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  1. Article ; Online: Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor.

    Chen, Jiakun / Stork, Tobias / Kang, Yunsik / Nardone, Katherine A M / Auer, Franziska / Farrell, Ryan J / Jay, Taylor R / Heo, Dongeun / Sheehan, Amy / Paton, Cameron / Nagel, Katherine I / Schoppik, David / Monk, Kelly R / Freeman, Marc R

    Neuron

    2023  Volume 112, Issue 1, Page(s) 93–112.e10

    Abstract: ... remain poorly defined. Here, we show the Drosophila lipid-binding G protein-coupled receptor (GPCR) Tre1 ...

    Abstract Astrocytes play crucial roles in regulating neural circuit function by forming a dense network of synapse-associated membrane specializations, but signaling pathways regulating astrocyte morphogenesis remain poorly defined. Here, we show the Drosophila lipid-binding G protein-coupled receptor (GPCR) Tre1 is required for astrocytes to establish their intricate morphology in vivo. The lipid phosphate phosphatases Wunen/Wunen2 also regulate astrocyte morphology and, via Tre1, mediate astrocyte-astrocyte competition for growth-promoting lipids. Loss of s1pr1, the functional analog of Tre1 in zebrafish, disrupts astrocyte process elaboration, and live imaging and pharmacology demonstrate that S1pr1 balances proper astrocyte process extension/retraction dynamics during growth. Loss of Tre1 in flies or S1pr1 in zebrafish results in defects in simple assays of motor behavior. Tre1 and S1pr1 are thus potent evolutionarily conserved regulators of the elaboration of astrocyte morphological complexity and, ultimately, astrocyte control of behavior.
    MeSH term(s) Animals ; Astrocytes/metabolism ; Drosophila/metabolism ; Drosophila Proteins/metabolism ; Phospholipids/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Sphingosine-1-Phosphate Receptors/metabolism ; Zebrafish
    Chemical Substances Drosophila Proteins ; Phospholipids ; Receptors, G-Protein-Coupled ; Sphingosine-1-Phosphate Receptors ; Tre1 protein, Drosophila
    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2023.11.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
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  2. Book ; Online ; E-Book: International dictionary of psychotherapy

    Nardone, Giorgio / Salvini, Alessandro

    2019  

    Author's details edited by Giorgio Nardone and Alessandro Salvini
    Keywords Psychotherapy
    Subject code 616.891403
    Language English
    Size 1 Online-Ressource (ix, 599 Seiten), Illustrationen
    Publisher Routledge
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020046025
    ISBN 978-0-429-65860-0 ; 978-0-429-02478-8 ; 9780367110949 ; 9780367110932 ; 0-429-65860-5 ; 0-429-02478-9 ; 0367110946 ; 0367110938
    DOI 10.4324/9780429024788
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Performance characteristics of an enzyme-linked immunosorbent assay for determining salivary immunoglobulin G response to Helicobacter pylori.

    De Pascalis, R / Del Pezzo, M / Nardone, G / Budillon, G / Lavitola, A

    Journal of clinical microbiology

    1999  Volume 37, Issue 2, Page(s) 430–432

    Abstract: We evaluated the salivary immunoglobulin G (IgG) immune response to Helicobacter pylori in 70 ...

    Abstract We evaluated the salivary immunoglobulin G (IgG) immune response to Helicobacter pylori in 70 subjects by enzyme-linked immunosorbent assay (ELISA). Subjects with a positive H. pylori culture showed significantly higher titers of antibodies than subjects with no detectable H. pylori: the overall sensitivity and specificity of the test were 84 and 90%, respectively. The detection of salivary anti-H. pylori IgG antibodies may be considered as an alternative to serum IgG detection for ease of sample collection or when blood samples are not available in screening of patients with dyspepsia.
    MeSH term(s) Antibodies, Bacterial/analysis ; Antibodies, Bacterial/blood ; Culture Media ; Enzyme-Linked Immunosorbent Assay/methods ; Evaluation Studies as Topic ; Helicobacter Infections/diagnosis ; Helicobacter Infections/immunology ; Helicobacter pylori/immunology ; Helicobacter pylori/isolation & purification ; Humans ; Immunoglobulin G/analysis ; Immunoglobulin G/blood ; Saliva/immunology ; Saliva/microbiology ; Sensitivity and Specificity
    Chemical Substances Antibodies, Bacterial ; Culture Media ; Immunoglobulin G
    Language English
    Publishing date 1999-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.37.2.430-432.1999
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  4. Article: Evaluation of a commercial serological kit for detection of salivary immunoglobulin G to Helicobacter pylori: a multicentre study.

    Luzza, F / Imeneo, M / Marasco, A / Crotta, S / Ierardi, E / Usai, P / Virgilio, C / Nardone, G / Marchi, S / Sanna, G / Perri, F / Maurizio Zagari, R / Bazzoli, F

    European journal of gastroenterology & hepatology

    2000  Volume 12, Issue 10, Page(s) 1117–1120

    Abstract: ... for detecting salivary immunoglobulin (Ig) G to Helicobacter pylori.: Design: Prospective, multicentre study ...

    Abstract Objective: To evaluate the usefulness of a commercial serological enzyme immunoassay (EIA) for detecting salivary immunoglobulin (Ig) G to Helicobacter pylori.
    Design: Prospective, multicentre study.
    Setting: The study was conducted at 11 gastroenterology hospital centres throughout Italy.
    Participants and interventions: Two hundred and thirteen dyspeptic patients underwent gastroscopy with antral biopsies. At each centre, two of the following three tests for H. pylori diagnosis were performed: urease quick test, histology, and 13C-urea breath test. Samples of unstimulated saliva and venous blood were collected from each patient. Salivary and serum H. pylori IgG were determined with the EIA Helori-test IgG (Eurospital, Trieste, Italy).
    Main outcome measures: Sensitivity, specificity, positive and negative predictive values, and accuracy of the salivary and serum EIAs.
    Results: By using a receiver operating characteristic curve, salivary EIA yielded 81% (95% confidence interval 73-87%) sensitivity, 73% (62-83%) specificity, 84% (76-90%) positive predictive value, 69% (58-79%) negative predictive value, and 78% (72-84%) accuracy. At the cut-off suggested by the manufacturer, serum EIA had 90% (84-95%) sensitivity, 78% (67-86%) specificity, 88% (81-93%) positive predictive value, 82% (71-90%) negative predictive value, and 86% (81-91%) accuracy.
    Conclusion: In this large multicentre study, detection of salivary H. pylori IgG with a commercial serological EIA was a fairly accurate diagnostic method. Data confirm that saliva testing does not compare favourably with serology in the assessment of H. pylori status.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Helicobacter Infections/diagnosis ; Helicobacter Infections/microbiology ; Helicobacter pylori/immunology ; Helicobacter pylori/isolation & purification ; Humans ; Immunoenzyme Techniques/methods ; Immunoglobulin G/analysis ; Immunoglobulin G/blood ; Male ; Middle Aged ; Predictive Value of Tests ; Prospective Studies ; ROC Curve ; Saliva/immunology ; Sensitivity and Specificity ; Serologic Tests
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2000-02-23
    Publishing country England
    Document type Evaluation Studies ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1034239-4
    ISSN 1473-5687 ; 0954-691X
    ISSN (online) 1473-5687
    ISSN 0954-691X
    DOI 10.1097/00042737-200012100-00008
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  5. Book: Systemische Kurztherapie bei Ess-Störungen

    Nardone, Giorgio

    Einführung und Fallstudien

    (Klinische Praxis)

    2003  

    Author's details Giorgio Nardone
    Series title Klinische Praxis
    Keywords Essstörung ; Kurzpsychotherapie ; Systemische Therapie
    Subject Essgewohnheit ; Essstörungen ; Systemische Psychotherapie ; Kurzzeitpsychotherapie ; Kurzzeittherapie ; Kurztherapie
    Language German
    Size 270 S.
    Edition 1. Aufl.
    Publisher Huber
    Publishing place Bern u.a.
    Publishing country Switzerland
    Document type Book
    Note Aus dem Engl. übers.
    HBZ-ID HT013646243
    ISBN 3-456-83961-8 ; 978-3-456-83961-5
    Database Catalogue ZB MED Medicine, Health

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    2003 A 2145 order for loan Magazin

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  6. Book: The strategic dialogue

    Nardone, Giorgio / Salvini, Alessandro

    rendering the diagnostic interview a real therapeutic intervention

    2007  

    Author's details Giorgio Nardone and Alessandro Salvini
    Language English
    Size XII, 122 S.
    Publisher Karnac
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015356933
    ISBN 978-1-85575-556-7 ; 1-85575-556-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2008 A 1359 order for loan Magazin

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  7. Book ; Conference proceedings: Controversies in gastrointestinal diseases

    Nardone, Gerardo

    (Digestive diseases ; 25,3)

    2007  

    Institution European Association for Gastroenterology and Endoscopy
    Event/congress European Bridging Meeting in Gastroenterology (8, 2006, Neapel)
    Author's details 8th European Bridging Meeting in Gastroenterology, EAGE postgraduate course, November 23 - 25, 2006, Naples, Italy. Ed. Gerardo Nardone
    Series title Digestive diseases ; 25,3
    Collection
    Keywords Gastrointestinale Krankheit
    Subject Magen-Darm-Krankheit ; Magen-Darm-Kanal
    Language English
    Size S. 170 - 289 : graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT015284913
    ISBN 978-3-8055-8333-6 ; 3-8055-8333-8
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1853 -25- not available for loan Zeitschriften-Lesesaal

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  8. Book: Prison of food

    Nardone, Giorgio / Verbitz, Tiziana / Milanese, Roberta

    research and treatment of eating disorders

    2005  

    Author's details Giorgio Nardone with Tiziana Verbitz and Roberta Milanese
    Language English
    Size X, 287 S. : graph. Darst.
    Publisher Karnac
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014233308
    ISBN 1-85575-367-7 ; 978-1-85575-367-9
    Database Catalogue ZB MED Medicine, Health

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  9. Article ; Online: Neck muscle spasticity in patients with disorder of consciousness: a pilot study.

    Pingue, Valeria / Mirando, Marta / Cazzulani, Benedetta / Bellaviti, Gianluca / Saporiti, Filippo / Zanga, Cristina / Nardone, Antonio

    European journal of physical and rehabilitation medicine

    2024  

    Abstract: ... of the other confounding variables at admission (e.g., age, severity of brain injury, functional assessment, and pain ...

    Abstract Background: Disorder of consciousness (DOC) is a state of prolonged altered consciousness due to severe acquired brain injury (ABI). DOC can be differentiated into coma, unresponsive wakefulness syndrome (UWS), or minimally conscious state (MCS) depending on the behavioral features observed and their relationship to the level of consciousness. Spasticity is one of the most frequently reported medical comorbidities in DOC patients. Since there is a critical lack of spasticity-focused studies and, in turn, of target treatment, we designed this pilot prospective study to evaluate cervical spine muscle spasticity and its effect on rehabilitation outcome in a large cohort of patients followed from the post-acute phase to 6 months after severe ABI.
    Aim: To evaluate neck muscle spasticity and investigate its impact on neurological and functional outcome in a large cohort of adult patients with DOC followed from post-acute to 6 months after severe ABI.
    Design: Single-center prospective pilot study.
    Setting: Highly specialized inpatient neurorehabilitation clinic.
    Population: Patients with severe ABI admitted within 3 months after the acute event to our Neurorehabilitation Unit between May 21
    Methods: In this single-center prospective pilot study demographic data, etiology of ABI (traumatic versus non-traumatic), DOC evaluated with the revised Coma Recovery Scale (CRS-R), and neurological and functional outcome assessed respectively with the Glasgow Coma Scale (GCS) and Functional Independence Measure (FIM) were considered. During cervical examination, we assessed spasticity with the Modified Ashworth Scale (MAS), deviation of head alignment with a goniometer, and pain with the Nociception Coma Scale-Revised (NCS-R).
    Results: Of the 48 patients, 41.7% were diagnosed with UWS and 58.3% were in a minimally conscious state (MCS). We found spasticity of neck muscles in 91.7% of patients, with no difference in severity (assessed with MAS) between UWV and MCS. The NCS-R score at cervical spine examination was lower in UWS than MCS. Spasticity was severer in patients with traumatic brain injury (TBI) compared to non-traumatic. At multiple linear regression analysis, younger age, hemisyndrome, and tetraparesis were independent predictors of severity of neck muscle spasticity in MCS. More severe spasticity was a predictor of worse neurological and functional outcome at discharge in UWS patients, independently of the other confounding variables at admission (e.g., age, severity of brain injury, functional assessment, and pain).
    Conclusions: Spasticity of neck muscles frequently develops in patients with DOC and is more severe in those after TBI. UWV and MCS have different spasticity profiles as regards risk factors and neurological and functional outcome. Severity of neck muscle spasticity in UWV patients may represent an early indicator of worse neurological and functional outcome after inpatient rehabilitation.
    Clinical rehabilitation impact: Our findings could prompt clinicians to redefine the rehabilitation aims regarding spasticity and to estimate the functional outcome in patients undergoing intensive rehabilitation after severe ABI.
    Language English
    Publishing date 2024-03-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2426908-6
    ISSN 1973-9095 ; 1973-9087
    ISSN (online) 1973-9095
    ISSN 1973-9087
    DOI 10.23736/S1973-9087.24.08176-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1388: Show issues Location:
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  10. Book: Systemische Kurztherapie bei Zwängen und Phobien

    Nardone, Giorgio

    Einführung in die Kunst der Lösung komplizierter Probleme mit einfachen Mitteln

    (Aus dem Programm Huber: Psychologie-Praxis)

    1997  

    Author's details Giorgio Nardone. Mit einem Vorw. von Paul Watzlawick
    Series title Aus dem Programm Huber: Psychologie-Praxis
    Keywords Obsessive-Compulsive Disorder / therapy ; Panic Disorder / therapy ; Phobic Disorders / therapy ; Psychotherapy, Brief / methods ; Phobie ; Kurzpsychotherapie ; Zwangsstörung
    Subject Kurzzeitpsychotherapie ; Kurzzeittherapie ; Kurztherapie ; Anankastische Neurose ; Anankastisches Syndrom ; Obsessionsneurose ; Zwangssyndrom ; Zwangskrankheit ; Zwangserkrankung ; Zwangserscheinung ; Zwangsneurose
    Language German
    Size 278 S.
    Edition 1. Aufl.
    Publisher Huber
    Publishing place Bern u.a.
    Publishing country Switzerland
    Document type Book
    Note Aus dem Engl. übers.
    HBZ-ID HT007491796
    ISBN 3-456-82864-0 ; 978-3-456-82864-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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