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  1. Article: Duchenne-Muskeldystrophie. Redaktion: K. Kempf, V. Bittner-Call, Kommentar: G. Bernert

    Kempf, K. / Bittner-Call, V. / Bernert, G.

    Universum Innere Medizin

    2019  Volume -, Issue 4 Sonderheft 'Seltene Erkrankungen', Page(s) 56

    Language German
    Document type Article
    ZDB-ID 2475266-6
    ISSN 1607-8861
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7126: Show issues Location:
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  2. Article ; Online: Protocol to analyze 3D neurodegenerative vacuoles in Drosophila melanogaster.

    Liu, Guangmei / Bandyadka, Shruthi / McCall, Kimberly

    STAR protocols

    2024  Volume 5, Issue 2, Page(s) 103017

    Abstract: Vacuole formation is a key hallmark of age-dependent neurodegeneration in the Drosophila brain. Here, we present a protocol to analyze 3D neurodegenerative vacuoles in the whole-mount Drosophila melanogaster brain. We describe steps for whole-brain ... ...

    Abstract Vacuole formation is a key hallmark of age-dependent neurodegeneration in the Drosophila brain. Here, we present a protocol to analyze 3D neurodegenerative vacuoles in the whole-mount Drosophila melanogaster brain. We describe steps for whole-brain dissection, staining, 3D imaging, and z-stack image processing using Fiji ImageJ. We then detail procedures for annotating and 3D-reconstructing neurodegenerative vacuoles with WEBKNOSSOS and Python, and performing statistical analysis in Python. This protocol enables measurement of parameters such as the number and volume of each vacuole. For complete details on the use and execution of this protocol, please refer to Elguero et al.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2024.103017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Mason & McCall Smith's law & medical ethics

    Laurie, G. T. / Harmon, Shawn H. E. / Porter, Gerard / Mason, John K. / McCall Smith, Alexander

    2016  

    Title variant Mason and McCall Smith's law and medical ethics ; Law & medical ethics ; Law and medical ethics
    Institution European Union
    Author's details G. T. Laurie, LLB PhD FRSE FMedSci FRCP(Edin); S. H. E. Harmon, Esq. BA LLB LLM PhD FHEA; G. Porter, LLB LLM
    Keywords Bioethical Issues ; Ethics, Medical ; Legislation, Medical ; Medical laws and legislation ; Medical ethics ; Europe
    Subject code 344.41041
    Language English
    Size liii, 740 Seiten, Diagramme, 25 cm
    Edition Tenth edition
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018971284
    ISBN 978-0-19-874751-2 ; 0-19-874751-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 1188 available for loan (reading room) Lesesaal EG

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  4. Article ; Online: The relationship between environmentally induced emotion and memory for a naturalistic virtual experience.

    Petrucci, Aria S / McCall, Cade / Schofield, Guy / Wardell, Victoria / Safi, Omran K / Palombo, Daniela J

    Cognition & emotion

    2024  , Page(s) 1–16

    Abstract: Emotional stimuli (e.g. words, images) are often remembered better than neutral stimuli ...

    Abstract Emotional stimuli (e.g. words, images) are often remembered better than neutral stimuli. However, little is known about how memory is affected by an environmentally induced emotional state (without any overtly emotional occurrences) - the focus of this study. Participants were randomly assigned to discovery (
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 639123-0
    ISSN 1464-0600 ; 0269-9931
    ISSN (online) 1464-0600
    ISSN 0269-9931
    DOI 10.1080/02699931.2024.2333067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Mason and McCall Smith's law and medical ethics

    Mason, John K. / Laurie, G. T. / McCall Smith, Alexander

    2013  

    Title variant Law and medical ethics
    Author's details J. K. Mason ; G. T. Laurie
    Keywords Legislation, Medical ; Ethics, Medical ; Bioethical Issues ; Great Britain
    Language English
    Size XLIX, 724 S. : Ill., graph. Darst.
    Edition 9. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017678967
    ISBN 978-0-19-965990-6 ; 0-19-965990-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 A 1376 available for loan (reading room) Lesesaal EG

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  6. Article ; Online: Prescribed safer supply during dual public health emergencies: a qualitative study examining service providers perspectives on early implementation.

    McCall, J / Hobbs, H / Ranger, C / Cameron, F / Stuart, H / Nelken, J / Majalahti, J / Urbanoski, K / Kolla, G / LeMaistre, J / Toombs, K / Herriot, R / Pauly, Bernie

    Substance abuse treatment, prevention, and policy

    2024  Volume 19, Issue 1, Page(s) 19

    Abstract: Background: Within North America and worldwide, drug related overdoses have increased dramatically over the past decade. COVID-19 escalated the need for a safer supply to replace unregulated substances and to reduce toxicity and overdoses. Service ... ...

    Abstract Background: Within North America and worldwide, drug related overdoses have increased dramatically over the past decade. COVID-19 escalated the need for a safer supply to replace unregulated substances and to reduce toxicity and overdoses. Service providers play an integral role in the delivery of safer supply but there is little empirical evidence that conceptualizes effective safer supply from their perspectives. This study explored early implementation and impacts of a safer supply program, capturing the perspectives of an interdisciplinary team of service providers on tensions and issues encountered in the development of the SAFER program.
    Methods: Using a community-based participatory approach, we conducted individual interviews with program providers (n = 9). The research team was composed of researchers from a local drug user organization, a local harm reduction organization, and academic researchers. The Consolidated Framework for Implementation Research (CFIR) informed the interview guide. Data was analyzed using thematic analysis.
    Results: There are six themes describing early implementation: (1) risk mitigation prescribing as context for early implementation; (2) developing SAFER specific clinical protocols; (3) accessibility challenges and program innovations; (4) interdisciplinary team and wraparound care; (5) program tensions between addiction medicine and harm reduction; (6) the successes of safer supply and future visions.
    Conclusion: Early implementation issues and tensions included prescriber concerns about safer supply prescribing in a highly politicized environment, accessibility challenges for service users such as stigma, encampment displacement, OAT requirements, program capacity and costs, and tensions between addiction medicine and harm reduction. Navigating these tensions included development of clinical protocols, innovations to reduce accessibility challenges such as outreach, wraparound care, program coverage of medication costs and prescribing safer supply with/without OAT. These findings contribute important insights for the development of prescribed safer supply programs.
    MeSH term(s) Humans ; Emergencies ; Public Health ; Addiction Medicine ; COVID-19/prevention & control ; Community Participation ; Drug Overdose
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2222956-5
    ISSN 1747-597X ; 1747-597X
    ISSN (online) 1747-597X
    ISSN 1747-597X
    DOI 10.1186/s13011-024-00598-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Mason and McCall Smith's law and medical ethics

    Mason, John K. / Laurie, G. T. / McCall Smith, Alexander / Aziz, Miriam

    2011  

    Title variant Law and medical ethics
    Author's details J. K. Mason ; G. T. Laurie. With a chapter by M. Aziz
    Keywords Legislation, Medical ; Ethics, Medical ; Bioethical Issues ; Great Britain
    Language English
    Size XLVI, 688 S.
    Edition 8. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016517146
    ISBN 978-0-19-922775-4 ; 0-19-922775-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 4675 order for loan Magazin

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  8. Article: Defective phagocytosis leads to neurodegeneration through systemic increased innate immune signaling.

    Elguero, Johnny E / Liu, Guangmei / Tiemeyer, Katherine / Gandevia, Heena / Duro, Lauren / McCall, Kimberly

    bioRxiv : the preprint server for biology

    2023  

    Abstract: In nervous system development, disease and injury, neurons undergo programmed cell death, leaving behind cell corpses that are removed by phagocytic glia. Altered glial phagocytosis has been implicated in several neurological diseases including Alzheimer' ...

    Abstract In nervous system development, disease and injury, neurons undergo programmed cell death, leaving behind cell corpses that are removed by phagocytic glia. Altered glial phagocytosis has been implicated in several neurological diseases including Alzheimer's disease, Parkinson's disease, and traumatic brain injury. To untangle the links between glial phagocytosis and neurodegeneration, we investigated
    Language English
    Publishing date 2023-01-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.08.523170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Olympic Weightlifting Training for Sprint Performance in Athletes: A Systematic Review with Meta-analysis.

    Crenshaw, Kristen / Zeppieri, Giorgio / Hung, Cheng-Ju / Schmitfranz, Tania / McCall, Patti / Castellini, Greta / Gianola, Silvia / Pozzi, Federico

    International journal of sports medicine

    2024  

    Abstract: This systematic review and meta-analysis aimed to determine whether Olympic weightlifting (OW) exercises would improve sprint performance when compared to a control intervention, (no training, standard sport-specific training, traditional resistance ... ...

    Abstract This systematic review and meta-analysis aimed to determine whether Olympic weightlifting (OW) exercises would improve sprint performance when compared to a control intervention, (no training, standard sport-specific training, traditional resistance training, or plyometric training). Medline, Web of Science, SportDiscus, CINAHL, and Biological Science from inception to September 2022 was searched. Two authors independently selected the included studies, extracted data, and appraised the risk of bias. Certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation methodology. The primary meta-analysis combined the results of the sprint performance over the full length of each sprint test. The secondary meta-analyses combined the results of the sprint performance at 5, 10, and 20 m distance to capture information about the acceleration phase of the sprint tests. Eight studies with 206 athletes (female n=10, age range: 18.9-24.2 years) were identified. Sprint performance did not differ significantly comparing OW to the control intervention, nor at the full length (standardized mean difference=-0.07, 95% CI=-0.47 to 0.34,
    Language English
    Publishing date 2024-02-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603122-5
    ISSN 1439-3964 ; 0172-4622 ; 0943-917X
    ISSN (online) 1439-3964
    ISSN 0172-4622 ; 0943-917X
    DOI 10.1055/a-2161-4867
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Zs.A 1561: Show issues Location:
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  10. Article ; Online: Bacterial Metabolism and Transport Genes Are Associated with the Preference of Drosophila melanogaster for Dietary Yeast.

    Call, Tanner B / Davis, Emma K / Bean, Joseph D / Lemmon, Skyler G / Chaston, John M

    Applied and environmental microbiology

    2022  Volume 88, Issue 16, Page(s) e0072022

    Abstract: Many animal traits are influenced by their associated microorganisms ("microbiota"). To expand our understanding of the relationship between microbial genotype and host phenotype, we report an analysis of the influence of the microbiota on the dietary ... ...

    Abstract Many animal traits are influenced by their associated microorganisms ("microbiota"). To expand our understanding of the relationship between microbial genotype and host phenotype, we report an analysis of the influence of the microbiota on the dietary preference of the fruit fly Drosophila melanogaster. First, we confirmed through experiments on flies reared bacteria-free ("axenic") or in monoassociation with two different strains of bacteria that the microbiota significantly influences fruit fly dietary preference across a range of ratios of dietary yeast:dietary glucose. Then, focusing on microbiota-dependent changes in fly dietary preference for yeast (DPY), we performed a metagenome-wide association (MGWA) study to define microbial species specificity for this trait and to predict bacterial genes that influence it. In a subsequent mutant analysis, we confirmed that disrupting a subset of the MGWA-predicted genes influences fly DPY, including for genes involved in thiamine biosynthesis and glucose transport. Follow-up tests revealed that the bacterial influence on fly DPY did not depend on bacterial modification of the glucose or protein content of the fly diet, suggesting that the bacteria mediate their effects independent of the fly diet or through more specific dietary changes than broad ratios of protein and glucose. Together, these findings provide additional insight into bacterial determinants of host nutrition and behavior by revealing specific genetic disruptions that influence D. melanogaster DPY.
    MeSH term(s) Animals ; Bacteria/genetics ; Diet ; Drosophila ; Drosophila melanogaster/microbiology ; Glucose/metabolism ; Microbiota/genetics ; Thiamine/metabolism
    Chemical Substances Glucose (IY9XDZ35W2) ; Thiamine (X66NSO3N35)
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.00720-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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