LIVIVO - Search results -

Search results

Result 1 - 10 of total 247

Search options

Article ; Online: Correlating Valence and 2p3d RIXS Spectroscopies: A Ligand-Field Study of Spin-Crossover Iron(II).

Van Stappen, Casey / Van Kuiken, Benjamin E / Mörtel, Max / Ruotsalainen, Kari O / Maganas, Dimitrios / Khusniyarov, Marat M / DeBeer, Serena

Inorganic chemistry

2024 Volume 63, Issue 16, Page(s) 7386–7400

Abstract: The molecular spin-crossover phenomenon between high-spin (HS) and low-spin (LS) states is a promising route to next-generation information storage, sensing applications, and molecular spintronics. Spin-crossover complexes also provide a unique ... ...

Abstract	The molecular spin-crossover phenomenon between high-spin (HS) and low-spin (LS) states is a promising route to next-generation information storage, sensing applications, and molecular spintronics. Spin-crossover complexes also provide a unique opportunity to study the ligand field (LF) properties of a system in both HS and LS states while maintaining the same ligand environment. Presently, we employ complementing valence and core-level spectroscopic methods to probe the electronic excited-state manifolds of the spin-crossover complex [Fe
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.4c00435
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Improving Health Equity Through Public Health Referrals.

Moore, Rosalind A / Van Kuiken, Debbie / Allen, Susan / Clark, Angela / Keller, Elizabeth

Journal of National Black Nurses' Association : JNBNA

2022 Volume 32, Issue 2, Page(s) 37–41

Abstract: Healthcare providers face certain barriers to fully assessing different social needs and referring patients to community resources appropriately, perpetuating healthcare disparities. The purpose of this quality improvement study was to create an ... ...

Abstract	Healthcare providers face certain barriers to fully assessing different social needs and referring patients to community resources appropriately, perpetuating healthcare disparities. The purpose of this quality improvement study was to create an intervention to increase assessment of social determinants of health (SDOH) and referrals. A module incorporating concepts of SDOH was developed and delivered during two training sessions. This module focused on: Partnership, Acceptance, Compassion, and Evocation (PACE). It was found that the public health providers at a local public health center were able to appropriately refer 55% of all new and annual patients screened with specific SDOH needs after the educational module was implemented. An overall increase in SDOH understanding and referrals was also found. SDOH training and ongoing social needs screenings could be incorporated in public health centers to decrease healthcare inequities present among minorities and individuals who live in poverty.
MeSH term(s)	Health Equity ; Healthcare Disparities ; Humans ; Public Health ; Referral and Consultation ; Social Determinants of Health
Language	English
Publishing date	2022-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225465-4
ISSN	0885-6028
ISSN	0885-6028
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4222: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair.

Andronikou, Christina / Burdova, Kamila / Dibitetto, Diego / Lieftink, Cor / Malzer, Elke / Kuiken, Hendrik J / Gogola, Ewa / Ray Chaudhuri, Arnab / Beijersbergen, Roderick L / Hanzlikova, Hana / Jonkers, Jos / Rottenberg, Sven

The EMBO journal

2024 Volume 43, Issue 6, Page(s) 1015–1042

Abstract: Targeting poly(ADP-ribose) glycohydrolase (PARG) is currently explored as a therapeutic approach to treat various cancer types, but we have a poor understanding of the specific genetic vulnerabilities that would make cancer cells susceptible to such a ... ...

Abstract	Targeting poly(ADP-ribose) glycohydrolase (PARG) is currently explored as a therapeutic approach to treat various cancer types, but we have a poor understanding of the specific genetic vulnerabilities that would make cancer cells susceptible to such a tailored therapy. Moreover, the identification of such vulnerabilities is of interest for targeting BRCA2;p53-deficient tumors that have acquired resistance to poly(ADP-ribose) polymerase inhibitors (PARPi) through loss of PARG expression. Here, by performing whole-genome CRISPR/Cas9 drop-out screens, we identify various genes involved in DNA repair to be essential for the survival of PARG;BRCA2;p53-deficient cells. In particular, our findings reveal EXO1 and FEN1 as major synthetic lethal interactors of PARG loss. We provide evidence for compromised replication fork progression, DNA single-strand break repair, and Okazaki fragment processing in PARG;BRCA2;p53-deficient cells, alterations that exacerbate the effects of EXO1/FEN1 inhibition and become lethal in this context. Since this sensitivity is dependent on BRCA2 defects, we propose to target EXO1/FEN1 in PARPi-resistant tumors that have lost PARG activity. Moreover, EXO1/FEN1 targeting may be a useful strategy for enhancing the effect of PARG inhibitors in homologous recombination-deficient tumors.
MeSH term(s)	Humans ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; DNA Repair ; DNA Damage ; Neoplasms/drug therapy ; Neoplasms/genetics ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Glycoside Hydrolases/genetics ; Glycoside Hydrolases/metabolism ; Flap Endonucleases/genetics ; Flap Endonucleases/metabolism ; Flap Endonucleases/therapeutic use ; Exodeoxyribonucleases/genetics ; DNA Repair Enzymes/genetics
Chemical Substances	Tumor Suppressor Protein p53 ; Poly(ADP-ribose) Polymerase Inhibitors ; Glycoside Hydrolases (EC 3.2.1.-) ; FEN1 protein, human (EC 3.1.11.-) ; Flap Endonucleases (EC 3.1.-) ; EXO1 protein, human (EC 3.1.-) ; Exodeoxyribonucleases (EC 3.1.-) ; DNA Repair Enzymes (EC 6.5.1.-)
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.1038/s44318-024-00043-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 100: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Assessment of the virulence for chickens of Newcastle Disease virus with an engineered multi-basic cleavage site in the fusion protein and disrupted V protein gene.

de Graaf, J F / van Nieuwkoop, S / de Meulder, D / Lexmond, P / Kuiken, T / Groeneveld, D / Fouchier, R A M / van den Hoogen, B G

Veterinary microbiology

2022 Volume 269, Page(s) 109437

Abstract: ... of the F protein (NDV F3aa-S- ...

Abstract	Newcastle Disease virus (NDV) has shown promise as an oncolytic virus for treatment of a wide range of tumours. NDV with a multi-basic cleavage site (MBCS) in the fusion (F) protein (NDV F3aa) has increased oncolytic efficacy in several tumour models, but also increased virulence in chickens compared to non-virulent NDV F0, raising potential environmental safety issues. Previously, we generated a variant of NDV F3aa with a disrupted V protein gene and a substitution of phenylalanine to serine at position 117 of the F protein (NDV F3aa-S-
MeSH term(s)	Animals ; Chickens ; Newcastle Disease ; Newcastle disease virus/genetics ; Poultry Diseases ; Viral Fusion Proteins/genetics ; Viral Fusion Proteins/metabolism ; Virulence/genetics
Chemical Substances	Viral Fusion Proteins
Language	English
Publishing date	2022-04-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2022.109437
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2917: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Levels of analysis in neuroscientific studies of emotion: Comment on "The quartet theory of human emotions: an integrative and neurofunctional model" by S. Koelsch et al.

Kuiken, Don / Douglas, Shawn

Physics of life reviews

2015 Volume 13, Page(s) 63–66

MeSH term(s)	Brain/physiology ; Emotions/physiology ; Humans ; Models, Neurological ; Models, Psychological
Language	English
Publishing date	2015-06
Publishing country	Netherlands
Document type	Comment ; Journal Article
ZDB-ID	2148883-6
ISSN	1873-1457 ; 1571-0645
ISSN (online)	1873-1457
ISSN	1571-0645
DOI	10.1016/j.plrev.2015.04.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A Dutch highly pathogenic H5N6 avian influenza virus showed remarkable tropism for extra-respiratory organs and caused severe disease but was not transmissible via air in the ferret model.

Herfst, Sander / Begeman, Lineke / Spronken, Monique I / Poen, Marjolein J / Eggink, Dirk / de Meulder, Dennis / Lexmond, Pascal / Bestebroer, Theo M / Koopmans, Marion P G / Kuiken, Thijs / Richard, Mathilde / Fouchier, Ron A M

mSphere

2023 Volume 8, Issue 4, Page(s) e0020023

Abstract: Continued circulation of A/H5N1 influenza viruses of the A/goose/Guangdong/1/96 lineage in poultry has resulted in the diversification in multiple genetic and antigenic clades. Since 2009, clade 2.3.4.4 hemagglutinin (HA) containing viruses harboring the ...

Abstract	Continued circulation of A/H5N1 influenza viruses of the A/goose/Guangdong/1/96 lineage in poultry has resulted in the diversification in multiple genetic and antigenic clades. Since 2009, clade 2.3.4.4 hemagglutinin (HA) containing viruses harboring the internal and neuraminidase (NA) genes of other avian influenza A viruses have been detected. As a result, various HA-NA combinations, such as A/H5N1, A/H5N2, A/H5N3, A/H5N5, A/H5N6, and A/H5N8 have been identified. As of January 2023, 83 humans have been infected with A/H5N6 viruses, thereby posing an apparent risk for public health. Here, as part of a risk assessment, the
MeSH term(s)	Humans ; Animals ; Influenza in Birds ; Ferrets ; Influenza A Virus, H5N1 Subtype/genetics ; Influenza A Virus, H5N2 Subtype/genetics ; Influenza A virus/genetics ; Poultry
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2379-5042
ISSN (online)	2379-5042
DOI	10.1128/msphere.00200-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: African American Men have Increased Risk of Prostate Cancer Detection Despite Similar Rates of Anterior Prostatic Lesions and PI-RADS Grade on Multiparametric Magnetic Resonance Imaging.

Patel, Hiten D / Doshi, Chirag P / Koehne, Elizabeth L / Hart, Spencer / Van Kuiken, Michelle / Quek, Marcus L / Flanigan, Robert C / Gupta, Gopal N

Urology

2021 Volume 163, Page(s) 132–137

Abstract: Objective: To determine whether the frequency of anterior prostate lesions (APL) on multiparametric magnetic resonance imaging (mpMRI) prior to biopsy differed between African American (AA) and non-AA men and evaluate implications of race and tumor ... ...

Abstract	Objective: To determine whether the frequency of anterior prostate lesions (APL) on multiparametric magnetic resonance imaging (mpMRI) prior to biopsy differed between African American (AA) and non-AA men and evaluate implications of race and tumor location for prostate cancer (PCa) detection. Methods: Patients from the Prospective Loyola University mpMRI (PLUM) Prostate Biopsy Cohort (January 2015-December 2020) without prior diagnosis of PCa were evaluated for APLs by race. Multivariable logistic regression models evaluated predictors of APLs and associations of APLs and race with detection of any PCa (grade group 1+) and clinically significant PCa (csPCa; grade group 2+). Additional stratified and propensity score matched analyses were conducted. Results: Of 1,239 men included, 190 (15.3%) were AA and 302 (24.4%) had at least one APL with no differences by race on multivariable analysis. While men with APLs were twice as likely to harbor PCa or csPCa, the unadjusted proportion of targeted biopsy-confirmed APL PCa (12.6% vs 12.0%) or csPCa (8.4% vs 8.9%) were similar for AA and non-AA men. AA men had higher risk of prostate cancer on targeted cores (OR 1.66 (95%CI 1.06 - 2.61), P = 0.026) which was independent of lesion location or PI-RADS. Conclusion: AA men were found to have similar rates of APLs on mpMRI to non-AA men indicating access to mpMRI may mitigate some of the historical racial disparity based on lesion location. AA men have increased risk of PCa detection compared to non-AA men independent of anterior location or lesion grade on mpMRI reinforcing the importance of identifying genetic, biologic, and socioeconomic drivers.
MeSH term(s)	African Americans ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Multiparametric Magnetic Resonance Imaging ; Prospective Studies ; Prostate/diagnostic imaging ; Prostate/pathology ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/epidemiology
Language	English
Publishing date	2021-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2021.07.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 275: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The Irrawaddy dolphin, Orcaella brevirostris from the Mekong river Cambodia: Preliminary health and toxicological investigations.

Schnitzler, Joseph G / Das, Krishna / Wohlsein, Peter / Kuiken, Thijs / Ludwig, Arne / Lieckfeldt, Dietmar / Phan, Channa / Phay, Somany / Siebert, Ursula

Aquatic toxicology (Amsterdam, Netherlands)

2021 Volume 234, Page(s) 105812

Abstract: ... of the mitochondrial d-loop sequences, was performed. Data indicate a genetic separation of the Mekong dolphins ...

Abstract	The subpopulation of the Irrawaddy dolphin (Orcaella brevirostris) living in the Mekong River, Cambodia, is considered to be critically endangered. The aim of the investigation was to gain information about the genetic variation, health status and exposure to toxic compounds of these dolphins. Tissue samples from 27 Irrawaddy river dolphins found dead along the Mekong River between 2004 and 2009 were analysed with regards to genetics, pathology and ecotoxicology. Genetic maternal lineage detection, based on polymorphisms of the mitochondrial d-loop sequences, was performed. Data indicate a genetic separation of the Mekong dolphins from both the coastal population and the Mahakam dolphins. Pathological investigations revealed acute moderate multifocal suppurative bronchopneumonia, moderate periportal hepatic lipidosis, moderate diffuse hepatic atrophy and acute severe diffuse suppurative leptomeningitis. Residue levels of organochlorines and polybrominated diphenyl ethers in Irrawaddy dolphins from the Mekong River were lower than the concentrations reported for other cetaceans in the coastal and riverine waters of Asia, except for Dichlorodiphenyltrichloroethane. A high percentage of organic mercury compared to the immuno-toxic methylmercury was observed. Due to numerous confounding factors, it is not possible to relate levels of pollutants to observed morphological lesions. However, it is likely that chemical contaminants do adversely impact on the health of the Irrawaddy dolphins at present, and have also affected previous generations.
MeSH term(s)	Animals ; Bronchopneumonia/pathology ; Cambodia ; Dolphins/genetics ; Dolphins/physiology ; Genetic Variation ; Halogenated Diphenyl Ethers/analysis ; Halogenated Diphenyl Ethers/toxicity ; Hydrocarbons, Chlorinated/analysis ; Hydrocarbons, Chlorinated/toxicity ; Liver/chemistry ; Liver/drug effects ; Liver/metabolism ; Organomercury Compounds/toxicity ; Rivers/chemistry ; Water Pollutants, Chemical/analysis ; Water Pollutants, Chemical/toxicity
Chemical Substances	Halogenated Diphenyl Ethers ; Hydrocarbons, Chlorinated ; Organomercury Compounds ; Water Pollutants, Chemical
Language	English
Publishing date	2021-03-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782699-0
ISSN	1879-1514 ; 0166-445X
ISSN (online)	1879-1514
ISSN	0166-445X
DOI	10.1016/j.aquatox.2021.105812
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4376: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The Irrawaddy dolphin, Orcaella brevirostris from the Mekong river Cambodia: Preliminary health and toxicological

Schnitzler, J. G. / Das, K. / Wohlsein, P. / Kuiken, T. / Ludwig, A. / Lieckfeldt, D. / Phan, C. / Phay, S. / Siebert, U.

Aquatic toxicology

2021 Volume 234, Issue -, Page(s) 105812

Language	English
Document type	Article
ZDB-ID	782699-0
ISSN	0166-445x
Database	Current Contents Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

Z 3881: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Assessment of the virulence for chickens of Newcastle Disease virus with an engineered multi-basic cleavage site in the fusion protein and disrupted V protein gene

de Graaf, J.F. / van Nieuwkoop, S. / de Meulder, D. / Lexmond, P. / Kuiken, T. / Groeneveld, D. / Fouchier, R.A.M. / van den Hoogen, B.G.

Veterinary microbiology. 2022 June, v. 269

2022

Abstract: ... of the F protein (NDV F3aa-S-STOPV). Compared to NDV F3aa this virus had decreased virulence in embryonated ... ICPI). Based on these data NDV F3aa-S-STOPV classified as a non-virulent virus. Although NDV F3aa was ... in chickens. In addition, these data show that F3aa-S-STOPV is safe to use in viro-immunotherapies ...

Abstract	Newcastle Disease virus (NDV) has shown promise as an oncolytic virus for treatment of a wide range of tumours. NDV with a multi-basic cleavage site (MBCS) in the fusion (F) protein (NDV F3aa) has increased oncolytic efficacy in several tumour models, but also increased virulence in chickens compared to non-virulent NDV F0, raising potential environmental safety issues. Previously, we generated a variant of NDV F3aa with a disrupted V protein gene and a substitution of phenylalanine to serine at position 117 of the F protein (NDV F3aa-S-STOPV). Compared to NDV F3aa this virus had decreased virulence in embryonated chicken eggs. In this study, the virulence of the virus was evaluated upon inoculation of six-week-old chickens through a natural infection route and by determination of the intracerebral pathogenicity index (ICPI). Based on these data NDV F3aa-S-STOPV classified as a non-virulent virus. Although NDV F3aa was classified as a virulent virus based on the ICPI, the virus was also less pathogenic than NDV F0 upon inoculation of six-week-old chickens. These data indicate that NDV with a MBCS is not necessarily pathogenic in chickens. In addition, these data show that F3aa-S-STOPV is safe to use in viro-immunotherapies without posing a threat for chickens upon accidental exposure.
Keywords	Avian orthoavulavirus 1 ; chickens ; genes ; neoplasms ; phenylalanine ; serine ; virulence ; viruses
Language	English
Dates of publication	2022-06
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2022.109437
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 2917: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito