LIVIVO - Search results -

Search results

Result 1 - 10 of total 13

Search options

Article: COVID-19 Incidence After Emergency Department Visit.

Balakumar, Jonathan / Pham, My-Phuong / Mak, Selene / Yip, Kathleen

Federal practitioner : for the health care professionals of the VA, DoD, and PHS

2023 Volume 40, Issue 7, Page(s) 224–227

Abstract: Background: The emergency department (ED) at the Veterans Affairs Greater Los Angeles Healthcare System (VAGLAHS) saw a decrease in the number of visits during the early stages of the COVID-19 pandemic. Little is known whether risk mitigation procedures ...

Abstract	Background: The emergency department (ED) at the Veterans Affairs Greater Los Angeles Healthcare System (VAGLAHS) saw a decrease in the number of visits during the early stages of the COVID-19 pandemic. Little is known whether risk mitigation procedures may help reduce the spread of COVID-19 infections for veterans visiting the ED. Therefore, we reviewed patient visits to the ED for diagnoses other than COVID-19 to assess whether these patients had an increased COVID-19 positivity rate within 21 days of the initial visit. Observations: Risk mitigation procedures instituted by the VAGLAHS ED included a COVID-19 outdoor testing tent, immediate isolation of persons under investigation for COVID-19, disinfection protocols between high-risk patient encounters, dedicated training in donning and doffing personal protective equipment, implementation of 2-physician airway teams for COVID-19 intubations, use of electronic tablets to communicate with COVID-19 patients, and implementation of social distancing initiatives in the waiting room to minimize COVID-19 exposures. The average positivity rate at the VAGLAHS ED during this time frame was 0% to 6.7%, compared with 6.9% to 33.3% within the wider VAGLAHS. Conclusions: Implementing risk mitigation procedures in the VAGLAHS ED helped minimize exposure and subsequent diagnosis of COVID-19 for veterans who visited the VAGLAHS ED for symptoms not associated with COVID-19 infection. Seeking acute medical care in the ED did not put patients at higher risk of contracting COVID-19.
Language	English
Publishing date	2023-07-12
Publishing country	United States
Document type	Journal Article
ISSN	1078-4497
ISSN	1078-4497
DOI	10.12788/fp.0384
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Reversal of Dabigatran with Idarucizumab in Acute Subarachnoid Hemorrhage.

Balakumar, Jonathan / Santiago, Ruben / Supino, Mark

Clinical practice and cases in emergency medicine

2017 Volume 1, Issue 4, Page(s) 349–353

Abstract: Dabigatran etexilate mesylate is a direct thrombin inhibitor used for reducing the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation. Dabigatran belongs to a new generation of oral agents for anticoagulation - the ... ...

Abstract	Dabigatran etexilate mesylate is a direct thrombin inhibitor used for reducing the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation. Dabigatran belongs to a new generation of oral agents for anticoagulation - the direct oral anticoagulants (DOACs). The DOACs also include the factor Xa inhibitors rivaroxaban, apixaban, and edoxaban. In the case of major or life-threatening bleeding and/or the need for emergent invasive procedures, a reversal agent is needed if a patient is taking one of these medications. Research has shown the efficacy of idarucizumab as an antidote in healthy volunteers, but data in the case of life-threatening bleeds remains limited. We report a case of a patient who suffered a traumatic subarachnoid hemorrhage and received effective treatment with idarucizumab. Along with other reports, our case demonstrates that dabigatran-related major and/or life-threatening bleeds may be effectively counteracted by idarucizumab. This provides an option to emergency department providers in managing clinically significant bleeds in patients taking dabigatran.
Language	English
Publishing date	2017-10-06
Publishing country	United States
Document type	Case Reports
ISSN	2474-252X
ISSN (online)	2474-252X
DOI	10.5811/cpcem.2017.6.34356
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Diff-DOPE

Tremblay, Jonathan / Wen, Bowen / Blukis, Valts / Sundaralingam, Balakumar / Tyree, Stephen / Birchfield, Stan

Differentiable Deep Object Pose Estimation

2023

Abstract: We introduce Diff-DOPE, a 6-DoF pose refiner that takes as input an image, a 3D textured model of an object, and an initial pose of the object. The method uses differentiable rendering to update the object pose to minimize the visual error between the ... ...

Abstract	We introduce Diff-DOPE, a 6-DoF pose refiner that takes as input an image, a 3D textured model of an object, and an initial pose of the object. The method uses differentiable rendering to update the object pose to minimize the visual error between the image and the projection of the model. We show that this simple, yet effective, idea is able to achieve state-of-the-art results on pose estimation datasets. Our approach is a departure from recent methods in which the pose refiner is a deep neural network trained on a large synthetic dataset to map inputs to refinement steps. Rather, our use of differentiable rendering allows us to avoid training altogether. Our approach performs multiple gradient descent optimizations in parallel with different random learning rates to avoid local minima from symmetric objects, similar appearances, or wrong step size. Various modalities can be used, e.g., RGB, depth, intensity edges, and object segmentation masks. We present experiments examining the effect of various choices, showing that the best results are found when the RGB image is accompanied by an object mask and depth image to guide the optimization process. Comment: Submitted to ICRA 2023. Project page is at https://diffdope.github.io
Keywords	Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Robotics
Subject code	004
Publishing date	2023-09-30
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: Joint Space Control via Deep Reinforcement Learning

Kumar, Visak / Hoeller, David / Sundaralingam, Balakumar / Tremblay, Jonathan / Birchfield, Stan

2020

Abstract: The dominant way to control a robot manipulator uses hand-crafted differential equations leveraging some form of inverse kinematics / dynamics. We propose a simple, versatile joint-level controller that dispenses with differential equations entirely. A ... ...

Abstract	The dominant way to control a robot manipulator uses hand-crafted differential equations leveraging some form of inverse kinematics / dynamics. We propose a simple, versatile joint-level controller that dispenses with differential equations entirely. A deep neural network, trained via model-free reinforcement learning, is used to map from task space to joint space. Experiments show the method capable of achieving similar error to traditional methods, while greatly simplifying the process by automatically handling redundancy, joint limits, and acceleration / deceleration profiles. The basic technique is extended to avoid obstacles by augmenting the input to the network with information about the nearest obstacles. Results are shown both in simulation and on a real robot via sim-to-real transfer of the learned policy. We show that it is possible to achieve sub-centimeter accuracy, both in simulation and the real world, with a moderate amount of training. Comment: Presented at IROS 2021. Video is at https://youtu.be/ICfve-GTTp8
Keywords	Computer Science - Robotics
Subject code	629
Publishing date	2020-11-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book ; Online: RGB-Only Reconstruction of Tabletop Scenes for Collision-Free Manipulator Control

Tang, Zhenggang / Sundaralingam, Balakumar / Tremblay, Jonathan / Wen, Bowen / Yuan, Ye / Tyree, Stephen / Loop, Charles / Schwing, Alexander / Birchfield, Stan

2022

Abstract: We present a system for collision-free control of a robot manipulator that uses only RGB views of the world. Perceptual input of a tabletop scene is provided by multiple images of an RGB camera (without depth) that is either handheld or mounted on the ... ...

Abstract	We present a system for collision-free control of a robot manipulator that uses only RGB views of the world. Perceptual input of a tabletop scene is provided by multiple images of an RGB camera (without depth) that is either handheld or mounted on the robot end effector. A NeRF-like process is used to reconstruct the 3D geometry of the scene, from which the Euclidean full signed distance function (ESDF) is computed. A model predictive control algorithm is then used to control the manipulator to reach a desired pose while avoiding obstacles in the ESDF. We show results on a real dataset collected and annotated in our lab. Comment: ICRA 2023. Project page at https://ngp-mpc.github.io/
Keywords	Computer Science - Robotics ; Computer Science - Computer Vision and Pattern Recognition
Publishing date	2022-10-20
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Simultaneous monitoring of multiple attributes of pyrrolobenzodiazepine antibody-drug conjugates by size exclusion chromatography - high resolution mass spectrometry.

Füssl, Florian / Barry, Conor S / Pugh, Kathryn M / Chooi, K Phin / Vijayakrishnan, Balakumar / Kang, Gyoung-Dong / von Bulow, Christina / Howard, Philip W / Bones, Jonathan

Journal of pharmaceutical and biomedical analysis

2021 Volume 205, Page(s) 114287

Abstract: Antibody-drug conjugates (ADCs) are an emerging class of oncology treatments combining the unique specificity of monoclonal antibodies with the highly cytotoxic properties of small molecule compounds. Pyrrolobenzodiazepines (PBDs) are highly potent ... ...

Abstract	Antibody-drug conjugates (ADCs) are an emerging class of oncology treatments combining the unique specificity of monoclonal antibodies with the highly cytotoxic properties of small molecule compounds. Pyrrolobenzodiazepines (PBDs) are highly potent agents capable of inhibiting cellular DNA replication which leads to apoptosis. To ensure efficacy and patient safety upon administration of such toxic and heterogeneous molecules, their structure and quality attributes must be closely monitored. Size exclusion chromatography (SEC) is a powerful, fast and robust tool for the separation of compounds varying in molecular weight. When using volatile components in the chromatographic mobile phase, SEC has also been shown to be amenable for interfacing to mass spectrometry, providing potential for reliable identification of protein isoforms across the size variants present. Here, we present a SEC-MS method developed for the characterisation of PBD-based ADCs on the intact molecular level. We demonstrate that information on ADC monomers such as the glycoform distribution and the average drug-antibody ratio (DAR) can be obtained in 15 minutes of analysis time. Qualitative and quantitative information on low and high molecular weight impurities such as aggregates and fragments, fundamental for critical quality attribute analysis of biopharmaceuticals, can be generated simultaneously. SEC-MS enables the characterisation of multiple product quality attributes of complex biotherapeutics at the same time.
MeSH term(s)	Antibodies, Monoclonal ; Benzodiazepines ; Chromatography, Gel ; Humans ; Immunoconjugates/analysis ; Mass Spectrometry ; Pyrroles
Chemical Substances	Antibodies, Monoclonal ; Immunoconjugates ; Pyrroles ; pyrrolo(2,1-c)(1,4)benzodiazepine ; Benzodiazepines (12794-10-4)
Language	English
Publishing date	2021-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2021.114287
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1850: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The characteristics and predictors of mortality in periprosthetic fractures around the knee.

Nasser, Ahmed A H H / Sidhu, Manpreet / Prakash, Rohan / Mahmood, Ansar / Osman, Khabab / Chauhan, Govind S / Nandra, Rajpal / Dewan, Varun / Davidson, Jerome / Al-Azzawi, Mohammed / Smith, Christian / Gawad, Mothana / Palaiologos, Ioannis / Cuthbert, Rory / Wignadasan, Warran / Banks, Daniel / Archer, James / Odeh, Abdulrahman / Moores, Thomas /

Tahir, Muaaz / Brooks, Margaret / Biring, Gurdeep / Jordan, Stevan / Elahi, Zain / Shaath, Mohammed / Veettil, Manoj / De, Chiranjit / Handford, Charles / Bansal, Mohit / Bawa, Akshdeep / Mattar, Ahmed / Tandra, Varun / Daadipour, Audrina / Taha, Ahmed / Gangoo, Shafat / Srinivasan, Sriram / Tarisai, Mandishona / Budair, Basil / Subbaraman, Krishna / Khan, Farrukh / Gomindes, Austin / Samuel, Arjun / Kang, Niel / Kapur, Karan / Mainwaring, Elizabeth / Bridgwater, Hannah / Lo, Andre / Ahmed, Usman / Khaleeq, Tahir / El-Bakoury, Ahmed / Rashed, Ramy / Hosny, Hazem / Yarlagadda, Rathan / Keenan, Jonathan / Hamed, Ahmed / Riemer, Bryan / Qureshi, Arham / Gupta, Vatsal / Waites, Matthew / Bleibleh, Sabri / Westacott, David / Phillips, Jonathan / East, Jamie / Huntley, Daniel / Masud, Saqib / Mirza, Yusuf / Mishra, Sandeep / Dunlop, David / Khalefa, Mohamed / Balakumar, Balasubramanian / Thibbaiah, Mahesh / Payton, Olivia / Berstock, James / Deano, Krisna / Sarraf, Khaled M / Logishetty, Kartik / Lee, George / Subbiah-Ponniah, Hariharan / Shah, Nirav / Venkatesan, Aakaash / Cheseldene-Culley, James / Ayathamattam, Joseph / Tross, Samantha / Randhawa, Sukhwinder / Mohammed, Faisal / Ali, Ramla / Bird, Jonathan / Khan, Kursheed / Akhtar, Muhammad A / Brunt, Andrew / Roupakiotis, Panagiotis / Subramanian, Padmanabhan / Bua, Nelson / Hakimi, Mounir / Bitar, Samer / Al Najjar, Majed / Radhakrishnan, Ajay / Gamble, Charlie / James, Andrew / Gilmore, Catherine / Dawson, Dan / Sofat, Rajesh / Antar, Mohamed / Raghu, Aashish / Heaton, Sam / Tawfeek, Waleed / Charles, Christerlyn / Burnand, Henry / Duffy, Sean / Taylor, Luke / Magill, Laura / Perry, Rita / Pettitt, Michala / Okoth, Kelvin / Pinkney, Thomas

The bone & joint journal

2024 Volume 106-B, Issue 2, Page(s) 158–165

Abstract: Aims: Periprosthetic fractures (PPFs) around the knee are challenging injuries. This study aims to describe the characteristics of knee PPFs and the impact of patient demographics, fracture types, and management modalities on in-hospital mortality.: ... ...

Abstract	Aims: Periprosthetic fractures (PPFs) around the knee are challenging injuries. This study aims to describe the characteristics of knee PPFs and the impact of patient demographics, fracture types, and management modalities on in-hospital mortality. Methods: Using a multicentre study design, independent of registry data, we included adult patients sustaining a PPF around a knee arthroplasty between 1 January 2010 and 31 December 2019. Univariate, then multivariable, logistic regression analyses were performed to study the impact of patient, fracture, and treatment on mortality. Results: Out of a total of 1,667 patients in the PPF study database, 420 patients were included. The in-hospital mortality rate was 6.4%. Multivariable analyses suggested that American Society of Anesthesiologists (ASA) grade, history of peripheral vascular disease (PVD), history of rheumatic disease, fracture around a loose implant, and cerebrovascular accident (CVA) during hospital stay were each independently associated with mortality. Each point increase in ASA grade independently correlated with a four-fold greater mortality risk (odds ratio (OR) 4.1 (95% confidence interval (CI) 1.19 to 14.06); p = 0.026). Patients with PVD have a nine-fold increase in mortality risk (OR 9.1 (95% CI 1.25 to 66.47); p = 0.030) and patients with rheumatic disease have a 6.8-fold increase in mortality risk (OR 6.8 (95% CI 1.32 to 34.68); p = 0.022). Patients with a fracture around a loose implant (Unified Classification System (UCS) B2) have a 20-fold increase in mortality, compared to UCS A1 (OR 20.9 (95% CI 1.61 to 271.38); p = 0.020). Mode of management was not a significant predictor of mortality. Patients managed with revision arthroplasty had a significantly longer length of stay (median 16 days; p = 0.029) and higher rates of return to theatre, compared to patients treated nonoperatively or with fixation. Conclusion: The mortality rate in PPFs around the knee is similar to that for native distal femur and neck of femur fragility fractures. Patients with certain modifiable risk factors should be optimized. A national PPF database and standardized management guidelines are currently required to understand these complex injuries and to improve patient outcomes.
MeSH term(s)	Adult ; Humans ; Periprosthetic Fractures/etiology ; Knee Joint/surgery ; Knee/surgery ; Arthroplasty, Replacement, Knee/adverse effects ; Femoral Fractures/surgery ; Rheumatic Diseases/etiology ; Rheumatic Diseases/surgery ; Retrospective Studies ; Reoperation
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.106B2.BJJ-2023-0700.R1
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6989: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: A new route to meso-formyl porphyrins.

Balakumar, Arumugham / Muthukumaran, Kannan / Lindsey, Jonathan S

The Journal of organic chemistry

2004 Volume 69, Issue 15, Page(s) 5112–5115

Abstract: Prior syntheses of porphyrins bearing meso-formyl groups have generally employed the Vilsmeier formylation of an acid-resistant copper or nickel porphyrin. A new approach for the synthesis of free base porphyrins bearing one or two (cis or trans) meso- ... ...

Abstract	Prior syntheses of porphyrins bearing meso-formyl groups have generally employed the Vilsmeier formylation of an acid-resistant copper or nickel porphyrin. A new approach for the synthesis of free base porphyrins bearing one or two (cis or trans) meso-formyl substituents entails the use of a dipyrromethane bearing an acetal group at the 5-position, a dipyrromethane-1-carbinol bearing an acetal group at the 5-position or carbinol position, or a dipyrromethane-1,9-dicarbinol bearing an acetal group at a carbinol position. Treatment of the resulting meso-acetal-substituted free base porphyrin to gentle acidic hydrolysis yields the corresponding meso-formyl porphyrin.
MeSH term(s)	Copper/chemistry ; Molecular Structure ; Nickel/chemistry ; Porphyrins/chemical synthesis ; Porphyrins/chemistry
Chemical Substances	Porphyrins ; Copper (789U1901C5) ; Nickel (7OV03QG267)
Language	English
Publishing date	2004-07-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/jo049819b
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4473: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Predictors of mortality in periprosthetic fractures of the hip: Results from the national PPF study.

Nasser, Ahmed Abdul Hadi Harb / Prakash, Rohan / Handford, Charles / Osman, Khabab / Chauhan, Govind Singh / Nandra, Rajpal / Mahmood, Ansar / Dewan, Varun / Davidson, Jerome / Al-Azzawi, Mohammed / Smith, Christian / Gawad, Mothana / Palaiologos, Ioannis / Cuthbert, Rory / Wignadasan, Warran / Banks, Daniel / Archer, James / Odeh, Abdulrahman / Moores, Thomas /

Tahir, Muaaz / Brooks, Margaret / Biring, Gurdeep / Jordan, Stevan / Elahi, Zain / Shaath, Mohammed / Veettil, Manoj / De, Chiranjit / Bansal, Mohit / Bawa, Akshdeep / Mattar, Ahmed / Tandra, Varun / Daadipour, Audrina / Taha, Ahmed / Gangoo, Shafat / Srinivasan, Sriram / Tarisai, Mandishona / Budair, Basil / Subbaraman, Krishna / Khan, Farrukh / Gomindes, Austin / Samuel, Arjun / Kang, Niel / Kapur, Karan / Mainwaring, Elizabeth / Bridgwater, Hannah / Lo, Andre / Ahmed, Usman / Khaleeq, Tahir / El-Bakoury, Ahmed / Rashed, Ramy / Hosny, Hazem / Yarlagadda, Rathan / Keenan, Jonathan / Hamed, Ahmed / Riemer, Bryan / Qureshi, Arham / Gupta, Vatsal / Waites, Matthew / Bleibleh, Sabri / Westacott, David / Phillips, Jonathan / East, Jamie / Huntley, Daniel / Masud, Saqib / Mirza, Yusuf / Mishra, Sandeep / Dunlop, David / Khalefa, Mohamed / Balasubramanian, Balakumar / Thibbaiah, Mahesh / Payton, Olivia / Berstock, James / Deano, Krisna / Sarraf, Khaled / Logishetty, Kartik / Lee, George / Subbiah-Ponniah, Hariharan / Shah, Nirav / Venkatesan, Aakaash / Cheseldene-Culley, James / Ayathamattam, Joseph / Tross, Samantha / Randhawa, Sukhwinder / Mohammed, Faisal / Ali, Ramla / Bird, Jonathan / Khan, Kursheed / Akhtar, Muhammad Adeel / Brunt, Andrew / Roupakiotis, Panagiotis / Subramanian, Padmanabhan / Bua, Nelson / Hakimi, Mounir / Bitar, Samer / Najjar, Majed Al / Radhakrishnan, Ajay / Gamble, Charlie / James, Andrew / Gilmore, Catherine / Dawson, Dan / Sofat, Rajesh / Antar, Mohamed / Raghu, Aashish / Heaton, Sam / Tawfeek, Waleed / Charles, Christerlyn / Burnand, Henry / Duffy, Sean / Taylor, Luke / Magill, Laura / Perry, Rita / Pettitt, Michala / Okoth, Kelvin / Pinkney, Thomas

Injury

2023 Volume 54, Issue 12, Page(s) 111152

Abstract: Introduction: Periprosthetic fractures (PPFs) around the hip joint are increasing in prevalence. In this collaborative study, we aimed to investigate the impact of patient demographics, fracture characteristics, and modes of management on in-hospital ... ...

Abstract	Introduction: Periprosthetic fractures (PPFs) around the hip joint are increasing in prevalence. In this collaborative study, we aimed to investigate the impact of patient demographics, fracture characteristics, and modes of management on in-hospital mortality of PPFs involving the hip. Methods: Using a multi-centre cohort study design, we retrospectively identified adults presenting with a PPF around the hip over a 10-year period. Univariate and multivariable logistic regression analyses were performed to study the independent correlation between patient, fracture, and treatment factors on mortality. Results: A total of 1,109 patients were included. The in-hospital mortality rate was 5.3%. Multivariable analyses suggested that age, male sex, abbreviated mental test score (AMTS), pneumonia, renal failure, history of peripheral vascular disease (PVD) and deep surgical site infection were each independently associated with mortality. Each yearly increase in age independently correlates with a 7% increase in mortality (OR 1.07, p=0.019). The odds of mortality was 2.99 times higher for patients diagnosed with pneumonia during their hospital stay [OR 2.99 (95% CI 1.07-8.37) p=0.037], and 7.25 times higher for patients that developed renal failure during their stay [OR 7.25 (95% CI 1.85-28.47) p=0.005]. Patients with history of PVD have a six-fold greater mortality risk (OR 6.06, p=0.003). Mode of treatment was not a significant predictor of mortality. Conclusion: The in-hospital mortality rate of PPFs around the hip exceeds 5%. The fracture subtype and mode of management are not independent predictors of mortality, while patient factors such as age, AMTS, history of PVD, pneumonia, and renal failure can independently predict mortality. Peri-operative optimisation of modifiable risk factors such as lung and kidney function in patients with PPFs around the hip during their hospital stay is of utmost importance.
MeSH term(s)	Adult ; Humans ; Male ; Periprosthetic Fractures ; Retrospective Studies ; Cohort Studies ; Arthroplasty, Replacement, Hip/adverse effects ; Peripheral Vascular Diseases/surgery ; Pneumonia ; Renal Insufficiency ; Hip Fractures ; Reoperation
Language	English
Publishing date	2023-10-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2023.111152
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 778: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 10: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Excited-state energy-transfer dynamics of self-assembled imine-linked porphyrin dyads.

Sazanovich, Igor V / Balakumar, Arumugham / Muthukumaran, Kannan / Hindin, Eve / Kirmaier, Christine / Diers, James R / Lindsey, Jonathan S / Bocian, David F / Holten, Dewey

Inorganic chemistry

2003 Volume 42, Issue 21, Page(s) 6616–6628

Abstract: Toward the development of new strategies for the synthesis of multiporphyrin arrays, we have prepared and characterized (electrochemistry and static/time-resolved optical spectroscopy) a series of dyads composed of a zinc porphyrin and a free base ... ...

Abstract	Toward the development of new strategies for the synthesis of multiporphyrin arrays, we have prepared and characterized (electrochemistry and static/time-resolved optical spectroscopy) a series of dyads composed of a zinc porphyrin and a free base porphyrin joined via imine-based linkers. One dyad contains two zinc porphyrins. Imine formation occurs under gentle conditions without alteration of the porphyrin metalation state. Five imine linkers were investigated by combination of formyl, benzaldehyde, and salicylaldehyde groups with aniline and benzoic hydrazide groups. The imine-linked dyads are quite stable to routine handling. The excited-state energy-transfer rate from zinc to free base porphyrin ranges from (70 ps)(-)(1) to (13 ps)(-)(1) in toluene at room temperature depending on the linker employed. The energy-transfer yield is generally very high (>97%), with low yields of deleterious hole/electron transfer. Collectively, this work provides the foundation for the design of multiporphyrin arrays that self-assemble via stable imine linkages, have predictable electronic properties, and have comparable or even enhanced energy-transfer characteristics relative to those of other types of covalently linked systems.
Language	English
Publishing date	2003-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/ic034558u
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito