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  1. Article ; Online: Retrospective screening for SARS-CoV-2 in Greater Glasgow and Clyde ICUs between December 2019 and February 2020.

    Tomb, Rachael M / MacLean, Alasdair R / Gunson, Rory N

    The Journal of infection

    2020  Volume 81, Issue 3, Page(s) 452–482

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Scotland
    Keywords covid19
    Language English
    Publishing date 2020-06-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.06.022
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  2. Article ; Online: Violet-blue 405-nm Light-based Photoinactivation for Pathogen Reduction of Human Plasma Provides Broad Antibacterial Efficacy Without Visible Degradation of Plasma Proteins.

    Stewart, Caitlin F / Tomb, Rachael M / Ralston, Heather J / Armstrong, Jack / Anderson, John G / MacGregor, Scott J / Atreya, Chintamani D / Maclean, Michelle

    Photochemistry and photobiology

    2022  Volume 98, Issue 2, Page(s) 504–512

    Abstract: In transfusion medicine, bacterial contamination can occur in ex vivo stored blood plasma, and there are continued efforts to improve blood safety and reduce the risk of transfusion-transmitted infections. Visible 405-nm violet-blue light has ... ...

    Abstract In transfusion medicine, bacterial contamination can occur in ex vivo stored blood plasma, and there are continued efforts to improve blood safety and reduce the risk of transfusion-transmitted infections. Visible 405-nm violet-blue light has demonstrated potential for in situ pathogen reduction in ex vivo stored plasma and platelet concentrates. This study investigates the broad-spectrum antibacterial efficacy and compatibility potential of 405-nm light for treatment of blood plasma. Human plasma seeded with bacteria at a range of densities (10
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteria ; Blood Proteins ; Escherichia coli ; Humans ; Light ; Plasma
    Chemical Substances Anti-Bacterial Agents ; Blood Proteins
    Language English
    Publishing date 2022-01-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/php.13584
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  3. Article: Retrospective screening for SARS-CoV-2 in Greater Glasgow and Clyde ICUs between December 2019 and February 2020

    Tomb, Rachael M / MacLean, Dr Alasdair R / Gunson, Professor Rory N

    J. infect

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32553840
    Database COVID19

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  4. Article: Retrospective screening for SARS-CoV-2 in Greater Glasgow and Clyde ICUs between December 2019 and February 2020

    Tomb, Rachael M / MacLean, Alasdair R / Gunson, Rory N

    J Infect

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #607907
    Database COVID19

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  5. Article ; Online: Retrospective screening for SARS-CoV-2 in Greater Glasgow and Clyde ICUs between December 2019 and February 2020

    Tomb, Rachael M. / MacLean, Alasdair R. / Gunson, Rory N.

    Journal of Infection

    2020  Volume 81, Issue 3, Page(s) 452–482

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.06.022
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  6. Article: Non-ionizing 405 nm Light as a Potential Bactericidal Technology for Platelet Safety: Evaluation of

    Maclean, Michelle / Gelderman, Monique P / Kulkarni, Sandhya / Tomb, Rachael M / Stewart, Caitlin F / Anderson, John G / MacGregor, Scott J / Atreya, Chintamani D

    Frontiers in medicine

    2020  Volume 6, Page(s) 331

    Abstract: Bacterial contamination ... ...

    Abstract Bacterial contamination of
    Language English
    Publishing date 2020-01-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2019.00331
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  7. Article ; Online: Assessment of the potential for resistance to antimicrobial violet-blue light in

    Tomb, Rachael M / Maclean, Michelle / Coia, John E / MacGregor, Scott J / Anderson, John G

    Antimicrobial resistance and infection control

    2017  Volume 6, Page(s) 100

    Abstract: Background: Antimicrobial violet-blue light in the region of 405 nm is emerging as an alternative technology for hospital decontamination and clinical treatment. The mechanism of action is the excitation of endogenous porphyrins within exposed ... ...

    Abstract Background: Antimicrobial violet-blue light in the region of 405 nm is emerging as an alternative technology for hospital decontamination and clinical treatment. The mechanism of action is the excitation of endogenous porphyrins within exposed microorganisms, resulting in ROS generation, oxidative damage and cell death. Although resistance to 405 nm light is not thought likely, little evidence has been published to support this. This study was designed to establish if there is potential for tolerance development, using the nosocomial pathogen
    Methods: The first stage of this study investigated the potential for
    Results: When cultured in low-level violet-blue light conditions,
    Conclusions: Repeated sub-lethal exposure of non-proliferating
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article
    ZDB-ID 2666706-X
    ISSN 2047-2994 ; 2047-2994
    ISSN (online) 2047-2994
    ISSN 2047-2994
    DOI 10.1186/s13756-017-0261-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Review of the Comparative Susceptibility of Microbial Species to Photoinactivation Using 380-480 nm Violet-Blue Light.

    Tomb, Rachael M / White, Tracy A / Coia, John E / Anderson, John G / MacGregor, Scott J / Maclean, Michelle

    Photochemistry and photobiology

    2018  Volume 94, Issue 3, Page(s) 445–458

    Abstract: Antimicrobial violet-blue light is an emerging technology designed for enhanced clinical decontamination and treatment applications, due to its safety, efficacy and ease of use. This systematized review was designed to compile the current knowledge on ... ...

    Abstract Antimicrobial violet-blue light is an emerging technology designed for enhanced clinical decontamination and treatment applications, due to its safety, efficacy and ease of use. This systematized review was designed to compile the current knowledge on the antimicrobial efficacy of 380-480 nm light on a range of health care and food-related pathogens including vegetative bacteria, bacterial endospores, fungi and viruses. Data were compiled from 79 studies, with the majority focussing on wavelengths in the region of 405 nm. Analysis indicated that Gram-positive and Gram-negative vegetative bacteria are the most susceptible organisms, while bacterial endospores, viruses and bacteriophage are the least. Evaluation of the dose required for a 1 log
    MeSH term(s) Bacteria/radiation effects ; Disinfection/methods ; Fungi/radiation effects ; Light ; Microbial Sensitivity Tests ; Microbial Viability/radiation effects ; Spores, Bacterial/radiation effects ; Viruses/radiation effects
    Language English
    Publishing date 2018-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/php.12883
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1686: Show issues Location:
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  9. Article ; Online: Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning.

    Nickbakhsh, Sema / Hughes, Joseph / Christofidis, Nicolaos / Griffiths, Emily / Shaaban, Sharif / Enright, Jessica / Smollett, Katherine / Nomikou, Kyriaki / Palmalux, Natasha / Tong, Lily / Carmichael, Stephen / Sreenu, Vattipally B / Orton, Richard / Goldstein, Emily J / Tomb, Rachael M / Templeton, Kate / Gunson, Rory N / da Silva Filipe, Ana / Milosevic, Catriona /
    Thomson, Emma / Robertson, David L / Holden, Matthew T G / Illingworth, Christopher J R / Smith-Palmer, Alison

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 11735

    Abstract: Whole genome sequencing of SARS-CoV-2 has occurred at an unprecedented scale, and can be exploited for characterising outbreak risks at the fine-scale needed to inform control strategies. One setting at continued risk of COVID-19 outbreaks are higher ... ...

    Abstract Whole genome sequencing of SARS-CoV-2 has occurred at an unprecedented scale, and can be exploited for characterising outbreak risks at the fine-scale needed to inform control strategies. One setting at continued risk of COVID-19 outbreaks are higher education institutions, associated with student movements at the start of term, close living conditions within residential halls, and high social contact rates. Here we analysed SARS-CoV-2 whole genome sequences in combination with epidemiological data to investigate a large cluster of student cases associated with University of Glasgow accommodation in autumn 2020, Scotland. We identified 519 student cases of SARS-CoV-2 infection associated with this large cluster through contact tracing data, with 30% sequencing coverage for further analysis. We estimated at least 11 independent introductions of SARS-CoV-2 into the student population, with four comprising the majority of detected cases and consistent with separate outbreaks. These four outbreaks were curtailed within a week following implementation of control measures. The impact of student infections on the local community was short-term despite an underlying increase in community infections. Our study highlights the need for context-specific information in the formation of public health policy for higher educational settings.
    MeSH term(s) COVID-19/epidemiology ; Disease Outbreaks ; Genomics ; Health Planning ; Humans ; SARS-CoV-2/genetics ; United States ; Universities
    Language English
    Publishing date 2022-07-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-15661-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Non-ionizing 405 nm Light as a Potential Bactericidal Technology for Platelet Safety

    Michelle Maclean / Monique P. Gelderman / Sandhya Kulkarni / Rachael M. Tomb / Caitlin F. Stewart / John G. Anderson / Scott J. MacGregor / Chintamani D. Atreya

    Frontiers in Medicine, Vol

    Evaluation of in vitro Bacterial Inactivation and in vivo Platelet Recovery in Severe Combined Immunodeficient Mice

    2020  Volume 6

    Abstract: Bacterial contamination of ex vivo stored platelets is a cause of transfusion-transmitted infection. Violet-blue 405 nm light has recently demonstrated efficacy in reducing the bacterial burden in blood plasma, and its operational benefits such as non- ... ...

    Abstract Bacterial contamination of ex vivo stored platelets is a cause of transfusion-transmitted infection. Violet-blue 405 nm light has recently demonstrated efficacy in reducing the bacterial burden in blood plasma, and its operational benefits such as non-ionizing nature, penetrability, and non-requirement for photosensitizing agents, provide a unique opportunity to develop this treatment for in situ treatment of ex vivo stored platelets as a tool for bacterial reduction. Sealed bags of platelet concentrates, seeded with low-level Staphylococcus aureus contamination, were 405 nm light-treated (3–10 mWcm−2) up to 8 h. Antimicrobial efficacy and dose efficiency was evaluated by quantification of the post-treatment surviving bacterial contamination levels. Platelets treated with 10 mWcm−2 for 8 h were further evaluated for survival and recovery in severe combined immunodeficient (SCID) mice. Significant inactivation of bacteria in platelet concentrates was achieved using all irradiance levels, with 99.6–100% inactivation achieved by 8 h (P < 0.05). Analysis of applied dose demonstrated that lower irradiance levels generally resulted in significant decontamination at lower doses: 180 Jcm−2/10 mWcm−2 (P = 0.008) compared to 43.2 Jcm−2/3 mWcm−2 (P = 0.002). Additionally, the recovery of light-treated platelets, compared to non-treated platelets, in the murine model showed no significant differences (P = >0.05). This report paves the way for further comprehensive studies to test 405 nm light treatment as a bactericidal technology for stored platelets.
    Keywords 405 nm light ; bacteria ; platelets ; inactivation ; violet-blue light ; pathogen reduction ; Medicine (General) ; R5-920
    Subject code 630
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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