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Article ; Online: Hepatic myxoinflammatory fibroblastic sarcoma: A case report and literature review.

Shan, Kunkun / Wen, Junye / Ma, Xiaoli / Yu, Hanxiang

2023 Volume 46, Issue 10, Page(s) 4444–4446

MeSH term(s)	Humans ; Fibrosarcoma/diagnostic imaging ; Fibrosarcoma/surgery ; Sarcoma/diagnostic imaging ; Sarcoma/surgery ; Liver/diagnostic imaging
Language	English
Publishing date	2023-05-03
Publishing country	Netherlands
Document type	Review ; Case Reports ; Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.04.102
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Article ; Online: Construction of Co-ZIF-derived CoS

Ou, Lian / Yang, Jie / Xu, Li / Zhao, Shan / Xiong, Xiaoli / Xiao, Ting

Environmental research

2024 Volume 246, Page(s) 118177

Abstract: As a neurotoxin, it is necessary to establish a low cost, stable and sensitive method for the quantitative detection of hydrazine. Using Co-ZIF (zeolite imidazole framework) nanorods as precursor, ... ...

Abstract	As a neurotoxin, it is necessary to establish a low cost, stable and sensitive method for the quantitative detection of hydrazine. Using Co-ZIF (zeolite imidazole framework) nanorods as precursor, CoS
MeSH term(s)	Electrochemical Techniques/methods ; Limit of Detection ; Nanotubes ; Carbon/chemistry ; Hydrazines ; Water
Chemical Substances	Carbon (7440-44-0) ; hydrazine (27RFH0GB4R) ; Hydrazines ; Water (059QF0KO0R)
Language	English
Publishing date	2024-01-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118177
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Article ; Online: CuCo

Liu, Yan / Xin, Yuying / Wang, Xin / Zhang, Xianfa / Xu, Yingming / Cheng, Xiaoli / Gao, Shan / Huo, Lihua

Mikrochimica acta

2024 Volume 191, Issue 4, Page(s) 218

Abstract: An electrochemical sensor for detecting ketoprofen was constructed by in-situ grown copper cobaltate ( ... ...

Abstract	An electrochemical sensor for detecting ketoprofen was constructed by in-situ grown copper cobaltate (CuCo
Language	English
Publishing date	2024-03-26
Publishing country	Austria
Document type	Journal Article
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-024-06299-z
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Article ; Online: Histone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation.

Shan, Liying / Yang, Xiaoli / Liao, Xiaoxia / Yang, Zheng / Zhou, Jie / Li, Xiaoxia / Wang, Baoli

Cell death & disease

2024 Volume 15, Issue 2, Page(s) 136

Abstract: Histone methylation plays a crucial role in various cellular processes. We previously reported the in vitro function of histone lysine demethylase 7 A (KDM7A) in osteoblast and adipocyte differentiation. The current study was undertaken to investigate ... ...

Abstract	Histone methylation plays a crucial role in various cellular processes. We previously reported the in vitro function of histone lysine demethylase 7 A (KDM7A) in osteoblast and adipocyte differentiation. The current study was undertaken to investigate the physiological role of KDM7A in bone homeostasis and elucidate the underlying mechanisms. A conditional strategy was employed to delete the Kdm7a gene specifically in osterix-expressing osteoprogenitor cells in mice. The resulting mutant mice exhibited a significant increase in cancellous bone mass, accompanied by an increase in osteoblasts and bone formation, as well as a reduction in osteoclasts, marrow adipocytes and bone resorption. The bone marrow stromal cells (BMSCs) and calvarial pre-osteoblastic cells derived from the mutant mice exhibited enhanced osteogenic differentiation and suppressed adipogenic differentiation. Additionally, osteoclastic precursor cells from the mutant mice exhibited impaired osteoclast differentiation. Co-culturing BMSCs from the mutant mice with wild-type osteoclast precursor cells resulted in the inhibition of osteoclast differentiation. Mechanistic investigation revealed that KDM7A was able to upregulate the expression of fibroblast activation protein α (FAP) and receptor activator of nuclear factor κB ligand (RANKL) in BMSCs through removing repressive di-methylation marks of H3K9 and H3K27 from Fap and Rankl promoters. Moreover, recombinant FAP attenuated the dysregulation of osteoblast and adipocyte differentiation in BMSCs from Kdm7a deficient mice. Finally, Kdm7a deficiency prevented ovariectomy-induced bone loss in mice. This study establish the role of KDM7A in bone homeostasis through its epigenetic regulation of osteoblast and osteoclast differentiation. Consequently, inhibiting KDM7A may prove beneficial in ameliorating osteoporosis. KDM7A suppresses osteoblast differentiation and bone formation through. upregulating FAP expression and inactivating canonical Wnt signaling, and conversely promotes osteoclast differentiation and bone resorption through upregulating RANKL expression. These are based on its epigenetic removal of the repressive H3K9me2 and H3K27me2 marks from Fap and Rankl promoters. As a result, the expression of KDM7A in osteoprogenitor cells tends to negatively modulate bone mass.
MeSH term(s)	Animals ; Female ; Mice ; Bone Resorption/genetics ; Bone Resorption/metabolism ; Cell Differentiation ; Epigenesis, Genetic ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Homeostasis ; Osteoblasts/metabolism ; Osteoclasts/metabolism ; Osteogenesis/genetics ; RANK Ligand/genetics ; RANK Ligand/metabolism ; Jumonji Domain-Containing Histone Demethylases/genetics ; Jumonji Domain-Containing Histone Demethylases/metabolism
Chemical Substances	Histone Demethylases (EC 1.14.11.-) ; RANK Ligand ; KDM7 protein, mouse (EC 1.14.11.-) ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-)
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-024-06521-z
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Article ; Online: Reduction in the activity of VTA/SNc dopaminergic neurons underlies aging-related decline in novelty seeking.

Shan, Qiang / Tian, Ye / Chen, Hang / Lin, Xiaoli / Tian, Yao

Communications biology

2023 Volume 6, Issue 1, Page(s) 1224

Abstract: Curiosity, or novelty seeking, is a fundamental mechanism motivating animals to explore and exploit environments to improve survival, and is also positively associated with cognitive, intrapersonal and interpersonal well-being in humans. However, ... ...

Abstract	Curiosity, or novelty seeking, is a fundamental mechanism motivating animals to explore and exploit environments to improve survival, and is also positively associated with cognitive, intrapersonal and interpersonal well-being in humans. However, curiosity declines as humans age, and the decline even positively predicts the extent of cognitive decline in Alzheimer's disease patients. Therefore, determining the underlying mechanism, which is currently unknown, is an urgent task for the present aging society that is growing at an unprecedented rate. This study finds that seeking behaviors for both social and inanimate novelties are compromised in aged mice, suggesting that the aging-related decline in curiosity and novelty-seeking is a biological process. This study further identifies an aging-related reduction in the activity (manifesting as a reduction in spontaneous firing) of dopaminergic neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). Finally, this study establishes that this reduction in activity causally underlies the aging-related decline in novelty-seeking behaviors. This study potentially provides an interventional strategy for maintaining high curiosity in the aged population, i.e., compensating for the reduced activity of VTA/SNc dopaminergic neurons, enabling the aged population to cope more smoothly with the present growing aging society, physically, cognitively and socioeconomically.
MeSH term(s)	Humans ; Mice ; Animals ; Aged ; Pars Compacta ; Dopaminergic Neurons/physiology ; Exploratory Behavior ; Substantia Nigra ; Ventral Tegmental Area/physiology ; Aging
Language	English
Publishing date	2023-12-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-05571-x
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Article ; Online: Reduced Activity of Glutamatergic Neurons in the Prelimbic Medial Prefrontal Cortex Underlies the Inherent Aging-Related Physiological Reduction in Social Dominance.

Shan, Qiang / Lin, Xiaoli / Yu, Xiaoxuan / Guo, Wenye / Tian, Yao

The journals of gerontology. Series A, Biological sciences and medical sciences

2023 Volume 78, Issue 12, Page(s) 2222–2229

Abstract: Human society is aging, and the percentage of the population of older adults is increasing at an unprecedented rate. It is increasingly appreciated that social behaviors change with aging. One such example is the possible aging-related reduction in ... ...

Abstract	Human society is aging, and the percentage of the population of older adults is increasing at an unprecedented rate. It is increasingly appreciated that social behaviors change with aging. One such example is the possible aging-related reduction in dominance status. This change has been thought to underlie older adults' peculiar vulnerability to fraud, which has become a major challenge in the present aging society. However, whether this change is an inherent physiological process, and, if so, its underlying microscopic physiological mechanism, is not known. This study used groups of mice in a design that minimized effects that could confound any inherent process of dominance and verified that social dominance does inherently reduce with aging. This study further identified an aging-related microscopic functional alteration, that is, a reduction in the activity of glutamatergic pyramidal neurons in the prelimbic medial prefrontal cortex; and established that this reduction in neuronal activity serves as an intrinsic physiological mechanism underlying the macroscopic aging-related reduction in dominance. This study, by exploiting modern neurobiological techniques, sheds light on our understanding of human social behaviors during aging and may help develop strategies to counter related social challenges among the older adults population.
MeSH term(s)	Humans ; Mice ; Animals ; Aged ; Prefrontal Cortex ; Neurons/physiology ; Social Dominance ; Aging
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glad219
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Article ; Online: A sensitive and versatile electrochemical sensor based on hybridization chain reaction and CRISPR/Cas12a system for antibiotic detection.

Zhang, Xuemei / Zhu, Li / Yang, Li / Liu, Guoyu / Qiu, Shan / Xiong, Xiaoli / Huang, Ke / Xiao, Ting / Zhu, Liping

Analytica chimica acta

2024 Volume 1304, Page(s) 342562

Abstract: A sensitive electrochemical platform was constructed with ... ...

Abstract	A sensitive electrochemical platform was constructed with NH
MeSH term(s)	Anti-Bacterial Agents ; Electrochemical Techniques/methods ; CRISPR-Cas Systems ; Biosensing Techniques/methods ; Nucleic Acid Hybridization
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2024-03-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2024.342562
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Article ; Online: Stachydrine hydrochloride protects the ischemic heart by ameliorating endoplasmic reticulum stress through a SERCA2a dependent way and maintaining intracellular Ca

Feng, Minghui / Chen, Yuwen / Chen, Jingzhi / Guo, Wei / Zhao, Pei / Zhang, Chen / Shan, Xiaoli / Chen, Huihua / Xu, Ming / Lu, Rong

European journal of pharmacology

2024 Volume 973, Page(s) 176585

Abstract: This study aimed to explore the effects and mechanism of action of stachydrine hydrochloride (Sta) against myocardial infarction (MI) through sarcoplasmic/endoplasmic reticulum stress-related injury. The targets of Sta against MI were screened using ... ...

Abstract	This study aimed to explore the effects and mechanism of action of stachydrine hydrochloride (Sta) against myocardial infarction (MI) through sarcoplasmic/endoplasmic reticulum stress-related injury. The targets of Sta against MI were screened using network pharmacology. C57BL/6 J mice after MI were treated with saline, Sta (6 or 12 mg kg
Language	English
Publishing date	2024-04-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2024.176585
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Article ; Online: Microplastic Accumulation in Agricultural Soils with Different Mulching Histories in Xinjiang, China

Shan Zhang / Anming Bao / Xiaoli Lin / Gongxu Jia / Qingling Zhang

Sustainability, Vol 15, Iss 5438, p

2023 Volume 5438

Abstract: Microplastics (MPs) in soils have been widely studied, yet very little is known about their distribution in agricultural soils and the impact of mulching history. In this study, soil samples were taken across 3 soil layers of 60 sites with varying years ... ...

Abstract	Microplastics (MPs) in soils have been widely studied, yet very little is known about their distribution in agricultural soils and the impact of mulching history. In this study, soil samples were taken across 3 soil layers of 60 sites with varying years of mulching history (<5 years, 5–10 years, 10–20 years and >20 years) in agricultural film-mulched cotton fields of Xinjiang, China. Microplastics were obtained from the soils using oil separation combined with density separation. Stereomicroscopy and Fourier transform infrared spectroscopy (FTIR) were used for identification. The average microplastic abundance of the sites with different years of mulching history are 538, 1484, 5812 and 9708 pieces/kg, respectively. The microplastics with sizes 1000–5000 and 200–500 μm are dominant in soils with less than 10 years and over 10 years of continuous mulching history, respectively. The results show that the abundance of microplastics increases and the size of microplastics decreases gradually as the number of years of mulching history increases. In addition, the best polynomial fitting curves were found between microplastic abundance (y) and mulching years (x) in different soil layers, and the relationship in the topsoil layer can be fitted as the following equation: y = 20.6x 2 = 41.39x + 198.65 ( p < 0.01, R 2 = 0.62). The results indicate that residual agricultural mulching film is the dominating source of microplastics in cotton fields. This study provides rationale for further research on microplastics prediction in agricultural film-mulched fields.
Keywords	cotton field ; mulching ; microplastic pollution ; agriculture ; soil ; distribution ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reduction in the activity of VTA/SNc dopaminergic neurons underlies aging-related decline in novelty seeking

Qiang Shan / Ye Tian / Hang Chen / Xiaoli Lin / Yao Tian

Communications Biology, Vol 6, Iss 1, Pp 1-

2023 Volume 16

Abstract: Abstract Curiosity, or novelty seeking, is a fundamental mechanism motivating animals to explore and exploit environments to improve survival, and is also positively associated with cognitive, intrapersonal and interpersonal well-being in humans. However, ...

Abstract	Abstract Curiosity, or novelty seeking, is a fundamental mechanism motivating animals to explore and exploit environments to improve survival, and is also positively associated with cognitive, intrapersonal and interpersonal well-being in humans. However, curiosity declines as humans age, and the decline even positively predicts the extent of cognitive decline in Alzheimer’s disease patients. Therefore, determining the underlying mechanism, which is currently unknown, is an urgent task for the present aging society that is growing at an unprecedented rate. This study finds that seeking behaviors for both social and inanimate novelties are compromised in aged mice, suggesting that the aging-related decline in curiosity and novelty-seeking is a biological process. This study further identifies an aging-related reduction in the activity (manifesting as a reduction in spontaneous firing) of dopaminergic neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc). Finally, this study establishes that this reduction in activity causally underlies the aging-related decline in novelty-seeking behaviors. This study potentially provides an interventional strategy for maintaining high curiosity in the aged population, i.e., compensating for the reduced activity of VTA/SNc dopaminergic neurons, enabling the aged population to cope more smoothly with the present growing aging society, physically, cognitively and socioeconomically.
Keywords	Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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