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  1. Article ; Online: Virtual Surgical Planning and Customized CAD/CAM Cranial Implants: Preoperative and Intraoperative Strategies for Temporal Intraosseous Meningioma Resection.

    Westarp, Emilia / Thieringer, Florian M / Roethlisberger, Michel

    The Journal of craniofacial surgery

    2024  

    Abstract: Primary intraosseous meningioma (PIM) is a rare subtype of extradural meningiomas, with the indication for surgical resection in most cases. With an increasing demand for efficient workflows with optimal functional and cosmetical results, techniques for ... ...

    Abstract Primary intraosseous meningioma (PIM) is a rare subtype of extradural meningiomas, with the indication for surgical resection in most cases. With an increasing demand for efficient workflows with optimal functional and cosmetical results, techniques for bone reconstruction after resection are developing rapidly. The authors present 2 cases with one-stage cranioplasty after resection of PIM, using 3D technology for preplanned patient-specific implants. In the first case, a premanufactured patient-specific PEEK implant was used for reconstruction; in the second case, a 3-dimensional (3D)-based premanufactured silicon mold was used to produce a customized PMMA implant intraoperatively. Both techniques enabled the surgeons to achieve optimal intraoperative fit of the implant after craniectomy, leading to satisfying functional and cosmetic results. The use of 3D technology, such as Computer-Aided Design and Computer-Aided Manufacturing (CAD/CAM) for the production of patient-specific implants can optimize 1-stage cranioplasty after PIM resection.
    Language English
    Publishing date 2024-03-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000010095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3761: Show issues Location:
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  2. Article ; Online: Precision Surgery for Orbital Cavernous Hemangiomas: The Role of Three-Dimensional Printing in Individualized Resection-An Educational Experience.

    Westarp, Emilia / Thieringer, Florian M / Roethlisberger, Michel

    The Journal of craniofacial surgery

    2023  Volume 35, Issue 1, Page(s) 220–222

    Abstract: Orbital cavernous hemangiomas are the most common primary orbital tumors in adults, providing challenges for optimal surgical approach planning within an anatomically complex area with close proximity to vital neurovascular structures. The authors ... ...

    Abstract Orbital cavernous hemangiomas are the most common primary orbital tumors in adults, providing challenges for optimal surgical approach planning within an anatomically complex area with close proximity to vital neurovascular structures. The authors present an individualized lateral mini-orbitozygomatic approach for the resection of an orbital cavernous haemangioma based on a preoperative 3-dimensional-printed model. This individualized approach enabled the surgeons to achieve optimal exposure while maintaining safety during the resection of the lesion, but also to respect the patient's physiognomy and hairline. In addition, the model was used for patient informed consent, helping the patient understand the procedure. Although adding additional effort to preoperative planning, 3-dimensional model-based approaches can offer great benefits when it comes to customizing surgical approaches, especially for anatomically challenging resections.
    MeSH term(s) Adult ; Humans ; Orbital Neoplasms/diagnostic imaging ; Orbital Neoplasms/surgery ; Orbital Neoplasms/pathology ; Hemangioma, Cavernous/diagnostic imaging ; Hemangioma, Cavernous/surgery ; Printing, Three-Dimensional
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000009640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Medical rehabilitation of chronic progressive disseminated encephalomyelitis (MS).

    Westarp, M E

    Journal of neurovirology

    2000  Volume 6 Suppl 2, Page(s) S176–8

    Abstract: ... we treat approximately 200 patients with progressive MS. Treatment consists of medication, i.e. agents ...

    Abstract Eight years after diagnosis, 40% of MS patients develop a chronically progressive form. Annually we treat approximately 200 patients with progressive MS. Treatment consists of medication, i.e. agents that help to prevent future impairment, or interferon-beta injections, and intervals of mitoxantrone infusions (Novantrone(R)), and in some cases cyclic cyclophosphamide (Endoxan(R)) or nucleoside analogue cladribin (Leustatin(R)). Without clear scientific evidence, we recommend unsaturated fatty acids (thistle or sunflower oil), sufficient protein, and freshly prepared fruits and vegetables as a sound basis for remyelination. Remyelination profits from general prophylaxis in the use of ascorbic acid to help prevent urinary infections via acidification, autogenic training to reduce fatigue, improve ventilation of deeper airways, and stimulate vagotonic regeneration, and prevention of unnecessary immune stimulation caused by insects and some food. We recommend the use of sun hats and disencourage blood donation (Allain 1998). Physiotherapy can improve strength, reduce spasticity, and train the patient to compensate for dysbalance and ataxia; supported by beta blockers and good antispastics, tremor and gait disturbances can be positively influenced. Music and motion, speech therapy, realistic training of daily activities, and prudent psychotherapy complete the range of measurements to reconstitute as much as possible of the patient's individual freedom. In the individual, we eventually provide prudent technical aids and careful prognostic estimations. Cooperating with local and regional patient networks, we reinforce long-term disease management and spread up-to-date medical research results, and finally gather valuable contextual information and clinical data on an increasingly frequent idiopathic disease of the human central nervous system.
    MeSH term(s) Adult ; Age Factors ; Disease Progression ; Encephalomyelitis/rehabilitation ; Encephalomyelitis/therapy ; Humans ; Middle Aged ; Multiple Sclerosis, Chronic Progressive/rehabilitation ; Multiple Sclerosis, Chronic Progressive/therapy
    Language English
    Publishing date 2000-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1283265-0
    ISSN 1538-2443 ; 1355-0284
    ISSN (online) 1538-2443
    ISSN 1355-0284
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    Zs.A 4426: Show issues Location:
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  4. Article: Motor neuron disease.

    Westarp, M E / Kornhuber, H H

    Journal of neurology, neurosurgery, and psychiatry

    1995  Volume 58, Issue 2, Page(s) 269

    MeSH term(s) Humans ; Motor Neuron Disease/nursing ; Terminal Care/methods
    Language English
    Publishing date 1995-02
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp.58.2.269
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  5. Article: Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation ((18)F-FDG, (64)Cu-ATSM and (18)F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring.

    Zornhagen, Kamilla Westarp / Clausen, Malene M / Hansen, Anders E / Law, Ian / McEvoy, Fintan J / Engelholm, Svend A / Kjær, Andreas / Kristensen, Annemarie T

    Diagnostics (Basel, Switzerland)

    2015  Volume 5, Issue 3, Page(s) 372–382

    Abstract: Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can ... ...

    Abstract Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using (18)F-FDG, (64)Cu-ATSM, and (18)F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in (18)F-FDG and (18)F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response.
    Language English
    Publishing date 2015-09-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics5030372
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  6. Article: Neurologische Intensivmedizin.

    Westarp, M E / Wollinsky, K H

    Krankenpflege Journal

    1991  Volume 29, Issue 11, Page(s) 509

    Title translation Neurologic intensive care units.
    MeSH term(s) Humans ; Intensive Care Units/organization & administration ; Nervous System Diseases/nursing ; Nervous System Diseases/therapy
    Language German
    Publishing date 1991-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603227-8
    ISSN 0174-108X ; 0048-9549
    ISSN 0174-108X ; 0048-9549
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  7. Article ; Online: Basement membrane stiffness determines metastases formation.

    Reuten, Raphael / Zendehroud, Sina / Nicolau, Monica / Fleischhauer, Lutz / Laitala, Anu / Kiderlen, Stefanie / Nikodemus, Denise / Wullkopf, Lena / Nielsen, Sebastian Rune / McNeilly, Sarah / Prein, Carina / Rafaeva, Maria / Schoof, Erwin M / Furtwängler, Benjamin / Porse, Bo T / Kim, Hyobin / Won, Kyoung Jae / Sudhop, Stefanie / Zornhagen, Kamilla Westarp /
    Suhr, Frank / Maniati, Eleni / Pearce, Oliver M T / Koch, Manuel / Oddershede, Lene Broeng / Van Agtmael, Tom / Madsen, Chris D / Mayorca-Guiliani, Alejandro E / Bloch, Wilhelm / Netz, Roland R / Clausen-Schaumann, Hauke / Erler, Janine T

    Nature materials

    2021  Volume 20, Issue 6, Page(s) 892–903

    Abstract: The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome multiple times to form metastases. Here we show that BM stiffness is a major determinant of metastases formation in several ... ...

    Abstract The basement membrane (BM) is a special type of extracellular matrix and presents the major barrier cancer cells have to overcome multiple times to form metastases. Here we show that BM stiffness is a major determinant of metastases formation in several tissues and identify netrin-4 (Net4) as a key regulator of BM stiffness. Mechanistically, our biophysical and functional analyses in combination with mathematical simulations show that Net4 softens the mechanical properties of native BMs by opening laminin node complexes, decreasing cancer cell potential to transmigrate this barrier despite creating bigger pores. Our results therefore reveal that BM stiffness is dominant over pore size, and that the mechanical properties of 'normal' BMs determine metastases formation and patient survival independent of cancer-mediated alterations. Thus, identifying individual Net4 protein levels within native BMs in major metastatic organs may have the potential to define patient survival even before tumour formation. The ratio of Net4 to laminin molecules determines BM stiffness, such that the more Net4, the softer the BM, thereby decreasing cancer cell invasion activity.
    MeSH term(s) Basement Membrane/metabolism ; Biomechanical Phenomena ; Cell Line, Tumor ; Humans ; Mechanical Phenomena ; Neoplasm Metastasis ; Netrins/metabolism
    Chemical Substances Netrins
    Language English
    Publishing date 2021-01-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/s41563-020-00894-0
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  8. Article: Kopfschmerz--kernpunkte und Klassifikation.

    Westarp, M E / Keppler, I

    Krankenpflege Journal

    1990  Volume 28, Issue 10, Page(s) 516–519

    Title translation Headache--essential points and classification.
    MeSH term(s) Headache/classification ; Humans
    Language German
    Publishing date 1990-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603227-8
    ISSN 0174-108X ; 0048-9549
    ISSN 0174-108X ; 0048-9549
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  9. Article: Vergiftung mit Desinfektionsmittel bei Vitamin-B12-Mangel.

    Westarp, M E / Wolf, H U

    Deutsche medizinische Wochenschrift (1946)

    1990  Volume 115, Issue 20, Page(s) 796–797

    Title translation Poisoning with disinfectants in vitamin B12 deficiency.
    MeSH term(s) Aged ; Disinfectants/poisoning ; Humans ; Vitamin B 12 Deficiency/metabolism
    Chemical Substances Disinfectants
    Language German
    Publishing date 1990-05-18
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
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  10. Article ; Online: Modeling Metastatic Colonization in a Decellularized Organ Scaffold-Based Perfusion Bioreactor.

    Rafaeva, Maria / Horton, Edward R / Jensen, Adina R D / Madsen, Chris D / Reuten, Raphael / Willacy, Oliver / Brøchner, Christian B / Jensen, Thomas H / Zornhagen, Kamilla Westarp / Crespo, Marina / Grønseth, Dina S / Nielsen, Sebastian R / Idorn, Manja / Straten, Per Thor / Rohrberg, Kristoffer / Spanggaard, Iben / Højgaard, Martin / Lassen, Ulrik / Erler, Janine T /
    Mayorca-Guiliani, Alejandro E

    Advanced healthcare materials

    2021  Volume 11, Issue 1, Page(s) e2100684

    Abstract: ... microscopically (e.g., proliferation, migration) within the organ scaffold. Cancer cells in this system ...

    Abstract Metastatic cancer spread is responsible for most cancer-related deaths. To colonize a new organ, invading cells adapt to, and remodel, the local extracellular matrix (ECM), a network of proteins and proteoglycans underpinning all tissues, and a critical regulator of homeostasis and disease. However, there is a major lack in tools to study cancer cell behavior within native 3D ECM. Here, an in-house designed bioreactor, where mouse organ ECM scaffolds are perfused and populated with cells that are challenged to colonize it, is presented. Using a specialized bioreactor chamber, it is possible to monitor cell behavior microscopically (e.g., proliferation, migration) within the organ scaffold. Cancer cells in this system recapitulate cell signaling observed in vivo and remodel complex native ECM. Moreover, the bioreactors are compatible with co-culturing cell types of different genetic origin comprising the normal and tumor microenvironment. This degree of experimental flexibility in an organ-specific and 3D context, opens new possibilities to study cell-cell and cell-ECM interplay and to model diseases in a controllable organ-specific system ex vivo.
    MeSH term(s) Animals ; Bioreactors ; Extracellular Matrix ; Mice ; Perfusion ; Proteoglycans ; Tissue Engineering ; Tissue Scaffolds
    Chemical Substances Proteoglycans
    Language English
    Publishing date 2021-11-17
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202100684
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