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  1. Article ; Online: Task shifting eating disorders prevention: A pilot study of selective interventions adapted for teacher-led universal delivery in secondary schools.

    Atkinson, Melissa J / Parnell, Jade / Diedrichs, Phillippa C

    The International journal of eating disorders

    2023  Volume 57, Issue 2, Page(s) 327–340

    Abstract: ... of mixed-gender adolescents.: Method: A three-arm controlled pilot study with Year 9 students (N = 288 ... of condition across post-intervention and follow-up for body esteem (DBI > CAU; Cohen's d = .34) and positive ... affect (MBI > CAU, d = .58). For girls only, both MBI and DBI improved body satisfaction and ...

    Abstract Objective: Increasing effectiveness and sustainability of universal school-based eating disorder prevention is needed. This study adapted two existing selective prevention programmes for universal delivery, investigating feasibility, acceptability, and preliminary effects when delivered by trained teachers to classes of mixed-gender adolescents.
    Method: A three-arm controlled pilot study with Year 9 students (N = 288; M
    Results: Delivery and evaluation were feasible, allowing for flexibility in scheduling, with good retention. Student and teacher ratings indicated moderate acceptability of both interventions, with recommendations for refinement. Mixed model analyses, controlling for baseline, showed significant effects of condition across post-intervention and follow-up for body esteem (DBI > CAU; Cohen's d = .34) and positive affect (MBI > CAU, d = .58). For girls only, both MBI and DBI improved body satisfaction and internalization, and the MBI additionally resulted in improved weight and shape concerns, negative affect, and life disengagement (d's = .39-1.12), across post-intervention and follow-up.
    Discussion: Selective eating disorder prevention programmes based on cognitive dissonance and mindfulness can be delivered universally in schools, by teachers, allowing for appropriate flexibility necessary for real world implementation. Moderate acceptability indicates areas for improving content and delivery; positive effects on key outcomes are encouraging. These findings provide support for further robust evaluation.
    Public significance: Existing universal eating disorder prevention is limited by small effects and reliance on highly trained facilitators. This study is the first to adapt mindfulness- and dissonance-based interventions for delivery by teachers, to adolescents of all genders in a classroom setting. Delivery was largely feasible and acceptable, and both interventions showed significant effects across key risk factors for eating disorders, with larger effect sizes than found previously. This underpins further robust evaluation.
    MeSH term(s) Adolescent ; Humans ; Male ; Female ; Middle Aged ; Pilot Projects ; Task Shifting ; Mindfulness ; Feeding and Eating Disorders/prevention & control ; Schools
    Language English
    Publishing date 2023-11-25
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 603170-5
    ISSN 1098-108X ; 0276-3478
    ISSN (online) 1098-108X
    ISSN 0276-3478
    DOI 10.1002/eat.24100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Proceedings of the 2022 annual meeting of the Fetal Alcohol Spectrum Disorders study group.

    Petrenko, Christie L M / Hamre, Kristin M / Brigman, Jonathan L / Parnell, Scott

    Alcohol (Fayetteville, N.Y.)

    2023  Volume 113, Page(s) 11–20

    Abstract: ... researcher. Invited plenary speakers included Jill Locke, Ph.D., who provided an engaging introduction ... to implementation science, and Jared Young, Ph.D., who discussed cross-species domain task specificity. The meeting ... on the Toward Health Outcomes intervention roadmap by Jacqueline Pei, Ph.D. ...

    Abstract The 2022 Fetal Alcohol Spectrum Disorders Study Group (FASDSG) meeting was held in coordination with the 45th annual Research Society on Alcoholism conference on June 25th, 2022. The theme of the meeting was "Enhancing the Relevance of Research for the Community." The program began with a moderated panel discussion on the value of community-engaged research, which included two self-advocates and a clinical and pre-clinical researcher. Invited plenary speakers included Jill Locke, Ph.D., who provided an engaging introduction to implementation science, and Jared Young, Ph.D., who discussed cross-species domain task specificity. The meeting also included updates from three government agencies, short presentations by junior and senior investigators showcasing late-breaking FASD research, trainee award winners, and a presentation on the Toward Health Outcomes intervention roadmap by Jacqueline Pei, Ph.D.
    MeSH term(s) Female ; Pregnancy ; Humans ; Fetal Alcohol Spectrum Disorders/diagnosis ; Alcoholism/diagnosis ; Awards and Prizes
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 605912-0
    ISSN 1873-6823 ; 0741-8329
    ISSN (online) 1873-6823
    ISSN 0741-8329
    DOI 10.1016/j.alcohol.2023.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Elevated UTI Biomarkers in Symptomatic Patients with Urine Microbial Densities of 10,000 CFU/mL Indicate a Lower Threshold for Diagnosing UTIs.

    Parnell, Laura K S / Luke, Natalie / Mathur, Mohit / Festa, Richard A / Haley, Emery / Wang, Jimin / Jiang, Yan / Anderson, Lori / Baunoch, David

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 16

    Abstract: The literature lacks consensus on the minimum microbial density required for diagnosing urinary tract infections (UTIs). This study categorized the microbial densities of urine specimens from symptomatic UTI patients aged ≥ 60 years and correlated them ... ...

    Abstract The literature lacks consensus on the minimum microbial density required for diagnosing urinary tract infections (UTIs). This study categorized the microbial densities of urine specimens from symptomatic UTI patients aged ≥ 60 years and correlated them with detected levels of the immune response biomarkers neutrophil gelatinase-associated lipocalin (NGAL), interleukin-8 (IL-8), and interleukin-1-beta (IL-1β). The objective was to identify the microbial densities associated with significant elevation of these biomarkers in order to determine an optimal threshold for diagnosing symptomatic UTIs. Biobanked midstream voided urine samples were analyzed for microbial identification and quantification using standard urine culture (SUC) and multiplex-polymerase chain reaction (M-PCR) testing, while NGAL, IL-8, and IL-1β levels were measured via enzyme-linked immunosorbent assay (ELISA). NGAL, IL-8, and IL-1β levels were all significantly elevated at microbial densities ≥ 10,000 cells/mL when measured via M-PCR (
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13162688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration.

    Cosway, Emilie J / James, Kieran D / White, Andrea J / Parnell, Sonia M / Bacon, Andrea / McKenzie, Andrew N J / Jenkinson, W E / Anderson, Graham

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 7201

    Abstract: As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from environmental ... ...

    Abstract As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from environmental factors and therapeutic interventions. Here, we show the alarmin interleukin (IL) 33 is a product of Sca1
    MeSH term(s) Interleukin-33 ; Alarmins ; Immunity, Innate ; Interleukin-4 ; Lymphocytes
    Chemical Substances Interleukin-33 ; Alarmins ; Interleukin-4 (207137-56-2)
    Language English
    Publishing date 2023-11-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43072-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Influence of translational vehicle dynamics on heavy vehicle noise emission.

    Peng, Jeffrey / Liu, Daipei / Parnell, Jeffrey / Kessissoglou, Nicole

    The Science of the total environment

    2019  Volume 689, Page(s) 1358–1369

    Abstract: Vehicle dynamics can play a significant role in the noise emission from heavy vehicles. In this work, a heavy vehicle noise emission model is presented to study the influence of translational vehicle dynamics on the sound power level emitted by heavy- ... ...

    Abstract Vehicle dynamics can play a significant role in the noise emission from heavy vehicles. In this work, a heavy vehicle noise emission model is presented to study the influence of translational vehicle dynamics on the sound power level emitted by heavy-duty trucks. Vehicle speed and acceleration are calculated using an analytical approximation that describes the tractive and retarding forces acting on a heavy vehicle on grade. Heavy vehicle noise emission associated with rolling noise is defined with reference to the Nordic traffic noise model that takes into account the number of axles for different articulated trucks. An expression for engine noise emission in terms of vehicle speed, weight, engine power, aerodynamic properties and road grade is derived. The individual and combined effects of engine noise and rolling noise for different vehicle mass combinations are examined. The influence of road grade on vehicle kinematics and noise emission is also investigated.
    Language English
    Publishing date 2019-06-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2019.06.426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Urine biomarkers individually and as a consensus model show high sensitivity and specificity for detecting UTIs.

    Akhlaghpour, Marzieh / Haley, Emery / Parnell, Laura / Luke, Natalie / Mathur, Mohit / Festa, Richard A / Percaccio, Michael / Magallon, Jesus / Remedios-Chan, Mariana / Rosas, Alain / Wang, Jimin / Jiang, Yan / Anderson, Lori / Baunoch, David

    BMC infectious diseases

    2024  Volume 24, Issue 1, Page(s) 153

    Abstract: Background: Current diagnoses of urinary tract infection (UTI) by standard urine culture (SUC) has significant limitations in sensitivity, especially for fastidious organisms, and the ability to identify organisms in polymicrobial infections. The ... ...

    Abstract Background: Current diagnoses of urinary tract infection (UTI) by standard urine culture (SUC) has significant limitations in sensitivity, especially for fastidious organisms, and the ability to identify organisms in polymicrobial infections. The significant rate of both SUC "negative" or "mixed flora/contamination" results in UTI cases and the high prevalence of asymptomatic bacteriuria indicate the need for an accurate diagnostic test to help identify true UTI cases. This study aimed to determine if infection-associated urinary biomarkers can differentiate definitive UTI cases from non-UTI controls.
    Methods: Midstream clean-catch voided urine samples were collected from asymptomatic volunteers and symptomatic subjects ≥ 60 years old diagnosed with a UTI in a urology specialty setting. Microbial identification and density were assessed using a multiplex PCR/pooled antibiotic susceptibility test (M-PCR/P-AST) and SUC. Three biomarkers [neutrophil gelatinase-associated lipocalin (NGAL), and Interleukins 8 and 1β (IL-8, and IL-1β)] were also measured via enzyme-linked immunosorbent assay (ELISA). Definitive UTI cases were defined as symptomatic subjects with a UTI diagnosis and positive microorganism detection by SUC and M-PCR, while definitive non-UTI cases were defined as asymptomatic volunteers.
    Results: We observed a strong positive correlation (R
    Conclusion: We demonstrated that positive infection-associated urinary biomarkers NGAL, IL-8, and IL-1β, in symptomatic subjects with positive SUC and/or M-PCR results was associated with definitive UTI cases. A consensus criterion with ≥ 2 of the biomarkers meeting the positivity thresholds showed a good balance of sensitivity (84.0%), specificity (91.2%), and accuracy (86.9%). Therefore, this biomarker consensus is an excellent supportive diagnostic tool for resolving the presence of active UTI, particularly if SUC and M-PCR results disagree.
    MeSH term(s) Humans ; Middle Aged ; Lipocalin-2 ; Interleukin-8 ; Consensus ; ROC Curve ; Urinary Tract Infections/diagnosis ; Biomarkers ; Sensitivity and Specificity
    Chemical Substances Lipocalin-2 ; Interleukin-8 ; Biomarkers
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-024-09044-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Compound-specific stable isotopes of amino acids reveal influences of trophic level and primary production sources on mercury concentrations in fishes from the Aleutian Islands, Alaska.

    Trifari, Michelle P / Wooller, Matthew J / Rea, Lorrie / O'Hara, Todd M / Lescord, Gretchen L / Parnell, Andrew C / Barst, Benjamin D

    The Science of the total environment

    2023  Volume 908, Page(s) 168242

    Abstract: ... the proportional contributions of primary production sources and trophic positions of eight prey species (n = 474 ...

    Abstract Total mercury concentrations ([THg]) exceed thresholds of concern in some Steller sea lion (Eumetopias jubatus) tissues from certain portions of the Aleutian Islands, Alaska. We applied compound-specific stable isotope analyses of both carbon and nitrogen in amino acids from fish muscle tissue to quantify the proportional contributions of primary production sources and trophic positions of eight prey species (n = 474 total) that are part of Steller sea lion diets. Previous THg analyses of fish muscle, coupled with monomethylmercury analyses of a subset of samples, substantiated previous findings that fishes from the west of Amchitka Pass, a discrete oceanographic boundary of the Aleutian Archipelago, have higher muscle Hg concentrations relative to fishes from the east. The δ
    MeSH term(s) Animals ; Mercury/analysis ; Alaska ; Amino Acids/metabolism ; Sea Lions/metabolism ; Water Pollutants, Chemical/analysis ; Fishes/metabolism ; Food Chain ; Nitrogen Isotopes/analysis ; Environmental Monitoring
    Chemical Substances Mercury (FXS1BY2PGL) ; Amino Acids ; Water Pollutants, Chemical ; Nitrogen Isotopes
    Language English
    Publishing date 2023-10-31
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.168242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Expression of CYP24A1 and other multiple sclerosis risk genes in peripheral blood indicates response to vitamin D in homeostatic and inflammatory conditions.

    Law, Samantha P L / Gatt, Prudence N / Schibeci, Stephen D / McKay, Fiona C / Vucic, Steve / Hart, Prue / Byrne, Scott N / Brown, David / Stewart, Graeme J / Liddle, Christopher / Parnell, Grant P / Booth, David R

    Genes and immunity

    2021  Volume 22, Issue 4, Page(s) 227–233

    Abstract: Although genetic and epidemiological evidence indicates vitamin D insufficiency contributes ... to multiple sclerosis (MS), and serum levels of vitamin D increase on treatment with cholecalciferol, recent metanalyses ... indicate that this vitamin D form does not ameliorate disease. Genetic variation in genes regulating ...

    Abstract Although genetic and epidemiological evidence indicates vitamin D insufficiency contributes to multiple sclerosis (MS), and serum levels of vitamin D increase on treatment with cholecalciferol, recent metanalyses indicate that this vitamin D form does not ameliorate disease. Genetic variation in genes regulating vitamin D, and regulated by vitamin D, affect MS risk. We evaluated if the expression of vitamin D responsive MS risk genes could be used to assess vitamin D response in immune cells. Peripheral blood mononuclear cells (PBMCs) were isolated from healthy controls and people with MS treated with dimethyl fumarate. We assayed changes in expression of vitamin D responsive MS risk (VDRMS) genes in response to treatment with 25 hydroxy vitamin D in the presence or absence of inflammatory stimuli. Expression of CYP24A1 and other VDRMS genes was significantly altered in PBMCs treated with vitamin D in the homeostatic and inflammatory models. Gene expression in MS samples had similar responses to controls, but lower initial expression of the risk genes. Vitamin D treatment abrogated these differences. Expression of CYP24A1 and other MS risk genes in blood immune cells indicate vitamin D response and could enable assessment of immunological response to vitamin D in clinical trials and on therapy.
    MeSH term(s) Humans ; Leukocytes, Mononuclear ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/genetics ; Vitamin D ; Vitamin D3 24-Hydroxylase/genetics
    Chemical Substances Vitamin D (1406-16-2) ; CYP24A1 protein, human (EC 1.14.15.16) ; Vitamin D3 24-Hydroxylase (EC 1.14.15.16)
    Language English
    Publishing date 2021-06-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2060566-3
    ISSN 1476-5470 ; 1466-4879
    ISSN (online) 1476-5470
    ISSN 1466-4879
    DOI 10.1038/s41435-021-00144-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration

    Emilie J. Cosway / Kieran D. James / Andrea J. White / Sonia M. Parnell / Andrea Bacon / Andrew N. J. McKenzie / W. E. Jenkinson / Graham Anderson

    Nature Communications, Vol 14, Iss 1, Pp 1-

    2023  Volume 11

    Abstract: Abstract As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from ... ...

    Abstract Abstract As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from environmental factors and therapeutic interventions. Here, we show the alarmin interleukin (IL) 33 is a product of Sca1+ thymic mesenchyme both necessary and sufficient for thymus regeneration via a type 2 innate immune network. IL33 stimulates expansion of IL5-producing type 2 innate lymphoid cells (ILC2), which triggers a cellular switch in the intrathymic availability of IL4. This enables eosinophil production of IL4 to re-establish thymic mesenchyme prior to recovery of thymopoiesis-inducing epithelial compartments. Collectively, we identify a positive feedback mechanism of type 2 innate immunity that regulates the recovery of thymus function following tissue injury.
    Keywords Science ; Q
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Quantitative multiplex polymerase chain reaction in copies ml-1 linearly correlates with standard urine culture in colonies ml-1 for urinary tract infection (UTI) pathogens.

    Festa, Richard A / Opel, Mike / Mathur, Mohit / Luke, Natalie / Parnell, Laura K S / Wang, Dakun / Zhao, Xinhua / Magallon, Jesus / Percaccio, Michael / Baunoch, David

    Letters in applied microbiology

    2023  Volume 76, Issue 8

    Abstract: Standard urine culture (SUC) is the current standard method for confirmation of a urinary tract infection (UTI). SUC identifies microorganisms in urine samples and semi-quantifies these as colony-forming units (CFUs) ml-1. In contrast, quantitative ... ...

    Abstract Standard urine culture (SUC) is the current standard method for confirmation of a urinary tract infection (UTI). SUC identifies microorganisms in urine samples and semi-quantifies these as colony-forming units (CFUs) ml-1. In contrast, quantitative multiplex polymerase chain reaction (q-MPCR) is a culture-independent assay in which the microbes are quantified by targeting genomic sequences and reported as cells ml-1, calculated from copies ml-1. Using serial dilutions within the 104-105 cells ml-1 range, the usual reporting range of SUC, this study compared the quantification results based on SUC and q-MPCR for four uropathogens with the control hemocytometer counts. The results revealed a linear relationship and a 1:1 correlation between the q-MPCR and SUC results. Additional q-MPCR quantification of 36 uropathogenic non-fastidious and fastidious bacteria and yeast indicated a reproducible linear correlation in a 1:1 manner with the control counts over a range of cell densities (103-106 cells ml-1). The results confirm that the quantifications by q-MPCR in cells ml-1 and by SUC in CFUs ml-1 are comparable and answer to the lingering question of how the results of these two methods correlate. Moreover, q-MPCR provided accurate quantification of various microorganisms over wider cell density ranges without the time required for microbial growth.
    MeSH term(s) Humans ; Multiplex Polymerase Chain Reaction/methods ; Sensitivity and Specificity ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/microbiology ; Urinalysis/methods ; Bacteria/genetics
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 632584-1
    ISSN 1472-765X ; 0266-8254
    ISSN (online) 1472-765X
    ISSN 0266-8254
    DOI 10.1093/lambio/ovad085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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