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Article ; Online: Experimental Identification of Potential Martian Biosignatures in Open and Closed Systems.

Ramkissoon, Nisha K / Macey, Michael C / Kucukkilic-Stephens, Ezgi / Barton, Timothy / Steele, Andrew / Johnson, David N / Stephens, Ben P / Schwenzer, Susanne P / Pearson, Victoria K / Olsson-Francis, Karen

Astrobiology

2024

Abstract: NASA's Perseverance and ESA's Rosalind Franklin rovers have the scientific goal of searching for evidence of ancient life on Mars. Geochemical biosignatures that form because of microbe-mineral interactions could play a key role in achieving this, as ... ...

Abstract	NASA's Perseverance and ESA's Rosalind Franklin rovers have the scientific goal of searching for evidence of ancient life on Mars. Geochemical biosignatures that form because of microbe-mineral interactions could play a key role in achieving this, as they can be preserved for millions of years on Earth, and the same could be true for Mars. Previous laboratory experiments have explored the formation of biosignatures under closed systems, but these do not represent the open systems that are found in natural martian environments, such as channels and lakes. In this study, we have conducted environmental simulation experiments using a global regolith simulant (OUCM-1), a thermochemically modelled groundwater, and an anaerobic microbial community to explore the formation of geochemical biosignatures within plausible open and closed systems on Mars. This initial investigation showed differences in the diversity of the microbial community developed after 28 days. In an open-system simulation (flow-through experiment), the acetogenic
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2047736-3
ISSN	1557-8070 ; 1531-1074
ISSN (online)	1557-8070
ISSN	1531-1074
DOI	10.1089/ast.2023.0013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Catalytic Ammonia Oxidation to Dinitrogen by a Nickel Complex.

Stephens, David N / Szilagyi, Robert K / Roehling, Paige N / Arulsamy, Navamoney / Mock, Michael T

Angewandte Chemie (International ed. in English)

2022 , Page(s) e202213462

Abstract: We report a nickel complex for catalytic oxidation of ammonia to dinitrogen under ambient conditions. Using the aryloxyl radical 2,4,6-tri-tert-butylphenoxyl ( ...

Abstract	We report a nickel complex for catalytic oxidation of ammonia to dinitrogen under ambient conditions. Using the aryloxyl radical 2,4,6-tri-tert-butylphenoxyl (
Language	English
Publishing date	2022-10-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202213462
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Article ; Online: Immune signaling in sex-specific neural and behavioral development: Adolescent opportunity.

King'uyu, David N / Stephens, Shannon B Z / Kopec, Ashley M

Current opinion in neurobiology

2022 Volume 77, Page(s) 102647

Abstract: Sex differences in neural and behavioral development are integral to understanding neurodevelopmental, mental health, and neurodegenerative disorders. Much of the literature has focused on late prenatal and early postnatal life as a critical juncture for ...

Abstract	Sex differences in neural and behavioral development are integral to understanding neurodevelopmental, mental health, and neurodegenerative disorders. Much of the literature has focused on late prenatal and early postnatal life as a critical juncture for establishing sex-specific developmental trajectories, and data are now clear that immune signaling plays a central role in establishing sex differences early in life. Adolescence is another developmental period during which sex differences arise. However, we know far less about how immune signaling plays a role in establishing sex differences during adolescence. Herein, we review well-defined examples of sex differences during adolescence and then survey the literature to speculate how immune signaling might be playing a role in defining sex-specific adolescent outcomes. We discuss open questions in the literature and propose experimental design tenets that may assist in better understanding adolescent neurodevelopment.
MeSH term(s)	Pregnancy ; Adolescent ; Humans ; Female ; Male ; Mental Health ; Sexual Maturation ; Sex Characteristics ; Signal Transduction
Language	English
Publishing date	2022-11-01
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2022.102647
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Zs.A 3260: Show issues

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Article: Characteristics and Physiologic Changes After 4% Albumin Fluid Boluses in a PICU.

Gelbart, Ben / Fulkoski, Nick / Stephens, David / Bellomo, Rinaldo

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2021 Volume 23, Issue 1, Page(s) e10–e19

Abstract: ... kg), and its duration 30 minutes (interquartile range, 14.0-40.0 min; n = 223). After the fluid bolus ...

Abstract	Objectives: To describe the characteristics, hemodynamic, and physiologic changes after 4% albumin fluid boluses in critically ill children. Design: Retrospective observational study. Setting: Single-center PICU. Patients: Children in a cardiac and general PICU. Interventions: None. Measurements and main results: Between January 2017 and May 2019, there were 1,003 fluid boluses of 4% albumin during 420 of 5,731 admissions (7.8%), most commonly in children with congenital/acquired heart disease (71.2%) and sepsis (7.9%). The median fluid bolus dose was 10 mL/kg (interquartile range, 5.8-14.6 mL/kg), and its duration 30 minutes (interquartile range, 14.0-40.0 min; n = 223). After the fluid bolus, a significant change in mean arterial pressure (2.3 mm Hg [5.1%], 2.7 mm Hg [5.8%], 2.9 mm Hg [6.1%], and 3.8 mm Hg [8.0%] at 1, 2, 3, and 4 hr, respectively [p ≤ 0.001]) only occurred in children less than or equal to 12 months old. A mean arterial pressure response, defined by an increase greater than or equal to 10% from baseline, occurred in 290 of 887 patients (33%) with maximal response at 1 hour. Hypotension at baseline predicted the magnitude of mean arterial pressure increase at 60 (coefficient 24.3 [95% CI, 0.79-7.87]; p = 0.04) and 120 minutes (coefficient 26.1 [95% CI, 2.75-48.2]; p = 0.02). There were no biochemical or hematocrit changes within 4 hours of the fluid bolus. Urine output for the entire cohort was 2 mL/kg/hr at baseline and did not change with the fluid bolus. Conclusions: Fluid boluses of 4% albumin were common and predominantly in children with cardiac disease and sepsis with a median dose of 10 mL/kg given over half an hour. Such treatment was associated with significant hemodynamic changes only in children less than 12 months old, and we failed to identify an association with urine output.
MeSH term(s)	Albumins ; Child ; Fluid Therapy/adverse effects ; Hemodynamics ; Humans ; Hypotension ; Infant ; Intensive Care Units, Pediatric
Chemical Substances	Albumins
Language	English
Publishing date	2021-07-15
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000002809
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Zs.A 5600: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 472: Show issues

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Article ; Online: Working Toward Solutions for Gender Disparity: Implications of the 2022 Congenital Workforce Survey.

Stephens, Elizabeth H / Romano, Jennifer C / Karamlou, Tara / Hayes, Sharonne N / Bontrager, Colleen E / Overman, David M / Fuller, Stephanie M

The Annals of thoracic surgery

2023 Volume 117, Issue 3, Page(s) 497–500

MeSH term(s)	Humans ; Workforce ; Surveys and Questionnaires
Language	English
Publishing date	2023-12-01
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2023.11.019
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Zs.A 252: Show issues

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Article ; Online: Impact of Genetic Disorders in the Surgical Management of Congenital Heart Disease.

Stephens, Elizabeth H / Dearani, Joseph A / Connolly, Heidi M / Gleich, Stephen J / Deyle, David R / Johnson, Jonathan N

World journal for pediatric & congenital heart surgery

2023 Volume 14, Issue 2, Page(s) 201–210

Abstract: The congenital heart surgeon frequently encounters patients with various genetic disorders requiring surgical intervention. Although the specifics of the genetics for these patients and their families lie in the purview of specialists in genetics, the ... ...

Abstract	The congenital heart surgeon frequently encounters patients with various genetic disorders requiring surgical intervention. Although the specifics of the genetics for these patients and their families lie in the purview of specialists in genetics, the surgeon is well-served to be familiar with aspects of specific syndromes that impact surgical management and perioperative care. This aids in counseling families in expectations for the hospital course and recovery as well as can impact intraoperative and surgical management. This review article summarizes key characteristics for the congenital heart surgeon to be familiar with for common genetic disorders as they help coordinate care.
MeSH term(s)	Humans ; Heart Defects, Congenital/genetics ; Heart Defects, Congenital/surgery ; Perioperative Care
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2550261-X
ISSN	2150-136X ; 2150-1351
ISSN (online)	2150-136X
ISSN	2150-1351
DOI	10.1177/21501351221139837
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Book ; Conference proceedings: Anxiolytic beta-carbolines

Stephens, David N.

from molecular biology to the clinic ; [Symposium, held in Nice, France, inJuly 1992]

(Psychopharmacology series ; 11)

1993

Author's details	ed. David N. Stephens
Series title	Psychopharmacology series ; 11
Collection
Keywords	Anti-Anxiety Agents / congresses ; Carbolines / pharmacology / congresses ; Receptors, GABA-Benzodiazepine / drug effects / congresses ; Drug Screening / congresses ; Abecarnil
Subject	CAS 111841-85-1
Language	English
Size	X, 151 S. : Ill., graph. Darst.
Publisher	Springer
Publishing place	Berlin u.a.
Document type	Book ; Conference proceedings
HBZ-ID	HT006300232
ISBN	3-540-57144-2 ; 0-387-57144-2 ; 978-3-540-57144-5 ; 978-0-387-57144-7
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
1994 A 2480	order for loan	Magazin

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Article ; Online: Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport.

Mukhopadhyay, Aakash G / Toropova, Katerina / Daly, Lydia / Wells, Jennifer N / Vuolo, Laura / Mladenov, Miroslav / Seda, Marian / Jenkins, Dagan / Stephens, David J / Roberts, Anthony J

The EMBO journal

2024 Volume 43, Issue 7, Page(s) 1257–1272

Abstract: ... more strongly on WDR60, because the unique N-terminal extension of WDR60 facilitates dynein-2 targeting ... to cilia. Strikingly, this N-terminal extension can be transplanted onto WDR34 and retain function ...

Abstract	Dynein-2 is a large multiprotein complex that powers retrograde intraflagellar transport (IFT) of cargoes within cilia/flagella, but the molecular mechanism underlying this function is still emerging. Distinctively, dynein-2 contains two identical force-generating heavy chains that interact with two different intermediate chains (WDR34 and WDR60). Here, we dissect regulation of dynein-2 function by WDR34 and WDR60 using an integrative approach including cryo-electron microscopy and CRISPR/Cas9-enabled cell biology. A 3.9 Å resolution structure shows how WDR34 and WDR60 use surprisingly different interactions to engage equivalent sites of the two heavy chains. We show that cilia can assemble in the absence of either WDR34 or WDR60 individually, but not both subunits. Dynein-2-dependent distribution of cargoes depends more strongly on WDR60, because the unique N-terminal extension of WDR60 facilitates dynein-2 targeting to cilia. Strikingly, this N-terminal extension can be transplanted onto WDR34 and retain function, suggesting it acts as a flexible tether to the IFT "trains" that assemble at the ciliary base. We discuss how use of unstructured tethers represents an emerging theme in IFT train interactions.
MeSH term(s)	Dyneins/metabolism ; Cryoelectron Microscopy ; Biological Transport ; Cilia/metabolism ; Flagella/metabolism
Chemical Substances	Dyneins (EC 3.6.4.2)
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.1038/s44318-024-00060-1
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Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: When should we tell patients there may be no blood? Evaluating the 'informed' consent process.

Booth, Garrett S / Jacobs, Jeremy W / Stephens, Laura D / Chooljian, David M / Savani, Bipin N / Gehrie, Eric A

British journal of haematology

2022 Volume 198, Issue 1, Page(s) e8–e10

MeSH term(s)	Humans ; Informed Consent ; Physician-Patient Relations
Language	English
Publishing date	2022-03-22
Publishing country	England
Document type	Letter
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18156
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Article ; Online: In-Clinic vs. Online Recruitment of Women with a History of Cervical Intraepithelial Neoplasia or Cervical Cancer to a Smoking Cessation Trial: A Post-hoc Comparison of Participant Characteristics, Study Retention, and Cessation Outcomes.

Fennell, Bethany Shorey / Jones, Sarah R / Sutton, Steven K / Hoogland, Charles E / Cottrell-Daniels, Cherell / Wetter, David W / Shih, Ya-Chen Tina / Simmons, Vani N / Stephens, Yesenia P / Vidrine, Damon J / Vidrine, Jennifer I

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

2024

Abstract: ... recruited from clinics within a university-based NCI-designated cancer center (n=87) and online nationally ... via Facebook (n=115). Baseline measures included sociodemographics, smoking history, and cancer or CIN ...

Abstract	Introduction: Recruiting special populations to smoking cessation trials is challenging and approaches beyond in-clinic recruitment may be beneficial. This secondary analysis of data from a smoking cessation RCT for individuals with a history of cervical cancer or cervical intraepithelial neoplasia (CIN) explored differences associated with in-clinic vs. online recruitment. Methods: Participants were recruited from clinics within a university-based NCI-designated cancer center (n=87) and online nationally via Facebook (n=115). Baseline measures included sociodemographics, smoking history, and cancer or CIN history. Study retention and smoking abstinence were assessed 12 months post-baseline. Group differences in baseline characteristics were evaluated. Retention and abstinence were evaluated while controlling for group differences and predictors. Results: Participants recruited online (vs. in-clinic) had higher educational attainment (p=.01) and health literacy (p=.003). They were more likely to have CIN vs. cancer, to be further from the time of diagnosis, and to have completed active treatment (p values<.001). While controlling for these group differences and independent predictors, retention was higher among participants recruited online (log-likelihood χ2(1)=11.41, p<.001). There were no recruitment differences in self-reported (p=.90) or biochemically confirmed smoking abstinence (p=.18). Conclusions: Compared to individuals recruited in-person, individuals recruited online were more educated, had higher health literacy, and presented with a different clinical profile (i.e., more likely to have CIN vs. cancer and to have completed active treatment). There were few differences in participant characteristics between recruitment approaches, and no differences on any smoking-related variables. Online recruitment has the potential to improve enrollment of cancer survivors to smoking cessation trials. Implications: People with a history of CIN or cervical cancer recruited to a smoking cessation RCT online (vs. in-clinic) were more likely to have a diagnosis of CIN vs. cancer and were more educated and health literate. Participants recruited online were more likely to be retained in the study and there were no differences in smoking abstinence rates at 12-months. Incorporating online recruitment increased the reach of tobacco treatment efforts to a larger and more diverse sample. This could reduce the burden of tobacco-related disease, improve CIN and cancer treatment outcomes, and reduce secondary malignancies and morbidity among this underserved group.
Language	English
Publishing date	2024-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1452315-2
ISSN	1469-994X ; 1462-2203
ISSN (online)	1469-994X
ISSN	1462-2203
DOI	10.1093/ntr/ntae049
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