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  1. Article: No evidence for direct thermal carryover effects on starvation tolerance in the obligate blood-feeder,

    Weaving, Hester / Lord, Jennifer S / Haines, Lee / English, Sinead

    Ecology and evolution

    2023  Volume 13, Issue 10, Page(s) e10652

    Abstract: Thermal stress during development can prime animals to cope better with similar conditions in later life. Alternatively, negative effects of thermal stress can persist across life stages and result in poorer quality adults (negative carryover effects). ... ...

    Abstract Thermal stress during development can prime animals to cope better with similar conditions in later life. Alternatively, negative effects of thermal stress can persist across life stages and result in poorer quality adults (negative carryover effects). As mean temperatures increase due to climate change, evidence for such effects across diverse taxa is required. Using
    Language English
    Publishing date 2023-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A global perspective on collision and non-collision match characteristics in male rugby union: Comparisons by age and playing standard.

    Till, Kevin / Hendricks, Sharief / Scantlebury, Sean / Dalton-Barron, Nick / Gill, Nicholas / den Hollander, Steve / Kemp, Simon / Kilding, Andrew E / Lambert, Mike / Mackreth, Peter / O'Reilly, John / Owen, Cameron / Spencer, Kirsten / Stokes, Keith / Tee, Jason / Tucker, Ross / Vaz, Luis / Weaving, Dan / Jones, Ben

    European journal of sport science

    2023  Volume 23, Issue 7, Page(s) 1131–1145

    Abstract: This study quantified and compared the collision and non-collision match characteristics across age categories (i.e. U12, U14, U16, U18, Senior) for both amateur and elite playing standards from Tier 1 rugby union nations (i.e. England, South Africa, New ...

    Abstract This study quantified and compared the collision and non-collision match characteristics across age categories (i.e. U12, U14, U16, U18, Senior) for both amateur and elite playing standards from Tier 1 rugby union nations (i.e. England, South Africa, New Zealand). Two-hundred and one male matches (5911 min ball-in-play) were coded using computerised notational analysis, including 193,708 match characteristics (e.g. 83,688 collisions, 33,052 tackles, 13,299 rucks, 1006 mauls, 2681 scrums, 2923 lineouts, 44,879 passes, 5568 kicks). Generalised linear mixed models with
    MeSH term(s) Humans ; Male ; Football ; Rugby ; Athletes ; South Africa
    Language English
    Publishing date 2023-02-19
    Publishing country England
    Document type Journal Article
    ISSN 1536-7290
    ISSN (online) 1536-7290
    DOI 10.1080/17461391.2022.2160938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 3D microstructure design of lithium-ion battery electrodes assisted by X-ray nano-computed tomography and modelling.

    Lu, Xuekun / Bertei, Antonio / Finegan, Donal P / Tan, Chun / Daemi, Sohrab R / Weaving, Julia S / O'Regan, Kieran B / Heenan, Thomas M M / Hinds, Gareth / Kendrick, Emma / Brett, Dan J L / Shearing, Paul R

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 2079

    Abstract: Driving range and fast charge capability of electric vehicles are heavily dependent on the 3D microstructure of lithium-ion batteries (LiBs) and substantial fundamental research is required to optimise electrode design for specific operating conditions. ... ...

    Abstract Driving range and fast charge capability of electric vehicles are heavily dependent on the 3D microstructure of lithium-ion batteries (LiBs) and substantial fundamental research is required to optimise electrode design for specific operating conditions. Here we have developed a full microstructure-resolved 3D model using a novel X-ray nano-computed tomography (CT) dual-scan superimposition technique that captures features of the carbon-binder domain. This elucidates how LiB performance is markedly affected by microstructural heterogeneities, particularly under high rate conditions. The elongated shape and wide size distribution of the active particles not only affect the lithium-ion transport but also lead to a heterogeneous current distribution and non-uniform lithiation between particles and along the through-thickness direction. Building on these insights, we propose and compare potential graded-microstructure designs for next-generation battery electrodes. To guide manufacturing of electrode architectures, in-situ X-ray CT is shown to reliably reveal the porosity and tortuosity changes with incremental calendering steps.
    Language English
    Publishing date 2020-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-15811-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exploring cycling induced crystallographic change in NMC with X-ray diffraction computed tomography.

    Daemi, Sohrab R / Tan, Chun / Vamvakeros, Antonis / Heenan, Thomas M M / Finegan, Donal P / Di Michiel, Marco / Beale, Andrew M / Cookson, James / Petrucco, Enrico / Weaving, Julia S / Jacques, Simon / Jervis, Rhodri / Brett, Dan J L / Shearing, Paul R

    Physical chemistry chemical physics : PCCP

    2020  Volume 22, Issue 32, Page(s) 17814–17823

    Abstract: This study presents the application of X-ray diffraction computed tomography for the first time to analyze the crystal dimensions of LiNi0.33Mn0.33Co0.33O2 electrodes cycled to 4.2 and 4.7 V in full cells with graphite as negative electrodes at 1 μm ... ...

    Abstract This study presents the application of X-ray diffraction computed tomography for the first time to analyze the crystal dimensions of LiNi0.33Mn0.33Co0.33O2 electrodes cycled to 4.2 and 4.7 V in full cells with graphite as negative electrodes at 1 μm spatial resolution to determine the change in unit cell dimensions as a result of electrochemical cycling. The nature of the technique permits the spatial localization of the diffraction information in 3D and mapping of heterogeneities from the electrode to the particle level. An overall decrease of 0.4% and 0.6% was observed for the unit cell volume after 100 cycles for the electrodes cycled to 4.2 and 4.7 V. Additionally, focused ion beam-scanning electron microscope cross-sections indicate extensive particle cracking as a function of upper cut-off voltage, further confirming that severe cycling stresses exacerbate degradation. Finally, the technique facilitates the detection of parts of the electrode that have inhomogeneous lattice parameters that deviate from the bulk of the sample, further highlighting the effectiveness of the technique as a diagnostic tool, bridging the gap between crystal structure and electrochemical performance.
    Language English
    Publishing date 2020-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d0cp01851a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: 3D microstructure design of lithium-ion battery electrodes assisted by X-ray nano-computed tomography and modelling

    Xuekun Lu / Antonio Bertei / Donal P. Finegan / Chun Tan / Sohrab R. Daemi / Julia S. Weaving / Kieran B. O’Regan / Thomas M. M. Heenan / Gareth Hinds / Emma Kendrick / Dan J. L. Brett / Paul R. Shearing

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 13

    Abstract: The 3D microstructure of the electrode predominantly determines the electrochemical performance of Li-ion batteries. Here, the authors show that the microstructural heterogeneities lead to non-uniform Li insertion and current distribution while graded- ... ...

    Abstract The 3D microstructure of the electrode predominantly determines the electrochemical performance of Li-ion batteries. Here, the authors show that the microstructural heterogeneities lead to non-uniform Li insertion and current distribution while graded-microstructures improve the performance.
    Keywords Science ; Q
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: 3D microstructure design of lithium-ion battery electrodes assisted by X-ray nano-computed tomography and modelling

    Xuekun Lu / Antonio Bertei / Donal P. Finegan / Chun Tan / Sohrab R. Daemi / Julia S. Weaving / Kieran B. O’Regan / Thomas M. M. Heenan / Gareth Hinds / Emma Kendrick / Dan J. L. Brett / Paul R. Shearing

    Nature Communications, Vol 11, Iss 1, Pp 1-

    2020  Volume 13

    Abstract: The 3D microstructure of the electrode predominantly determines the electrochemical performance of Li-ion batteries. Here, the authors show that the microstructural heterogeneities lead to non-uniform Li insertion and current distribution while graded- ... ...

    Abstract The 3D microstructure of the electrode predominantly determines the electrochemical performance of Li-ion batteries. Here, the authors show that the microstructural heterogeneities lead to non-uniform Li insertion and current distribution while graded-microstructures improve the performance.
    Keywords Science ; Q
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Rett syndrome: clinical review and genetic update.

    Weaving, L S / Ellaway, C J / Gécz, J / Christodoulou, J

    Journal of medical genetics

    2005  Volume 42, Issue 1, Page(s) 1–7

    Abstract: Rett syndrome (RS) is a severe neurodevelopmental disorder that contributes significantly to severe intellectual disability in females worldwide. It is caused by mutations in MECP2 in the majority of cases, but a proportion of atypical cases may result ... ...

    Abstract Rett syndrome (RS) is a severe neurodevelopmental disorder that contributes significantly to severe intellectual disability in females worldwide. It is caused by mutations in MECP2 in the majority of cases, but a proportion of atypical cases may result from mutations in CDKL5, particularly the early onset seizure variant. The relationship between MECP2 and CDKL5, and whether they cause RS through the same or different mechanisms is unknown, but is worthy of investigation. Mutations in MECP2 appear to give a growth disadvantage to both neuronal and lymphoblast cells, often resulting in skewing of X inactivation that may contribute to the large degree of phenotypic variation. MeCP2 was originally thought to be a global transcriptional repressor, but recent evidence suggests that it may have a role in regulating neuronal activity dependent expression of specific genes such as Hairy2a in Xenopus and Bdnf in mouse and rat.
    MeSH term(s) Animals ; Disease Models, Animal ; Humans ; Methyl-CpG-Binding Protein 2/genetics ; Mutation ; Neurons/physiology ; Protein-Serine-Threonine Kinases/genetics ; Rett Syndrome/genetics
    Chemical Substances MECP2 protein, human ; Methyl-CpG-Binding Protein 2 ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; CDKL5 protein, human (EC 2.7.11.22)
    Language English
    Publishing date 2005-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 220881-7
    ISSN 1468-6244 ; 0022-2593
    ISSN (online) 1468-6244
    ISSN 0022-2593
    DOI 10.1136/jmg.2004.027730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Behavioural and psychological symptoms of Alzheimer type dementia are not correlated with plasma homocysteine concentration.

    Tabet, N / Rafi, H / Weaving, G / Lyons, B / Iversen, S A

    Dementia and geriatric cognitive disorders

    2006  Volume 22, Issue 5-6, Page(s) 432–438

    Abstract: ... micromol/l) and AD patients without BPSD (17.34 micromol/l). Similarly, there was no significant difference ...

    Abstract Background/aims: Vitamin B12 and folate deficiencies have been associated with cognitive impairment and various psychiatric symptoms but not specifically with behavioural and psychological symptoms of dementia (BPSD). A limitation of previous studies in dementia was lack of concurrent homocysteine measurement especially as it may provide a better indicator of tissue activities of these vitamins. This study was designed to clarify whether a relationship exists between plasma homocysteine concentration and BPSD.
    Methods: Plasma homocysteine, serum vitamin B12 and folate were measured in 23 Alzheimer's disease (AD) patients with BPSD and 27 AD patients without BPSD as determined through the use of the Neuropsychiatric Inventory (NPI). Blood levels of measured substances were also correlated with individual NPI scores and with cumulative NPI scores for different cluster of symptoms.
    Results: There was no significant difference (p = 0.956) in the mean plasma homocysteine levels between AD patients with BPSD (17.48 micromol/l) and AD patients without BPSD (17.34 micromol/l). Similarly, there was no significant difference between the two groups in the mean serum B12 (382.61 and 391.60 pg/ml, respectively) and folate (7.95 and 10.02 ng/ml, respectively). Mean levels for both vitamins were well within the laboratory reference range. Neither individual nor cluster NPI scores correlated significantly with plasma homocysteine.
    Conclusion: This study shows for the first time that BPSD are not associated with hyperhomocysteinaemia in Alzheimer dementia. Although previous studies have identified homocysteine as an independent risk factor in AD, the results reported here do not lend weight to an aetiological role for homocysteine specifically in BPSD.
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/blood ; Alzheimer Disease/diagnosis ; Alzheimer Disease/psychology ; Female ; Folic Acid/blood ; Homocysteine/blood ; Humans ; Male ; Mental Disorders/diagnosis ; Mental Disorders/etiology ; Mental Disorders/psychology ; Neuropsychological Tests ; Psychological Tests ; Severity of Illness Index ; Vitamin B 12/blood
    Chemical Substances Homocysteine (0LVT1QZ0BA) ; Folic Acid (935E97BOY8) ; Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2006
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1026007-9
    ISSN 1420-8008 ; 1013-7424
    ISSN 1420-8008 ; 1013-7424
    DOI 10.1159/000095802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Refining the phenotype of common mutations in Rett syndrome.

    Colvin, L / Leonard, H / de Klerk, N / Davis, M / Weaving, L / Williamson, S / Christodoulou, J

    Journal of medical genetics

    2003  Volume 41, Issue 1, Page(s) 25–30

    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Chromosomal Proteins, Non-Histone ; Chromosomes, Human, X/genetics ; Cohort Studies ; CpG Islands/genetics ; DNA-Binding Proteins/genetics ; Dosage Compensation, Genetic ; Female ; Humans ; Male ; Methyl-CpG-Binding Protein 2 ; Mutation/genetics ; Phenotype ; Repressor Proteins/genetics ; Rett Syndrome/genetics
    Chemical Substances Chromosomal Proteins, Non-Histone ; DNA-Binding Proteins ; MECP2 protein, human ; Methyl-CpG-Binding Protein 2 ; Repressor Proteins
    Language English
    Publishing date 2003-10-01
    Publishing country England
    Document type Letter ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 220881-7
    ISSN 1468-6244 ; 0022-2593
    ISSN (online) 1468-6244
    ISSN 0022-2593
    DOI 10.1136/jmg.2003.011130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: 07.03 FETUIN-A IS INDEPENDENTLY ASSOCIATED WITH PROGRESSIVE AORTIC STIFFNESS IN PATIENTS WITH CHRONIC KIDNEY DISEASE

    L.A. Tomlinson / S.G. Holt / E.R. Smith / G. Weaving / B.F. Rocks / C. Rajkumar

    Artery Research, Vol 2, Iss

    2008  Volume 3

    Keywords Specialties of internal medicine ; RC581-951 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
    Language English
    Publishing date 2008-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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