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Article ; Online: Return to Driving Following Concussion: A Research Priority.

Dawson, Jennifer / Johnston, Sharon / Marshall, Shawn / Schweizer, Tom A / Reed, Nick / Devos, Hannes / Schmidt, Julianne / Lithopoulos, Alexander / Zemek, Roger

The Journal of head trauma rehabilitation

2023 Volume 38, Issue 3, Page(s) 277–278

MeSH term(s)	Humans ; Brain Concussion ; Students ; Research ; Athletic Injuries
Language	English
Publishing date	2023-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	639221-0
ISSN	1550-509X ; 0885-9701
ISSN (online)	1550-509X
ISSN	0885-9701
DOI	10.1097/HTR.0000000000000849
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Article ; Online: Disease Evolution Monitored by Serial Cerebrospinal Fluid Liquid Biopsies in Two Cases of Recurrent Medulloblastoma.

O'Halloran, Katrina / Margol, Ashley / Davidson, Tom B / Estrine, Dolores / Tamrazi, Benita / Cotter, Jennifer A / Ji, Jianling / Biegel, Jaclyn A

International journal of molecular sciences

2024 Volume 25, Issue 9

Abstract: Medulloblastoma is the most common malignant brain tumor in childhood. Initial treatment generally includes surgery, irradiation, and chemotherapy. Approximately 20-30% of patients will experience a recurrence, which portends a very poor prognosis. The ... ...

Abstract	Medulloblastoma is the most common malignant brain tumor in childhood. Initial treatment generally includes surgery, irradiation, and chemotherapy. Approximately 20-30% of patients will experience a recurrence, which portends a very poor prognosis. The current standard of care for evaluation for relapse includes radiographic surveillance with magnetic resonance imaging at regular intervals. The presence of circulating tumor DNA in the cerebrospinal fluid has been demonstrated to be a predictor of a higher risk of progression in a research setting for patients with medulloblastoma treated on a prospective single institution clinical trial. We have previously published and clinically validated a liquid-biopsy-based genetic assay utilizing low-pass whole genome sequencing to detect copy number alterations in circulating tumor DNA. Here, we present two teenage patients with posterior fossa medulloblastoma with recurrent disease who have been monitored with serial liquid biopsies showing tumor evolution over time, demonstrating the clinical utility of these approaches.
MeSH term(s)	Humans ; Medulloblastoma/cerebrospinal fluid ; Medulloblastoma/genetics ; Medulloblastoma/diagnosis ; Medulloblastoma/pathology ; Medulloblastoma/diagnostic imaging ; Liquid Biopsy/methods ; Neoplasm Recurrence, Local/cerebrospinal fluid ; Neoplasm Recurrence, Local/genetics ; Adolescent ; Cerebellar Neoplasms/cerebrospinal fluid ; Cerebellar Neoplasms/diagnosis ; Cerebellar Neoplasms/pathology ; Cerebellar Neoplasms/genetics ; Male ; Circulating Tumor DNA/cerebrospinal fluid ; Circulating Tumor DNA/genetics ; Circulating Tumor DNA/blood ; Female ; Disease Progression ; Magnetic Resonance Imaging
Chemical Substances	Circulating Tumor DNA
Language	English
Publishing date	2024-04-30
Publishing country	Switzerland
Document type	Case Reports ; Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25094882
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Article ; Online: Applying the adverse outcome pathway concept to questions in anaesthetic neurotoxicity.

Waspe, Jennifer / Chico, Timothy J A / Hansen, Tom G

British journal of anaesthesia

2021 Volume 126, Issue 6, Page(s) 1097–1102

MeSH term(s)	Adverse Outcome Pathways ; Anesthetics/adverse effects ; Animals ; Humans ; Nervous System/drug effects ; Nervous System/metabolism ; Nervous System/pathology ; Nervous System/physiopathology ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/metabolism ; Neurotoxicity Syndromes/pathology ; Neurotoxicity Syndromes/physiopathology ; Risk Factors
Chemical Substances	Anesthetics
Language	English
Publishing date	2021-04-20
Publishing country	England
Document type	Editorial
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2021.03.009
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Article ; Online: Rehabilitation via HOMe-Based gaming exercise for the Upper limb post Stroke (RHOMBUS)

Cherry Kilbride / Daniel J M Scott / Tom Butcher / Meriel Norris / Alyson Warland / Karen Baker / Dimitrios A Athanasiou / Guillem Singla-Buxarrais / Jennifer Ryan / Elizabeth Cassidy

BMJ Open, Vol 14, Iss

a qualitative analysis of participants’ experience

2024 Volume 1

Abstract: Objective To report participants’ experiences of trial processes and use of the Neurofenix platform for home-based rehabilitation following stroke. The platform, consisting of the NeuroBall device and Neurofenix app, is a non-immersive virtual reality ... ...

Abstract	Objective To report participants’ experiences of trial processes and use of the Neurofenix platform for home-based rehabilitation following stroke. The platform, consisting of the NeuroBall device and Neurofenix app, is a non-immersive virtual reality tool to facilitate upper limb rehabilitation following stroke. The platform has recently been evaluated and demonstrated to be safe and effective through a non-randomised feasibility trial (RHOMBUS).Design Qualitative approach using semistructured interviews. Interviews were audio recorded, transcribed verbatim and analysed using the framework method.Setting Participants’ homes, South-East England.Participants Purposeful sample of 18 adults (≥18 years), minimum 12 weeks following stroke, not receiving upper limb rehabilitation prior to the RHOMBUS trial, scoring 9–25 on the Motricity Index (elbow and shoulder), with sufficient cognitive and communicative abilities to participate.Results Five themes were developed which explored both trial processes and experiences of using the platform. Factors that influenced participant’s decision to take part in the trial, their perceptions of support provided during the trial and communication with the research team were found to be important contextual factors effecting participants’ overall experience. Specific themes around usability and comfort of the NeuroBall device, factors motivating persistence and perceived effectiveness of the intervention were highlighted as being central to the usability and acceptability of the platform.Conclusion This study demonstrated the overall acceptability of the platform and identified areas for enhancement which have since been implemented by Neurofenix. The findings add to the developing literature on the interface between virtual reality systems and user experience.Trial registration number ISRCTN60291412.
Keywords	Medicine ; R
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differential IgG4-Producing Plasma Cell Infiltration in Non- and Post-Transplant Plasma Cell Hepatitis.

Horwich, Brian H / Liang, Tom Z / Dodge, Jennifer L / Chopra, Shefali / Kahn, Jeffrey A / Saito, Takeshi

Transplant international : official journal of the European Society for Organ Transplantation

2022 Volume 35, Page(s) 10182

Abstract: Autoimmune hepatitis (AIH), post-transplant recurrent AIH (rAIH), and plasma cell-rich rejection (PCR) are clinical diagnoses with the shared histopathologic hallmark of plasma cell hepatitis (PCH). As these histologically and serologically ... ...

Abstract	Autoimmune hepatitis (AIH), post-transplant recurrent AIH (rAIH), and plasma cell-rich rejection (PCR) are clinical diagnoses with the shared histopathologic hallmark of plasma cell hepatitis (PCH). As these histologically and serologically indistinguishable diagnoses are differentiated by clinical context, it remains uncertain whether they represent distinct immunologic phenomena. Improved understanding of immunoglobulin subclass 4-producing plasma cells (IgG4-PC) has brought attention to IgG4 as an immunophenotypic biomarker. To date, degree and clinical significance of IgG4-PC infiltration in PCH remain elusive. This retrospective, single-center study assessed IgG4-PC infiltration in AIH, rAIH, and PCR via standardized immunohistochemistry analysis. Identified cases from 2005 to 2020 (
MeSH term(s)	Hepatitis, Autoimmune/diagnosis ; Hepatitis, Autoimmune/drug therapy ; Humans ; Immunoglobulin G ; Plasma Cells ; Retrospective Studies ; Transplants/pathology
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2022-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2022.10182
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Article ; Online: Rehabilitation via HOMe-Based gaming exercise for the Upper limb post Stroke (RHOMBUS): a qualitative analysis of participants' experience.

Kilbride, Cherry / Butcher, Tom / Warland, Alyson / Ryan, Jennifer / Scott, Daniel J M / Cassidy, Elizabeth / Athanasiou, Dimitrios A / Singla-Buxarrais, Guillem / Baker, Karen / Norris, Meriel

BMJ open

2024 Volume 14, Issue 1, Page(s) e075821

Abstract: Objective: To report participants' experiences of trial processes and use of the Neurofenix platform for home-based rehabilitation following stroke. The platform, consisting of the NeuroBall device and Neurofenix app, is a non-immersive virtual reality ... ...

Abstract	Objective: To report participants' experiences of trial processes and use of the Neurofenix platform for home-based rehabilitation following stroke. The platform, consisting of the NeuroBall device and Neurofenix app, is a non-immersive virtual reality tool to facilitate upper limb rehabilitation following stroke. The platform has recently been evaluated and demonstrated to be safe and effective through a non-randomised feasibility trial (RHOMBUS). Design: Qualitative approach using semistructured interviews. Interviews were audio recorded, transcribed verbatim and analysed using the framework method. Setting: Participants' homes, South-East England. Participants: Purposeful sample of 18 adults (≥18 years), minimum 12 weeks following stroke, not receiving upper limb rehabilitation prior to the RHOMBUS trial, scoring 9-25 on the Motricity Index (elbow and shoulder), with sufficient cognitive and communicative abilities to participate. Results: Five themes were developed which explored both trial processes and experiences of using the platform. Factors that influenced participant's decision to take part in the trial, their perceptions of support provided during the trial and communication with the research team were found to be important contextual factors effecting participants' overall experience. Specific themes around usability and comfort of the NeuroBall device, factors motivating persistence and perceived effectiveness of the intervention were highlighted as being central to the usability and acceptability of the platform. Conclusion: This study demonstrated the overall acceptability of the platform and identified areas for enhancement which have since been implemented by Neurofenix. The findings add to the developing literature on the interface between virtual reality systems and user experience. Trial registration number: ISRCTN60291412.
MeSH term(s)	Adult ; Humans ; Exercise ; Stroke/psychology ; Stroke Rehabilitation/methods ; Upper Extremity ; Video Games ; Clinical Trials as Topic ; Qualitative Research
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-075821
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Article ; Online: Extensive Literature Review of 46, XX Newborns with Congenital Adrenal Hyperplasia (CAH) and Severe Genital Masculinization: Should They be Assigned and Reared Male?

Mazur, Tom / O'Donnell, Jennifer / Lee, Peter A

Journal of clinical research in pediatric endocrinology

2023

Abstract: 46, XX individuals born with severely masculinized genitals due to congenital adrenal hyperplasia (CAH) who have been assigned males at birth and reared male can successfully establish a male gender identity/role, find employment, marry, function ... ...

Abstract	46, XX individuals born with severely masculinized genitals due to congenital adrenal hyperplasia (CAH) who have been assigned males at birth and reared male can successfully establish a male gender identity/role, find employment, marry, function sexually with a female partner, and develop positive mental health status. While there were a few individuals who reportedly did not fare well or who changed gender to female, the majority of those identifying as males appear to have an overall good quality of life. Parental/family support, along with the support of others, appears essential to a positive outcome as a male or as a female. Reasons are given to support why serious consideration of a male gender assignment and rearing, in certain situations, is justified and should be seriously considered. Disorders of Sex Differentiation (DSD) teams should inform parents of the option of male assignment and rearing in 46, XX CAH infants with severe genital masculinization, a rare condition. To provide this option is concordant with the principles of ethics, transparency and with the Endocrine Society Guidelines and the American Academy of Pediatrics' policy of fully informed consent.
Language	English
Publishing date	2023-12-27
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2641608-6
ISSN	1308-5735 ; 1308-5727
ISSN (online)	1308-5735
ISSN	1308-5727
DOI	10.4274/jcrpe.galenos.2023.2023-10-17
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Article ; Online: Safety, feasibility, acceptability and preliminary effects of the Neurofenix platform for Rehabilitation via HOMe Based gaming exercise for the Upper-limb post Stroke (RHOMBUS)

Cherry Kilbride / Daniel J M Scott / Tom Butcher / Meriel Norris / Nana Anokye / Alyson Warland / Karen Baker / Dimitrios A Athanasiou / Guillem Singla-Buxarrais / Alexander Nowicky / Jennifer Ryan / Elizabeth Cassidy

BMJ Open, Vol 12, Iss

results of a feasibility intervention study

2022 Volume 2

Keywords	Medicine ; R
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb post Stroke (RHOMBUS II)

Cherry Kilbride / Tom Butcher / Meriel Norris / Nana Anokye / Alyson Warland / Karen Baker / Dimitrios A Athanasiou / Guillem Singla-Buxarrais / Jennifer Ryan / Francesca Gowing / Carole Pound / Victoria Stewart / Basaam Aweid / Arul Samiyappan

BMJ Open, Vol 12, Iss

protocol of a feasibility randomised controlled trial

2022 Volume 6

Keywords	Medicine ; R
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: New Users of Angiotensin II Receptor Blocker-Versus Angiotensin-Converting Enzyme Inhibitor-Based Antihypertensive Medication Regimens and Cardiovascular Disease Events: A Secondary Analysis of ACCORD-BP and SPRINT.

King, Jordan B / Berchie, Ransmond O / Derington, Catherine G / Marcum, Zachary A / Scharfstein, Daniel O / Greene, Tom H / Herrick, Jennifer S / Jacobs, Joshua A / Zheutlin, Alexander R / Bress, Adam P / Cohen, Jordana B

Journal of the American Heart Association

2023 Volume 12, Issue 17, Page(s) e030311

Abstract: BACKGROUND Angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) block distinct components of the renin-angiotensin system. Whether this translates into differential effects on cardiovascular disease events remains ... ...

Abstract	BACKGROUND Angiotensin II receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) block distinct components of the renin-angiotensin system. Whether this translates into differential effects on cardiovascular disease events remains unclear. METHODS AND RESULTS We used the ACCORD-BP (Action to Control Cardiovascular Risk in Diabetes-Blood Pressure) trial and the SPRINT (Systolic Blood Pressure Intervention Trial) to emulate target trials of new users of ARBs versus ACEIs on cardiovascular disease events (primary outcome) and death (secondary outcome). We estimated marginal cause-specific hazard ratios (HRs) and treatment-specific cumulative incidence functions with inverse probability of treatment weights. We identified 3298 new users of ARBs or ACEIs (ACCORD-BP: 374 ARB versus 884 ACEI; SPRINT: 727 ARB versus 1313 ACEI). For participants initiating ARBs versus ACEIs, the inverse probability of treatment weight rate of the primary outcome was 3.2 versus 3.5 per 100 person-years in ACCORD-BP (HR, 0.91 [95% CI, 0.63-1.31]) and 1.8 versus 2.2 per 100 person-years in SPRINT (HR, 0.81 [95% CI, 0.56-1.18]). There were no appreciable differences in pooled analyses, except that ARBs versus ACEIs were associated with a lower death rate (HR, 0.56 [95% CI, 0.37-0.85]). ARBs were associated with a lower rate of the primary outcome among subgroups of male versus female participants, non-Hispanic Black versus non-Hispanic White participants, and those randomly assigned to standard versus intensive blood pressure (
MeSH term(s)	Female ; Male ; Humans ; Antihypertensive Agents/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Angiotensin Receptor Antagonists/therapeutic use ; Cardiovascular Diseases/epidemiology ; Renin-Angiotensin System ; Antiviral Agents
Chemical Substances	Antihypertensive Agents ; Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists ; Antiviral Agents
Language	English
Publishing date	2023-08-30
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.030311
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