LIVIVO - Search results -

Search results

Result 1 - 10 of total 28

Search options

Article: Epidemiological characteristics of a population visiting a patient-centered informative website about irritable bowel syndrome.

Van Malderen, K / De Man, J G / De Winter, B Y / De Schepper, H U

2023 Volume 86, Issue 1, Page(s) 17–25

Abstract: Background and aims: Irritable bowel syndrome (IBS) is a chronic disorder characterized by abdominal pain and an altered bowel habit. The aim of this study was to evaluate the characteristics of a population visiting a patient-centered informative ... ...

Abstract	Background and aims: Irritable bowel syndrome (IBS) is a chronic disorder characterized by abdominal pain and an altered bowel habit. The aim of this study was to evaluate the characteristics of a population visiting a patient-centered informative website about IBS. Methods: Five digital surveys were used to assess the Rome IV criteria, red flag symptoms, healthcare use, psychological comorbidities, quality of life, symptom severity, diet, physical activity. Patients were divided into a Rome positive and negative population with the Rome positive population being further subtyped based on dominant stool pattern. Results: Red flag symptoms (42%) and comorbid psychological disorders (65% anxiety and 39% depression) were common. Despite consulting health care professionals and therapy, most patients (96%) still experienced moderate to severe symptoms with an average impact on quality of life. 73% performed regular physical exercise and 25% of the Rome positive population followed the FODMAP diet. Almost all participants consulted a health care professional at one point in time and used some form of therapy. 54% of the patients believed there is generally sufficient information available and 57% thinks that their physician takes IBS seriously. However, only 41% thinks that their physician has sufficient knowledge about IBS. Conclusions: This study underlines the importance of a thorough characterization of IBS patients. Furthermore, patients expressed an urgent need for high quality information and education for both health care professionals and patients.
MeSH term(s)	Humans ; Irritable Bowel Syndrome/epidemiology ; Irritable Bowel Syndrome/therapy ; Irritable Bowel Syndrome/diagnosis ; Quality of Life ; Surveys and Questionnaires ; Abdominal Pain ; Patient-Centered Care
Language	English
Publishing date	2023-02-21
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	127060-6
ISSN	1784-3227 ; 0001-5644
ISSN	1784-3227 ; 0001-5644
DOI	10.51821/86.1.10885
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui V Zs.37: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Case series of Cryptogenic Multifocal Ulcerating Stenosing Enteritis (CMUSE).

Ooms, H / De Schepper, H U / Moreels, T G

Acta gastro-enterologica Belgica

2017 Volume 80, Issue 3, Page(s) 361–364

Abstract: Background and study aims: Small bowel ulceration poses a limited, but difficult differential diagnosis. The most common causes are Crohn's disease (CD), NSAID-associated enteritis, lymphoma, cytomegaly virus infection and tuberculosis. A less known and ...

Abstract	Background and study aims: Small bowel ulceration poses a limited, but difficult differential diagnosis. The most common causes are Crohn's disease (CD), NSAID-associated enteritis, lymphoma, cytomegaly virus infection and tuberculosis. A less known and relatively novel differential diagnosis is cryptogenic multifocal ulcerative stenosing enteritis (CMUSE). Patients and methods: ive patients referred for balloon-assisted enteroscopy for various reasons showed endoscopic features of CMUSE. These findings and, when available, medical imaging were reviewed in order to increase general knowledge on CMUSE. Results: Five patients, 3 males and 2 females, with a mean age of 39±5 years, underwent balloon-assisted enteroscopy. Typical short, circular, ulcerative stenoses were detected in the jejunum in 2 and in the ileum in 3 patients. The number of stenoses ranged from 1 to 7 per patient. Histopathology revealed nonspecific granulocyte inflammation without specific CD findings. Stenoses were often missed on pre-enteroscopy CT or MRI enteroclysis due to their short length. Treatment consisted of endoscopic balloon dilation in 3, corticosteroids in 3, azathioprine in 1 and anti-TNFα biologicals in 3 patients. 3 patients needed additional surgery because of ongoing symptomatic small bowel stenosis or retained wireless videocapsule. Conclusion: In patients with short, ulcerative small intestinal stenoses CMUSE is an important but often neglected differential diagnosis. The pathophysiology and relationship to CD are subject of ongoing debate, but specific endoscopic characteristics, different histopathological findings and lack of clear abnormalities on CT or MRI enterography suggest that CMUSE is a distinct albeit rare chronic inflammatory bowel disease.
MeSH term(s)	Adult ; Capsule Endoscopy/methods ; Colitis, Ulcerative/diagnosis ; Constriction, Pathologic/etiology ; Constriction, Pathologic/pathology ; Constriction, Pathologic/therapy ; Crohn Disease/diagnosis ; Diagnosis, Differential ; Dilatation/methods ; Enteritis/etiology ; Enteritis/pathology ; Enteritis/physiopathology ; Enteritis/therapy ; Female ; Glucocorticoids/administration & dosage ; Humans ; Intestinal Obstruction/etiology ; Intestinal Obstruction/therapy ; Intestine, Small/diagnostic imaging ; Intestine, Small/pathology ; Intraabdominal Infections/diagnosis ; Male ; Middle Aged ; Reoperation/methods ; Treatment Outcome ; Ulcer/complications ; Ulcer/pathology ; Ulcer/physiopathology
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2017-07
Publishing country	Belgium
Document type	Case Reports ; Journal Article
ZDB-ID	127060-6
ISSN	1784-3227 ; 0001-5644
ISSN	1784-3227 ; 0001-5644
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui V Zs.37: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Buoyancy forcing

B. Risebrobakken / M. F. Jensen / H. R. Langehaug / T. Eldevik / A. B. Sandø / C. Li / A. Born / E. L. McClymont / U. Salzmann / S. De Schepper

Climate of the Past, Vol 19, Pp 1101-

a key driver of northern North Atlantic sea surface temperature variability across multiple timescales

2023 Volume 1123

Abstract: Analyses of observational data (from year 1870 AD) show that sea surface temperature (SST) anomalies along the pathway of Atlantic Water transport in the North Atlantic, the Norwegian Sea and the Iceland Sea are spatially coherent at multidecadal ... ...

Abstract	Analyses of observational data (from year 1870 AD) show that sea surface temperature (SST) anomalies along the pathway of Atlantic Water transport in the North Atlantic, the Norwegian Sea and the Iceland Sea are spatially coherent at multidecadal timescales. Spatially coherent SST anomalies are also observed over hundreds of thousands of years during parts of the Pliocene (5.23–5.03, 4.63–4.43, and 4.33–4.03 Ma). However, when investigating CMIP6 (Coupled Model Intercomparison Project 6) SSP126 (Shared Socioeconomic Pathway) future scenario runs (next century) and other Pliocene time intervals, the following three additional SST relations emerge: (1) the Norwegian Sea SST anomaly is dissimilar to the North Atlantic and the Iceland Sea SST anomalies (Pliocene; 4.93–4.73 and 3.93–3.63 Ma), (2) the Iceland Sea SST anomaly is dissimilar to the North Atlantic and the Norwegian Sea SST anomalies (Pliocene; 3.43–3.23 Ma), and (3) the North Atlantic SST anomaly is dissimilar to the SST anomalies of the Norwegian and Iceland seas (future trend). Hence, spatially non-coherent SST anomalies may occur in equilibrium climates (Pliocene), as well as in response to transient forcing (CMIP6 SSP126 low-emission future scenario). Since buoyancy is a key forcing for the inflow of Atlantic Water to the Norwegian Sea, we investigate the impacts of buoyancy forcing on spatial relations between SST anomalies seen in the North Atlantic and the Norwegian and Iceland seas. This is done by performing a range of idealized experiments using the Massachusetts Institute of Technology general circulation model (MITgcm). Through these idealized experiments we can reproduce three out of four of the documented SST anomaly relations: being spatially coherent under weak to intermediate freshwater forcing over the Nordic Seas, the Iceland Sea being dissimilar to the North Atlantic and the Norwegian Sea under weak atmospheric warming over the Nordic Seas, and the North Atlantic being dissimilar to the Norwegian and Iceland seas under strong ...
Keywords	Environmental pollution ; TD172-193.5 ; Environmental protection ; TD169-171.8 ; Environmental sciences ; GE1-350
Subject code	551
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Local Colonic Administration of a Serine Protease Inhibitor Improves Post-Inflammatory Visceral Hypersensitivity in Rats.

Hanning, Nikita / De Bruyn, Michelle / Ceuleers, Hannah / Boogaerts, Tim / Berg, Maya / Smet, Annemieke / De Schepper, Heiko U / Joossens, Jurgen / van Nuijs, Alexander L N / De Man, Joris G / Augustyns, Koen / De Meester, Ingrid / De Winter, Benedicte Y

Pharmaceutics

2021 Volume 13, Issue 6

Abstract: ... its vehicle alone (5% DMSO in H ...

Abstract	Dysregulation of the protease-antiprotease balance in the gastrointestinal tract has been suggested as a mechanism underlying visceral hypersensitivity in conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). We aimed to study the potential therapeutic role of an intracolonically administered serine protease inhibitor for the treatment of abdominal pain in a post-inflammatory rat model for IBS. An enema containing 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to induce colitis in male Sprague-Dawley rats, whereas controls received a saline solution. Colonoscopies were performed to confirm colitis and follow-up mucosal healing. In the post-inflammatory phase, the serine protease inhibitor UAMC-00050 (0.1-5 mg/kg) or its vehicle alone (5% DMSO in H
Language	English
Publishing date	2021-05-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics13060811
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Comparison of side-viewing duodenoscope and single-balloon enteroscope to perform ERCP in patients with Billroth II gastrectomy.

Mbatshi, G / Macken, E J / De Schepper, H U / Piessevaux, H / Deprez, P H / Moreels, T G

Acta gastro-enterologica Belgica

2017 Volume 80, Issue 4, Page(s) 493–497

Abstract: Endoscopic retrograde cholangiopancreatography (ERCP) in Billroth II patients is challenging and different endoscopes can be used. We retrospectively analysed 67 ERCP procedures in 38 Billroth II patients focussing on endoscope type and respective ... ...

Abstract	Endoscopic retrograde cholangiopancreatography (ERCP) in Billroth II patients is challenging and different endoscopes can be used. We retrospectively analysed 67 ERCP procedures in 38 Billroth II patients focussing on endoscope type and respective technical success and adverse event rate. 33 (49.2 %) ERCPs were performed using a duodenoscope, 87.9 % were successful and 3 were completed with the single-balloon enteroscope. 28 (41.8 %) ERCPs were performed with the single-balloon enteroscope, 82.1 % were successful and 2 were completed with a paediatric colonoscope. For 6 (9.0 %) ERCPs a paediatric colonoscope was used but only 3 (50.0 %) were successful. Overall technical success rate was 82.1 % without difference between the success rate of the duodenoscope and the single-balloon enteroscope. Overall adverse event rate was 10.5 %: 6.1 % duodenoscope,10.7 % single-balloon enteroscope, 33.3 % paediatric colonoscope. The duodenoscope allowed all conventional ERCP procedures, whereas the singleballoon enteroscope required dedicated ERCP catheters and did not allow metallic stent placement. However, the single-balloon enteroscope facilitated access to the papilla and sphincteroplasty allowed direct cholangioscopy. ERCP indications were bile duct stones (53.7 %), cholangitis (20.9 %), chronic pancreatitis (20.9 %), pancreatic cancer (1.5 %) and liver transplantation (3%). Therapeutic ERCP success rate is high in patients with Billroth II gastrectomy using either a conventional duodenoscope or the single-balloon enteroscope, with an acceptable and comparable adverse event rate. The choice of endoscope may depend on local experience, post-operative anatomy and therapeutic indication.
MeSH term(s)	Aged ; Aged, 80 and over ; Balloon Enteroscopy/adverse effects ; Belgium ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Cholangiopancreatography, Endoscopic Retrograde/instrumentation ; Duodenoscopes/adverse effects ; Female ; Fluoroscopy ; Gastrectomy/methods ; Gastroenterostomy ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Treatment Outcome
Language	English
Publishing date	2017-10
Publishing country	Belgium
Document type	Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	127060-6
ISSN	1784-3227 ; 0001-5644
ISSN	1784-3227 ; 0001-5644
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui V Zs.37: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Single-day and multi-day exposure to orogastric gavages does not affect intestinal barrier function in mice.

Hanning, Nikita / Verboven, Rosanne / De Man, Joris G / Ceuleers, Hannah / De Schepper, Heiko U / Smet, Annemieke / De Winter, Benedicte Y

American journal of physiology. Gastrointestinal and liver physiology

2023 Volume 324, Issue 4, Page(s) G281–G294

Abstract: Animals involved in common laboratory procedures experience minor levels of stress. The direct effect of limited amounts of stress on gastrointestinal function has not been reported yet. Therefore, this study aimed to assess the effect of single-day and ... ...

Abstract	Animals involved in common laboratory procedures experience minor levels of stress. The direct effect of limited amounts of stress on gastrointestinal function has not been reported yet. Therefore, this study aimed to assess the effect of single-day and multi-day orogastric gavages on gut physiology in mice. To this end, 12-wk-old female C57Bl6/J mice were randomized to receive treatment with sterile water (200 µL) delivered by orogastric gavages twice daily for a total of 1 or 10 day(s). Control animals did not receive any treatment. Subsequently, gastrointestinal function was assessed by measuring fecal pellet production. Furthermore, ex vivo intestinal barrier and secretory function of the distal colon, proximal colon, and terminal ileum were quantified in Ussing chambers. In mice, single-day gavages did neither influence corticosterone levels nor gastrointestinal function. In mice exposed to multi-day gavages, corticosterone levels were slightly but significantly increased compared with controls after 10 days of treatment. Gastrointestinal motor function was altered, as evidenced by increased fecal pellet counts and a small increase in fecal water content. However, exposure to repeated gavages did not lead to detectable alterations in gastrointestinal barrier function as quantified by the paracellular flux of the probe 4 kDa FITC-dextran as well as transepithelial resistance measurements. Thus, the administration of drugs via single-day or multi-day orogastric gavages leads to no or minor stress in mice, respectively. In both cases, it does not hamper the study of the intestinal barrier function and therefore remains a valuable administration route in preclinical pharmacological research.
MeSH term(s)	Animals ; Female ; Mice ; Colon ; Corticosterone/pharmacology ; Gastrointestinal Tract ; Ileum ; Intestinal Mucosa ; Permeability
Chemical Substances	Corticosterone (W980KJ009P)
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603840-2
ISSN	1522-1547 ; 0193-1857
ISSN (online)	1522-1547
ISSN	0193-1857
DOI	10.1152/ajpgi.00203.2022
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.89: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Distal esophageal spasm and the Chicago classification: is timing everything?

De Schepper, H U / Ponds, F A M / Oors, J M / Smout, A J P M / Bredenoord, A J

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

2016 Volume 28, Issue 2, Page(s) 260–265

Abstract: Background: According to the Chicago classification of esophageal motility disorders, distal esophageal spasm (DES) is defined as premature esophageal contractions (distal latency [DL] <4.5 s) for ≥20% of swallows, in the presence of a normal mean ... ...

Abstract	Background: According to the Chicago classification of esophageal motility disorders, distal esophageal spasm (DES) is defined as premature esophageal contractions (distal latency [DL] <4.5 s) for ≥20% of swallows, in the presence of a normal mean integral relaxation pressure (IRP). However, some patients with symptoms of DES have rapid contractions with a normal DL. The aim of this study was to characterize these patients and compare their clinical characteristics to those of patients classified as DES. Methods: We retrospectively compared clinical characteristics and high-resolution manometry findings of patients with rapid contractions with normal latency to those meeting the Chicago classification criteria for DES. Key results: Over a 3-year period, nine patients were diagnosed with DES and 14 showed rapid contractions in the distal esophagus with normal latency. The latter were younger than DES patients (60 ± 4 vs 72 ± 3 years, p < 0.05). Dysphagia and retrosternal pain occurred to a similar degree in both groups. Weight loss and abnormal barium esophagogram tended to be more frequent in DES patients. There was no difference in contractile front velocity (CFV) and in distal contractile integral (DCI) between patients with DES and rapid contractions with normal latency. Lower esophageal sphincter pressures were not different between groups. However, IRP was significantly higher in DES compared to rapid contractions with normal latency (11.7 ± 0.6 mmHg vs 7.6 ± 1.2 mmHg, p < 0.05), albeit still within the normal range. Conclusions & inferences: These data suggest that patients with simultaneous contractions with normal latency represent a group of patients with many features similar to DES.
MeSH term(s)	Aged ; Esophageal Spasm, Diffuse/diagnosis ; Esophageal Spasm, Diffuse/physiopathology ; Esophagus/physiopathology ; Female ; Humans ; Male ; Manometry ; Middle Aged ; Retrospective Studies
Language	English
Publishing date	2016-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.12721
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2979: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Impact of spatial resolution on results of esophageal high-resolution manometry.

De Schepper, H U / Kessing, B F / Weijenborg, P W / Oors, J M / Smout, A J P M / Bredenoord, A J

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

2014 Volume 26, Issue 7, Page(s) 922–928

Abstract: Background: The Chicago classification for esophageal motility disorders was designed for a 36-channel manometry system with sensors spaced at 1 cm. However, many motility laboratories outside the USA use catheters with a lower resolution in the ... ...

Abstract	Background: The Chicago classification for esophageal motility disorders was designed for a 36-channel manometry system with sensors spaced at 1 cm. However, many motility laboratories outside the USA use catheters with a lower resolution in the segments outside the esophagogastric junction. Our aim was to investigate the effect of spatial resolution on the Chicago metrics and diagnosis. Methods: In 20 healthy volunteers and 47 patients with upper gastrointestinal symptoms, high-resolution manometric studies of the esophagus were retrospectively reanalyzed using the original 1-cm spacing in the segments outside the 7-cm esophagogastric junction segment, and again after manually increasing the spacing between sensors to 2, 3, and 4 cm (above the lower esophageal sphincter region). Measurements were analyzed in random order and the investigator was blinded to the outcome of the analyses performed in another resolution of the same patient. Intra-class correlation coefficients (ICC) and Kappa values were determined. Key results: There was a very strong correlation between the 1-cm and 2-cm analysis for all Chicago metrics studied in healthy volunteers (ICCs: distal contractile integral 0.998; contractile front velocity (CFV) 0.964; distal latency 0.919; peristaltic break size 0.941). The 2-cm spacing analysis also correlated very well with the 1-cm analysis for the different Chicago diagnoses obtained in the patients (Kappa values ranging from 0.665 to 1.000). When the sensor spacing was increased to 3 and 4 cm, the correlation was reduced to moderate for the Chicago metrics, especially for break size and CFV of peristalsis. Conclusions & inferences: The Chicago classification for esophageal motility disorders is still valid and the same normal values can be used when catheters with a slightly lower resolution are used (i.e., 2-cm vs 1-cm spacing). For larger sensor intervals, the classification and the normal values will need to be adjusted.
MeSH term(s)	Esophageal Motility Disorders/diagnosis ; Esophageal Motility Disorders/physiopathology ; Esophagus/physiopathology ; Humans ; Manometry/methods ; Reference Values ; Retrospective Studies
Language	English
Publishing date	2014-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.12345
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2979: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Mechanisms contributing to visceral hypersensitivity: focus on splanchnic afferent nerve signaling.

Deiteren, A / De Man, J G / Keating, C / Jiang, W / De Schepper, H U / Pelckmans, P A / Francque, S M / De Winter, B Y

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society

2015 Volume 27, Issue 12, Page(s) 1709–1720

Abstract: Background: Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated with visceral ... ...

Abstract	Background: Visceral hypersensitivity is a main characteristic of functional bowel disorders and is mediated by both peripheral and central factors. We investigated whether enhanced splanchnic afferent signaling in vitro is associated with visceral hypersensitivity in vivo in an acute and postinflammatory rat model of colitis. Methods: Trinitrobenzene sulfonic acid (TNBS)-colitis was monitored individually by colonoscopy to confirm colitis and follow convalescence and endoscopic healing in each rat. Experiments were performed in controls, rats with acute colitis and in postcolitis rats. Colonic afferent mechanosensitivity was assessed in vivo by quantifying visceromotor responses (VMRs), and by making extracellular afferent recordings from splanchnic nerve bundles in vitro. Multiunit afferent activity was classified into single units identified as low threshold (LT), wide dynamic range (WDR), high threshold (HT), and mechanically insensitive afferents (MIA). Key results: During acute TNBS-colitis, VMRs were significantly increased and splanchnic nerve recordings showed proportionally less MIA and increased WDR and HT afferents. Acute colitis gave rise to an enhanced spontaneous activity of both LT and MIA and augmented afferent mechanosensitivity in LT, WDR and HT afferents. Postcolitis, VMRs remained significantly increased, whereas splanchnic nerve recordings showed that the proportion of LT, WDR, HT and MIA had normalized to control values. However, LT and MIA continued to show increased spontaneous activity and WDR and HT remained sensitized to colorectal distension. Conclusions & inferences: Visceral hypersensitivity in vivo is associated with sensitized splanchnic afferent responses both during acute colitis and in the postinflammatory phase. However, splanchnic afferent subpopulations are affected differentially at both time points.
MeSH term(s)	Animals ; Colitis/physiopathology ; Compliance/physiology ; Disease Models, Animal ; Electromyography ; Male ; Manometry ; Rats ; Rats, Sprague-Dawley ; Splanchnic Nerves/physiopathology ; Viscera/innervation ; Viscera/physiopathology
Language	English
Publishing date	2015-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1186328-6
ISSN	1365-2982 ; 1350-1925
ISSN (online)	1365-2982
ISSN	1350-1925
DOI	10.1111/nmo.12667
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2979: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Volatile organic compound profiling as a potential biomarker in irritable bowel syndrome: A feasibility study.

Van Malderen, Kathleen / Hanning, Nikita / Lambrechts, Helen / Haverhals, Tine / Van Marcke, Silke / Ceuleers, Hannah / De Man, Joris G / De Winter, Benedicte Y / Lamote, Kevin / De Schepper, Heiko U

Frontiers in medicine

2022 Volume 9, Page(s) 960000

Abstract: Background: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder for which no diagnostic tools are currently available. Patients are diagnosed using the Rome IV criteria and subtyped into a diarrhea, constipation, or mixed phenotype ... ...

Abstract	Background: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder for which no diagnostic tools are currently available. Patients are diagnosed using the Rome IV criteria and subtyped into a diarrhea, constipation, or mixed phenotype based on their dominant stool pattern. A recent development in the biomarker area is the analysis of volatile organic compounds (VOCs). The aim of this study was to evaluate the potential of VOCs as diagnostic and phenotypic biomarkers for IBS in breath and fecal samples. Materials and methods: Breath and fecal samples from IBS patients and healthy asymptomatic controls (HC) were analyzed with multicapillary column/ion mobility spectrometry (MCC/IMS) and classification models were created based upon VOCs and clinical characteristics. Discussion: Irritable bowel syndrome patients were differentiated from HC by means of volatile profiling in both breath and fecal samples with area under the curve (AUCs) of respectively 0.62 and 0.80. Patient subtypes could also be differentiated from each other with AUCs ranging between 0.65 and 0.78. Furthermore, VOC models could differentiate IBS patients based on clinical characteristics like psychological comorbidities and microbiota-influencing therapies. Conclusion: This study is the first to demonstrate the use of VOC profiling with the help of MCC/IMS to differentiate IBS patients. Furthermore, the importance of clinical characteristics beside the dominant stool pattern in the differentiation of IBS patients was emphasized.
Language	English
Publishing date	2022-08-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.960000
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito