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Article ; Online: P

Siegel, Patrick M / Sander, Laura / Fricke, Alba / Stamm, Johannes / Wang, Xiaowei / Sharma, Prerna / Bassler, Nicole / Ying, Ya-Lan / Olivier, Christoph B / Eisenhardt, Steffen U / Bode, Christoph / Ahrens, Ingo / Diehl, Philipp / Peter, Karlheinz

Scientific reports

2021 Volume 11, Issue 1, Page(s) 17459

Abstract: P ...

Abstract	P
MeSH term(s)	Acute Coronary Syndrome/blood ; Acute Coronary Syndrome/pathology ; Adenosine Diphosphate/metabolism ; Anti-Inflammatory Agents/pharmacology ; Case-Control Studies ; Coronary Artery Disease/blood ; Coronary Artery Disease/pathology ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Macrophages/drug effects ; Macrophages/metabolism ; Monocytes/drug effects ; Monocytes/metabolism ; Phosphorylation ; Purinergic P2Y Receptor Antagonists/pharmacology ; Receptors, Purinergic P2Y12 ; THP-1 Cells
Chemical Substances	Anti-Inflammatory Agents ; Purinergic P2Y Receptor Antagonists ; Receptors, Purinergic P2Y12 ; Adenosine Diphosphate (61D2G4IYVH)
Language	English
Publishing date	2021-08-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-95710-3
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Article ; Online: P. gingivalis

Verma, Ambika / Azhar, Gohar / Zhang, Xiaomin / Patyal, Pankaj / Kc, Grishma / Sharma, Shakshi / Che, Yingni / Wei, Jeanne Y

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Porphyromonas gingivalis (P. gingivalis), ...

Abstract	Porphyromonas gingivalis (P. gingivalis),
MeSH term(s)	Humans ; Adult ; Lipopolysaccharides/pharmacology ; Neuroinflammatory Diseases ; Signal Transduction ; Porphyromonas gingivalis/metabolism ; Oxidative Stress ; Mitochondria/metabolism
Chemical Substances	Lipopolysaccharides
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24020950
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Article ; Online: PI(4,5)P

Johnson, Kristen A / Budicini, Melissa R / Bhattarai, Nisha / Sharma, Tej / Urata, Sarah / Gerstman, Bernard S / Chapagain, Prem P / Li, Sheng / Stahelin, Robert V

Journal of lipid research

2024 Volume 65, Issue 3, Page(s) 100512

Abstract: ... bisphosphate (PI(4,5)P ...

Abstract	Ebola virus (EBOV) causes severe hemorrhagic fever in humans and is lethal in a large percentage of those infected. The EBOV matrix protein viral protein 40 kDa (VP40) is a peripheral binding protein that forms a shell beneath the lipid bilayer in virions and virus-like particles (VLPs). VP40 is required for virus assembly and budding from the host cell plasma membrane. VP40 is a dimer that can rearrange into oligomers at the plasma membrane interface, but it is unclear how these structures form and how they are stabilized. We therefore investigated the ability of VP40 to form stable oligomers using in vitro and cellular assays. We characterized two lysine-rich regions in the VP40 C-terminal domain (CTD) that bind phosphatidylinositol-4,5-bisphosphate (PI(4,5)P
MeSH term(s)	Humans ; Ebolavirus/metabolism ; Hemorrhagic Fever, Ebola/metabolism ; Lysine/metabolism ; Binding Sites ; Lipids ; Protein Binding
Chemical Substances	Lysine (K3Z4F929H6) ; Lipids
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80154-9
ISSN	1539-7262 ; 0022-2275
ISSN (online)	1539-7262
ISSN	0022-2275
DOI	10.1016/j.jlr.2024.100512
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Article ; Online: Pharmacological potential of (L.) P. Royen (Sapodilla): a narrative review.

Sharma, Priyanka / Deep, Aakash / Kumar, Harish / Bansal, Nitin / Kumar, Sanjiv / Arun / Kumar, Davinder

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2024 Volume 44, Issue 2, Page(s) 403–407

Abstract: Herbal medicine is safe and effective in treating various diseases. Traditional herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications, hence herbal medicine requires remarkable attention in further ... ...

Abstract	Herbal medicine is safe and effective in treating various diseases. Traditional herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications, hence herbal medicine requires remarkable attention in further research for the development of numerous active formulations for treatment of health troubles. The plant needs special consideration for development and research of unidentified compound and characterization of novel active molecules that overcome multiple pathological abnormalities. The genus Manilkara contains 135 plants around the world. This overview discusses all the virtues of most important and commonly used plant
MeSH term(s)	Humans ; Manilkara ; Plant Extracts/pharmacology ; Plants, Medicinal
Chemical Substances	Plant Extracts
Language	English
Publishing date	2024-03-20
Publishing country	China
Document type	Review ; Journal Article
ZDB-ID	603186-9
ISSN	2589-451X ; 0254-6272 ; 0255-2922
ISSN (online)	2589-451X ; 0254-6272
ISSN	0255-2922
DOI	10.19852/j.cnki.jtcm.2024.02.001
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Article: PI(3,5)P

Sun, Jiachen / Song, Seohyeon / Singaram, Indira / Sharma, Ashutosh / Wang, Wei / Hu, Yusi / Lo, Wen-Ting / Koch, Philipp Alexander / Zhao, Jean J / Haucke, Volker / Gao, Ruixuan / Cho, Wonhwa

bioRxiv : the preprint server for biology

2023

Abstract: ... Among 3'-phosphoinositides, phosphatidylinositol-3,5-bisphosphate (PI(3,5)P ...

Abstract	3'-Phosphoinositides are ubiquitous cellular lipids that play pivotal regulatory roles in health and disease. Generation of 3'-phosphoinositides are driven by three families of phosphoinositide 3-kinases (PI3K) but the mechanisms underlying their regulation and cross-talk are not fully understood. Among 3'-phosphoinositides, phosphatidylinositol-3,5-bisphosphate (PI(3,5)P
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.01.25.525550
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Article ; Online: Circular economical approach of extracting nanocarbons from waste pea peel for sensing of p-nitrophenol and its conversion into paracetamol.

Laddha, Harshita / Yadav, Priya / Sharma, Priya / Agarwal, Madhu / Gupta, Ragini

Chemosphere

2024 Volume 356, Page(s) 141930

Abstract: ... waste pea peel (wPP) into low-cost carbon nanomaterials for sensing and conversion of p-nitrophenol (p ... with a quantum yield (QY) of 8.82 %, which were exploited for the fluorescence sensing of p-NP with 4.20 μM limit ... of detection. Pyrolyzed biochar acting as an efficient catalyst effectively reduces p-NP to p-aminophenol (p-AP ...

Abstract	An important paradigm shift towards the circular economy is to prioritize waste prevention, reuse, recycling, and recovery before disposal is necessary. In this context, a sustainable protocol of converting waste pea peel (wPP) into low-cost carbon nanomaterials for sensing and conversion of p-nitrophenol (p-NP) into value-added paracetamol is being reported. Two fractions of the carbonaceous nanomaterials were obtained after the hydrothermal treatment (HT) of wPP, firstly an aqueous portion containing water-soluble carbon dots (wPP-CDs) and a solid residue, which was converted into carbonized biochar (wPP-BC). Blue-colored fluorescent wPP-CDs displayed excitation-dependent and pH-independent properties with a quantum yield (QY) of 8.82 %, which were exploited for the fluorescence sensing of p-NP with 4.20 μM limit of detection. Pyrolyzed biochar acting as an efficient catalyst effectively reduces p-NP to p-aminophenol (p-AP) in just 16 min with a 0.237 min
Language	English
Publishing date	2024-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141930
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Article ; Online: Prof. L. P. Agarwal:

Sen, Mrittika / Sharma, Kavita A / Honavar, Santosh G

Indian journal of ophthalmology

2022 Volume 70, Issue 12, Page(s) 4101–4103

MeSH term(s)	Humans ; Male ; Fathers ; Nuclear Family
Language	English
Publishing date	2022-11-30
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_2162_22
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Article: Author Reply Re: Sharma G, Shah M, Ahluwalia P, Dasgupta P, Challacombe BJ, Bhandari M,

Sharma, Gopal / Ahluwalia, Puneet / Gautam, Gagan

Indian journal of urology : IJU : journal of the Urological Society of India

2022 Volume 39, Issue 1, Page(s) 80–81

Language	English
Publishing date	2022-12-29
Publishing country	India
Document type	Journal Article
ZDB-ID	639268-4
ISSN	1998-3824 ; 0970-1591
ISSN (online)	1998-3824
ISSN	0970-1591
DOI	10.4103/iju.iju_393_22
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Article ; Online: A Novel PINK1 p.F385S Loss-of-Function Mutation in an Indian Family with Parkinson's Disease.

Sharma, Karan / Kishore, Asha / Lechado-Terradas, Anna / Passannanti, Raffaele / Raimondi, Francesco / Sturm, Marc / Sreelatha, Ashwin Ashok Kumar / Puthenveedu, Divya Kalikavila / Sarma, Gangadhara / Casadei, Nicolas / Krüger, Rejko / Gasser, Thomas / Kahle, Philipp / Riess, Olaf / Fitzgerald, Julia C / Sharma, Manu

Movement disorders : official journal of the Movement Disorder Society

2024

Abstract: ... We identified a homozygous chr1:20648535-20648535 T>C on GRCh38 (p.F385S) mutation in exon 6 of PINK1, which was ...

Abstract	Background: Most Parkinson's disease (PD) loci have shown low prevalence in the Indian population, highlighting the need for further research. Objective: The aim of this study was to characterize a novel phosphatase tensin homolog-induced serine/threonine kinase 1 (PINK1) mutation causing PD in an Indian family. Methods: Exome sequencing of a well-characterized Indian family with PD. A novel PINK1 mutation was studied by in silico modeling using AlphaFold2, expression of mutant PINK1 in human cells depleted of functional endogenous PINK1, followed by quantitative image analysis and biochemical assessment. Results: We identified a homozygous chr1:20648535-20648535 T>C on GRCh38 (p.F385S) mutation in exon 6 of PINK1, which was absent in 1029 genomes from India and in other known databases. PINK1 F385S lies within the highly conserved Deutsche Forschungsgemeinschaft (DFG) motif, destabilizes its active state, and impairs phosphorylation of ubiquitin at serine 65 and proper engagement of parkin upon mitochondrial depolarization. Conclusions: We characterized a novel nonconservative mutation in the DFG motif of PINK1, which causes loss of its ubiquitin kinase activity and inhibition of mitophagy. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.29792
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Article ; Online: Measurement of Direct-Photon Cross Section and Double-Helicity Asymmetry at sqrt[s]=510 GeV in p[over →]+p[over →] Collisions.

Abdulameer, N J / Acharya, U / Adare, A / Aidala, C / Ajitanand, N N / Akiba, Y / Akimoto, R / Alfred, M / Apadula, N / Aramaki, Y / Asano, H / Atomssa, E T / Awes, T C / Azmoun, B / Babintsev, V / Bai, M / Bandara, N S / Bannier, B / Barish, K N /

Bathe, S / Bazilevsky, A / Beaumier, M / Beckman, S / Belmont, R / Berdnikov, A / Berdnikov, Y / Bichon, L / Black, D / Blankenship, B / Bok, J S / Borisov, V / Boyle, K / Brooks, M L / Bryslawskyj, J / Buesching, H / Bumazhnov, V / Campbell, S / Canoa Roman, V / Chen, C-H / Chiu, M / Chi, C Y / Choi, I J / Choi, J B / Chujo, T / Citron, Z / Connors, M / Corliss, R / Corrales Morales, Y / Csanád, M / Csörgő, T / Datta, A / Daugherity, M S / David, G / Dean, C T / DeBlasio, K / Dehmelt, K / Denisov, A / Deshpande, A / Desmond, E J / Ding, L / Dion, A / Doomra, V / Do, J H / Drees, A / Drees, K A / Durham, J M / Durum, A / En'yo, H / Enokizono, A / Esha, R / Fadem, B / Fan, W / Feege, N / Fields, D E / Finger, M / Firak, D / Fitzgerald, D / Fokin, S L / Frantz, J E / Franz, A / Frawley, A D / Gallus, P / Gal, C / Garg, P / Ge, H / Giles, M / Giordano, F / Glenn, A / Goto, Y / Grau, N / Greene, S V / Grosse Perdekamp, M / Gunji, T / Guragain, H / Gu, Y / Hachiya, T / Haggerty, J S / Hahn, K I / Hamagaki, H / Hanks, J / Han, S Y / Harvey, M / Hasegawa, S / Hemmick, T K / He, X / Hill, J C / Hodges, A / Hollis, R S / Homma, K / Hong, B / Hoshino, T / Huang, J / Ikeda, Y / Imai, K / Imazu, Y / Inaba, M / Iordanova, A / Isenhower, D / Ivanishchev, D / Jacak, B V / Jeon, S J / Jezghani, M / Jiang, X / Ji, Z / Johnson, B M / Joo, E / Joo, K S / Jouan, D / Jumper, D S / Kang, J H / Kang, J S / Kawall, D / Kazantsev, A V / Key, J A / Khachatryan, V / Khanzadeev, A / Khatiwada, A / Kihara, K / Kim, C / Kim, D H / Kim, D J / Kim, E-J / Kim, H-J / Kim, M / Kim, T / Kim, Y K / Kincses, D / Kingan, A / Kistenev, E / Klatsky, J / Kleinjan, D / Kline, P / Koblesky, T / Kofarago, M / Koster, J / Kotov, D / Kovacs, L / Kurgyis, B / Kurita, K / Kurosawa, M / Kwon, Y / Lajoie, J G / Larionova, D / Lebedev, A / Lee, K B / Lee, S H / Leitch, M J / Leitgab, M / Lewis, N A / Lim, S H / Liu, M X / Li, X / Loomis, D A / Lynch, D / Lökös, S / Majoros, T / Makdisi, Y I / Makek, M / Manion, A / Manko, V I / Mannel, E / McCumber, M / McGaughey, P L / McGlinchey, D / McKinney, C / Meles, A / Mendoza, M / Meredith, B / Miake, Y / Mignerey, A C / Miller, A J / Milov, A / Mishra, D K / Mitchell, J T / Mitrankova, M / Mitrankov, Iu / Miyasaka, S / Mizuno, S / Mondal, M M / Montuenga, P / Moon, T / Morrison, D P / Moukhanova, T V / Muhammad, A / Mulilo, B / Murakami, T / Murata, J / Mwai, A / Nagamiya, S / Nagle, J L / Nagy, M I / Nakagawa, I / Nakagomi, H / Nakano, K / Nattrass, C / Nelson, S / Netrakanti, P K / Nihashi, M / Niida, T / Nouicer, R / Novitzky, N / Nukazuka, G / Nyanin, A S / O'Brien, E / Ogilvie, C A / Oh, J / Orjuela Koop, J D / Orosz, M / Osborn, J D / Oskarsson, A / Ozawa, K / Pak, R / Pantuev, V / Papavassiliou, V / Park, J S / Park, S / Patel, L / Patel, M / Pate, S F / Peng, J-C / Peng, W / Perepelitsa, D V / Perera, G D N / Peressounko, D Yu / PerezLara, C E / Perry, J / Petti, R / Pinkenburg, C / Pinson, R / Pisani, R P / Potekhin, M / Pun, A / Purschke, M L / Radzevich, P V / Rak, J / Ramasubramanian, N / Ravinovich, I / Read, K F / Reynolds, D / Riabov, V / Riabov, Y / Richford, D / Riveli, N / Roach, D / Rolnick, S D / Rosati, M / Rowan, Z / Rubin, J G / Runchey, J / Saito, N / Sakaguchi, T / Sako, H / Samsonov, V / Sarsour, M / Sato, S / Sawada, S / Schaefer, B / Schmoll, B K / Sedgwick, K / Seele, J / Seidl, R / Sen, A / Seto, R / Sett, P / Sexton, A / Sharma, D / Shein, I / Shibata, M / Shibata, T-A / Shigaki, K / Shimomura, M / Shi, Z / Shukla, P / Sickles, A / Silva, C L / Silvermyr, D / Singh, B K / Singh, C P / Singh, V / Slunečka, M / Smith, K L / Soltz, R A / Sondheim, W E / Sorensen, S P / Sourikova, I V / Stankus, P W / Stepanov, M / Stoll, S P / Sugitate, T / Sukhanov, A / Sumita, T / Sun, J / Sun, Z / Sziklai, J / Takahama, R / Takahara, A / Taketani, A / Tanida, K / Tannenbaum, M J / Tarafdar, S / Taranenko, A / Timilsina, A / Todoroki, T / Tomášek, M / Torii, H / Towell, M / Towell, R / Towell, R S / Tserruya, I / Ueda, Y / Ujvari, B / van Hecke, H W / Vargyas, M / Velkovska, J / Virius, M / Vrba, V / Vznuzdaev, E / Wang, X R / Wang, Z / Watanabe, D / Watanabe, Y / Watanabe, Y S / Wei, F / Whitaker, S / Wolin, S / Wong, C P / Woody, C L / Wysocki, M / Xia, B / Xue, L / Yalcin, S / Yamaguchi, Y L / Yanovich, A / Yoon, I / Younus, I / Yushmanov, I E / Zajc, W A / Zelenski, A / Zou, L

Physical review letters

2023 Volume 130, Issue 25, Page(s) 251901

Abstract: ... production in p[over →]+p[over →] collisions at sqrt[s]=510 GeV. The measurements have been performed ...

Abstract	We present measurements of the cross section and double-helicity asymmetry A_{LL} of direct-photon production in p[over →]+p[over →] collisions at sqrt[s]=510 GeV. The measurements have been performed at midrapidity (\|η\|<0.25) with the PHENIX detector at the Relativistic Heavy Ion Collider. At relativistic energies, direct photons are dominantly produced from the initial quark-gluon hard scattering and do not interact via the strong force at leading order. Therefore, at sqrt[s]=510 GeV, where leading-order-effects dominate, these measurements provide clean and direct access to the gluon helicity in the polarized proton in the gluon-momentum-fraction range 0.02<x<0.08, with direct sensitivity to the sign of the gluon contribution.<br />
MeSH term(s)	Photons ; Food ; Motion
Language	English
Publishing date	2023-07-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.251901
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