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  1. Article: La déferlante COVID-19 : la PCR à la rescousse ! Chronique d’une gestion de crise au Laboratoire de Microbiologie clinique du CHU de Liège.

    Hayette, M P / Meex, C / Bontems, S / Diop, C / Nizet, A / Lamtiri, M / Descy, J / Vaira, D / Jacques, J / Thys, M / Gillet, P / Melin, P

    Revue medicale de Liege

    2020  Volume 75, Issue S1, Page(s) 55–61

    Abstract: Chronicle of a crisis management at the Clinical Microbiology Laboratory of CHU Liège The SARS-CoV-2 outbreak in December 2019 in China and its expansion across the world and Europe have requested the participation of clinical laboratories as major ... ...

    Title translation The COVID-19 breaker : PCR to the rescue !
    Abstract Chronicle of a crisis management at the Clinical Microbiology Laboratory of CHU Liège The SARS-CoV-2 outbreak in December 2019 in China and its expansion across the world and Europe have requested the participation of clinical laboratories as major players in the diagnosis of COVID-19, to perform PCR tests mainly on nasopharyngeal swabs. In Belgium, the first confirmed COVID-19 patient was diagnosed in early February, the first of many, especially travelers returning from winter sports. In order to meet the ever-increasing demands for testing, the Clinical Microbiology Laboratory of the CHU of Liege had to adapt to this situation: firstly, by developing manual PCR tests and then automated solutions, permitting to increase the number of analyzes by ensuring a short turnaround time of results. Then, a system for the communication of results on a large scale has been set up, and finally solutions to deal with the lack of sampling devices have been found. This first wave of the pandemic has also highlighted an unprecedented solidarity within the institution. In this article, we recount the chronology of the management of this unprecedented health crisis within the Clinical Microbiology Laboratory of the CHU of Liege.
    MeSH term(s) Belgium ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Europe ; Humans ; Pandemics ; Pneumonia, Viral ; Polymerase Chain Reaction ; SARS-CoV-2
    Keywords covid19
    Language French
    Publishing date 2020-11-19
    Publishing country Belgium
    Document type Journal Article
    ZDB-ID 414001-1
    ISSN 0370-629X ; 0035-3663
    ISSN 0370-629X ; 0035-3663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Helicobacter pylori eradication and aspirin: a puzzle yet to be solved.

    Gatta, Luigi / Zullo, Angelo / Vaira, Dino

    Lancet (London, England)

    2023  Volume 401, Issue 10384, Page(s) 1265–1266

    MeSH term(s) Humans ; Aspirin/therapeutic use ; Helicobacter pylori ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Helicobacter Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Aspirin (R16CO5Y76E) ; Anti-Inflammatory Agents, Non-Steroidal ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-04-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)00279-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Changing prevalence of Helicobacter pylori infection and peptic ulcer among dyspeptic patients.

    Vaira, Dino

    Internal and emergency medicine

    2015  Volume 10, Issue 7, Page(s) 763–764

    MeSH term(s) Dyspepsia ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Peptic Ulcer/epidemiology ; Prevalence
    Language English
    Publishing date 2015-10
    Publishing country Italy
    Document type Comment ; Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-015-1296-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Diagnosing small bowel malabsorption.

    Vaira, Dino

    Internal and emergency medicine

    2013  Volume 9, Issue 1, Page(s) 1–2

    MeSH term(s) Citrulline/blood ; Humans ; Malabsorption Syndromes/diagnosis
    Chemical Substances Citrulline (29VT07BGDA)
    Language English
    Publishing date 2013-11-30
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-013-1021-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hepatic Encephalopathy and Helicobacter pylori.

    Ponzetto, Antonio / Vaira, Dino

    Digestive diseases and sciences

    2018  Volume 63, Issue 5, Page(s) 1368–1369

    MeSH term(s) Helicobacter Infections ; Helicobacter pylori ; Hepatic Encephalopathy ; Humans ; Liver Cirrhosis
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-018-5038-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comparison of prevalence and evolution of COVID-19 olfactory disorders in patients infected by D614 (wild) and B.1.1.7. Alpha variant: a brief report.

    Lechien, Jerome R / Wajsblat, Shannon / Horoi, Mihaela / Boscolo-Rizzo, Paolo / Le Bon, Serge D / Vaira, Luigi A / Saussez, Sven

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2023  Volume 280, Issue 7, Page(s) 3461–3467

    Abstract: Objectives: To investigate the prevalence and the evolution of olfactory disorders (OD) related to coronavirus disease 2019 (COVID-19) in patients infected during the first and the second European waves.: Methods: From March 2020 to October 2020, ... ...

    Abstract Objectives: To investigate the prevalence and the evolution of olfactory disorders (OD) related to coronavirus disease 2019 (COVID-19) in patients infected during the first and the second European waves.
    Methods: From March 2020 to October 2020, COVID-19 patients with OD were recruited and followed over the 12-month post-infection. The following data were collected: demographic, treatments, vaccination status, and olfactory function. Olfaction was assessed with the Olfactory Disorder Questionnaire (ODQ), and threshold, discrimination, and identification (TDI) test. Outcomes were compared between patients of the first wave (group 1: wild/D614G virus) and the second wave (group 2: B.1.1.7. Alpha variant) at 1-, 3- and 12-month post-infection.
    Results: Sixty patients completed the evaluations accounting for 33 and 27 patients in group 1 and 2, respectively. The 1-month TDI score (23.7 ± 5.3) was significantly lower in group 2 compared to group 1 (29.8 ± 8.7; p = 0.017). Proportion of normosmic patients at 1-month post-infection was significantly higher in group 1 compared to group 2 (p = 0.009). TDI scores only significantly increased from 1- to 3-month post-infection in anosmic and hyposmic patients. Focusing on There was a negative association between the 1-month ODQ and the 1-month TDI (r
    Conclusions: Patients of the second wave (Alpha B.1.1.7. variant) reported significant higher proportion of psychophysical test abnormalities at 1-month post-infection than patients infected during the first wave (D614G virus).
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/complications ; SARS-CoV-2 ; Prevalence ; Olfaction Disorders/etiology ; Olfaction Disorders/complications ; Smell
    Language English
    Publishing date 2023-03-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-023-07923-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Impact of coronavirus pandemic and containment measures on HIV diagnosis.

    Darcis, Gilles / Vaira, Dolores / Moutschen, Michel

    Epidemiology and infection

    2020  Volume 148, Page(s) e185

    Abstract: During the last months and following the implementation of containment measures in the context of coronavirus disease 2019 (COVID-19) pandemic, the number of new human immunodeficiency virus (HIV) diagnoses radically decreased in Liege AIDS Reference ... ...

    Abstract During the last months and following the implementation of containment measures in the context of coronavirus disease 2019 (COVID-19) pandemic, the number of new human immunodeficiency virus (HIV) diagnoses radically decreased in Liege AIDS Reference Center, Belgium. The number of HIV screening tests has also dramatically dropped down to an unprecedented level. This decline of HIV diagnosis is caused by missed diagnoses of individuals infected before the establishment of such measures and to the reduction of high-risk sexual behaviours during the COVID-19 pandemic.
    MeSH term(s) Belgium ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/transmission ; Humans ; Mass Screening/statistics & numerical data ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Sexual Behavior/statistics & numerical data
    Keywords covid19
    Language English
    Publishing date 2020-08-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632982-2
    ISSN 1469-4409 ; 0950-2688
    ISSN (online) 1469-4409
    ISSN 0950-2688
    DOI 10.1017/S0950268820001867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Kinetic Perimetry on Virtual Reality Headset.

    Terracciano, Rossana / Mascolo, Alice / Venturo, Laura / Guidi, Federica / Vaira, Mariangela / Eandi, Chiara M / Demarchi, Danilo

    IEEE transactions on biomedical circuits and systems

    2023  Volume 17, Issue 3, Page(s) 413–419

    Abstract: Objective: We present a portable automatic kinetic perimeter based on a virtual reality (VR) headset device as an innovative and alternative solution for the screening of clinical visual fields. We compared the performances of our solution with a gold ... ...

    Abstract Objective: We present a portable automatic kinetic perimeter based on a virtual reality (VR) headset device as an innovative and alternative solution for the screening of clinical visual fields. We compared the performances of our solution with a gold standard perimeter, validating the test on healthy subjects.
    Methods: The system is composed of an Oculus Quest 2 VR headset with a clicker for participant response feedback. An Android app was designed in Unity to generate moving stimuli along vectors, following a standard Goldmann kinetic perimetry approach. Sensitivity thresholds are obtained by moving centripetally three different targets (V/4e, IV/1e, III/1e) along 24 or 12 vectors from an area of non-seeing to an area of seeing and then transmitted wirelessly to a PC. A Python real-time algorithm processes the incoming kinetic results and displays the hill of vision in a two-dimensional map (isopter). We involved 21 subjects (5 males and 16 females, age range 22-73 years) for a total of 42 eyes tested with our proposed solution, and results were compared with a Humphrey visual field analyzer to test reproducibility and efficacy.
    Results: isopters generated with the Oculus headset were in good agreement with those acquired with a commercial device (Pearson's correlation values r > 0.83 for each target).
    Conclusions: we demonstrate the feasibility of VR kinetic perimetry by comparing performances between our system and a clinically used perimeter in healthy subjects.
    Significance: proposed device leads the way for a portable and more accessible visual field test, overcoming challenges in current kinetic perimetry practices.
    MeSH term(s) Kinetics ; Visual Field Tests/instrumentation ; Visual Field Tests/methods ; Humans ; Male ; Female ; Young Adult ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Virtual Reality ; Wearable Electronic Devices ; Reproducibility of Results ; Healthy Volunteers
    Language English
    Publishing date 2023-07-12
    Publishing country United States
    Document type Journal Article
    ISSN 1940-9990
    ISSN (online) 1940-9990
    DOI 10.1109/TBCAS.2023.3249045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SARS-CoV-2 Effects on Psychophysical Olfactory Scores: Prospective Study With Evaluation Before and 60-Days After Infection.

    Vaira, Luigi Angelo / Lechien, Jerome R / Salzano, Giovanni / Maglitto, Fabio / Boscolo-Rizzo, Paolo / Hopkins, Claire / De Riu, Giacomo

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2023  Volume 168, Issue 5, Page(s) 1249–1252

    Abstract: ... but not for odor discrimination (D) (p = .443) and identification (I) (p = .159). SARS-CoV-2 causes ...

    Abstract The aim of this study was to prospectively evaluate the olfactory function in a series of individuals infected with SARS-CoV-2 and who had undergone psychophysical olfactory assessment prior to infection. Individuals unexposed to SARS-CoV-2 infection underwent a psychophysical evaluation of smell with the Sniffin' Sticks test. The subjects were followed prospectively and included in the study if they developed SARS-CoV-2 infection with a second test 60 days after recovery. At the 60-day follow-up of the 41 included subjects, 2 (4.9%) self-reported persistent olfactory dysfunction (OD). The differences between TDI scores before and after infection were statistically significant (37 [interquartile range (IQR), 34.25-39.25] vs 34.75 [IQR, 32.25-38]; p = .021). Analyzing the individual olfactory domains, the differences were significant for threshold (T) (9.75 [IQR, 9-11.25] vs 8.25 [IQR, 7.25-10.25]; p = .009) but not for odor discrimination (D) (p = .443) and identification (I) (p = .159). SARS-CoV-2 causes a significant reduction in the olfactory function, in particular affecting the olfactory threshold, even in subjects who do not self-report an OD.
    MeSH term(s) Humans ; Smell ; SARS-CoV-2 ; Prospective Studies ; Olfaction Disorders/diagnosis ; Olfaction Disorders/etiology ; COVID-19/complications
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: First-line therapies for H. pylori infection in Italy: a pooled-data analysis.

    De Francesco, V / Zullo, A / Manta, R / Pavoni, M / Saracino, I M / Fiorini, G / Giostra, F / Monti, G / Vaira, D

    Acta gastro-enterologica Belgica

    2022  Volume 85, Issue 2, Page(s) 295–299

    Abstract: Background: Curing H. pylori infection remains challenging, and the use of most effective first-line therapy represents a therapeutic cornerstone. To monitor the efficacy of first-line therapies in Italy, we designed a systematic review with pooled- ... ...

    Abstract Background: Curing H. pylori infection remains challenging, and the use of most effective first-line therapy represents a therapeutic cornerstone. To monitor the efficacy of first-line therapies in Italy, we designed a systematic review with pooled- data analysis of data published in the last 15 years.
    Methods: The search was focused on standard regimens and adult patients. Studies that included modified therapy regimens, pediatric patients, case series with less than 5 patients, and those in language other than English were excluded.
    Results: A total of 40 studies, with 74 therapeutic arms and 13,539 patients were evaluated. Among the 14-day triple therapies, the combination with proton pump inhibitor (PPI), clarithromycin and amoxicillin achieved the highest (77.9%) success rate, whilst the lowest success rate (62.7%) was observed following the 14-day PPI, clarithromycin and tinidazole regimen. The overall efficacy of triple therapies significantly decreased from 75.7% to 72.1% in the last decade. Sequential (88.3% on 3431 patients), concomitant (88.8% on 376 patients), and the bismuth-based quadruple therapy with three-in-one capsule, containing bismuth subcitrate potassium (140 mg), metronidazole (125 mg), tetracycline (125 mg) (90.4% on 999 patients) achieved similarly high eradication rates, but data on concomitant are still limited. The bismuth-based was associated with the higher (38.7%) incidence of side-effects.
    Conclusions: Data found that all triple therapies, irrespective of drug combination and therapy duration, should be abandoned in Italy due to their unacceptable low success rates. Monitoring the efficacy of standard first-line therapies in other countries could be clinically useful for both patients and clinicians.
    MeSH term(s) Adult ; Amoxicillin/therapeutic use ; Anti-Bacterial Agents/adverse effects ; Bismuth/therapeutic use ; Child ; Clarithromycin/pharmacology ; Clarithromycin/therapeutic use ; Data Analysis ; Drug Therapy, Combination ; Helicobacter Infections/drug therapy ; Helicobacter pylori ; Humans ; Metronidazole/therapeutic use ; Proton Pump Inhibitors/pharmacology ; Proton Pump Inhibitors/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Proton Pump Inhibitors ; Metronidazole (140QMO216E) ; Amoxicillin (804826J2HU) ; Clarithromycin (H1250JIK0A) ; Bismuth (U015TT5I8H)
    Language English
    Publishing date 2022-06-13
    Publishing country Belgium
    Document type Journal Article ; Systematic Review
    ZDB-ID 127060-6
    ISSN 1784-3227 ; 0001-5644
    ISSN 1784-3227 ; 0001-5644
    DOI 10.51821/85.2.9680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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