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  1. Book ; Online ; E-Book: Oxford handbook of respiratory nursing

    Scullion, Jane / Robinson, Terry E.

    (Oxford handbooks in nursing)

    2021  

    Abstract: This handbook gives a systematic account of the main respiratory diseases in adults, covering assessment, diagnosis and nursing management. It highlights the multiple needs of respiratory patients - not only the physical requirements but also ... ...

    Author's details edited by Terry Robinson, Jane E. Scullion
    Series title Oxford handbooks in nursing
    Abstract This handbook gives a systematic account of the main respiratory diseases in adults, covering assessment, diagnosis and nursing management. It highlights the multiple needs of respiratory patients - not only the physical requirements but also psychosocial needs, including palliative care and end of life issues.
    Keywords Respiratory organs/Diseases/Nursing
    Subject code 616.2004231
    Language English
    Size 1 online resource (656 pages) :, illustrations (black and white, and colour).
    Edition Second edition.
    Publisher Oxford University Press
    Publishing place Oxford
    Document type Book ; Online ; E-Book
    Note This edition also issued in print: 2021.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-19-256772-1 ; 0-19-256771-3 ; 0-19-188658-0 ; 0-19-883181-1 ; 978-0-19-256772-7 ; 978-0-19-256771-0 ; 978-0-19-188658-4 ; 978-0-19-883181-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Comment on Pohorala et al.: Sign-tracking as a predictor of addiction vulnerability.

    Flagel, Shelly B / Robinson, Terry E / Sarter, Martin

    Psychopharmacology

    2021  Volume 238, Issue 9, Page(s) 2661–2664

    MeSH term(s) Behavior, Addictive ; Reward
    Language English
    Publishing date 2021-07-26
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-021-05927-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex.

    Catalfio, Amanda M / Fetterly, Tracy L / Nieto, Allison M / Robinson, Terry E / Ferrario, Carrie R

    Biology of sex differences

    2023  Volume 14, Issue 1, Page(s) 41

    Abstract: Background: The development and persistence of addiction is mediated in part by drug-induced alterations in nucleus accumbens (NAc) function. AMPA-type glutamate receptors (AMPARs) provide the main source of excitatory drive to the NAc and enhancements ... ...

    Abstract Background: The development and persistence of addiction is mediated in part by drug-induced alterations in nucleus accumbens (NAc) function. AMPA-type glutamate receptors (AMPARs) provide the main source of excitatory drive to the NAc and enhancements in transmission of calcium-permeable AMPARs (CP-AMPARs) mediate increased cue-triggered drug-seeking following prolonged withdrawal. Cocaine treatment regimens that result in psychomotor sensitization enhance subsequent drug-seeking and drug-taking behaviors. Furthermore, cocaine-induced locomotor sensitization followed by 14 days of withdrawal results in an increase in glutamatergic synaptic transmission. However, very few studies have examined cocaine-induced alterations in synaptic transmission of females or potential effects of experimenter-administered cocaine on NAc CP-AMPAR-mediated transmission in either sex.
    Methods: Male and female rats were given repeated systemic cocaine injections to induce psychomotor sensitization (15 mg/kg, i.p. 1 injection/day, 8 days). Controls received repeated saline (1 mL/kg, i.p). After 14-16 days of withdrawal brain slices were prepared and whole-cell patch-clamp approaches in the NAc core were used to measure spontaneous excitatory post-synaptic currents (sEPSC), paired pulse ratio, and CP-AMPAR transmission. Additional female rats from this same cohort were also given a challenge injection of cocaine at withdrawal day 14 to assess the expression of sensitization.
    Results: Repeated cocaine produced psychomotor sensitization in both sexes. In males this was accompanied by an increase in sEPSC frequency, but not amplitude, and there was no effect on the paired pulse ratio. Males treated with cocaine and saline had similar sensitivity to Naspm. In contrast, in females there were no significant differences between cocaine and saline groups on any measure, despite females showing robust psychomotor sensitization both during the induction and expression phase.
    Conclusions: Overall, these data reveal striking sex differences in cocaine-induced NAc glutamate plasticity that accompany the induction of psychomotor sensitization. This suggests that the neural adaptations that contribute to sensitization vary by sex.
    MeSH term(s) Female ; Rats ; Male ; Animals ; Cocaine/pharmacology ; Cocaine/metabolism ; Nucleus Accumbens ; Rats, Sprague-Dawley ; Glutamic Acid/metabolism ; Glutamic Acid/pharmacology ; Synaptic Transmission ; Receptors, AMPA/metabolism
    Chemical Substances Cocaine (I5Y540LHVR) ; Glutamic Acid (3KX376GY7L) ; Receptors, AMPA
    Language English
    Publishing date 2023-06-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2587352-0
    ISSN 2042-6410 ; 2042-6410
    ISSN (online) 2042-6410
    ISSN 2042-6410
    DOI 10.1186/s13293-023-00525-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Studying dopamine in addiction: the cart should follow the horse.

    Robinson, Terry E / Khoo, Shaun Y-S / Ferrario, Carrie R / Samaha, Anne-Noël

    Trends in neurosciences

    2021  Volume 44, Issue 8, Page(s) 595–596

    MeSH term(s) Animals ; Behavior, Addictive ; Dopamine ; Horses ; Substance-Related Disorders
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2021-07-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 282488-7
    ISSN 1878-108X ; 0378-5912 ; 0166-2236
    ISSN (online) 1878-108X
    ISSN 0378-5912 ; 0166-2236
    DOI 10.1016/j.tins.2021.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Microdialysis in the neurosciences

    Robinson, Terry E.

    (Techniques in the behavioral and neural sciences ; 7)

    1991  

    Author's details ed. T. E. Robinson
    Series title Techniques in the behavioral and neural sciences ; 7
    Collection
    Keywords Brain Chemistry ; Dialysis / methods ; Neurotransmitters / metabolism ; Gehirn ; Neurochemie ; Methode ; Hirnfunktion ; Mikrodialyse
    Subject Microdialysis ; Gehirn ; Hirnleistung ; Hirnaktivität ; Hirnphysiologie ; Gehirnphysiologie ; Gehirnaktivität ; Gehirnfunktion ; Methodik ; Verfahren ; Technik ; Methoden ; Biochemie ; Neurobiochemie ; Cerebrum ; Hirn ; Encephalon ; Enzephalon ; Hirngewebe ; Hirnmasse ; Gehirnmasse
    Language English
    Size XXVI, 450 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT004210775
    ISBN 0-444-81194-X ; 978-0-444-81194-3
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: Sex differences in incentive-sensitization produced by intermittent access cocaine self-administration.

    Kawa, Alex B / Robinson, Terry E

    Psychopharmacology

    2018  Volume 236, Issue 2, Page(s) 625–639

    Abstract: Rationale: Intermittent Access (IntA) cocaine self-administration, which models intermittent patterns of cocaine use in humans during the transition to addiction, is especially effective in producing incentive-sensitization and other addiction-like ... ...

    Abstract Rationale: Intermittent Access (IntA) cocaine self-administration, which models intermittent patterns of cocaine use in humans during the transition to addiction, is especially effective in producing incentive-sensitization and other addiction-like behavior in male rats. However, female rats show more robust psychomotor sensitization than males, and following initial use, women develop problematic patterns of drug use more readily than men. We hypothesized, therefore, that female rats might be more susceptible to the incentive-sensitization produced by IntA experience.
    Objective: To assess changes in motivation for cocaine, using a behavioral economic indicator of cocaine demand ("elasticity" of demand curves), and other addiction-like behavior, as a function of IntA cocaine self-administration experience in male and female rats.
    Results: IntA experience produced a progressive increase in motivation for cocaine in both males and females, as indicated by a decrease in the elasticity of cocaine demand curves, and this persisted undiminished following 14 days of abstinence. However, IntA produced a more rapid and greater increase in motivation for cocaine (incentive-sensitization) in females than males. Females also consumed more cocaine than males, although this did not predict changes in motivation. On the other hand, there were no sex differences in the preferred level of cocaine consumption when cost was low (Q
    Conclusions: The observation that females are more susceptible to incentive-sensitization when intermittently exposed to cocaine may provide a mechanism for the more rapid development of problematic drug use in females ("telescoping effect") reported in clinical studies.
    MeSH term(s) Animals ; Behavior, Addictive ; Cocaine/administration & dosage ; Cocaine-Related Disorders ; Dopamine Uptake Inhibitors/administration & dosage ; Drug-Seeking Behavior ; Economics, Behavioral ; Female ; Male ; Motivation ; Rats ; Rats, Sprague-Dawley ; Self Administration ; Sex Factors
    Chemical Substances Dopamine Uptake Inhibitors ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2018-10-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-018-5091-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intermittent access cocaine self-administration produces psychomotor sensitization: effects of withdrawal, sex and cross-sensitization.

    Carr, Crystal C / Ferrario, Carrie R / Robinson, Terry E

    Psychopharmacology

    2020  Volume 237, Issue 6, Page(s) 1795–1812

    Abstract: Rationale: With repeated administration, the psychomotor activating effects of drugs such as cocaine or amphetamine can change in very different ways-showing sensitization or tolerance-depending on whether they are administered more or less ... ...

    Abstract Rationale: With repeated administration, the psychomotor activating effects of drugs such as cocaine or amphetamine can change in very different ways-showing sensitization or tolerance-depending on whether they are administered more or less intermittently. This behavioral plasticity is thought to reflect, at least in part, changes in dopamine (DA) neurotransmission, and therefore, may provide insights into the development of substance use disorders. Indeed, the most widely used preclinical model of cocaine addiction, which involves Long Access (LgA) self-administration procedures, is reported to produce tolerance to cocaine's psychomotor activating effects and effects on DA activity. In contrast, Intermittent Access (IntA) cocaine self-administration is more effective than LgA in producing addiction-like behavior, but sensitizes DA neurotransmission. There is, however, very little information concerning the effects of IntA experience on the psychomotor activating effects of cocaine.
    Objective: The objective of this study was to determine whether IntA experience produces psychomotor sensitization with similar characteristics to that produced by the intermittent, noncontingent administration of cocaine.
    Results: IntA to cocaine did indeed produce psychomotor sensitization that (1) was greater after a long (30 days) vs. short (1 day) period of withdrawal, (2) was greater in females than males, and (3) resulted in cross-sensitization to another psychomotor stimulant drug, amphetamine.
    Conclusion: The tolerance sometimes associated with LgA cocaine self-administration has been cited in support of the idea that, in addiction, drug-seeking and drug-taking is motivated to overcome a DA deficiency and associated anhedonia. In contrast, the neurobehavioral sensitization associated with IntA cocaine self-administration favors an incentive-sensitization view.
    MeSH term(s) Administration, Intravenous ; Animals ; Behavior, Addictive/physiopathology ; Behavior, Addictive/psychology ; Central Nervous System Stimulants/administration & dosage ; Cocaine/administration & dosage ; Cocaine-Related Disorders/physiopathology ; Cocaine-Related Disorders/psychology ; Dopamine Uptake Inhibitors/administration & dosage ; Dose-Response Relationship, Drug ; Female ; Male ; Motivation/drug effects ; Motivation/physiology ; Psychomotor Performance/drug effects ; Psychomotor Performance/physiology ; Rats ; Rats, Sprague-Dawley ; Self Administration ; Sex Factors ; Substance Withdrawal Syndrome/physiopathology ; Substance Withdrawal Syndrome/psychology
    Chemical Substances Central Nervous System Stimulants ; Dopamine Uptake Inhibitors ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2020-03-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-020-05500-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core

    Amanda M. Catalfio / Tracy L. Fetterly / Allison M. Nieto / Terry E. Robinson / Carrie R. Ferrario

    Biology of Sex Differences, Vol 14, Iss 1, Pp 1-

    effects of sex

    2023  Volume 10

    Abstract: Abstract Background The development and persistence of addiction is mediated in part by drug-induced alterations in nucleus accumbens (NAc) function. AMPA-type glutamate receptors (AMPARs) provide the main source of excitatory drive to the NAc and ... ...

    Abstract Abstract Background The development and persistence of addiction is mediated in part by drug-induced alterations in nucleus accumbens (NAc) function. AMPA-type glutamate receptors (AMPARs) provide the main source of excitatory drive to the NAc and enhancements in transmission of calcium-permeable AMPARs (CP-AMPARs) mediate increased cue-triggered drug-seeking following prolonged withdrawal. Cocaine treatment regimens that result in psychomotor sensitization enhance subsequent drug-seeking and drug-taking behaviors. Furthermore, cocaine-induced locomotor sensitization followed by 14 days of withdrawal results in an increase in glutamatergic synaptic transmission. However, very few studies have examined cocaine-induced alterations in synaptic transmission of females or potential effects of experimenter-administered cocaine on NAc CP-AMPAR-mediated transmission in either sex. Methods Male and female rats were given repeated systemic cocaine injections to induce psychomotor sensitization (15 mg/kg, i.p. 1 injection/day, 8 days). Controls received repeated saline (1 mL/kg, i.p). After 14–16 days of withdrawal brain slices were prepared and whole-cell patch-clamp approaches in the NAc core were used to measure spontaneous excitatory post-synaptic currents (sEPSC), paired pulse ratio, and CP-AMPAR transmission. Additional female rats from this same cohort were also given a challenge injection of cocaine at withdrawal day 14 to assess the expression of sensitization. Results Repeated cocaine produced psychomotor sensitization in both sexes. In males this was accompanied by an increase in sEPSC frequency, but not amplitude, and there was no effect on the paired pulse ratio. Males treated with cocaine and saline had similar sensitivity to Naspm. In contrast, in females there were no significant differences between cocaine and saline groups on any measure, despite females showing robust psychomotor sensitization both during the induction and expression phase. Conclusions Overall, these data reveal striking sex differences ...
    Keywords Medicine ; R ; Physiology ; QP1-981
    Subject code 590
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Neurobiological Basis of Individual Variation in Stimulus-Reward Learning.

    Flagel, Shelly B / Robinson, Terry E

    Current opinion in behavioral sciences

    2017  Volume 13, Page(s) 178–185

    Abstract: Cues in the environment can guide behavior in adaptive ways, leading one towards valuable resources such as food, water, or a potential mate. However, cues in the environment may also serve as powerful motivators that lead to maladaptive patterns of ... ...

    Abstract Cues in the environment can guide behavior in adaptive ways, leading one towards valuable resources such as food, water, or a potential mate. However, cues in the environment may also serve as powerful motivators that lead to maladaptive patterns of behavior, such as addiction. Importantly, and central to this article, there is considerable individual variation in the extent to which reward cues gain motivational control over behavior. Here we describe an animal model that captures this individual variation, allowing us to better understand the psychological and neurobiological processes that contribute to cue-evoked behaviors. When a discrete cue is paired with a food reward in a Pavlovian manner it acquires greater control over motivated behavior in some rats ("sign-trackers, STs) than in others ("goal-trackers", GTs). We review studies that have exploited this animal model to parse the neurobiological mechanisms involved in learning associations between stimuli vs. those involved in attributing incentive salience to those same stimuli. The latter seems to be dependent on dopamine and subcortical circuits, whereas the former may engage more cortical "top-down" mechanisms.
    Language English
    Publishing date 2017-01-05
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2352-1546
    ISSN 2352-1546
    DOI 10.1016/j.cobeha.2016.12.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Implementation and evaluation of ultra-low dose CT in early cystic fibrosis lung disease.

    Bayfield, Katie J / Weinheimer, Oliver / Boyton, Christie / Fitzpatrick, Rachel / Middleton, Anna / Kennedy, Brendan / Blaxland, Anneliese / Jayasuriya, Geshani / Caplain, Neil / Issa, Hana / Goetti, Robert / Wielpütz, Mark O / Yu, Lifeng / Galban, Craig J / Robinson, Terry E / Bartholmai, Brian / Fitzgerald, Dominic / Selvadurai, Hiran / Robinson, Paul D

    The European respiratory journal

    2023  Volume 62, Issue 1

    MeSH term(s) Humans ; Cystic Fibrosis/diagnostic imaging ; Lung/diagnostic imaging ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00286-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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