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  1. Article ; Online: Choosing a Prokinetic.

    Guslandi, Mario

    The American journal of gastroenterology

    2020  Volume 115, Issue 5, Page(s) 795

    MeSH term(s) Gastric Emptying/drug effects ; Gastrointestinal Agents/pharmacology ; Humans ; Metoclopramide/pharmacology
    Chemical Substances Gastrointestinal Agents ; Metoclopramide (L4YEB44I46)
    Language English
    Publishing date 2020-02-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000000568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Role of Probiotics in Crohn's Disease and in Pouchitis.

    Guslandi, Mario

    Journal of clinical gastroenterology

    2015  Volume 49 Suppl 1, Page(s) S46–9

    Abstract: The alterations in the gut microbiota observed in patients with inflammatory bowel disease and in particular in Crohn's disease and in ulcerative colitis patients with pouchitis, provide the rationale for administering probiotic agents in the medical ... ...

    Abstract The alterations in the gut microbiota observed in patients with inflammatory bowel disease and in particular in Crohn's disease and in ulcerative colitis patients with pouchitis, provide the rationale for administering probiotic agents in the medical treatment of those conditions. In the maintenance treatment of inactive Crohn's disease probiotics, when administered alone, were found ineffective in preventing clinical and/or endoscopic recurrence. By contrast, a combination of a probiotic agent (eg, Saccharomyces boulardii) with standard pharmacological therapy can promote clinical benefit. In patients with pouchitis, so far only the probiotic mixture VSL #3 proved to effectively prevent relapses after successful antibiotic treatment of active inflammation. Further controlled studies, enrolling higher numbers of patients, are needed to better identify the exact role of probiotics in this area.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Crohn Disease/microbiology ; Crohn Disease/therapy ; Gastrointestinal Microbiome ; Humans ; Pouchitis/microbiology ; Pouchitis/therapy ; Probiotics/therapeutic use ; Recurrence ; Saccharomyces
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/MCG.0000000000000351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Patologia gastroduodenale da farmaci antinfiammatori non steroidei

    Guslandi, Mario

    1995  

    Author's details Mario Guslandi
    Keywords Gastric Mucosa / drug effects ; Gastrointestinal Diseases / chemically induced ; Anti-Inflammatory Agents, Non-Steroidal / adverse effects ; Nichtsteroidales Antiphlogistikum ; Gastrointestinale Krankheit ; Arzneimittelschaden
    Subject Arzneimittel ; Magen-Darm-Krankheit ; Magen-Darm-Kanal ; Nonsteroidal anti-inflammatory drug ; NSAID ; Nichtsteroidales Antirheumatikum ; NSAR ; Nicht-opioides Analgetikum
    Language Italian
    Size 113 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Document type Book
    HBZ-ID HT007153407
    ISBN 3-540-75006-1 ; 978-3-540-75006-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1996 A 2393 order for loan Magazin

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  4. Article: Steroid ulcers: Any news?

    Guslandi, Mario

    World journal of gastrointestinal pharmacology and therapeutics

    2013  Volume 4, Issue 3, Page(s) 39–40

    Abstract: Steroid ulcers, although a common feature in experimental studies, seldom develop in clinical practice, as observed by the meta-analyses carried out in the 90s. Corticosteroids alone become ulcerogenic only if treatment lasts longer than one month and ... ...

    Abstract Steroid ulcers, although a common feature in experimental studies, seldom develop in clinical practice, as observed by the meta-analyses carried out in the 90s. Corticosteroids alone become ulcerogenic only if treatment lasts longer than one month and the total administered dose exceeds 1000 mg. On the other hand concomitant intake of non-steroidal anti-inflammatory drugs results in a synergistic, highly damaging effect on the gastroduodenal mucosa. Thus, despite the survival of the steroid ulcer myth in the medical culture, pharmacological protection against steroid-induced peptic ulcers is a rare necessity while the best prophylactic strategy still remains to be determined.
    Language English
    Publishing date 2013-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583480-0
    ISSN 2150-5349
    ISSN 2150-5349
    DOI 10.4292/wjgpt.v4.i3.39
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  5. Article ; Online: Increased vulnerability of the aging stomach to NSAIDs.

    Guslandi, Mario

    Digestive diseases and sciences

    2013  Volume 58, Issue 5, Page(s) 1443

    MeSH term(s) Aging/physiology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Indomethacin/adverse effects ; Male ; Stomach/drug effects ; Stomach/physiology
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Indomethacin (XXE1CET956)
    Language English
    Publishing date 2013-03-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-013-2616-y
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  6. Article ; Online: Probiotics in diverticular disease: not ready for prime time?

    Guslandi, Mario

    Expert review of gastroenterology & hepatology

    2013  Volume 7, Issue 7, Page(s) 585–586

    MeSH term(s) Animals ; Colon/microbiology ; Diverticulitis, Colonic/microbiology ; Diverticulitis, Colonic/therapy ; Diverticulosis, Colonic/microbiology ; Diverticulosis, Colonic/therapy ; Humans ; Probiotics/adverse effects ; Probiotics/therapeutic use ; Recurrence ; Treatment Outcome
    Language English
    Publishing date 2013-09
    Publishing country England
    Document type Editorial
    ZDB-ID 2481021-6
    ISSN 1747-4132 ; 1747-4124
    ISSN (online) 1747-4132
    ISSN 1747-4124
    DOI 10.1586/17474124.2013.832491
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  7. Article ; Online: Role of probiotics in the management of pouchitis.

    Guslandi, Mario

    Current pharmaceutical design

    2013  Volume 20, Issue 28, Page(s) 4561–4564

    Abstract: The concept that the gut microbiota plays a major role in the development of pouchitis in ulcerative colitis patients after restorative proctocolectomy with ileal pouch-anal anastomosis, is widely accepted and supported by a widespread use of some ... ...

    Abstract The concept that the gut microbiota plays a major role in the development of pouchitis in ulcerative colitis patients after restorative proctocolectomy with ileal pouch-anal anastomosis, is widely accepted and supported by a widespread use of some antibiotics (metronidazole and/or ciprofloxacin, rifaximin) to treat this condition. A possible, safer therapeutic alternative is represented by probiotics. To date the controlled studies addressing the possible efficacy of probiotic agents in the treatment of active pouchitis are few and inconclusive. By contrast the prophylactic use of a probiotic mixture (VSL #3) appears to be able to prevent development of pouchitis. The most convincing results have been observed in the maintenance of remission, where the probiotic mixture has been found, in most of the performed controlled trials, significantly effective in preventing pouchitis recurrence.
    MeSH term(s) Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Ciprofloxacin/administration & dosage ; Ciprofloxacin/therapeutic use ; Colitis, Ulcerative/surgery ; Humans ; Intestines/microbiology ; Metronidazole/administration & dosage ; Metronidazole/therapeutic use ; Pouchitis/etiology ; Pouchitis/prevention & control ; Pouchitis/therapy ; Probiotics/therapeutic use ; Proctocolectomy, Restorative/methods ; Recurrence ; Rifamycins/administration & dosage ; Rifamycins/therapeutic use ; Rifaximin
    Chemical Substances Anti-Bacterial Agents ; Rifamycins ; Metronidazole (140QMO216E) ; Ciprofloxacin (5E8K9I0O4U) ; Rifaximin (L36O5T016N)
    Language English
    Publishing date 2013-05-07
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/13816128113196660724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Methotrexate for inflammatory bowel disease.

    Guslandi, Mario

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2013  Volume 11, Issue 8, Page(s) 1039

    MeSH term(s) Crohn Disease/drug therapy ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Mercaptopurine/therapeutic use ; Methotrexate/therapeutic use
    Chemical Substances Immunosuppressive Agents ; Mercaptopurine (E7WED276I5) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2013-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2013.02.019
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  9. Article ; Online: Microscopic colitis: a therapeutic challenge.

    Guslandi, Mario

    World journal of gastroenterology

    2013  Volume 19, Issue 23, Page(s) 3531–3533

    Abstract: The treatment of microscopic colitis is mainly based on the use of budesonide, the only drug found effective in controlled clinical trials. After an initial course at a dose of 9 mg daily, however, most patients relapse when the drug is discontinued, ... ...

    Abstract The treatment of microscopic colitis is mainly based on the use of budesonide, the only drug found effective in controlled clinical trials. After an initial course at a dose of 9 mg daily, however, most patients relapse when the drug is discontinued, hence a maintenance therapy at doses of 6 mg daily or lower is necessary. In order to avoid steroid dependence and drug toxicity different pharmacological agents should be considered as an alternative to indefinite long-term budesonide treatment. Evidence-based guidelines are currently lacking due to the lack of conclusive data concerning the use of either immunosuppressive or anti-tumor necrosis factor agents. For the time being in clinical practice the skilled physician should therefore tailor long term management of microscopic colitis on the single patient.
    MeSH term(s) Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/adverse effects ; Budesonide/administration & dosage ; Budesonide/adverse effects ; Colitis, Microscopic/diagnosis ; Colitis, Microscopic/drug therapy ; Drug Administration Schedule ; Glucocorticoids/administration & dosage ; Glucocorticoids/adverse effects ; Humans ; Immunosuppressive Agents/administration & dosage ; Recurrence ; Remission Induction ; Risk Factors ; Time Factors ; Treatment Outcome
    Chemical Substances Anti-Inflammatory Agents ; Glucocorticoids ; Immunosuppressive Agents ; Budesonide (51333-22-3)
    Language English
    Publishing date 2013-06-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v19.i23.3531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Non-steroidal anti-inflammatory drugs-induced small intestinal injury and probiotic agents.

    Guslandi, Mario

    World journal of gastroenterology

    2012  Volume 18, Issue 31, Page(s) 4241–4242

    Abstract: Intestinal bacteria play a role in the development of non-steroidal anti-inflammatory drugs (NSAID)-induced small intestinal injury. Agents such as probiotics, able to modify the gut ecology, might theoretically be useful in preventing small intestinal ... ...

    Abstract Intestinal bacteria play a role in the development of non-steroidal anti-inflammatory drugs (NSAID)-induced small intestinal injury. Agents such as probiotics, able to modify the gut ecology, might theoretically be useful in preventing small intestinal damage induced by NSAIDs. The clinical studies available so far do suggest that some probiotic agents can be effective in this respect.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Capsule Endoscopy ; Humans ; Incidence ; Intestinal Diseases/epidemiology ; Intestinal Diseases/pathology ; Intestinal Diseases/prevention & control ; Intestine, Small/drug effects ; Intestine, Small/injuries ; Intestine, Small/pathology ; Probiotics/therapeutic use ; Treatment Outcome
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2012-01-11
    Publishing country United States
    Document type Letter
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v18.i31.4241
    Database MEDical Literature Analysis and Retrieval System OnLINE

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