LIVIVO - Search results -

Search results

Result 1 - 10 of total 43

Search options

Article ; Online: Revelations in our own backyard: Chandra's unique Galactic Center discoveries.

Markoff, Sera

Proceedings of the National Academy of Sciences of the United States of America

2010 Volume 107, Issue 16, Page(s) 7196–7201

Abstract: Before the launch of Chandra, our Galactic Center supermassive black hole, Sgr A*, had never been positively identified outside the radio bands. A great deal has changed in the past decade, starting with the discovery that our own backyard harbors a very ...

Abstract	Before the launch of Chandra, our Galactic Center supermassive black hole, Sgr A*, had never been positively identified outside the radio bands. A great deal has changed in the past decade, starting with the discovery that our own backyard harbors a very weak, yet clearly active, galactic nucleus. I will review how this revelation has been a boon for accretion studies around black holes in general and has helped us place our own Galaxy in context within the active galactic nuclei (AGN) zoology. Chandra's exquisite resolution has also unveiled entirely new populations of faint sources and transients, as well as regions of extreme gas dynamics and hints of prior, more typical AGN-like activity in our Galactic Center.
Language	English
Publishing date	2010-04-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.0914070107
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1148: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Revelations in our own backyard: Chandra's unique Galactic Center discoveries

Markoff, Sera

Proceedings of the National Academy of Sciences of the United States of America. 2010 Apr. 20, v. 107, no. 16

2010

Abstract	Before the launch of Chandra, our Galactic Center supermassive black hole, Sgr A*, had never been positively identified outside the radio bands. A great deal has changed in the past decade, starting with the discovery that our own backyard harbors a very weak, yet clearly active, galactic nucleus. I will review how this revelation has been a boon for accretion studies around black holes in general and has helped us place our own Galaxy in context within the active galactic nuclei (AGN) zoology. Chandra's exquisite resolution has also unveiled entirely new populations of faint sources and transients, as well as regions of extreme gas dynamics and hints of prior, more typical AGN-like activity in our Galactic Center.
Keywords	energy ; radio waves ; research
Language	English
Dates of publication	2010-0420
Size	p. 7196-7201.
Publishing place	National Academy of Sciences
Document type	Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.0914070107
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 4' 63/44: Show issues
87/25270: Show issues
Qa 4' 169/3: Show issues
Z 8.7: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Differences in susceptibilities of the lymphogranuloma venereum and trachoma biovars of Chlamydia trachomatis to neutralization by immune sera.

Peterson, E M / Hoshiko, M / Markoff, B A / Lauermann, M W / de la Maza, L M

Infection and immunity

1990 Volume 58, Issue 4, Page(s) 938–943

Abstract: Sera from seven patients from whom a C. trachomatis serovar L2 strain was isolated were tested ... lymph node was culture positive, whereas the remaining six patients had positive rectal biopsies. Sera ... was resistant to neutralization by the homologous sera. However, the same sera effectively neutralized ...

Abstract	Sera from seven patients from whom a C. trachomatis serovar L2 strain was isolated were tested in vitro for their ability to neutralize the infectivity of this organism. In one patient an inguinal lymph node was culture positive, whereas the remaining six patients had positive rectal biopsies. Sera from four of the patients, including the patient with the lymph node isolate, failed to neutralize serovar L2(434). In addition, the homologous strain recovered from the inguinal lymph node was available and was resistant to neutralization by the homologous sera. However, the same sera effectively neutralized a trachoma serovar, E(Bour). All four sera had inclusion immunofluorescent-antibody titers to C. trachomatis serovar L2 of 2,048 to 16,384 and microimmunofluorescent-antibody titers to the lymphogranuloma venereum biovar were equal or higher in all cases than to the 12 serovars of the trachoma biovar. The three remaining sera, while neutralizing the infectivity of the L2 strains tested, neutralized serovar E to a greater extent. These sera had the same inclusion immunofluorescent antibody titers as the sera that failed to neutralize serovar L2. To see whether this difference in the sensitivity of the biovars toward neutralization could be characterized, sera were obtained from mice immunized with different doses of both serovars L2 and E. Sera obtained from mice immunized with serovar E were able to effectively neutralize the homologous strain. In contrast, neutralization of the immunizing strain, L2(UCI-20), was not seen with sera obtained on days 7, 14, and 21 after immunization from animals receiving 8 x 10(5) and 8 x 10(4) inclusion-forming units of L2(UCI-20); however, these same sera neutralized serovar E. However, with a higher immunizing dose of L2 (10(7) IFUs), both E and L2 were neutralized with sera obtained 7 and 14 days after immunization. Therefore, the relative resistance to neutralization by serovar L2 compared with that of serovar E in the mouse model was inoculum dependent.
MeSH term(s)	Animals ; Antibodies, Bacterial/analysis ; Chlamydia trachomatis/immunology ; Chlamydia trachomatis/pathogenicity ; Female ; Humans ; Immune Sera/immunology ; Immunization ; Lymphogranuloma Venereum/microbiology ; Mice ; Mice, Inbred BALB C ; Neutralization Tests ; Trachoma/microbiology ; Virulence
Chemical Substances	Antibodies, Bacterial ; Immune Sera
Language	English
Publishing date	1990-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	218698-6
ISSN	1098-5522 ; 0019-9567
ISSN (online)	1098-5522
ISSN	0019-9567
DOI	10.1128/iai.58.4.938-943.1990
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 684: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Elsberg syndrome in HSV-2 infection.

Belfaqeeh, Omar / Markley, Alexandria / Patel, Mudita / Markoff, Brian / Osorio, Georgina

IDCases

2023 Volume 31, Page(s) e01714

Abstract: ... Based on clinical, radiographic, and serological testing the patient was diagnosed with HSV2 lumbosacral ...

Abstract	Elsberg syndrome (ES) is a neuroinflammatory disease that causes acute or subacute lumbosacral radiculitis, with or without myelitis which accounts for approximately 5-10% of cauda equina syndrome and myelitis. We herein present a case of a middle-aged female who recently returned from the Dominican Republic and presented to the emergency room with complaints of a 10-day history of progressive lower extremity sensory changes and weakness preceded by transient bilateral arm pain and neck and head pressure. Based on clinical, radiographic, and serological testing the patient was diagnosed with HSV2 lumbosacral radiculitis (ES). After 21 days of Acyclovir, 5 days of high dose IV methylprednisolone, and one month of inpatient rehab, our patient was discharged home walking with a cane. As ES is poorly defined and rarely reported, it can be unrecognized in patients with acute cauda equina syndrome (CES). Appropriate testing for viral infection in a timely manner facilitates reaching a definitive diagnosis and prompt initiation of treatment, which is essential for resolution of symptoms.
Language	English
Publishing date	2023-02-16
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2023.e01714
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Searching for Primordial Black Holes in the Radio and X-Ray Sky.

Gaggero, Daniele / Bertone, Gianfranco / Calore, Francesca / Connors, Riley M T / Lovell, Mark / Markoff, Sera / Storm, Emma

Physical review letters

2017 Volume 118, Issue 24, Page(s) 241101

Abstract: We model the accretion of gas onto a population of massive primordial black holes in the Milky Way and compare the predicted radio and x-ray emission with observational data. We show that, under conservative assumptions on the accretion process, the ... ...

Abstract	We model the accretion of gas onto a population of massive primordial black holes in the Milky Way and compare the predicted radio and x-ray emission with observational data. We show that, under conservative assumptions on the accretion process, the possibility that O(10)M_{⊙} primordial black holes can account for all of the dark matter in the Milky Way is excluded at 5σ by a comparison with a Very Large Array radio catalog at 1.4 GHz and at ≃40σ by a comparison with a Chandra x-ray catalog (0.5-8 keV). We argue that this method can be used to identify such a population of primordial black holes with more sensitive future radio and x-ray surveys.
Language	English
Publishing date	2017-06-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.118.241101
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 58/153: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cygnus X-1 contains a 21-solar mass black hole-Implications for massive star winds.

Miller-Jones, James C A / Bahramian, Arash / Orosz, Jerome A / Mandel, Ilya / Gou, Lijun / Maccarone, Thomas J / Neijssel, Coenraad J / Zhao, Xueshan / Ziółkowski, Janusz / Reid, Mark J / Uttley, Phil / Zheng, Xueying / Byun, Do-Young / Dodson, Richard / Grinberg, Victoria / Jung, Taehyun / Kim, Jeong-Sook / Marcote, Benito / Markoff, Sera /

Rioja, María J / Rushton, Anthony P / Russell, David M / Sivakoff, Gregory R / Tetarenko, Alexandra J / Tudose, Valeriu / Wilms, Joern

Science (New York, N.Y.)

2021 Volume 371, Issue 6533, Page(s) 1046–1049

Abstract: The evolution of massive stars is influenced by the mass lost to stellar winds over their lifetimes. These winds limit the masses of the stellar remnants (such as black holes) that the stars ultimately produce. We used radio astrometry to refine the ... ...

Abstract	The evolution of massive stars is influenced by the mass lost to stellar winds over their lifetimes. These winds limit the masses of the stellar remnants (such as black holes) that the stars ultimately produce. We used radio astrometry to refine the distance to the black hole x-ray binary Cygnus X-1, which we found to be [Formula: see text] kiloparsecs. When combined with archival optical data, this implies a black hole mass of 21.2 ± 2.2 solar masses, which is higher than previous measurements. The formation of such a high-mass black hole in a high-metallicity system (within the Milky Way) constrains wind mass loss from massive stars.
Language	English
Publishing date	2021-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abb3363
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A rapidly changing jet orientation in the stellar-mass black-hole system V404 Cygni.

Nature

2019 Volume 569, Issue 7756, Page(s) 374–377

Abstract: Powerful relativistic jets are one of the main ways in which accreting black holes provide kinetic feedback to their surroundings. Jets launched from or redirected by the accretion flow that powers them are expected to be affected by the dynamics of the ... ...

Abstract	Powerful relativistic jets are one of the main ways in which accreting black holes provide kinetic feedback to their surroundings. Jets launched from or redirected by the accretion flow that powers them are expected to be affected by the dynamics of the flow, which for accreting stellar-mass black holes has shown evidence for precession
Language	English
Publishing date	2019-04-29
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-019-1152-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 9: Show issues
Zs.MO 244: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The nature of the IR emission in LLAGN at parsec scales

Fernández-Ontiveros Juan Antonio / Almudena Prieto M. / Acosta-Pulido Jose Antonio / Markoff Sera / González-Martín Omaira

EPJ Web of Conferences, Vol 61, p

2013 Volume 04005

Abstract: The vast majority of AGN belong to the low-luminosity class (LLAGN): they exhibit a low radiation effciency (L ≲ 1042 erg s−1; L/Ledd ≲ 10−3) and the absence of the big blue bump in their spectrum, a signature of the accretion disk. The study of LLAGN is ...

Abstract	The vast majority of AGN belong to the low-luminosity class (LLAGN): they exhibit a low radiation effciency (L ≲ 1042 erg s−1; L/Ledd ≲ 10−3) and the absence of the big blue bump in their spectrum, a signature of the accretion disk. The study of LLAGN is a complex task due to the contribution of the host galaxy, whose light outshines these faint nuclei. As a consequence, numerical models are usually compared with relatively poorly defined spectral energy distributions (SEDs). For a sample of six prototype nearby LLAGN, a multiwavelength dataset including radio, IR, optical/UV and X-ray measurements with a few tenths of arcsec resolution has been collected. These high-spatial resolution SEDs reveal that: i) the mid-IR bump, indicative of thermal emission from the torus, is missing in LLAGN; ii) the continuum emission of these nuclei is largely described by a self-absorbed synchrotron spectrum, suggesting that jet emission dominates the overall energy output in these objects. The optically thin radiation in the IR-to-UV range is produced in the jet launching region, very close to the central black hole. The very steep slope found in this component –with a spectral index in the 1-3 range– suggests that a large number of LLAGN are powered by young and compact jets with very high radiative losses.
Keywords	Physics ; QC1-999 ; Science ; Q ; DOAJ:Physics (General) ; DOAJ:Physics and Astronomy
Subject code	520
Language	English
Publishing date	2013-12-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Ethics of a partially effective dengue vaccine: Lessons from the Philippines.

Halstead, Scott B / Katzelnick, Leah C / Russell, Philip K / Markoff, Lewis / Aguiar, Maira / Dans, Leonila R / Dans, Antonio L

Vaccine

2020 Volume 38, Issue 35, Page(s) 5572–5576

Abstract: ... children who had prior dengue virus (DENV) infections but sensitized seronegative children to breakthrough ... vaccinated seronegative and seropositive children hospitalized for severe dengue. Assisting these children ... of an acceptable serological screening test these unresolved ethical issues suggest Dengvaxia be given only ...

Abstract	Dengvaxia, a chimeric yellow fever tetravalent dengue vaccine developed by SanofiPasteur is widely licensed in dengue-endemic countries. In a large cohort study Dengvaxia was found to partially protect children who had prior dengue virus (DENV) infections but sensitized seronegative children to breakthrough DENV disease of enhanced severity. In 2019, the European Medicines Agency and the US FDA issued licenses that reconciled safety issues by restricting vaccine to individuals with prior dengue infections. Using revised Dengvaxia efficacy and safety data we sought to estimate hospitalized and severe dengue cases among the more than 800,000 9 year-old children vaccinated in the Philippines. Despite an overall vaccine efficacy of 69% during 4 years post-vaccination we project there will be more than one thousand vaccinated seronegative and seropositive children hospitalized for severe dengue. Assisting these children through a program of enhanced surveillance leading to improved care deserves widespread support. Clinical responses observed during breakthrough dengue infections in vaccinated individuals counsel prudence in design of vaccine policies. Recommendations concerning continued use of this dengue vaccine are: (1) obtain a better definition of vaccine efficacy and safety through enhanced phase 4 surveillance, (2) obtain a valid, accessible, sensitive, specific and affordable serological test that identifies past wild-type dengue virus infection and (3) clarify safety and efficacy of Dengvaxia in flavivirus immunes. In the absence of an acceptable serological screening test these unresolved ethical issues suggest Dengvaxia be given only to those signing informed consent.
MeSH term(s)	Antibodies, Viral ; Child ; Cohort Studies ; Dengue/prevention & control ; Dengue Vaccines/adverse effects ; Humans ; Philippines ; Vaccines, Attenuated
Chemical Substances	Antibodies, Viral ; Dengue Vaccines ; Vaccines, Attenuated
Keywords	covid19
Language	English
Publishing date	2020-07-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2020.06.079
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Points to consider in the development of a surrogate for efficacy of novel Japanese encephalitis virus vaccines.

Markoff, L

Vaccine

2000 Volume 18 Suppl 2, Page(s) 26–32

Abstract: ... for the efficacy of JE vaccines should be established. Detection of virus-neutralizing antibodies in sera ... by the vaccines and protection from encephalitis. In addition, sera of subjects receiving the novel live JEV ...

Abstract	Although an effective killed virus vaccine to prevent illness due to Japanese encephalitis virus (JEV) infection exists, many authorities recognize that a safe, effective live JEV vaccine is desirable in order to reduce the cost and the number of doses of vaccine required per immunization. A large-scale clinical efficacy trail for such a vaccine would be both unethical and impractical. Therefore, a surrogate for the efficacy of JE vaccines should be established. Detection of virus-neutralizing antibodies in sera of vaccinees could constitute such a surrogate for efficacy. Field studies of vaccinees in endemic areas and studies done in mice already exist to support this concept. Also, titers of virus-neutralizing antibodies are already accepted as a surrogate for the efficacy of yellow fever virus vaccines and for the efficacy of other viral vaccines as well. In developing a correlation between N antibody titers and protection from JEV infection, standard procedures must be validated and adopted for both measuring N antibodies and for testing in animals. A novel live virus vaccine could be tested in the mouse and/or the monkey model of JEV infection to establish a correlation between virus-neutralizing antibodies elicited by the vaccines and protection from encephalitis. In addition, sera of subjects receiving the novel live JEV vaccine in early clinical trials could be passively transferred to mice or monkeys in order to establish the protective immunogenicity of the vaccine in humans. A monkey model for JEV infection was recently established by scientists at WRAIR in the US. From this group, pools of JEV of known infectivity for Rhesus macaques may be obtained for testing of immunity elicited by live JE vaccine virus.
MeSH term(s)	Animals ; Clinical Trials as Topic ; Dose-Response Relationship, Immunologic ; Encephalitis Virus, Japanese/immunology ; Encephalitis, Japanese/epidemiology ; Encephalitis, Japanese/immunology ; Encephalitis, Japanese/prevention & control ; Humans ; Practice Guidelines as Topic ; Vaccines, Attenuated/adverse effects ; Vaccines, Attenuated/economics ; Vaccines, Attenuated/standards ; Vaccines, Attenuated/therapeutic use ; Viral Vaccines/adverse effects ; Viral Vaccines/economics ; Viral Vaccines/standards ; Viral Vaccines/therapeutic use
Chemical Substances	Vaccines, Attenuated ; Viral Vaccines
Language	English
Publishing date	2000-05-26
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/s0264-410x(00)00038-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito