-3
    ISSN 1920-2903 ; 0008-4123
    ISSN (online) 1920-2903
    ISSN 0008-4123
    DOI 10.4212/cjhp.3528
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    Zs.B 1844: Show issues Location:
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  5. Article ; Online: Disponibilité de l'information médicale requise pour la déclaration d'une réaction indésirable médicamenteuse à Santé Canada: une étude exploratoire.

    Saint-Vil, Laurent / Jean-Baptiste, Thaïna-Rafi / Martel-Côté, Nicolas / Lebel, Denis / Bussières, Jean-François

    The Canadian journal of hospital pharmacy

    2024  Volume 77, Issue 1, Page(s) e3489

    Abstract: Background: Since 2019, health care facilities have been required to report serious adverse drug reactions (ADRs) to Health Canada.: Objectives: To describe the availability of information required for reporting an ADR to Health Canada from medical ... ...

    Abstract Background: Since 2019, health care facilities have been required to report serious adverse drug reactions (ADRs) to Health Canada.
    Objectives: To describe the availability of information required for reporting an ADR to Health Canada from medical records using 2 methods (systematic and in-depth reporting) and to compare the time required to find the information.
    Methods: This retrospective and prospective descriptive study involved serious ADRs occurring in a mother-child centre and reported between April 1, 2021, and March 31, 2023. The variables needed to complete the Health Canada reporting form were collected using 2 distinct methods.
    Results: Among the 270 serious ADRs reported retrospectively, 140 were sampled. The average availability of variables was 82.3% (standard deviation [SD] 11.3%), with average data collection time of 50 (SD 25) minutes. For the prospective part of the study, 15 serious ADRs were studied. The availability of variables was 82.8% (SD 6.9%) and 91.9% (SD 7.8%), for systematic and in-depth reporting, respectively, with data collection times of 44 (SD 17) and 130 (SD 33) minutes, respectively.
    Conclusions: The challenge of finding, in patients' medical records, all of the information needed for reporting an ADR to Health Canada required an in-depth approach. However, the in-depth method took 3 times as long as a search limited to places in the record where specific information should be found. To improve record keeping, additional training for clinicians could be considered and, potentially, development of a computerized clinical record that includes a dedicated form for documenting ADRs.
    Language English
    Publishing date 2024-02-14
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 413450-3
    ISSN 1920-2903 ; 0008-4123
    ISSN (online) 1920-2903
    ISSN 0008-4123
    DOI 10.4212/cjhp.3489
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  6. Article ; Online: [No title information]

    Verret, Lucie / Racine, Marie-Claude / Vo, Diem / Paradis, François / Cayer, Geneviève / Lecours, Cécile / Nolet, Isabelle / Bussières, Jean-François

    The Canadian journal of hospital pharmacy

    2022  Volume 75, Issue 1, Page(s) 54–57

    Title translation Gestion des approvisionnements en médicaments pendant la pandémie de COVID-19 : expérience québécoise en établissement de santé.
    Language French
    Publishing date 2022-01-05
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 413450-3
    ISSN 1920-2903 ; 0008-4123
    ISSN (online) 1920-2903
    ISSN 0008-4123
    DOI 10.4212/cjhp.v75i1.3090
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  7. Article ; Online: Attentional and executive functions in children and adolescents with developmental coordination disorder and the influence of comorbid disorders: A systematic review of the literature.

    Lachambre, Catherine / Proteau-Lemieux, Mélodie / Lepage, Jean-François / Bussières, Eve-Line / Lippé, Sarah

    PloS one

    2021  Volume 16, Issue 6, Page(s) e0252043

    Abstract: Developmental coordination disorder (DCD) is a neurodevelopmental disorder affecting primarily motor skills, but attentional and executive impairments are common in affected individuals. Moreover, the presence of neurodevelopmental comorbidities is ... ...

    Abstract Developmental coordination disorder (DCD) is a neurodevelopmental disorder affecting primarily motor skills, but attentional and executive impairments are common in affected individuals. Moreover, the presence of neurodevelopmental comorbidities is frequent in this population, which certainly influences the cognitive profile of the children concerned. Previous studies have reported deficits in visuospatial/nonverbal and planning tasks. This systematic review of the literature aims to determine if impairments can be found in other attentional and executive functions as well. The type of cognitive tasks, the tasks' modality (verbal/nonverbal), and the influence of comorbid disorders on attentional and executive profiles are systematically considered. Forty-one studies were identified through the PubMed/Medline and PsycINFO databases according to pre-established eligibility criteria. The results reveal weaknesses in inhibitory control, working memory, planning, nonverbal fluency, and general executive functioning in children with DCD. The presence of comorbid disorders seemingly contributes to the verbal working memory difficulties findings. This review contributes to a better understanding of the cognitive impairments in DCD and of the needs of children with this disorder, allowing to optimize practitioners' therapeutic interventions.
    MeSH term(s) Adolescent ; Attention/physiology ; Child ; Cognition/physiology ; Cognitive Dysfunction/physiopathology ; Executive Function/physiology ; Humans ; Memory, Short-Term/physiology ; Motor Skills/physiology ; Motor Skills Disorders/physiopathology
    Language English
    Publishing date 2021-06-04
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0252043
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  8. Article ; Online: Occupational exposure to antineoplastic drugs: what about hospital sanitation personnel?

    Labrèche, France / Ouellet, Capucine / Roberge, Brigitte / Caron, Nicolas J / Yennek, Ahmed / Bussières, Jean-François

    International archives of occupational and environmental health

    2021  Volume 94, Issue 8, Page(s) 1877–1888

    Abstract: Objective: Occupational exposure to antineoplastic drugs (ANPs) occurs mainly through dermal contact. Our study was set up to assess the potential exposure of hospital sanitation (HS) personnel, for whom almost no data are available, through ... ...

    Abstract Objective: Occupational exposure to antineoplastic drugs (ANPs) occurs mainly through dermal contact. Our study was set up to assess the potential exposure of hospital sanitation (HS) personnel, for whom almost no data are available, through contamination of surfaces they regularly touch.
    Methods: In the oncology departments of two hospitals around Montreal, surface wipe samples of 120-2000 cm
    Results: Overall, 60.9% of 212 surface samples presented at least one ANP above the limits of detection (LOD). Cyclophosphamide and gemcitabine were most often detected (52% and 31% of samples respectively), followed by 5-fluorouracil and irinotecan (15% each). Highest concentrations of five ANPs were found in outpatient clinics on toilet floors (5-fluorouracil, 49 ng/cm
    Conclusions: A notable proportion of surfaces showed measurable levels of ANPs, with highest concentrations found on surfaces cleaned by HS personnel, who would benefit from appropriate preventive training. As potential sources of worker exposure, several hospital surfaces need to be regularly monitored to evaluate environmental contamination and efficacy of cleaning.
    MeSH term(s) Adult ; Antineoplastic Agents/analysis ; Cyclophosphamide/analysis ; Cytarabine/analysis ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/analysis ; Docetaxel/analysis ; Female ; Fluorouracil/analysis ; Hand ; Hospitals ; Humans ; Ifosfamide/analysis ; Irinotecan/analysis ; Male ; Methotrexate/analysis ; Middle Aged ; Occupational Exposure/analysis ; Paclitaxel/analysis ; Personnel, Hospital ; Sanitation ; Skin/chemistry ; Vinorelbine/analysis
    Chemical Substances Antineoplastic Agents ; Cytarabine (04079A1RDZ) ; Deoxycytidine (0W860991D6) ; Docetaxel (15H5577CQD) ; Irinotecan (7673326042) ; Cyclophosphamide (8N3DW7272P) ; gemcitabine (B76N6SBZ8R) ; Paclitaxel (P88XT4IS4D) ; Vinorelbine (Q6C979R91Y) ; Fluorouracil (U3P01618RT) ; Ifosfamide (UM20QQM95Y) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2021-08-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 129038-1
    ISSN 1432-1246 ; 0340-0131 ; 0367-9977
    ISSN (online) 1432-1246
    ISSN 0340-0131 ; 0367-9977
    DOI 10.1007/s00420-021-01731-w
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  9. Article ; Online: Attentional and executive functions in children and adolescents with developmental coordination disorder and the influence of comorbid disorders

    Catherine Lachambre / Mélodie Proteau-Lemieux / Jean-François Lepage / Eve-Line Bussières / Sarah Lippé

    PLoS ONE, Vol 16, Iss 6, p e

    A systematic review of the literature.

    2021  Volume 0252043

    Abstract: Developmental coordination disorder (DCD) is a neurodevelopmental disorder affecting primarily motor skills, but attentional and executive impairments are common in affected individuals. Moreover, the presence of neurodevelopmental comorbidities is ... ...

    Abstract Developmental coordination disorder (DCD) is a neurodevelopmental disorder affecting primarily motor skills, but attentional and executive impairments are common in affected individuals. Moreover, the presence of neurodevelopmental comorbidities is frequent in this population, which certainly influences the cognitive profile of the children concerned. Previous studies have reported deficits in visuospatial/nonverbal and planning tasks. This systematic review of the literature aims to determine if impairments can be found in other attentional and executive functions as well. The type of cognitive tasks, the tasks' modality (verbal/nonverbal), and the influence of comorbid disorders on attentional and executive profiles are systematically considered. Forty-one studies were identified through the PubMed/Medline and PsycINFO databases according to pre-established eligibility criteria. The results reveal weaknesses in inhibitory control, working memory, planning, nonverbal fluency, and general executive functioning in children with DCD. The presence of comorbid disorders seemingly contributes to the verbal working memory difficulties findings. This review contributes to a better understanding of the cognitive impairments in DCD and of the needs of children with this disorder, allowing to optimize practitioners' therapeutic interventions.
    Keywords Medicine ; R ; Science ; Q
    Subject code 150
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: [No title information]

    Soubieux, Annaelle / Plante, Caroline / Ouellette-Frève, Johann-François / Chouinard, Audrey / Bussières, Jean-François

    The Canadian journal of hospital pharmacy

    2020  Volume 73, Issue 1, Page(s) 27–36

    Abstract: Background: Many strategies aim to reduce the risk of work-related exposure to hazardous drugs for health care workers; these strategies include the use of specific systems to prepare and administer these drugs.: Objective: To compare the cost of ... ...

    Title translation Analyse de minimisation de coût des fournitures utilisées pour la préparation et l’administration d’une dose d’antinéoplasique en établissement de santé.
    Abstract Background: Many strategies aim to reduce the risk of work-related exposure to hazardous drugs for health care workers; these strategies include the use of specific systems to prepare and administer these drugs.
    Objective: To compare the cost of supplies used for preparing and administering one IV dose of antineoplastic in an adult health care facility in Canada between the traditional approach and one using a closed-system drug transfer device (CSTD).
    Method: This study was a cost reduction analysis conducted from the perspective of a typical university health care facility. The assessment focused only on the cost of supplies used to prepare and administer one IV dose of antineoplastic. It was not necessary to account for discounting. We developed 12 scenarios involving some of the 11 possible steps in preparing and administering one IV dose of antineoplastic.
    Results: The cost of supplies used to prepare and administer one IV dose of antineoplastic ranged between $9.89 and $22.37 per dose with the classical system, and between $12.34 and $64.19 per dose for systems involving a CSTD. The annual average extra cost of systems involving a CSTD was 1.63 to 3.15 higher than the cost with the classical system and represents extra spending of between $363 566 and $1 238 072 each year for a typical adult health care institution.
    Conclusion: This cost reduction analysis presents original data relating to the preparation and administration of IV antineoplastics. Given the significant costs associated with preparing and administering antineoplastic drugs, decision-makers should perform a thorough analysis of costs and consequences to allow informed decisions to be made.
    Language French
    Publishing date 2020-02-01
    Publishing country Canada
    Document type English Abstract ; Journal Article
    ZDB-ID 413450-3
    ISSN 1920-2903 ; 0008-4123
    ISSN (online) 1920-2903
    ISSN 0008-4123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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