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  1. Article ; Online: Editorial: Pip pip to PIPs (post- inflammatory polyps) as a neoplasia risk factor in IBD? Authors' reply.

    Kirchgesner, Julien / Beaugerie, Laurent

    Alimentary pharmacology & therapeutics

    2023  Volume 58, Issue 3, Page(s) 363

    MeSH term(s) Humans ; Risk Factors ; Inflammatory Bowel Diseases ; Colorectal Neoplasms
    Language English
    Publishing date 2023-07-15
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17612
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply.

    Kirchgesner, Julien / Beaugerie, Laurent

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2021  Volume 20, Issue 2, Page(s) e345

    Language English
    Publishing date 2021-05-28
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2021.05.047
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    Zs.A 5836: Show issues Location:
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  3. Article ; Online: Risk of colorectal neoplasia according to histologic disease activity in patients with inflammatory bowel disease and colonic post-inflammatory polyps.

    Wolf, Thomas / Lewis, Ayanna / Beaugerie, Laurent / Svrcek, Magali / Kirchgesner, Julien

    Alimentary pharmacology & therapeutics

    2023  Volume 57, Issue 12, Page(s) 1445–1452

    Abstract: Background and aims: While post-inflammatory polyps (PIPs) have historically been a risk factor for colorectal neoplasia (CRN), histologic activity may explain this association. We aimed to assess the impact of histologic activity on CRN occurrence in ... ...

    Abstract Background and aims: While post-inflammatory polyps (PIPs) have historically been a risk factor for colorectal neoplasia (CRN), histologic activity may explain this association. We aimed to assess the impact of histologic activity on CRN occurrence in IBD patients with colonic PIPs.
    Methods: Patients with PIPs on surveillance colonoscopy at Saint-Antoine hospital between 1 January 1996 and 31 December 2020 were included and subsequent colonoscopies were assessed. Histologic IBD activity was assessed by the Nancy histologic index. Survival and Cox regression analysis were performed to assess the strength of the association of PIPs and other patient variables with progression to CRN.
    Results: A total of 173 patients with at least two surveillance colonoscopies with PIPs at index colonoscopy were compared to a similar group of 252 patients without PIPs. In survival analysis, the presence or PIPs at index colonoscopy did not impact the risk of CRN in patients with histological inflammation (p = 0.83) and in patients without histological inflammation (p = 0.98). The risk of CRN was associated with increasing Nancy index score of 3 or 4 (HR: 4.16; 95% CI 1.50-11.52 and HR: 3.44; 95% CI 1.63-7.24), age (HR per 10-year increase: 1.37; 95% CI 1.13-1.66) and first-degree family history of colorectal cancer (HR: 5.87; v 1.31-26.26), but not PIPs (HR: 1.17; 95% CI 0.63-2.17).
    Conclusions: After controlling for histologic activity, PIPs do not increase the risk of CRN in IBD patients. Histologic activity rather than PIPs should be considered in the risk assessment of CRN.
    MeSH term(s) Humans ; Colorectal Neoplasms/etiology ; Colorectal Neoplasms/epidemiology ; Inflammatory Bowel Diseases/complications ; Colitis, Ulcerative/epidemiology ; Colonic Polyps/diagnosis ; Colonic Polyps/complications ; Colonic Polyps/epidemiology ; Risk Factors ; Colonoscopy ; Inflammation/complications
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Do Thiopurines Really Decrease the Risk of Colorectal Cancer in Ulcerative Colitis? The Light is Coming from Concept-based Subgroup Analyses.

    Beaugerie, Laurent

    Journal of Crohn's & colitis

    2015  Volume 9, Issue 12, Page(s) 1061–1062

    MeSH term(s) Colitis, Ulcerative ; Colorectal Neoplasms ; Humans ; Risk
    Language English
    Publishing date 2015-12
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 2390120-2
    ISSN 1876-4479 ; 1873-9946
    ISSN (online) 1876-4479
    ISSN 1873-9946
    DOI 10.1093/ecco-jcc/jjv155
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    Zs.A 6634: Show issues Location:
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  5. Article ; Online: Impact of thiopurines and tumour necrosis factor antagonists on primary sclerosing cholangitis outcomes in patients with inflammatory bowel disease.

    Biron, Amélie / Beaugerie, Laurent / Chazouillères, Olivier / Kirchgesner, Julien

    Alimentary pharmacology & therapeutics

    2022  Volume 56, Issue 5, Page(s) 857–868

    Abstract: Background: Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) are at risk of biliary tract cancer and liver damage (possibly leading to liver transplantation), and are often treated for IBD with thiopurines and/or ... ...

    Abstract Background: Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) are at risk of biliary tract cancer and liver damage (possibly leading to liver transplantation), and are often treated for IBD with thiopurines and/or tumour necrosis factor antagonists (anti-TNF) on a long-term basis.
    Aims: To assess the risk of biliary tract cancer and liver transplantation in patients exposed to thiopurines and/or anti TNF agents in a French nationwide cohort.
    Methods: We performed a population-based study of patients aged 18 years or older with PSC and IBD in the French national health insurance database. Patients were followed from 1 January 2009 to 31 December 2018. The risks of biliary tract cancer and liver transplantation associated with thiopurines and anti-TNF exposure were assessed with marginal structural Cox proportional hazard models, adjusting for baseline demographics and comorbidities, and time-varying medications and PSC activity.
    Results: Among the 1929 patients with PSC and IBD included, 37 biliary tract cancers and 83 liver transplantations occurred. Compared with patients not exposed to thiopurines or anti-TNF agents, patients exposed to thiopurines (hazard ratio [HR], 1.05; 95% confidence interval [CI], 0.39-2.82) or anti-TNF agents (HR, 0.59; 95% CI, 0.13-2.80) had no excess risk of biliary tract cancer. Similarly, patients exposed to thiopurines (HR, 0.67; 95% CI, 0.30-1.48) or anti-TNF agents (HR, 0.68; CI, 0.22-2.09) had no excess risk of liver transplantation.
    Conclusions: Patients with PSC and IBD who are exposed to thiopurines or anti-TNF agents are not at excess risk of biliary tract cancer or liver transplantation.
    MeSH term(s) Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/drug therapy ; Humans ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Liver Transplantation/adverse effects ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Tumor Necrosis Factor Inhibitors/adverse effects
    Chemical Substances Tumor Necrosis Factor Inhibitors
    Language English
    Publishing date 2022-07-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Commentary: monitoring for myelosuppression in IBD.

    Beaugerie, L

    Alimentary pharmacology & therapeutics

    2013  Volume 37, Issue 1, Page(s) 154–5; discussion 155

    MeSH term(s) Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Inflammatory Bowel Diseases/drug therapy ; Leukopenia/diagnosis ; Male ; Medical Audit
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2013-01
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.12108
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  7. Article: Complications non digestives des maladies chroniques inflammatoires intestinales.

    Beaugerie, Laurent

    La Revue du praticien

    2014  Volume 64, Issue 9, Page(s) 1230–1231

    Title translation Non-digestive complications of inflammatory bowel diseases.
    MeSH term(s) Drug-Related Side Effects and Adverse Reactions/complications ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Humans ; Immunosuppressive Agents/therapeutic use ; Infection/epidemiology ; Infection/etiology ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/epidemiology ; Neoplasms/epidemiology ; Neoplasms/etiology
    Chemical Substances Immunosuppressive Agents
    Language French
    Publishing date 2014-11
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  8. Article: Histoire naturelle de l'atteinte intestinale des maladies inflammatoires chroniques de l'intestin.

    Beaugerie, Laurent

    La Revue du praticien

    2014  Volume 64, Issue 9, Page(s) 1226–1229

    Abstract: Crohn's disease may involve any part of the digestive tract from mouth to anus, but affects mainly the distal ileum and the,colon. At diagnosis, perianal lesions are observed in 20% of the cases. During the disease course, strictures develop in the ... ...

    Title translation Natural history of intestinal lesions in inflammatory bowel disease.
    Abstract Crohn's disease may involve any part of the digestive tract from mouth to anus, but affects mainly the distal ileum and the,colon. At diagnosis, perianal lesions are observed in 20% of the cases. During the disease course, strictures develop in the majority of patients with ileal disease, while penetrating lesions (fistulas and abscesses) develop in half of the patients. Only one third of patients with colonic involvement will develop structuring or penetrating lesions. Intestinal lesions of ulcerative colitis involve constantly the rectum and may extend continuously throughout the colon. At diagnosis, lesions involve the rectum, the left colon and most of the colon in similar proportions. Subsequent extension of the lesions over 20 years is observed in half of the patients. In Crohn's disease, 40%-50% of the patients require intestinal resection at 10 years. The risk of colectomy in ulcerative colitis is about 1% per year Dysplasia and cancer may complicate longstanding extensive colonic lesions in Crohn's disease and ulcerative colitis. Malignant transformation of chronic inflammatory lesions may also occur in patients with longstanding lesions of the small bowel in Crohn's disease.
    MeSH term(s) Adenocarcinoma/pathology ; Carcinoma/pathology ; Cell Transformation, Neoplastic/pathology ; Crohn Disease/diagnosis ; Crohn Disease/pathology ; Disease Progression ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/pathology ; Intestinal Neoplasms/pathology ; Intestines/pathology ; Proctocolitis/diagnosis ; Proctocolitis/pathology
    Language French
    Publishing date 2014-11
    Publishing country France
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Mici et sur-risque de cancer: quelle réalité?

    Beaugerie, Laurent

    Revue de l'infirmiere

    2014  , Issue 199, Page(s) 28

    Abstract: Inflammatory bowel diseases can favour the occurrence of colon cancer while their treatments can increase the risk of certain other cancers. The doctor's skill lies in striking the right benefit-risk balance of the treatments. ...

    Title translation IBD and increased risk of cancer: what is the reality?.
    Abstract Inflammatory bowel diseases can favour the occurrence of colon cancer while their treatments can increase the risk of certain other cancers. The doctor's skill lies in striking the right benefit-risk balance of the treatments.
    MeSH term(s) Choice Behavior ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/therapy ; Humans ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/therapy ; Physician's Role ; Risk Assessment ; Risk Factors
    Language French
    Publishing date 2014-04-15
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 632538-5
    ISSN 1293-8505 ; 0397-7900
    ISSN 1293-8505 ; 0397-7900
    DOI 10.1016/j.revinf.2013.12.011
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    Zs.B 2782: Show issues Location:
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  10. Article ; Online: Management of inflammatory bowel disease patients with a cancer history.

    Beaugerie, Laurent

    Current drug targets

    2014  Volume 15, Issue 11, Page(s) 1042–1048

    Abstract: In inflammatory bowel disease (IBD) patients, thiopurines promote carcinogenesis of Epstein-Barr Virus (EBV)-related lymphomas, non-melanoma skin cancers and urinary tract cancers, while anti-TNF agents could promote carcinogenesis of melanomas. Patients ...

    Abstract In inflammatory bowel disease (IBD) patients, thiopurines promote carcinogenesis of Epstein-Barr Virus (EBV)-related lymphomas, non-melanoma skin cancers and urinary tract cancers, while anti-TNF agents could promote carcinogenesis of melanomas. Patients with IBD and previous cancer are at a higher risk of developing new or recurrent cancer than IBD patients without a history of cancer, irrespective of the use of immunosuppressants. In transplant recipients, the use of thiopurines is associated with a high rate of cancer recurrence, particularly within the first two years following transplantation. In patients with chronic inflammatory disease, limited data suggest that no dramatic incidence of cancer recurrence is associated with the use of thiopurines or anti-TNF agents. However, there is a rationale for a two-year drug holiday from immunosuppressants after the diagnosis and treatment of the majority of incident cancers, as often as possible. Extending the duration of the immunosuppressant drug holiday to 5 years in patients with previous cancers associated with a high risk of recurrence in the post-transplant state should be considered. The immunosuppressants that can be initiated or resumed after cancer treatment should be chosen according to the type of the previous cancer. All individual decisions should be made on a case-by-case basis, together with the oncologist, according to characteristics and expected evolution of the index cancer, expected impact of the immunosuppressants on cancer evolution, and intrinsic severity of IBD, with its associated risks.
    MeSH term(s) Humans ; Immunosuppressive Agents/adverse effects ; Incidence ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Neoplasms/chemically induced ; Risk Factors
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2014-08-20
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2064859-5
    ISSN 1873-5592 ; 1389-4501
    ISSN (online) 1873-5592
    ISSN 1389-4501
    DOI 10.2174/1389450115666140821113330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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