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Article ; Online: The Dutch multidisciplinary guideline osteoporosis and fracture prevention, taking a local guideline to the international arena.

van den Bergh, J P / Geusens, P / Appelman-Dijkstra, N M / van den Broek, H J G / Elders, P J M / de Klerk, G / van Oostwaard, M / Willems, H C / Zillikens, M C / Lems, W F

Archives of osteoporosis

2024 Volume 19, Issue 1, Page(s) 23

Abstract: Background: In 2018, a grant was provided for an evidence-based guideline on osteoporosis and fracture prevention based on 10 clinically relevant questions.: Methods: A multidisciplinary working group was formed with delegates from Dutch scientific ... ...

Abstract	Background: In 2018, a grant was provided for an evidence-based guideline on osteoporosis and fracture prevention based on 10 clinically relevant questions. Methods: A multidisciplinary working group was formed with delegates from Dutch scientific and professional societies, including representatives from the patient's organization and the Dutch Institute for Medical Knowledge. The purpose was to obtain a broad consensus among all participating societies to facilitate the implementation of the updated guideline. Results: Novel recommendations in our guideline are as follows: - In patients with an indication for DXA of the lumbar spine and hips, there is also an indication for VFA. - Directly starting with anabolic drugs (teriparatide or romosozumab) in patients with a very high fracture risk; - Directly starting with zoledronic acid in patients 75 years and over with a hip fracture (independent of DXA); - Directly starting with parenteral drugs (denosumab, teriparatide, zoledronic acid) in glucocorticoid-induced osteoporosis with very high fracture risk; - A lifelong fracture risk management, including lifestyle, is indicated from the start of the first treatment. Conclusion: In our new multidisciplinary guideline osteoporosis and fracture prevention, we developed 5 "relatively new statements" that are all a crucial step forward in the optimization of diagnosis and treatment for fracture prevention. We also developed 5 flowcharts, and we suppose that this may be helpful for individual doctors and their patients in daily practice and may facilitate implementation.
MeSH term(s)	Humans ; Teriparatide ; Zoledronic Acid ; Osteoporosis/drug therapy ; Ethnicity ; Hip Fractures/prevention & control
Chemical Substances	Teriparatide (10T9CSU89I) ; Zoledronic Acid (6XC1PAD3KF)
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2253231-6
ISSN	1862-3514 ; 1862-3522
ISSN (online)	1862-3514
ISSN	1862-3522
DOI	10.1007/s11657-024-01378-3
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Article ; Online: Acute pain management after thoracoscopic lung resection: a systematic review and explorative meta-analysis.

Spaans, Louisa N / Bousema, Jelle E / Meijer, Patrick / Bouwman, R A Arthur / van den Broek, Renee / Mourisse, Jo / Dijkgraaf, Marcel G W / Verhagen, Ad F T M / van den Broek, Frank J C

Interdisciplinary cardiovascular and thoracic surgery

2022 Volume 36, Issue 1

Abstract: Objectives: Pain after thoracoscopic surgery may increase the incidence of postoperative complications and impair recovery. Guidelines lack consensus regarding postoperative analgesia. We performed a systematic review and meta-analysis to determine the ... ...

Abstract	Objectives: Pain after thoracoscopic surgery may increase the incidence of postoperative complications and impair recovery. Guidelines lack consensus regarding postoperative analgesia. We performed a systematic review and meta-analysis to determine the mean pain scores of different analgesic techniques (thoracic epidural analgesia, continuous or single-shot unilateral regional analgesia and only systemic analgesia) after thoracoscopic anatomical lung resection. Methods: Medline, Embase and Cochrane databases were searched until 1 October 2022. Patients undergoing at least >70% anatomical resections through thoracoscopy reporting postoperative pain scores were included. Due to a high inter-study variability an explorative meta-analysis next to an analytic meta-analysis was performed. The quality of evidence has been evaluated using the Grading of Recommendations Assessment, Development and Evaluation system. Results: A total of 51 studies comprising 5573 patients were included. Mean 24, 48 and 72 h pain scores with 95% confidence interval on a 0-10 scale were calculated. Length of hospital stay, postoperative nausea and vomiting, additional opioids and the use of rescue analgesia were analysed as secondary outcomes. A common-effect size was estimated with an extreme high heterogeneity for which pooling of the studies was not appropriate. An exploratory meta-analysis demonstrated acceptable mean pain scores of Numeric Rating Scale <4 for all analgesic techniques. Conclusions: This extensive literature review and attempt to pool mean pain scores for meta-analysis demonstrates that unilateral regional analgesia is gaining popularity over thoracic epidural analgesia in thoracoscopic anatomical lung resection, despite great heterogeneity and limitations of current studies precluding such recommendations. Prospero registration: ID number 205311.
Language	English
Publishing date	2022-08-22
Publishing country	England
Document type	Journal Article
ISSN	2753-670X
ISSN (online)	2753-670X
DOI	10.1093/icvts/ivad003
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Article ; Online: Does formative assessment help students to acquire prescribing skills?

Kalfsvel, L S / Peeters, L E J / Hoek, K / Bethlehem, C / van der Sijs, I H / van der Kuy, P H M / van den Broek, W W / Versmissen, J / van Rosse, F

European journal of clinical pharmacology

2023 Volume 79, Issue 4, Page(s) 533–540

Abstract: Purpose: Formative assessments can help motivate students and ease students' learning through feedback. There is a pressing need for improvement of clinical pharmacotherapy (CPT) education since junior doctors make many prescribing errors. The aim of ... ...

Abstract	Purpose: Formative assessments can help motivate students and ease students' learning through feedback. There is a pressing need for improvement of clinical pharmacotherapy (CPT) education since junior doctors make many prescribing errors. The aim of this study was to determine whether a formative assessment with personalized narrative feedback helps medical students to increase their prescribing skills. Methods: This retrospective cohort study was conducted among masters' medical students at Erasmus Medical Centre, The Netherlands. Students made a formative and a summative skill-based prescription assessment, both during clerkships as part of their regular curriculum. Errors in both assessments were categorized by type and possible consequence and compared with each other. Results: A total of 388 students made 1964 errors in the formative assessment and 1016 in the summative assessment. Most improvements after the formative assessment were seen for mentioning the weight of a child on the prescription (n = 242, 19%). Most new and repeated errors in the summative assessment were missing usage instructions (n = 82, 16% and n = 121, 41%). Conclusions: This formative assessment with personalized and individual narrative feedback has helped students to increase the technical correctness of their prescriptions. However, errors repeated after the feedback were predominantly errors showing that only one formative assessment has not yet enhanced the clinical prescribing enough.
MeSH term(s)	Child ; Humans ; Educational Measurement ; Retrospective Studies ; Curriculum ; Feedback ; Students, Medical ; Education, Medical, Undergraduate ; Clinical Competence
Language	English
Publishing date	2023-02-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	121960-1
ISSN	1432-1041 ; 0031-6970
ISSN (online)	1432-1041
ISSN	0031-6970
DOI	10.1007/s00228-023-03456-w
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Zs.A 672: Show issues

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Article ; Online: Endosonography With or Without Confirmatory Mediastinoscopy for Resectable Lung Cancer: A Randomized Clinical Trial.

Bousema, Jelle E / Dijkgraaf, Marcel G W / van der Heijden, Erik H F M / Verhagen, Ad F T M / Annema, Jouke T / van den Broek, Frank J C

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2023 Volume 41, Issue 22, Page(s) 3805–3815

Abstract: Purpose: Resectable non-small-cell lung cancer (NSCLC) with a high probability of mediastinal nodal involvement requires mediastinal staging by endosonography and, in the absence of nodal metastases, confirmatory mediastinoscopy according to current ... ...

Abstract	Purpose: Resectable non-small-cell lung cancer (NSCLC) with a high probability of mediastinal nodal involvement requires mediastinal staging by endosonography and, in the absence of nodal metastases, confirmatory mediastinoscopy according to current guidelines. However, randomized data regarding immediate lung tumor resection after systematic endosonography versus additional confirmatory mediastinoscopy before resection are lacking. Methods: Patients with (suspected) resectable NSCLC and an indication for mediastinal staging after negative systematic endosonography were randomly assigned to immediate lung tumor resection or confirmatory mediastinoscopy followed by tumor resection. The primary outcome in this noninferiority trial (noninferiority margin of 8% that previously showed to not compromise survival, Results: Between July 17, 2017, and October 5, 2020, 360 patients were randomly assigned, 178 to immediate lung tumor resection (seven dropouts) and 182 to confirmatory mediastinoscopy first (seven dropouts before and six after mediastinoscopy). Mediastinoscopy detected metastases in 8.0% (14/175; 95% CI, 4.8 to 13.0) of patients. Unforeseen N2 rate after immediate resection (8.8%) was noninferior compared with mediastinoscopy first (7.7%) in both intention-to-treat (Δ, 1.03%; UL 95% CIΔ, 7.2%; Conclusion: On the basis of our chosen noninferiority margin in the rate of unforeseen N2, confirmatory mediastinoscopy after negative systematic endosonography can be omitted in patients with resectable NSCLC and an indication for mediastinal staging.
MeSH term(s)	Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Lung Neoplasms/pathology ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/surgery ; Carcinoma, Non-Small-Cell Lung/pathology ; Mediastinoscopy/methods ; Endosonography/methods ; Neoplasm Staging ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/surgery ; Lymph Nodes/pathology
Language	English
Publishing date	2023-04-05
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.22.01728
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Study Protocol of the Exercise Study: Unraveling Limitations for Physical Activity in Children With Chronic Diseases in Order to Target Them With Tailored Interventions-A Randomized Cross Over Trial.

Scheffers, Linda E / Helbing, Willem A / Utens, Elisabeth M W J / Dieleman, Gwen C / Dulfer, Karolijn / Noske, Josefien / van den Broek, Eline A / Walet, Sylvia / Olieman, Joanne F / Escher, Johanna C / Pijnenburg, Marielle W / van der Ploeg, Ans T / van den Berg, Linda E

Frontiers in pediatrics

2022 Volume 9, Page(s) 791701

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2022-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2021.791701
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Article ; Online: Trastuzumab-Emtansine and Osimertinib Combination Therapy to Target

Jebbink, M / de Langen, A J / Monkhorst, K / Boelens, M C / van den Broek, D / van der Noort, V / de Gooijer, C J / Mahn, M / van der Wekken, A J / Hendriks, L / Hashemi, S M S / Paats, M S / Dingemans, A C / Smit, E F

JTO clinical and research reports

2023 Volume 4, Issue 4, Page(s) 100481

Abstract: Introduction: EGFR: Methods: In this multicenter, single-arm, phase 1-2 study (NCT03784599), patients with : Results: From January 2019 to April 2021, 27 patients were enrolled. ORR after 12 weeks of treatment was 4% (1 of 27). Median progression- ... ...

Abstract	Introduction: EGFR Methods: In this multicenter, single-arm, phase 1-2 study (NCT03784599), patients with Results: From January 2019 to April 2021, 27 patients were enrolled. ORR after 12 weeks of treatment was 4% (1 of 27). Median progression-free survival was 2.8 months (95% confidence interval: 1.4-4.6 mo). Most frequent treatment-related adverse events of any grade were fatigue, diarrhea, and nausea, among these, grade 3 in four patients. There were no grade 4 or 5 therapy-related adverse events. Conclusions: TRAEMOS (Trastuzumab-Emtansine and Osimertinib) is the first trial combining T-DM1 and osimertinib in patients with
Language	English
Publishing date	2023-02-24
Publishing country	United States
Document type	Journal Article
ISSN	2666-3643
ISSN (online)	2666-3643
DOI	10.1016/j.jtocrr.2023.100481
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Article ; Online: Eculizumab impairs killing of Neisseria meningitidis serogroup B in atypical hemolytic uremic syndrome patients vaccinated with MenB-4C.

van den Broek, Bryan / van der Flier, Michiel / van de Kar, Nicole C A J / Wetzels, Jack F M / de Jonge, Marien I / de Groot, Ronald / Wijnsma, Kioa L / Langereis, Jeroen D

Kidney international

2022 Volume 101, Issue 6, Page(s) 1293–1295

MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Atypical Hemolytic Uremic Syndrome/drug therapy ; Humans ; Neisseria meningitidis, Serogroup B ; Serogroup
Chemical Substances	Antibodies, Monoclonal, Humanized ; eculizumab (A3ULP0F556)
Language	English
Publishing date	2022-05-18
Publishing country	United States
Document type	Letter
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2022.03.010
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Zs.A 797: Show issues

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Article: Calibrating the Bacterial Growth Rate Speedometer: A Re-evaluation of the Relationship Between Basal ppGpp, Growth, and RNA Synthesis in

Imholz, Nicole C E / Noga, Marek J / van den Broek, Niels J F / Bokinsky, Gregory

Frontiers in microbiology

2020 Volume 11, Page(s) 574872

Abstract: The molecule guanosine tetraphophosphate (ppGpp) is most commonly considered an alarmone produced during acute stress. However, ppGpp is also present at low concentrations during steady-state growth. Whether ppGpp controls the same cellular targets at ... ...

Abstract	The molecule guanosine tetraphophosphate (ppGpp) is most commonly considered an alarmone produced during acute stress. However, ppGpp is also present at low concentrations during steady-state growth. Whether ppGpp controls the same cellular targets at both low and high concentrations remains an open question and is vital for understanding growth rate regulation. It is widely assumed that basal ppGpp concentrations vary inversely with growth rate, and that the main function of basal ppGpp is to regulate transcription of ribosomal RNA in response to environmental conditions. Unfortunately, studies to confirm this relationship and to define regulatory targets of basal ppGpp are limited by difficulties in quantifying basal ppGpp. In this Perspective we compare reported concentrations of basal ppGpp in
Language	English
Publishing date	2020-09-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2020.574872
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Article ; Online: Combining variant detection and fragment length analysis improves detection of minimal residual disease in postsurgery circulating tumour DNA of stage II-IIIA NSCLC patients.

Vessies, Daan C L / Schuurbiers, Milou M F / van der Noort, Vincent / Schouten, Irene / Linders, Theodora C / Lanfermeijer, Mirthe / Ramkisoensing, Kalpana L / Hartemink, Koen J / Monkhorst, Kim / van den Heuvel, Michel M / van den Broek, Daan

Molecular oncology

2022 Volume 16, Issue 14, Page(s) 2719–2732

Abstract: Stage II-IIIA nonsmall cell lung cancer (NSCLC) patients receive adjuvant chemotherapy after surgery as standard-of-care treatment, even though only approximately 5.8% of patients will benefit. Identifying patients with minimal residual disease (MRD) ... ...

Abstract	Stage II-IIIA nonsmall cell lung cancer (NSCLC) patients receive adjuvant chemotherapy after surgery as standard-of-care treatment, even though only approximately 5.8% of patients will benefit. Identifying patients with minimal residual disease (MRD) after surgery using tissue-informed testing of postoperative plasma circulating cell-free tumour DNA (ctDNA) may allow adjuvant therapy to be withheld from patients without MRD. However, the detection of MRD in the postoperative setting is challenging, and more sensitive methods are urgently needed. We developed a method that combines variant calling and a novel ctDNA fragment length analysis using hybrid capture sequencing data. Among 36 stage II-IIIA NSCLC patients, this method distinguished patients with and without recurrence of disease in a 20 times repeated 10-fold cross validation with 75% accuracy (P = 0.0029). In contrast, using only variant calling or only fragment length analysis, no signification distinction between patients was shown (P = 0.24 and P = 0.074 respectively). In addition, a variant-level fragmentation score was developed that was able to classify variants detected in plasma cfDNA into tumour-derived or white-blood-cell-derived variants with 84% accuracy. The findings in this study may help drive the integration of various types of information from the same data, eventually leading to cheaper and more sensitive techniques to be used in this challenging clinical setting.
MeSH term(s)	Biomarkers, Tumor/genetics ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/surgery ; Cell-Free Nucleic Acids ; Circulating Tumor DNA/genetics ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Lung Neoplasms/surgery ; Neoplasm, Residual/diagnosis ; Neoplasm, Residual/genetics ; Neoplasm, Residual/pathology
Chemical Substances	Biomarkers, Tumor ; Cell-Free Nucleic Acids ; Circulating Tumor DNA
Language	English
Publishing date	2022-06-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2415106-3
ISSN	1878-0261 ; 1574-7891
ISSN (online)	1878-0261
ISSN	1574-7891
DOI	10.1002/1878-0261.13267
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Zs.A 6637: Show issues

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Article ; Online: De banaan

Kema, G.H.J. / van Rijn, F.C. / Govers, F. / Reumer, J. / van den Broek, J. / Smit, A.

de onbekende wereld achter ons favoriete fruit

2022

Abstract: ... Nederbanaan’ haar tropische zus van de ondergang redden?Hierover gaat De banaan. En over veel meer. Je kunt ... er zelfs papier, lingerie of pallets van maken. En dit exotische fruit is ook bijzonder populair in de ...

Abstract	Diverse soorten schimmels bedreigen de wereldwijde teelt. Met grote hoeveelheden bestrijdingsmiddelen wordt de productie overeind gehouden, maar hoe lang nog? En er is nog een probleem: de bananenproductie heeft een aanzienlijke ecologische voetafdruk. De banaan wordt immers in de tropen verbouwd en naar Europa verscheept. Bovendien smaakt de vruchtvoor de vele kleinschalige boeren met een schamel inkomen een stuk minder ‘zoet’. Naar welke oplossingen zoeken telers en wetenschappers? Kan de ‘Nederbanaan’ haar tropische zus van de ondergang redden?Hierover gaat De banaan. En over veel meer. Je kunt er zelfs papier, lingerie of pallets van maken. En dit exotische fruit is ook bijzonder populair in de kunst. Na dit boek smaken bananen voor altijd anders.
Keywords	Life Science
Language	Dutch
Publisher	Uitgeverij Lias
Publishing country	nl
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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