LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 115

Search options

  1. Article ; Online: Dödligheten i hjärt–kärlsjukdomar minskar: - Läkare som ordinerar statiner bör läsa översikt i Lancet.

    Dunér, Hans

    Lakartidningen

    2017  Volume 114

    Title translation The mortality in cardiovascular disease is decreasing: Doctors who prescribe statins should read review in the Lancet.
    MeSH term(s) Cardiovascular Diseases/mortality ; Cardiovascular Diseases/prevention & control ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language Swedish
    Publishing date 2017-08-11
    Publishing country Sweden
    Document type Letter
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Older migrants' perceptions of places to meet: Insights for social work practice.

    Mac Innes, Hanna / Dunér, Anna / Gustafsson, Susanne / Lindahl, Lisbet

    PloS one

    2023  Volume 18, Issue 11, Page(s) e0292730

    Abstract: This study aimed to explore the experiences of older migrants' (70+) access to and participation in different meeting places. Qualitative interviews were conducted with participants originating from Finland and four countries in the Western Balkans: ... ...

    Abstract This study aimed to explore the experiences of older migrants' (70+) access to and participation in different meeting places. Qualitative interviews were conducted with participants originating from Finland and four countries in the Western Balkans: Bosnia- Herzegovina, Croatia, Montenegro, and Serbia. The participants used everyday places in the neighborhood, which were not primarily meant to be meeting places, to create and uphold social contacts. These meeting places contributed to experiences of community and trust. Both everyday meeting places and organized meeting places were used to establish and develop relationships that could result in an exchange of both practical and emotional support. Perceptions of "not belonging", limited proficiency in Swedish, and a strained financial situation created barriers to accessing some meeting places. The results of this study demonstrate the significance of meeting places that are not purposefully aimed at older people in general or older people from a specific country.
    MeSH term(s) Humans ; Aged ; Transients and Migrants ; Serbia ; Bosnia and Herzegovina ; Montenegro ; Social Work
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0292730
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Inhibitory effect of UDP-glucose on cAMP generation and insulin secretion.

    Parandeh, Fariborz / Amisten, Stefan / Verma, Gaurav / Mohammed Al-Amily, Israa / Dunér, Pontus / Salehi, Albert

    The Journal of biological chemistry

    2020  Volume 295, Issue 45, Page(s) 15245–15252

    Abstract: ... the UDP-G effect. 12-h pretreatment of human islets with pertussis-toxin (PTX) improved GSIS and prevented ... for 72 h and exacerbated the negative effect of 20 mm glucose on the cell viability during culture period ... T2D donor islets displayed a lower reductive capacity when cultured at 5 mm glucose for 72 h that was ...

    Abstract Type-2 diabetes (T2D) is a global disease caused by the inability of pancreatic β-cells to secrete adequate insulin. However, the molecular mechanisms underlying the failure of β-cells to respond to glucose in T2D remains unknown. Here, we investigated the relative contribution of UDP-glucose (UDP-G), a P2Y14-specific agonist, in the regulation of insulin release using human isolated pancreatic islets and INS-1 cells. P2Y14 was expressed in both human and rodent pancreatic β-cells. Dose-dependent activation of P2Y14 by UDP-G suppressed glucose-stimulated insulin secretion (GSIS) and knockdown of P2Y14 abolished the UDP-G effect. 12-h pretreatment of human islets with pertussis-toxin (PTX) improved GSIS and prevented the inhibitory effect of UDP-G on GSIS. UDP-G on GSIS suppression was associated with suppression of cAMP in INS-1 cells. UDP-G decreased the reductive capacity of nondiabetic human islets cultured at 5 mm glucose for 72 h and exacerbated the negative effect of 20 mm glucose on the cell viability during culture period. T2D donor islets displayed a lower reductive capacity when cultured at 5 mm glucose for 72 h that was further decreased in the presence of 20 mm glucose and UDP-G. Presence of a nonmetabolizable cAMP analog during culture period counteracted the effect of glucose and UDP-G. Islet cultures at 20 mm glucose increased apoptosis, which was further amplified when UDP-G was present. UDP-G modulated glucose-induced proliferation of INS-1 cells. The data provide intriguing evidence for P2Y14 and UDP-G's role in the regulation of pancreatic β-cell function.
    MeSH term(s) Animals ; Cyclic AMP/biosynthesis ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Female ; Humans ; Insulin Secretion/drug effects ; Insulin-Secreting Cells/drug effects ; Insulin-Secreting Cells/metabolism ; Mice ; Mice, Inbred C57BL ; Pertussis Toxin/pharmacology ; Rats ; Tumor Cells, Cultured ; Uridine Diphosphate Glucose/antagonists & inhibitors ; Uridine Diphosphate Glucose/metabolism
    Chemical Substances Cyclic AMP (E0399OZS9N) ; Pertussis Toxin (EC 2.4.2.31) ; Uridine Diphosphate Glucose (V50K1D7P4Y)
    Language English
    Publishing date 2020-08-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.RA120.012929
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: Defective regulation of cholangiocyte Cl-/HCO3(-) and Na+/H+ exchanger activities in primary biliary cirrhosis.

    Melero, Saida / Spirlì, Carlo / Zsembery, Akos / Medina, Juan F / Joplin, Ruth E / Duner, Elena / Zuin, Massimo / Neuberger, James M / Prieto, Jesús / Strazzabosco, Mario

    Hepatology (Baltimore, Md.)

    2002  Volume 35, Issue 6, Page(s) 1513–1521

    Abstract: ... transport by analyzing the activities of 2 ion exchangers, Cl(-)/HCO3(-) anion exchanger 2 (AE2) and Na(+)/H ... of carriers involved in transepithelial H(+)/HCO3(-) transport, thus, providing a molecular basis ...

    Abstract Primary biliary cirrhosis (PBC) is a disorder of unknown origin with autoimmune features. Recently, impaired biliary secretion of bicarbonate has been shown in patients with PBC. Here we have investigated whether bile duct epithelial cells isolated from PBC patients exhibit defects in transepithelial bicarbonate transport by analyzing the activities of 2 ion exchangers, Cl(-)/HCO3(-) anion exchanger 2 (AE2) and Na(+)/H(+) exchanger (NHE) in isolated cholangiocytes. AE2 and NHE activities were studied in basal conditions and after stimulation with cyclic adenosine monophosphate (cAMP) and extracellular adenosine triphosphate (ATP), respectively. Cholangiocytes were grown from needle liver biopsies from 12 PBC patients, 8 normal controls, and 9 patients with other liver diseases. Also, intrahepatic cholangiocytes were cultured after immunomagnetic isolation from normal liver tissue (n = 6), and from recipients undergoing liver transplantation for end-stage PBC (n = 9) and other forms of liver disease (n = 8). In needle-biopsy cholangiocytes, basal AE2 activity was significantly decreased in PBC as compared with normal livers and disease controls. In addition, we observed that though cAMP increased AE2 activity in cholangiocytes from both normal and non-PBC livers, this effect was absent in PBC cholangiocytes. Similarly, though in cholangiocytes from normal and disease control livers extracellular ATP induced a marked enhancement of NHE activity, cholangiocytes from PBC patients failed to respond to purinergic stimulation. In conclusion, our findings provide functional evidence that PBC cholangiocytes exhibit a widespread failure in the regulation of carriers involved in transepithelial H(+)/HCO3(-) transport, thus, providing a molecular basis for the impaired bicarbonate secretion in this cholestatic syndrome.
    MeSH term(s) Acid-Base Equilibrium ; Adenosine Triphosphate/metabolism ; Anion Transport Proteins ; Antiporters ; Bile Ducts/cytology ; Bile Ducts/metabolism ; Biopsy, Needle ; Cells, Cultured ; Cyclic AMP/metabolism ; Epithelial Cells/metabolism ; Gene Expression ; Humans ; Liver/cytology ; Liver/metabolism ; Liver Cirrhosis, Biliary/metabolism ; Liver Cirrhosis, Biliary/physiopathology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; RNA, Messenger/analysis ; SLC4A Proteins ; Sodium-Hydrogen Exchangers/genetics ; Sodium-Hydrogen Exchangers/metabolism
    Chemical Substances Anion Transport Proteins ; Antiporters ; Membrane Proteins ; RNA, Messenger ; SLC4A Proteins ; Sodium-Hydrogen Exchangers ; Adenosine Triphosphate (8L70Q75FXE) ; Cyclic AMP (E0399OZS9N)
    Language English
    Publishing date 2002-05-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1053/jhep.2002.33634
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Significance of scientific evidence in organizing care processes.

    Hasson, Henna / Blomberg, Staffan / Dunér, Anna / Sarvimäki, Anneli

    Journal of health organization and management

    2016  Volume 30, Issue 4, Page(s) 597–612

    Abstract: Purpose - The purpose of this paper is to analyze how staff and managers in health and social care organizations use scientific evidence when making decisions about the organization of care practices. Design/methodology/approach - Document analysis and ... ...

    Abstract Purpose - The purpose of this paper is to analyze how staff and managers in health and social care organizations use scientific evidence when making decisions about the organization of care practices. Design/methodology/approach - Document analysis and repeated interviews (2008-2010) with staff (n=39) and managers (n=26) in health and social care organizations. The respondents were involved in a randomized controlled study about testing a continuum of care model for older people. Findings - Scientific evidence had no practical function in the social care organization, while it was a prioritized source of information in the health care organization. This meant that the decision making regarding care practices was different in these organizations. Social care tended to rely on ad hoc practice-based information and political decisions when organizing care, while health care to some extent also relied in an unreflected manner on the scientific knowledge. Originality/value - The study illustrates several difficulties that might occur when managers and staff try to consider scientific evidence when making complicated decisions about care practices.
    MeSH term(s) Aged ; Continuity of Patient Care ; Decision Making, Organizational ; Evidence-Based Practice ; Geriatric Nursing/organization & administration ; Humans ; Interviews as Topic ; Organizational Innovation ; Qualitative Research
    Language English
    Publishing date 2016-06-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2109532-2
    ISSN 1758-7247 ; 1477-7266
    ISSN (online) 1758-7247
    ISSN 1477-7266
    DOI 10.1108/JHOM-12-2013-0271
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions.

    Mantani, Polyxeni T / Dunér, Pontus / Ljungcrantz, Irena / Nilsson, Jan / Björkbacka, Harry / Fredrikson, Gunilla Nordin

    BMC immunology

    2019  Volume 20, Issue 1, Page(s) 47

    Abstract: Background: Expansion of type 2 innate lymphoid cells (ILC2s) in hypercholesterolaemic mice protects against atherosclerosis while different ILC2 subsets have been described (natural, inflammatory) based on their suppression of tumorigenicity 2 (ST2) ... ...

    Abstract Background: Expansion of type 2 innate lymphoid cells (ILC2s) in hypercholesterolaemic mice protects against atherosclerosis while different ILC2 subsets have been described (natural, inflammatory) based on their suppression of tumorigenicity 2 (ST2) and killer-cell lectin like receptor G1 (KLRG1) expression. The aim of the current study is to characterize the interleukin 25 (IL25)-induced splenic ILC2 population (Lin
    Results: Immunomagnetically enriched, FACS-sorted ILC2s from the spleens of IL-25 treated apoE
    Conclusions: With the current data we designate the IL25-induced ILC2 population to decrease the lipid content of atherosclerotic lesions in apoE
    MeSH term(s) Adoptive Transfer ; Animals ; Apolipoproteins E/deficiency ; Atherosclerosis/etiology ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Biomarkers ; Cytokines/metabolism ; Disease Models, Animal ; Immunity, Innate ; Immunophenotyping ; Lipids/blood ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Mice ; Mice, Knockout
    Chemical Substances Apolipoproteins E ; Biomarkers ; Cytokines ; Lipids
    Language English
    Publishing date 2019-12-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2172
    ISSN (online) 1471-2172
    DOI 10.1186/s12865-019-0330-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Ablation of GPR56 Causes β-Cell Dysfunction by ATP Loss through Mistargeting of Mitochondrial VDAC1 to the Plasma Membrane.

    Mohammad Al-Amily, Israa / Sjögren, Marie / Duner, Pontus / Tariq, Mohammad / Wollheim, Claes B / Salehi, Albert

    Biomolecules

    2023  Volume 13, Issue 3

    Abstract: ... STAT5 phosphorylation/activity in INS-1 cells cultured at 20 mM glucose (glucotoxicity) for 72 h. GPR56 ...

    Abstract The activation of G Protein-Coupled Receptor 56 (GPR56), also referred to as Adhesion G-Protein-Coupled Ceceptor G1 (ADGRG1), by Collagen Type III (Coll III) prompts cell growth, proliferation, and survival, among other attributes. We investigated the signaling cascades mediating this functional effect in relation to the mitochondrial outer membrane voltage-dependent anion Channel-1 (VDAC1) expression in pancreatic β-cells. GPR56KD attenuated the Coll III-induced suppression of P70S6K, JNK, AKT, NFκB, STAT3, and STAT5 phosphorylation/activity in INS-1 cells cultured at 20 mM glucose (glucotoxicity) for 72 h. GPR56-KD also increased Chrebp, Txnip, and Vdac1 while decreasing Vdac2 mRNA expression. In GPR56-KD islet β-cells, Vdac1 was co-localized with SNAP-25, demonstrating its plasma membrane translocation. This resulted in ATP loss, reduced cAMP production and impaired glucose-stimulated insulin secretion (GSIS) in INS-1 and human EndoC βH1 cells. The latter defects were reversed by an acute inhibition of VDAC1 with an antibody or the VDAC1 inhibitor VBIT-4. We demonstrate that Coll III potentiates GSIS by increasing cAMP and preserving β-cell functionality under glucotoxic conditions in a GPR56-dependent manner by attenuating the inflammatory response. These results emphasize GPR56 and VDAC1 as drug targets in conditions with impaired β-cell function.
    MeSH term(s) Humans ; Adenosine Triphosphate/metabolism ; Cell Membrane/metabolism ; Collagen Type III/metabolism ; Glucose/pharmacology ; Glucose/metabolism ; Islets of Langerhans/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Voltage-Dependent Anion Channel 1/genetics ; Voltage-Dependent Anion Channel 1/metabolism
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Collagen Type III ; Glucose (IY9XDZ35W2) ; Receptors, G-Protein-Coupled ; VDAC1 protein, human ; Voltage-Dependent Anion Channel 1 (EC 1.6.-) ; ADGRG1 protein, human
    Language English
    Publishing date 2023-03-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom13030557
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article: Abnormal Na+/H+ antiport activity in cultured fibroblasts from NIDDM patients with hypertension and microalbuminuria.

    Trevisan, R / Cipollina, M R / Duner, E / Trevisan, M / Nosadini, R

    Diabetologia

    1996  Volume 39, Issue 6, Page(s) 717–724

    Abstract: An increased activity of Na+/H+ antiport has been reported in leukocytes and fibroblasts ... hypertension, we examined intracellular pHi and Na+/H+ antiport activity, using the pH sensitive dye 2', 7'-bis ... than in Group 4 and normal subjects. This was due to higher Vmax values of Na+/H+ antiport activity in cultured ...

    Abstract An increased activity of Na+/H+ antiport has been reported in leukocytes and fibroblasts from insulin-dependent diabetic (IDDM) patients with nephropathy. To test whether a similar abnormality is present in fibroblasts from non-insulin-dependent diabetic (NIDDM) patients with microalbuminuria and hypertension, we examined intracellular pHi and Na+/H+ antiport activity, using the pH sensitive dye 2', 7'-bis (2-carboxyethyl-5(6)-carboxyfluorescein (BCECF), in cultured skin fibroblasts obtained from 34 NIDDM patients, divided into four groups based upon whether they had microalbuminuria or hypertension, or both: Group 1, nine NIDDM patients with microalbuminuria and hypertension. Group 2, nine NIDDM patients with hypertension and normal albumin excretion rate. Group 3, seven NIDDM patients with microalbuminuria and normal blood pressure. Group 4, nine NIDDM patients with normal blood pressure and normal albumin excretion rate. Nine normal subjects served as control group. Resting pHi was more alkaline in fibroblasts from Group 1 (7.22 +/- 0.03; p < 0.05), Group 2 (7.21 +/- 0.02; p < 0.05) and Group 3 (7.19 +/- 0.02, p = 0.17) than in Group 4 and normal subjects. This was due to higher Vmax values of Na+/H+ antiport activity in cultured fibroblasts from Group 1 (52.1 +/- 5.3 mmol H+/min; p < 0.05), Group 2 (57.7 +/- 8.3; p < 0.05) and Group 3 (60.6 +/- 7.4, p < 0.05) than those from Group 4 (31.2 +/- 3.6) or control subjects (31.3 +/- 3.5). The intracellular pH for half-maximal activation, Hill coefficient and buffering power capacity was similar in all the groups. These data suggest that in vitro phenotypic abnormalities of long-term cultured fibroblasts from NIDDM patients with microalbuminuria and/ or hypertension are likely to be, at least in part, independent of the degree of metabolic control in vivo and to be an intrinsic feature of these cells.
    MeSH term(s) Albuminuria/complications ; Albuminuria/metabolism ; Blood Pressure ; Body Mass Index ; Cells, Cultured ; Cholesterol/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/metabolism ; Female ; Fibroblasts/metabolism ; Fluoresceins/chemistry ; Fluorescent Dyes/chemistry ; Humans ; Hydrogen-Ion Concentration ; Hypertension/complications ; Hypertension/metabolism ; Male ; Middle Aged ; Skin/cytology ; Sodium-Hydrogen Exchangers/metabolism ; Spectrometry, Fluorescence ; Triglycerides/blood
    Chemical Substances Fluoresceins ; Fluorescent Dyes ; Sodium-Hydrogen Exchangers ; Triglycerides ; 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein (85138-49-4) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 1996-06
    Publishing country Germany
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/bf00418544
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: Organizing integrated care for older persons: strategies in Sweden during the past decade.

    Berglund, Helene / Blomberg, Staffan / Dunér, Anna / Kjellgren, Karin

    Journal of health organization and management

    2015  Volume 29, Issue 1, Page(s) 128–151

    Abstract: Purpose: The purpose of this paper is to describe and analyse ways of organizing integrated care for older persons in Sweden during the past decade.: Design/methodology/approach: The data consist of 62 cases of development work, described in official ...

    Abstract Purpose: The purpose of this paper is to describe and analyse ways of organizing integrated care for older persons in Sweden during the past decade.
    Design/methodology/approach: The data consist of 62 cases of development work, described in official reports. A meta-analysis of cases was performed, including content analysis of each case. A theoretical framework comprising different forms of integration (co-ordination, contracting, co-operation and collaboration) was applied.
    Findings: Co-operation was common and collaboration, including multiprofessional teamwork, was rare in the cases. Contracting can be questioned as being a form of integration, and the introduction of consumer choice models appeared problematic in inter-organization integration. Goals stated in the cases concerned steering and designing care, rather than outcome specifications for older persons. Explicit goals to improve integration in itself could imply that the organizations adapt to strong normative expectations in society. Trends over the decade comprised development of local health care systems, introduction of consumer choice models and contracting out.
    Research limitations/implications: Most cases were projects, but others comprised evaluations of regular organization of integrated care. These evaluations were often written normatively, but constituted the conditions for practice and were important study contributions.
    Practical implications: Guiding clinical practice to be aware of importance of setting follow-up goals.
    Social implications: Awareness of the risk that special funds may impede sustainable strategies development.
    Originality/value: A theoretical framework of forms of integration was applied to several different strategies, which had been carried out mostly in practice. The study contributes to understanding of how different strategies have been developed and applied to organize integrated care, and highlights some relationships between integration theory and practice.
    MeSH term(s) Aged ; Delivery of Health Care, Integrated/organization & administration ; Health Services for the Aged/organization & administration ; Humans ; Sweden
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 2109532-2
    ISSN 1758-7247 ; 1477-7266
    ISSN (online) 1758-7247
    ISSN 1477-7266
    DOI 10.1108/JHOM-04-2013-0082
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Dags att minska användningen av antibiotika vid rosacea - Isotretinoin bör övervägas vid frekventa recidiv – lokalbehandling fortfarande förstahandsterapi.

    Mobacken, Håkan / Berg, Mats / Angesjö, Eva / Dunér, Kari / Svensson, Margareta / Synnerstad, Ingrid

    Lakartidningen

    2018  Volume 115

    Abstract: Rosacea is a chronic inflammatory disease with facial erythema and papulopustules. It is common in middle-aged/elderly persons and often affects self-perception and social well-being. It is generally classified into four subtypes. Improved understanding ... ...

    Title translation Time to limit the use of antibiotics in rosacea!
    Abstract Rosacea is a chronic inflammatory disease with facial erythema and papulopustules. It is common in middle-aged/elderly persons and often affects self-perception and social well-being. It is generally classified into four subtypes. Improved understanding of pathophysiology has resulted in novel treatment approaches, but routine management in health care usually follows old trails. Most patients are managed in primary care. Greater attention to the reduced skin barrier, avoidance of exacerbating factors, better topicals and encouragement to topical maintenance treatment should reduce the use of oral tetracyclines. Low-dose isotretinoin is reserved for treatment-resistant patients, but relapses are frequent unlike its use in acne. In order to reduce antibiotic use, we propose that patients should be referred to a dermatologist for optimization of therapy including consideration of isotretinoin following tetracycline treatment of a maximum of 4-6 months.
    MeSH term(s) Administration, Topical ; Adult ; Aged ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/therapeutic use ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/therapeutic use ; Comorbidity ; Dermatologic Agents/administration & dosage ; Dermatologic Agents/therapeutic use ; Humans ; Isotretinoin/administration & dosage ; Isotretinoin/therapeutic use ; Middle Aged ; Recurrence ; Rosacea/drug therapy ; Rosacea/epidemiology ; Rosacea/etiology ; Rosacea/pathology
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Anti-Inflammatory Agents ; Dermatologic Agents ; Isotretinoin (EH28UP18IF)
    Language Swedish
    Publishing date 2018-04-24
    Publishing country Sweden
    Document type Journal Article ; Review
    ZDB-ID 391010-6
    ISSN 1652-7518 ; 0023-7205
    ISSN (online) 1652-7518
    ISSN 0023-7205
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top