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  1. Article ; Online: Perfil sensorial ideal para el cabanossi con carne de llama (Lama glama) de tres sistemas de alimentación usando el método CATA (Check-all-that-apply)

    Miriam Ramos / Oscar Jordán / Marcial Silva-Jaimes / Bettit Salvá-Ruíz / Reynaldo J. Silva-Paz

    Scientia Agropecuaria, Vol 12, Iss

    2021  Volume 3

    Abstract: El desarrollo de alimentos involucra el uso de herramientas sensoriales rápidas y que permitan explorar la percepción del consumidor. Se determinó el perfil sensorial ideal de cabanossi con carne de llamas alimentadas con tres tipos de piensos (pastura ... ...

    Abstract El desarrollo de alimentos involucra el uso de herramientas sensoriales rápidas y que permitan explorar la percepción del consumidor. Se determinó el perfil sensorial ideal de cabanossi con carne de llamas alimentadas con tres tipos de piensos (pastura natural, alfalfa y con vitaminas) empleando el método CATA, en comparación a dos muestras comerciales (CC1 y CC2). Se evaluaron la humedad, pH, actividad de agua, color y la textura. La humedad y color externo (L*) e interno (a*, b*, C*) fueron semejantes entre los cabanossi con carne de llama, pero diferentes a los comerciales. Los parámetros mecánicos (dureza y masticabilidad) fueron superiores para las muestras de cabanossi con carne de llama. Participaron 80 consumidores en el perfil ideal basado en preguntas CATA, encontrando diferencias significativas en todos los descriptores utilizados. Los atributos sensoriales indispensables para la aceptabilidad fueron: salado, olor característico/embutido y masticable. Referente al análisis de penalidad, se encontraron atributos positivos (masticable y blando/suave) y negativos (duro, olor humo y color marrón), que se deben considerar para reformular el producto. El cabanossi procedente del sistema de alimentación con pastura natural (CS1) fue semejante al producto ideal. Esto evidencia que el origen de la materia prima repercute en las características de calidad del producto terminado (sensoriales, fisicoquímicas y mecánicas) vinculadas a las necesidades que el consumidor idealiza.
    Keywords Aceptabilidad ; cabanossi ; carne de llama ; CATA ideal ; análisis de penalización ; Agriculture ; S ; Agriculture (General) ; S1-972
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Universidad Nacional de Trujillo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Nebulization with alkaline hipertonic ibuprofen induces a rapid increase in platelets circulating in COVID-19 patients but not in healthy subjects.

    Salva, Oscar / Alasino, Roxana / Giller, Celia / Borello, Julieta / Doresky, Alexis / Karayan, Galia / Beltramo, Dante

    Platelets

    2021  Volume 33, Issue 3, Page(s) 471–478

    Abstract: We analyze changes in circulating platelets in COVID-19 positive patients who received conventional treatment Dexamethasone and Enoxaparin (Dexa-Enoxa) compared to patients treated with conventional therapy plus nebulization with alkaline hypertonic ... ...

    Abstract We analyze changes in circulating platelets in COVID-19 positive patients who received conventional treatment Dexamethasone and Enoxaparin (Dexa-Enoxa) compared to patients treated with conventional therapy plus nebulization with alkaline hypertonic ibuprofenate (AHI). Results show that after 24 h of nebulization with AHI, circulating platelets shows an increase about 40% at 24 h and reach 65% at 96 h. In patients with platelets content below 200,000 by microliter the increase was 49% and 79% at 24 and 96 h respectively. In patients with platelets above 200,000 by microliter the increase was 24% and 31% at 24 and 96 h, respectively. The increase of platelets via AHI was similar in both, men and women.To evaluate whether this action of AHI was related to platelets from COVID-19 positive patients or also for healthy people, two controls were included: one of them with 10 healthy volunteers and another one with COVID-19 positive patients hospitalized and treated only with Dexa-Enoxa. Results show that, in healthy volunteers, the number of circulating platelets remains unchanged even after 7 days of treatment with AHI. In COVID-19 positive patients treated only with Dexa-Enoxa for 4 days, platelets increased only 16%.
    MeSH term(s) Adult ; Blood Platelets/metabolism ; COVID-19/blood ; COVID-19/drug therapy ; Enoxaparin/administration & dosage ; Female ; Humans ; Ibuprofen/administration & dosage ; Male ; Middle Aged ; Nebulizers and Vaporizers ; Platelet Count ; SARS-CoV-2/metabolism
    Chemical Substances Enoxaparin ; Ibuprofen (WK2XYI10QM)
    Language English
    Publishing date 2021-08-22
    Publishing country England
    Document type Clinical Trial ; Comparative Study ; Journal Article
    ZDB-ID 1034283-7
    ISSN 1369-1635 ; 0953-7104
    ISSN (online) 1369-1635
    ISSN 0953-7104
    DOI 10.1080/09537104.2021.1967918
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  3. Article ; Online: Five successive waves of SARS-CoV-2 infection in the Central African Republic: a prospective observational study from 2020-2022.

    Rafaï, Clotaire Donatien / Heredeibona, Luc Salva / Lango-Yaya, Ernest / Belizaire, Roseline Darnicka / Senzongo, Oscar / Mbala, Placide / Fa-Ti-Gbia, Maurel Ouoko / Bengba, Javan Allon / Pounguinza, Simon / Kandou, Jephté Estimé Kaleb / Gonessa, Daniel Yvon / Koyaweda, Wilfried / Vickos, Ulrich / Kalla, Ginette Claude / Nambei, Wilfried Sylvain / Somse, Pierre / Bélec, Laurent / Grésenguet, Gérard / Koffi, Boniface /
    Mbopi-Keou, François-Xavier

    The Pan African medical journal

    2023  Volume 46, Page(s) 120

    Abstract: Introduction: the National Laboratory of Clinical Biology and Public Health (NLBPH) in Bangui in the Central African Republic (CAR) carries out the vast majority of molecular screening tests for SARS-CoV-2 infection nationwide. This study aimed to show ... ...

    Abstract Introduction: the National Laboratory of Clinical Biology and Public Health (NLBPH) in Bangui in the Central African Republic (CAR) carries out the vast majority of molecular screening tests for SARS-CoV-2 infection nationwide. This study aimed to show the contribution of molecular diagnosis and genomic surveillance in monitoring the evolution of longitudinal variations of the SARS-CoV-2 infection epidemic in CAR between 2020 and the end of 2022.
    Methods: this is an observational study on the variations in the prevalence of detection of SARS-CoV-2 by RT-PCR at the NLCBPH from nasopharyngeal samples taken prospectively over a period of 3 years since the beginning of the COVID-19 epidemic. A subgroup of SARS-CoV-2 positive samples was selected for molecular sequencing performed by Illumina® and MinIon® at the National Institute for Biomedical Research in Kinshasa, Democratic Republic of the Congo.
    Results: from March 2020 to December 31
    Conclusion: this prospective study over a period of 3 years, marked by 5 successive waves, made it possible to report that age, sex and the presence of clinical symptoms are associated with RT-PCR positivity. Among the different variants identified during successive waves, the Omicron variant predominated during the last two waves.
    MeSH term(s) Adult ; Humans ; Central African Republic/epidemiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; Democratic Republic of the Congo ; Prospective Studies ; SARS-CoV-2 ; Male ; Female ; Middle Aged ; Aged ; Aged, 80 and over
    Language English
    Publishing date 2023-12-28
    Publishing country Uganda
    Document type Observational Study ; Journal Article
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2023.46.120.39511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis.

    Vara, Covadonga / Paytuví-Gallart, Andreu / Cuartero, Yasmina / Le Dily, François / Garcia, Francisca / Salvà-Castro, Judit / Gómez-H, Laura / Julià, Eva / Moutinho, Catia / Aiese Cigliano, Riccardo / Sanseverino, Walter / Fornas, Oscar / Pendás, Alberto M / Heyn, Holger / Waters, Paul D / Marti-Renom, Marc A / Ruiz-Herrera, Aurora

    Cell reports

    2019  Volume 28, Issue 2, Page(s) 352–367.e9

    Abstract: Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas of mouse spermatogenesis by ... ...

    Abstract Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas of mouse spermatogenesis by combining in situ chromosome conformation capture sequencing (Hi-C), RNA sequencing (RNA-seq), and chromatin immunoprecipitation sequencing (ChIP-seq) of CCCTC-binding factor (CTCF) and meiotic cohesins, coupled with confocal and super-resolution microscopy. Spermatogonia presents well-defined compartment patterns and topological domains. However, chromosome occupancy and compartmentalization are highly re-arranged during prophase I, with cohesins bound to active promoters in DNA loops out of the chromosomal axes. Compartment patterns re-emerge in round spermatids, where cohesin occupancy correlates with transcriptional activity of key developmental genes. The compact sperm genome contains compartments with actively transcribed genes but no fine-scale topological domains, concomitant with the presence of protamines. Overall, we demonstrate how genome-wide cohesin occupancy and transcriptional activity is associated with three-dimensional (3D) remodeling during spermatogenesis, ultimately reprogramming the genome for the next generation.
    MeSH term(s) Cell Cycle Proteins/metabolism ; Chromosomal Proteins, Non-Histone/metabolism ; Genomics/methods ; Humans ; Male ; Molecular Conformation ; Spermatogenesis/genetics ; Cohesins
    Chemical Substances Cell Cycle Proteins ; Chromosomal Proteins, Non-Histone
    Language English
    Publishing date 2019-09-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2019.06.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Three-Dimensional Genomic Structure and Cohesin Occupancy Correlate with Transcriptional Activity during Spermatogenesis

    Covadonga Vara / Andreu Paytuví-Gallart / Yasmina Cuartero / François Le Dily / Francisca Garcia / Judit Salvà-Castro / Laura Gómez-H / Eva Julià / Catia Moutinho / Riccardo Aiese Cigliano / Walter Sanseverino / Oscar Fornas / Alberto M. Pendás / Holger Heyn / Paul D. Waters / Marc A. Marti-Renom / Aurora Ruiz-Herrera

    Cell Reports, Vol 28, Iss 2, Pp 352-367.e

    2019  Volume 9

    Abstract: Summary: Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas of mouse spermatogenesis ...

    Abstract Summary: Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling, whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive high-resolution structural and functional atlas of mouse spermatogenesis by combining in situ chromosome conformation capture sequencing (Hi-C), RNA sequencing (RNA-seq), and chromatin immunoprecipitation sequencing (ChIP-seq) of CCCTC-binding factor (CTCF) and meiotic cohesins, coupled with confocal and super-resolution microscopy. Spermatogonia presents well-defined compartment patterns and topological domains. However, chromosome occupancy and compartmentalization are highly re-arranged during prophase I, with cohesins bound to active promoters in DNA loops out of the chromosomal axes. Compartment patterns re-emerge in round spermatids, where cohesin occupancy correlates with transcriptional activity of key developmental genes. The compact sperm genome contains compartments with actively transcribed genes but no fine-scale topological domains, concomitant with the presence of protamines. Overall, we demonstrate how genome-wide cohesin occupancy and transcriptional activity is associated with three-dimensional (3D) remodeling during spermatogenesis, ultimately reprogramming the genome for the next generation. : The formation of mammalian germ cells involves dramatic chromosomal movements and chromatin remodeling, whose regulatory pathways are far from understood. Vara et al. show how the dynamics of insulator proteins’ occupancy and transcriptional activity are coupled during the 3D genome re-organization that takes place during mouse spermatogenesis.
    Keywords Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2019-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  6. Article: Reversal of SARS-CoV2-Induced Hypoxia by Nebulized Sodium Ibuprofenate in a Compassionate Use Program.

    Salva, Oscar / Doreski, Pablo A / Giler, Celia S / Quinodoz, Dario C / Guzmán, Lucia G / Muñoz, Sonia E / Carrillo, Mariana N / Porta, Daniela J / Ambasch, Germán / Coscia, Esteban / Diaz, Jorge L Tambini / Bueno, Germán D / Fandi, Jorge O / Maldonado, Miriam A / Peña Chiappero, Leandro E / Fournier, Fernando / Pérez, Hernán A / Quiroga, Mauro A / Sala Mercado, Javier A /
    Martínez Picco, Carlos / Beltrán, Marcelo Alejandro / Argañarás, Luis A / Ríos, Nicolás Martínez / Kalayan, Galia I / Beltramo, Dante M / García, Néstor H

    Infectious diseases and therapy

    2021  Volume 10, Issue 4, Page(s) 2511–2524

    Abstract: Introduction: Sodium ibuprofenate in hypertonic saline (NaIHS) administered directly to the lungs by nebulization and inhalation has antibacterial and anti-inflammatory effects, with the potential to deliver these benefits to hypoxic patients. We ... ...

    Abstract Introduction: Sodium ibuprofenate in hypertonic saline (NaIHS) administered directly to the lungs by nebulization and inhalation has antibacterial and anti-inflammatory effects, with the potential to deliver these benefits to hypoxic patients. We describe a compassionate use program that offered this therapy to hospitalized COVID-19 patients.
    Methods: NaIHS (50 mg ibuprofen, tid) was provided in addition to standard of care (SOC) to hospitalized COVID-19 patients until oxygen saturation levels of > 94% were achieved on ambient air. Patients wore a containment hood to diminish aerosolization. Outcome data from participating patients treated at multiple hospitals in Argentina between April 4 and October 31, 2020, are summarized. Results were compared with a retrospective contemporaneous control (CC) group of hospitalized COVID-19 patients with SOC alone during the same time frame from a subset of participating hospitals from Córdoba and Buenos Aires.
    Results: The evolution of 383 patients treated with SOC + NaIHS [56 on mechanical ventilation (MV) at baseline] and 195 CC (21 on MV at baseline) are summarized. At baseline, NaIHS-treated patients had basal oxygen saturation of 90.7 ± 0.2% (74.3% were on supplemental oxygen at baseline) and a basal respiratory rate of 22.7 ± 0.3 breath/min. In the CC group, basal oxygen saturation was 92.6 ± 0.4% (52.1% were on oxygen supplementation at baseline) and respiratory rate was 19.3 ± 0.3 breath/min. Despite greater pulmonary compromise at baseline in the NaIHS-treated group, the length of treatment (LOT) was 9.1 ± 0.2 gs with an average length of stay (ALOS) of 11.5 ± 0.3 days, in comparison with an ALOS of 13.3 ± 0.9 days in the CC group. In patients on MV who received NaIHS, the ALOS was lower than in the CC group. In both NaIHS-treated groups, a rapid reversal of deterioration in oxygenation and NEWS2 scores was observed acutely after initiation of NaIHS therapy. No serious adverse events were considered related to ibuprofen therapy. Mortality was lower in both NaIHS groups compared with CC groups.
    Conclusions: Treatment of COVID-19 pneumonitis with inhalational nebulized NaIHS was associated with rapid improvement in hypoxia and vital signs, with no serious adverse events attributed to therapy. Nebulized NaIHS s worthy of further study in randomized, placebo-controlled trials (ClinicalTrials.gov: NCT04382768).
    Language English
    Publishing date 2021-08-30
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2701611-0
    ISSN 2193-6382 ; 2193-8229
    ISSN (online) 2193-6382
    ISSN 2193-8229
    DOI 10.1007/s40121-021-00527-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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