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Article ; Online: Reply to V. Pitini et al and L.J. Costa.

Thompson, Carrie A / Ghesquieres, Herve / Maurer, Matthew J / Cerhan, James R / Link, Brian K

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2015 Volume 33, Issue 14, Page(s) 1625–1626

MeSH term(s)	Antineoplastic Agents/therapeutic use ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse/diagnostic imaging ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Male ; Neoplasm Recurrence, Local/diagnostic imaging ; Tomography, X-Ray Computed
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2015-05-10
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2014.60.5535
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article: A new break in V(D)J recombination.

Ferguson, S E / Thompson, C B

Current biology : CB

1993 Volume 3, Issue 1, Page(s) 51–53

Language	English
Publishing date	1993-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/0960-9822(93)90150-m
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Zs.A 3208: Show issues

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Article: New insights into V(D)J recombination and its role in the evolution of the immune system.

Thompson, C B

Immunity

1995 Volume 3, Issue 5, Page(s) 531–539

MeSH term(s)	Animals ; Biological Evolution ; Cell Differentiation/genetics ; DNA Nucleotidyltransferases/physiology ; DNA Transposable Elements/genetics ; DNA-Binding Proteins ; Epitopes/genetics ; Gene Rearrangement, B-Lymphocyte/genetics ; Gene Rearrangement, B-Lymphocyte/immunology ; Gene Rearrangement, T-Lymphocyte/genetics ; Gene Rearrangement, T-Lymphocyte/immunology ; Genes, Immunoglobulin/genetics ; Homeodomain Proteins ; Humans ; Immune System/cytology ; Immune System/growth & development ; Nuclear Proteins ; Proteins/genetics ; Receptors, Antigen, B-Cell/genetics ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Receptors, Antigen, T-Cell, gamma-delta/genetics ; Recombination, Genetic/genetics ; Regulatory Sequences, Nucleic Acid/genetics ; VDJ Recombinases ; Vertebrates/genetics ; Vertebrates/immunology
Chemical Substances	DNA Transposable Elements ; DNA-Binding Proteins ; Epitopes ; Homeodomain Proteins ; Nuclear Proteins ; Proteins ; RAG2 protein, human ; Receptors, Antigen, B-Cell ; Receptors, Antigen, T-Cell, alpha-beta ; Receptors, Antigen, T-Cell, gamma-delta ; V(D)J recombination activating protein 2 ; RAG-1 protein (128559-51-3) ; DNA Nucleotidyltransferases (EC 2.7.7.-) ; VDJ Recombinases (EC 2.7.7.-)
Language	English
Publishing date	1995-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/1074-7613(95)90124-8
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: Re: Location of extrarenal tumor extension does not impact survival of patients with pT3a renal cell carcinoma. V. Margulis, P. Tamboli, S. F. Matin, M. Meisner, D. A. Swanson and C. G. Wood. J Urol 2007; 178: 1878-1882.

Thompson, R Houston / Cheville, John C / Leibovich, Bradley C / Blute, Michael L

The Journal of urology

2008 Volume 180, Issue 1, Page(s) 409; author reply 409–10

MeSH term(s)	Carcinoma, Renal Cell/mortality ; Carcinoma, Renal Cell/pathology ; Humans ; Kidney Neoplasms/mortality ; Kidney Neoplasms/pathology ; Neoplasm Invasiveness ; Neoplasm Staging ; Survival Rate
Language	English
Publishing date	2008-07
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	3176-8
ISSN	1527-3792 ; 0022-5347
ISSN (online)	1527-3792
ISSN	0022-5347
DOI	10.1016/j.juro.2008.03.073
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Ui VI Zs.91: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 331: Show issues

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Book ; Online: Isotope ratios and trace element concentrations of basalts from DSDP Leg 15 sites (Appendix 1), supplementary data to: Thompson, Patricia M E; Kempton, Pamela D; White, Rosalind V; Kerr, Andrew C; Tarney, J; Saunders, Andrew D; Fitton, J Godfrey; McBirney, A (2003): Hf-Nd isotope constraints on the origin of the Cretaceous Caribbean plateau and its relationship to the Galápagos plume. Earth and Planetary Science Letters, 217(1-2), 59-75

Thompson, Patricia M E / Fitton, J Godfrey / Kempton, Pamela D / Kerr, Andrew C / McBirney, A / Saunders, Andrew D / Tarney, J / White, Rosalind V

2003

Abstract: Formation of the Cretaceous Caribbean plateau, including the komatiites of Gorgona, has been linked to the currently active Galápagos hotspot. We use Hf-Nd isotopes and trace element data to characterise both the Caribbean plateau and the Galápagos ... ...

Abstract	Formation of the Cretaceous Caribbean plateau, including the komatiites of Gorgona, has been linked to the currently active Galápagos hotspot. We use Hf-Nd isotopes and trace element data to characterise both the Caribbean plateau and the Galápagos hotspot, and to investigate the relationship between them. Four geochemical components are identified in the Galápagos mantle plume: two 'enriched' components with epsilon-Hf and epsilon-Nd similar to enriched components observed in other mantle plumes, one moderately enriched component with high Nb/Y, and a fourth component which most likely represents depleted MORB source mantle. The Caribbean plateau basalt data form a linear array in Hf-Nd isotope space, consistent with mixing between two mantle components. Combined Hf-Nd-Pb-Sr-He isotope and trace element data from this study and the literature suggest that the more enriched Caribbean end member corresponds to one or both of the enriched components identified on Galápagos. Likewise, the depleted end member of the array is geochemically indistinguishable from MORB and corresponds to the depleted component of the Galápagos system. Enriched basalts from Gorgona partially overlap with the Caribbean plateau array in epsilon-Hf vs. epsilon-Nd, whereas depleted basalts, picrites and komatiites from Gorgona have a high epsilon-Hf for a given epsilon-Nd, defining a high-epsilon-Hf depleted end member that is not observed elsewhere within the Caribbean plateau sequences. This component is similar, however, in terms of Hf-Nd-Pb-He isotopes and trace elements to the depleted plume component recognised in basalts from Iceland and along the Reykjanes Ridge. We suggest that the Caribbean plateau represents the initial outpourings of the ancestral Galápagos plume. Absence of a moderately enriched, high Nb/Y component in the older Caribbean plateau (but found today on the island of Floreana) is either due to changing source compositions of the plume over its 90 Ma history, or is an artifact of limited sampling. The high-epsilon-Hf depleted component sampled by the Gorgona komatiites and depleted basalts is unique to Gorgona and is not found in the Caribbean plateau. This may be an indication of the scale of heterogeneity of the Caribbean plateau system; alternatively Gorgona may represent a separate oceanic plateau derived from a completely different Pacific plume, such as the Sala y Gomez.
Language	English
Dates of publication	2003-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1016/S0012-821X(03)00542-9
DOI	10.1594/PANGAEA.725469
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Excision products of TCR V alpha recombination contain in-frame rearrangements: evidence for continued V(D)J recombination in TCR+ thymocytes.

McCormack, W T / Liu, M / Postema, C / Thompson, C B / Turka, L A

International immunology

1993 Volume 5, Issue 7, Page(s) 801–804

Abstract: ... sufficient for V(D)J recombination to occur, this finding suggests that productive TCR gene rearrangement ... events. Our data shows that TCR alpha excision products from TCR+ thymocytes contain in-frame V-J joints ... and thus support the concept that V(D)J recombinatorial activity may continue even in thymocytes ...

Abstract	Cortical thymocytes that express a TCR on their surface continue to express mRNA for the recombination activating genes RAG-1 and RAG-2. As the expression of these genes appears to be necessary and sufficient for V(D)J recombination to occur, this finding suggests that productive TCR gene rearrangement may not by itself terminate TCR recombination. To further study this question, we have utilized a polymerase chain reaction-based strategy to isolate and sequence excision products of secondary TCR alpha gene rearrangement events. Our data shows that TCR alpha excision products from TCR+ thymocytes contain in-frame V-J joints and thus support the concept that V(D)J recombinatorial activity may continue even in thymocytes which have undergone productive TCR gene rearrangement.
MeSH term(s)	Base Sequence ; Child, Preschool ; DNA, Circular/analysis ; DNA-Binding Proteins ; Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor ; Homeodomain Proteins ; Humans ; Infant ; Infant, Newborn ; Molecular Sequence Data ; Nuclear Proteins ; Polymerase Chain Reaction ; Proteins/genetics ; Receptors, Antigen, T-Cell, alpha-beta/analysis ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Recombination, Genetic ; T-Lymphocytes/immunology
Chemical Substances	DNA, Circular ; DNA-Binding Proteins ; Homeodomain Proteins ; Nuclear Proteins ; Proteins ; RAG2 protein, human ; Receptors, Antigen, T-Cell, alpha-beta ; V(D)J recombination activating protein 2 ; RAG-1 protein (128559-51-3)
Language	English
Publishing date	1993-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1013745-2
ISSN	1460-2377 ; 0953-8178
ISSN (online)	1460-2377
ISSN	0953-8178
DOI	10.1093/intimm/5.7.801
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Zs.A 2619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 70: Show issues

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Article: Differential regulation of V(D)J recombination during development of avian B and T cells.

Pickel, J M / McCormack, W T / Chen, C H / Cooper, M D / Thompson, C B

International immunology

1993 Volume 5, Issue 8, Page(s) 919–927

Abstract: ... of individual members of variable (V), diversity (D), and joining (J) gene segment families during embryonic ... undergo V(D)J recombination following migration to the thymus. Thus, distinct developmental mechanisms ... from the V beta 1 gene family can be detected beginning on day 12 of development, while rearrangements ...

Abstract	The lymphoid immune system is comprised of two major cell types, B cells and T cells, originally identified in avian species. Although both lineages arise from hematopoietic stem cells, avian B cells require a period of development in the bursa of Fabricius while T cells undergo development in the thymus. Each cell type expresses a lineage-specific antigen receptor encoded by genes created by the rearrangement of individual members of variable (V), diversity (D), and joining (J) gene segment families during embryonic development. In this report, we demonstrate that productive rearrangement of the TCR beta gene occurs exclusively in the thymus during normal development. TCR beta rearrangements involving gene segments from the V beta 1 gene family can be detected beginning on day 12 of development, while rearrangements involving the other family of V beta gene segments, V beta 2, were first detected on day 14 of embryogenesis. In contrast, productive rearrangements of Ig light (IgL) and heavy (IgH) chain genes were not restricted to the bursa of Fabricius. Instead, VH-DJH heavy chain rearrangements and VL-JL light chain rearrangements were detected primarily in the embryonic spleen, beginning as early as embryonic day 10, even in birds bursectomized at 60 h of development. Within the spleen, Ig rearrangement was confined to the subset of cells that express the chB6 surface protein. Unlike bursal lymphocytes, which express the recombinase activating gene (RAG)-2 but not RAG-1, splenic B cell precursors also express RAG-1. The data indicate that, while B cell precursors initiate recombination prior to migration of the bursa of Fabricius, T cell precursors undergo V(D)J recombination following migration to the thymus. Thus, distinct developmental mechanisms appear to regulate the process of receptor rearrangement during avian B and T cell development.
MeSH term(s)	Animals ; B-Lymphocytes/immunology ; Base Sequence ; Chick Embryo ; Gene Rearrangement ; Genes, Immunoglobulin ; Homeodomain Proteins ; Immunoglobulin Joining Region/genetics ; Immunoglobulin Light Chains/genetics ; Immunoglobulin Variable Region/genetics ; Molecular Sequence Data ; Proteins/genetics ; RNA, Messenger/analysis ; Receptors, Antigen, T-Cell/genetics ; Recombination, Genetic ; T-Lymphocytes/immunology
Chemical Substances	Homeodomain Proteins ; Immunoglobulin Joining Region ; Immunoglobulin Light Chains ; Immunoglobulin Variable Region ; Proteins ; RNA, Messenger ; Receptors, Antigen, T-Cell ; RAG-1 protein (128559-51-3)
Language	English
Publishing date	1993-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1013745-2
ISSN	1460-2377 ; 0953-8178
ISSN (online)	1460-2377
ISSN	0953-8178
DOI	10.1093/intimm/5.8.919
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Zs.A 2619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Restricted immunoglobulin junctional diversity in neonatal B cells results from developmental selection rather than homology-based V(D)J joining.

Pandey, A / Tjoelker, L W / Thompson, C B

The Journal of experimental medicine

1993 Volume 177, Issue 2, Page(s) 329–337

Abstract: ... whether these sequence homologies play any direct role in favoring coding joint formation by influencing the V(D)J recombination ... of coding joints during V(D)J recombination in vivo. Instead, during embryonic development, B cells ... in directing V(D)J recombination. Instead, we propose that limited Ig junctional diversity results ...

Abstract	The mechanism by which coding ends are joined during immunoglobulin (Ig) recombination is poorly understood. Recently, short sequence similarities (2-6 bp) observed at the ends of certain variable (V), diversity (D), and joining (J) gene segments of Ig have been correlated with limited junctional diversity observed in coding exons assembled from these elements. However, it is unclear whether these sequence homologies play any direct role in favoring coding joint formation by influencing the V(D)J recombination process. In this report, we demonstrate that coding sequence similarities do not influence the position of coding joints during V(D)J recombination in vivo. Instead, during embryonic development, B cells with certain joining products undergo progressive selection. Developmental selection is completed before exposure to external antigens and appears to be determined by the amino acid sequence encoded by the coding joint. We conclude that the nucleotide sequences of the coding regions do not play a major role in directing V(D)J recombination. Instead, we propose that limited Ig junctional diversity results from prenatal developmental selection of B cells based on the protein sequence of their surface Ig antigen-binding site. Sequence identities at the ends of coding segments may have evolved because they increase the likelihood that a selectable antigen-binding site is created during a random recombination process.
MeSH term(s)	Animals ; Animals, Newborn/immunology ; Antibody Diversity ; B-Lymphocytes/cytology ; Base Sequence ; Bursa of Fabricius/embryology ; Ducks ; Gene Rearrangement, B-Lymphocyte, Light Chain ; Genes, Immunoglobulin ; Molecular Sequence Data ; Oligodeoxyribonucleotides/chemistry ; Polymerase Chain Reaction ; Recombination, Genetic ; Spleen/cytology ; Spleen/embryology
Chemical Substances	Oligodeoxyribonucleotides
Language	English
Publishing date	1993-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.177.2.329
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Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: RAG-1 and RAG-2 gene expression and V(D)J recombinase activity are enhanced by protein phosphatase 1 and 2A inhibition in lymphocyte cell lines.

Casillas, A M / Thompson, A D / Cheshier, S / Hernandez, S / Aguilera, R J

Molecular immunology

1995 Volume 32, Issue 3, Page(s) 167–175

Abstract: Expression of the recombination activating genes, RAG-1 and RAG-2, in lymphocytes, has been shown to depend on second messenger systems. An increase in intracellular cAMP upon stimulation with caffeine increases RAG expression while activation of protein ...

Abstract	Expression of the recombination activating genes, RAG-1 and RAG-2, in lymphocytes, has been shown to depend on second messenger systems. An increase in intracellular cAMP upon stimulation with caffeine increases RAG expression while activation of protein kinase C (PKC) with phorbol myristate acetate (PMA) results in decreased RAG expression. The stringent regulation of recombination appears to be partially dependent on protein kinase activities which, alone, are not likely to be sufficient to regulate recombinase activity. We provide evidence implicating a role for serine/threonine phosphatases in the signal transduction pathway which regulates RAG gene expression and consequently the recombination process in lymphocytes. The cell permeable tumor promoter, calyculin-A (CLA), which is a potent inhibitor of the type 1 and 2A serine/threonine protein phosphatases (PP1 and PP2A, respectively), was shown to upregulate the expression of RAG-1 and RAG-2 in pre-B as well as mature B- and T-lymphocyte cell lines. Although agents such as caffeine known to increase intracellular cAMP levels induce RAG expression, synergy between CLA and caffeine was not detected in pre-B cells. An in vivo assessment of recombination activity after transfection of pre-B cells with an extrachromosomal recombination vector revealed a moderate increase in recombinase activity which paralleled RAG expression after CLA stimulation. Although increased cAMP levels in pre-B cells has been associated with upregulation of RAG expression we found no such upregulation in a surface immunoglobulin M positive (sIgM+) cell line, WEHI-231, and a T cell receptor positive (TCR+) murine cell line, EL-4. Moreover, in these mature lymphocyte cell lines there was no evidence of synergy in the regulation of RAG-1 and RAG-2 mRNA upon stimulation with CLA and caffeine. These results suggest novel intracellular mechanisms for the upregulation of RAG gene expression and confirm a role for type 1 and 2A phosphatases in the control of RAG gene expression and recombinase activity in lymphocyte cell lines.
MeSH term(s)	Animals ; B-Lymphocytes/metabolism ; Base Sequence ; Cell Line ; DNA Nucleotidyltransferases/metabolism ; DNA-Binding Proteins ; Gene Rearrangement, B-Lymphocyte/genetics ; Homeodomain Proteins ; Mice ; Molecular Sequence Data ; Oxazoles/pharmacology ; Phosphoprotein Phosphatases/antagonists & inhibitors ; Phosphoprotein Phosphatases/physiology ; Polymerase Chain Reaction ; Protein Biosynthesis ; Protein Phosphatase 1 ; Proteins/genetics ; Recombination, Genetic/physiology ; Transfection/genetics ; Up-Regulation/genetics ; VDJ Recombinases
Chemical Substances	DNA-Binding Proteins ; Homeodomain Proteins ; Oxazoles ; Proteins ; Rag2 protein, mouse ; V(D)J recombination activating protein 2 ; RAG-1 protein (128559-51-3) ; calyculin A (7D07U14TK3) ; DNA Nucleotidyltransferases (EC 2.7.7.-) ; VDJ Recombinases (EC 2.7.7.-) ; Phosphoprotein Phosphatases (EC 3.1.3.16) ; Protein Phosphatase 1 (EC 3.1.3.16)
Language	English
Publishing date	1995-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/0161-5890(94)00142-n
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Article ; Online: Spreading violaceous neck plaques in a fatigued man.

Thompson, H J / Patrick, A / Liu, V

Clinical and experimental dermatology

2021 Volume 46, Issue 4, Page(s) 778–781

MeSH term(s)	Aged ; Fatigue/etiology ; Head and Neck Neoplasms/complications ; Head and Neck Neoplasms/pathology ; Humans ; Leukemia, Prolymphocytic, T-Cell/complications ; Leukemia, Prolymphocytic, T-Cell/pathology ; Male
Language	English
Publishing date	2021-01-10
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.14545
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