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  1. Book ; Online ; E-Book: Unravelling trauma and weaving resilience with systemic and narrative therapy

    Vermeire, Sabine

    playful collaborations with children, families and networks

    (The Systemic Thinking and Practice)

    2023  

    Author's details Sabine Vermeire
    Series title The Systemic Thinking and Practice
    Keywords Psychic trauma in children/Treatment ; Narrative therapy ; Family violence
    Subject code 616.89165
    Language English
    Size 1 online resource (256 pages)
    Publisher Routledge
    Publishing place London, England ; New York, New York
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-000-78785-0 ; 0-367-76638-8 ; 978-1-000-78785-6 ; 978-0-367-76638-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Conference proceedings: Clinical and endoscopic response to ustekinumab in Crohn’s disease: Week 16 interim analysis of the STARDUST trial

    Danese, S / Vermeire, S / Haens, G / Panés, J / Dignass, A / Magro, F / Nazar, M / Le Bars, M / Sloan, S / Lahaye, M / Ni, L / Daperno, M / Lukas, M / Armuzzi, A / Löwenberg, M / Gaya, D / Peyrin-Biroulet, L

    Zeitschrift für Gastroenterologie

    2020  Volume 58, Issue 05

    Event/congress 53. Jahrestagung der Österreichischen Gesellschaft für Gastroenterologie & Hepatologie (ÖGGH) (online), online, 2020-06-18
    Language German
    Publishing date 2020-05-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0040-1712249
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 111: Show issues Location:
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  3. Article ; Online: Integrated analysis of microbe-host interactions in Crohn’s disease reveals potential mechanisms of microbial proteins on host gene expression

    Padhmanand Sudhakar / Tahila Andrighetti / Sare Verstockt / Clara Caenepeel / Marc Ferrante / João Sabino / Bram Verstockt / Severine Vermeire

    iScience, Vol 25, Iss 5, Pp 103963- (2022)

    2022  

    Abstract: ... with Crohn’s disease (CD), a chronic inflammatory bowel disease (IBD), are associated with gut microbial alterations ...

    Abstract Summary: Inflammatory responses of the intestinal epithelial barrier in patients with Crohn’s disease (CD), a chronic inflammatory bowel disease (IBD), are associated with gut microbial alterations. At a community level, there is scarce mechanistic evidence on the effects of gut microbial alterations on host mucosal barrier responses. We used a computational microbe-host interaction prediction framework based on network diffusion and systems biology to integrate publicly available paired gut microbial and intestinal gene expression datasets. The ileal signaling network potentially modulated by the microbiota was enriched with immune-related pathways such as those associated with IL-4, IL-2, IL-13, NFkB, and toll-like receptors. We identified bacterial proteins eliciting post-translational modifications on host receptors, resulting in the de-repression of pro-inflammatory cytokines via critical hub proteins such as NFkB. The signaling networks were over-represented with CD associated genes and CD drug targets. Using datasets generated from our validation cohorts, we confirmed some of the results.
    Keywords Gastroenterology ; Molecular genetics ; Microbiome ; Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Combination biologic therapy for ulcerative colitis.

    Vermeire, Severine

    The lancet. Gastroenterology & hepatology

    2023  Volume 8, Issue 4, Page(s) 288–290

    MeSH term(s) Humans ; Colitis, Ulcerative/therapy ; Infliximab ; Combined Modality Therapy ; Biological Therapy
    Chemical Substances Infliximab (B72HH48FLU)
    Language English
    Publishing date 2023-02-01
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(23)00008-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply to Dr. Caprilli et al.'s letter.

    Ferrante, Marc / Vermeire, Séverine / Van Assche, Gert / Rutgeerts, Paul

    Journal of Crohn's & colitis

    2009  Volume 3, Issue 1, Page(s) 45

    Language English
    Publishing date 2009-02
    Publishing country England
    Document type Letter
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1016/j.crohns.2008.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6634: Show issues Location:
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  6. Article ; Online: Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn’s Disease

    G. Hoarau / P. K. Mukherjee / C. Gower-Rousseau / C. Hager / J. Chandra / M. A. Retuerto / C. Neut / S. Vermeire / J. Clemente / J. F. Colombel / H. Fujioka / D. Poulain / B. Sendid / M. A. Ghannoum

    mBio, Vol 7, Iss 5, p e01250-

    2016  Volume 16

    Abstract: Crohn’s disease (CD) results from a complex interplay between host genetic factors and endogenous ... Saccharomyces cerevisiae antibodies (ASCA). The abundance of C. tropicalis was positively correlated with S. marcescens and ... species (C. tropicalis plus S. marcescens plus E. coli) biofilm were significantly greater ...

    Abstract Crohn’s disease (CD) results from a complex interplay between host genetic factors and endogenous microbial communities. In the current study, we used Ion Torrent sequencing to characterize the gut bacterial microbiota (bacteriome) and fungal community (mycobiome) in patients with CD and their nondiseased first-degree relatives (NCDR) in 9 familial clusters living in northern France-Belgium and in healthy individuals from 4 families living in the same area (non-CD unrelated [NCDU]). Principal component, diversity, and abundance analyses were conducted, and CD-associated inter- and intrakingdom microbial correlations were determined. Significant microbial interactions were identified and validated using single- and mixed-species biofilms. CD and NCDR groups clustered together in the mycobiome but not in the bacteriome. Microbiotas of familial (CD and NCDR) samples were distinct from those of nonfamilial (NCDU) samples. The abundance of Serratia marcescens and Escherichia coli was elevated in CD patients, while that of beneficial bacteria was decreased. The abundance of the fungus Candida tropicalis was significantly higher in CD than in NCDR (P = 0.003) samples and positively correlated with levels of anti-Saccharomyces cerevisiae antibodies (ASCA). The abundance of C. tropicalis was positively correlated with S. marcescens and E. coli, suggesting that these organisms interact in the gut. The mass and thickness of triple-species (C. tropicalis plus S. marcescens plus E. coli) biofilm were significantly greater than those of single- and double-species biofilms. C. tropicalis biofilms comprised blastospores, while double- and triple-species biofilms were enriched in hyphae. S. marcescens used fimbriae to coaggregate or attach with C. tropicalis/E. coli, while E. coli was closely apposed with C. tropicalis. Specific interkingdom microbial interactions may be key determinants in CD.
    Keywords Science ; Q ; Microbiology ; QR1-502
    Subject code 590
    Language English
    Publishing date 2016-09-01T00:00:00Z
    Publisher American Society for Microbiology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Upgrading therapeutic ambitions and treatment outcomes.

    Kotze, Paulo Gustavo / Vermeire, Severine

    Nature reviews. Gastroenterology & hepatology

    2023  Volume 21, Issue 2, Page(s) 84–85

    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-023-00885-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Music perception in electric acoustic stimulation users as assessed by the Mu.S.I.C. test.

    Brockmeier, S J / Peterreins, M / Lorens, A / Vermeire, K / Helbig, S / Anderson, I / Skarzynski, H / Van de Heyning, P / Gstoettner, W / Kiefer, J

    Advances in oto-rhino-laryngology

    2009  Volume 67, Page(s) 70–80

    Abstract: ... using the Musical Sounds in Cochlear Implants (Mu.S.I.C.) test.: Results: No difference was found ...

    Abstract Aims: This study compared the music perception abilities of 13 electric acoustic stimulation (EAS) users with two control groups: unilateral cochlear implant (CI) users and normal-hearing (NH) listeners.
    Methods: Groups were matched according to age and musical experience before hearing loss (HL) and tested using the Musical Sounds in Cochlear Implants (Mu.S.I.C.) test.
    Results: No difference was found on rhythm perception, chord discrimination, dissonance rating, and emotion rating subtest performance between groups. Mean frequency discrimination scores were significantly better in EAS participants than in CI participants and not significantly worse than in NH participants. However, the EAS and CI groups scored similarly (significantly worse than NH participants) on both instrument detection and identification. Results for EAS participants were not significantly worse when the hearing aid component was removed. Frequency of listening to music before HL was negatively correlated with EAS participants' frequency discrimination scores, though singing and playing an instrument appeared to have no effect. EAS participants who indicated many reasons for listening to music and who listen to many genres after implantation scored higher on instrument detection and instrument identification. Better results on these two subtests were correlated with EAS participants' better postoperative auditory thresholds at 250 and 500 Hz.
    Conclusions: Though EAS participants performed better on music perception testing (though not timbre-based tasks) than CI participants, their scores did not reach the level of NH participants. This indicates that acoustic hearing in the low frequencies is helpful for music perception, though not the only important factor.
    MeSH term(s) Acoustic Stimulation/methods ; Adult ; Aged ; Auditory Perception/physiology ; Auditory Threshold/physiology ; Cochlear Implants ; Electric Stimulation/methods ; Follow-Up Studies ; Hearing Loss/physiopathology ; Hearing Loss/therapy ; Humans ; Middle Aged ; Music ; Prognosis
    Language English
    Publishing date 2009-11-25
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ISSN 0065-3071
    ISSN 0065-3071
    DOI 10.1159/000262598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Crohn's disease.

    Dolinger, Michael / Torres, Joana / Vermeire, Severine

    Lancet (London, England)

    2024  Volume 403, Issue 10432, Page(s) 1177–1191

    Abstract: Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract that might lead to progressive bowel damage and disability. The exact cause of Crohn's disease is unknown, but evidence points towards multifactorial events causing ... ...

    Abstract Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract that might lead to progressive bowel damage and disability. The exact cause of Crohn's disease is unknown, but evidence points towards multifactorial events causing dysregulation of the innate immune system in genetically susceptible people. Commonly affecting the terminal ileum and proximal colon, Crohn's disease inflammation is often discontinuous and patchy, segmental, and transmural. Identification of characteristic findings on ileocolonoscopy and histology remains the diagnostic gold standard, but complete assessment involves laboratory abnormalities, including micronutrient deficiencies, cross-sectional imaging to identify transmural disease extent, severity and complications, and a psychosocial assessment. Treatment strategies for patients with Crohn's disease now go beyond achieving clinical remission to include deeper targets of endoscopic healing and consideration of adjunctive histological and transmural targets to alter disease progression potentially further. The use of early effective advanced therapies and development of therapies targeting alternative novel pathways with improved safety profiles have resulted in a new era of healing in Crohn's disease management. Future combination of advanced therapies with diet or other biological drugs and small molecules, together with improvements in tight control monitoring tools and predictive biomarkers might continue to improve outcomes for patients with Crohn's disease.
    MeSH term(s) Humans ; Crohn Disease/therapy ; Crohn Disease/drug therapy ; Ileum/pathology ; Endoscopy ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02586-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Dystonic cerebral palsy like presentation caused by a novel TCF20 variant.

    Prasun, Pankaj / Vermeire, Kylie / Ferimer, Stephanie

    Journal of movement disorders

    2024  

    Language English
    Publishing date 2024-04-26
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 3021788-X
    ISSN 2093-4939 ; 2005-940X
    ISSN (online) 2093-4939
    ISSN 2005-940X
    DOI 10.14802/jmd.24007
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