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  1. Article: Research progress on the cannabinoid type-2 receptor and Parkinson's disease.

    Yu, Xiaoqi / Jia, Yi / Dong, Yuan

    Frontiers in aging neuroscience

    2024  Volume 15, Page(s) 1298166

    Abstract: Parkinson's disease (PD) is featured by movement impairments, including tremors, bradykinesia, muscle stiffness, and imbalance. PD is also associated with many non-motor symptoms, such as cognitive impairments, dementia, and mental disorders. Previous ... ...

    Abstract Parkinson's disease (PD) is featured by movement impairments, including tremors, bradykinesia, muscle stiffness, and imbalance. PD is also associated with many non-motor symptoms, such as cognitive impairments, dementia, and mental disorders. Previous studies identify the associations between PD progression and factors such as α-synuclein aggregation, mitochondrial dysfunction, inflammation, and cell death. The cannabinoid type-2 receptor (CB
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1298166
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  2. Article ; Online: Alterations in brain functional connectivity in patients with mild cognitive impairment: A systematic review and meta-analysis of functional near-infrared spectroscopy studies.

    Wang, Shuangyan / Wang, Weijia / Chen, Jinglong / Yu, Xiaoqi

    Brain and behavior

    2024  Volume 14, Issue 4, Page(s) e3414

    Abstract: Emerging evidences suggest that cognitive deficits in individuals with mild cognitive impairment (MCI) are associated with disruptions in brain functional connectivity (FC). This systematic review and meta-analysis aimed to comprehensively evaluate ... ...

    Abstract Emerging evidences suggest that cognitive deficits in individuals with mild cognitive impairment (MCI) are associated with disruptions in brain functional connectivity (FC). This systematic review and meta-analysis aimed to comprehensively evaluate alterations in FC between MCI individuals and healthy control (HC) using functional near-infrared spectroscopy (fNIRS). Thirteen studies were included in qualitative analysis, with two studies synthesized for quantitative meta-analysis. Overall, MCI patients exhibited reduced resting-state FC, predominantly in the prefrontal, parietal, and occipital cortex. Meta-analysis of two studies revealed a significant reduction in resting-state FC from the right prefrontal to right occipital cortex (standardized mean difference [SMD] = -.56; p < .001), left prefrontal to left occipital cortex (SMD = -.68; p < .001), and right prefrontal to left occipital cortex (SMD = -.53; p < .001) in MCI patients compared to HC. During naming animal-walking task, MCI patients exhibited enhanced FC in the prefrontal, motor, and occipital cortex, whereas a decrease in FC was observed in the right prefrontal to left prefrontal cortex during calculating-walking task. In working memory tasks, MCI predominantly showed increased FC in the medial and left prefrontal cortex. However, a decreased in prefrontal FC and a shifted in distribution from the left to the right prefrontal cortex were noted in MCI patients during a verbal frequency task. In conclusion, fNIRS effectively identified abnormalities in FC between MCI and HC, indicating disrupted FC as potential markers for the early detection of MCI. Future studies should investigate the use of task- and region-specific FC alterations as a sensitive biomarker for MCI.
    MeSH term(s) Animals ; Humans ; Spectroscopy, Near-Infrared ; Brain/diagnostic imaging ; Cognitive Dysfunction/diagnostic imaging ; Cognition Disorders ; Prefrontal Cortex/diagnostic imaging
    Language English
    Publishing date 2024-04-14
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.3414
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  3. Article ; Online: A novel triple-network hydrogel based on borate ester groups: from structural modulation to rapid wound hemostasis.

    Wang, Nan / Yu, Kangkang / Li, Kun / Yu, Xiaoqi

    Journal of materials chemistry. B

    2023  Volume 11, Issue 6, Page(s) 1232–1239

    Abstract: Supramolecular hydrogels have received widespread attention due to their soft texture, strong hygroscopicity, and good biocompatibility. These materials have become particularly attractive for sensing, tissue engineering, fluorescence encoding, wound ... ...

    Abstract Supramolecular hydrogels have received widespread attention due to their soft texture, strong hygroscopicity, and good biocompatibility. These materials have become particularly attractive for sensing, tissue engineering, fluorescence encoding, wound healing,
    MeSH term(s) Borates/pharmacology ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Wound Healing ; Hemostasis ; Hemostatics/pharmacology
    Chemical Substances Borates ; Hydrogels ; Hemostatics
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d2tb02537j
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  4. Article ; Online: Biological Activities of Secondary Metabolites from the Edible-Medicinal Macrofungi.

    Sun, Xiaoqi / Shi, Ying / Shi, Dongxiao / Tu, Yu / Liu, Ling

    Journal of fungi (Basel, Switzerland)

    2024  Volume 10, Issue 2

    Abstract: Macrofungi are well-known as edible-medicinal mushrooms, which belong mostly to Basidiomycota, with a few from Ascomycota. In recent years, macrofungi have been recognized as a rich resource of structurally unique secondary metabolites, demonstrating a ... ...

    Abstract Macrofungi are well-known as edible-medicinal mushrooms, which belong mostly to Basidiomycota, with a few from Ascomycota. In recent years, macrofungi have been recognized as a rich resource of structurally unique secondary metabolites, demonstrating a wide range of bioactivities, including anti-tumor, antioxidant, anti-inflammatory, antimicrobial, antimalarial, neuro-protective, hypoglycemic, and hypolipidemic activities. This review highlights over 270 natural products produced by 17 families of macrofungi covering 2017 to 2023, including their structures, bioactivities, and related molecular mechanisms.
    Language English
    Publishing date 2024-02-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof10020144
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  5. Article ; Online: Clinical applications of circulating HBV RNA as a potential surrogate biomarker for intrahepatic cccDNA transcriptional activity.

    Yu, Xiaoqi / Pfefferkorn, Maria / van Bömmel, Florian / Zhang, Xinxin / Berg, Thomas

    Gut

    2024  Volume 73, Issue 4, Page(s) 563–566

    MeSH term(s) Humans ; Hepatitis B virus/genetics ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; Biomarkers ; RNA ; DNA, Viral/genetics ; DNA, Circular ; Liver
    Chemical Substances Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; Biomarkers ; RNA (63231-63-0) ; DNA, Viral ; DNA, Circular
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-331217
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Synthesis of a BINOL-Based C

    Lu, Kai / Guo, Hongyu / Jiang, Yixuan / Yang, Jiaqiao / Yu, Shanshan / Yu, Xiaoqi / Pu, Lin

    ChemPlusChem

    2023  Volume 88, Issue 3, Page(s) e202300036

    Abstract: ... A novel ... ...

    Abstract A novel C
    Language English
    Publishing date 2023-03-09
    Publishing country Germany
    Document type Journal Article
    ISSN 2192-6506
    ISSN (online) 2192-6506
    DOI 10.1002/cplu.202300036
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  7. Article ; Online: GMAlignNet: multi-scale lightweight brain tumor image segmentation with enhanced semantic information consistency.

    Song, Jianli / Lu, Xiaoqi / Gu, Yu

    Physics in medicine and biology

    2024  

    Abstract: Although the U-shaped architecture, represented by UNet, has become a major network model for brain tumor segmentation, the repeated convolution and sampling operations can easily lead to the loss of crucial information. Additionally, directly fusing ... ...

    Abstract Although the U-shaped architecture, represented by UNet, has become a major network model for brain tumor segmentation, the repeated convolution and sampling operations can easily lead to the loss of crucial information. Additionally, directly fusing features from different levels without distinction can easily result in feature misalignment, affecting segmentation accuracy. On the other hand, traditional convolutional blocks used for feature extraction cannot capture the abundant multi-scale information present in brain tumor images. This paper proposes a multi-scale feature-aligned segmentation model called GMAlignNet that fully utilizes Ghost convolution to solve these problems. Ghost Hierarchical Decoupled Fusion Unit and Ghost Hierarchical Decoupled Unit are used instead of standard convolutions in the encoding and decoding paths. This transformation replaces the holistic learning of volume structures by traditional convolutional blocks with multi-level learning on a specific view, facilitating the acquisition of abundant multi-scale contextual information through low-cost operations. Furthermore, a feature alignment unit is proposed that can utilize semantic information flow to guide the recovery of upsampled features. It performs pixel-level semantic information correction on misaligned features due to feature fusion. The proposed method is also employed to optimize three classic networks, namely DMFNet, HDCNet, and 3D UNet, demonstrating its effectiveness in automatic brain tumor segmentation. The proposed network model was applied to the BraTS 2018 dataset, and the results indicate that the proposed GMAlignNet achieved Dice coefficients of 81.65%, 90.07%, and 85.16% for enhancing tumor, whole tumor, and tumor core segmentation, respectively. Moreover, with only 0.29M parameters and 26.88G FLOPs, it demonstrates better potential in terms of computational efficiency and possesses the advantages of lightweight. Extensive experiments on the BraTS 2018, BraTS 2019, and BraTS 2020 datasets suggest that the proposed model exhibits better potential in handling edge details and contour recognition.
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ad4301
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
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  8. Article ; Online: A Review of the Relationship between Gel Polymer Electrolytes and Solid Electrolyte Interfaces in Lithium Metal Batteries

    Xiaoqi Yu / Zipeng Jiang / Renlu Yuan / Huaihe Song

    Nanomaterials, Vol 13, Iss 1789, p

    2023  Volume 1789

    Abstract: Lithium metal batteries (LMBs) are a dazzling star in electrochemical energy storage thanks to their high energy density and low redox potential. However, LMBs have a deadly lithium dendrite problem. Among the various methods for inhibiting lithium ... ...

    Abstract Lithium metal batteries (LMBs) are a dazzling star in electrochemical energy storage thanks to their high energy density and low redox potential. However, LMBs have a deadly lithium dendrite problem. Among the various methods for inhibiting lithium dendrites, gel polymer electrolytes (GPEs) possess the advantages of good interfacial compatibility, similar ionic conductivity to liquid electrolytes, and better interfacial tension. In recent years, there have been many reviews of GPEs, but few papers discussed the relationship between GPEs and solid electrolyte interfaces (SEIs). In this review, the mechanisms and advantages of GPEs in inhibiting lithium dendrites are first reviewed. Then, the relationship between GPEs and SEIs is examined. In addition, the effects of GPE preparation methods, plasticizer selections, polymer substrates, and additives on the SEI layer are summarized. Finally, the challenges of using GPEs and SEIs in dendrite suppression are listed and a perspective on GPEs and SEIs is considered.
    Keywords lithium dendrite ; gel polymer electrolyte ; solid electrolyte interface ; lithium metal battery ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: The "Hand as Foot" teaching method in the upper cervical anatomy.

    Liu, Xiaoqi / Liu, Xingyu / Yu, Enming / Hao, Haijing

    Asian journal of surgery

    2022  Volume 45, Issue 11, Page(s) 2578–2579

    MeSH term(s) Foot/anatomy & histology ; Hand ; Humans ; Lower Extremity ; Upper Extremity
    Language English
    Publishing date 2022-06-13
    Publishing country China
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2022.05.162
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  10. Article: A Review of the Relationship between Gel Polymer Electrolytes and Solid Electrolyte Interfaces in Lithium Metal Batteries.

    Yu, Xiaoqi / Jiang, Zipeng / Yuan, Renlu / Song, Huaihe

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 11

    Abstract: Lithium metal batteries (LMBs) are a dazzling star in electrochemical energy storage thanks to their high energy density and low redox potential. However, LMBs have a deadly lithium dendrite problem. Among the various methods for inhibiting lithium ... ...

    Abstract Lithium metal batteries (LMBs) are a dazzling star in electrochemical energy storage thanks to their high energy density and low redox potential. However, LMBs have a deadly lithium dendrite problem. Among the various methods for inhibiting lithium dendrites, gel polymer electrolytes (GPEs) possess the advantages of good interfacial compatibility, similar ionic conductivity to liquid electrolytes, and better interfacial tension. In recent years, there have been many reviews of GPEs, but few papers discussed the relationship between GPEs and solid electrolyte interfaces (SEIs). In this review, the mechanisms and advantages of GPEs in inhibiting lithium dendrites are first reviewed. Then, the relationship between GPEs and SEIs is examined. In addition, the effects of GPE preparation methods, plasticizer selections, polymer substrates, and additives on the SEI layer are summarized. Finally, the challenges of using GPEs and SEIs in dendrite suppression are listed and a perspective on GPEs and SEIs is considered.
    Language English
    Publishing date 2023-06-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13111789
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