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  1. Article: The B.C.G. lesion in sarcoidosis.

    FORGACS, P / MCDONALD, C K / SKELTON, M O

    Lancet (London, England)

    2003  Volume 272, Issue 6961, Page(s) 188–190

    MeSH term(s) Humans ; Sarcoidosis/pathology
    Language English
    Publishing date 2003-03-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0140-6736 ; 0023-7507
    ISSN (online) 1474-547X
    ISSN 0140-6736 ; 0023-7507
    DOI 10.1016/s0140-6736(57)92489-3
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
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  2. Article ; Online: Functional nociceptin receptors are upregulated on human umbilical vein endothelial cells during experimental in vitro sepsis.

    Bird, M F / McDonald, J / Gallacher-Horley, B / Guerrini, R / Calo, G / Ye, S / Thompson, J P / Lambert, D G

    British journal of anaesthesia

    2024  Volume 124, Issue 4, Page(s) e205–e206

    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2019.11.012
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.80: Show issues Location:
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  3. Article ; Online: Simulated digestions of free oligosaccharides and mucin-type O-glycans reveal a potential role for Clostridium perfringens.

    McDonald, Andrew G / Lisacek, Frédérique

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 1649

    Abstract: ... HMO and mucin-type O-glycans. B. bifidum, B. longum and C. perfringens species were predicted to have ...

    Abstract The development of a stable human gut microbiota occurs within the first year of life. Many open questions remain about how microfloral species are influenced by the composition of milk, in particular its content of human milk oligosaccharides (HMOs). The objective is to investigate the effect of the human HMO glycome on bacterial symbiosis and competition, based on the glycoside hydrolase (GH) enzyme activities known to be present in microbial species. We extracted from UniProt a list of all bacterial species catalysing glycoside hydrolase activities (EC 3.2.1.-), cross-referencing with the BRENDA database, and obtained a set of taxonomic lineages and CAZy family data. A set of 13 documented enzyme activities was selected and modelled within an enzyme simulator according to a method described previously in the context of biosynthesis. A diverse population of experimentally observed HMOs was fed to the simulator, and the enzymes matching specific bacterial species were recorded, based on their appearance of individual enzymes in the UniProt dataset. Pairs of bacterial species were identified that possessed complementary enzyme profiles enabling the digestion of the HMO glycome, from which potential symbioses could be inferred. Conversely, bacterial species having similar GH enzyme profiles were considered likely to be in competition for the same set of dietary HMOs within the gut of the newborn. We generated a set of putative biodegradative networks from the simulator output, which provides a visualisation of the ability of organisms to digest HMO and mucin-type O-glycans. B. bifidum, B. longum and C. perfringens species were predicted to have the most diverse GH activity and therefore to excel in their ability to digest these substrates. The expected cooperative role of Bifidobacteriales contrasts with the surprising capacities of the pathogen. These findings indicate that potential pathogens may associate in human gut based on their shared glycoside hydrolase digestive apparatus, and which, in the event of colonisation, might result in dysbiosis. The methods described can readily be adapted to other enzyme categories and species as well as being easily fine-tuneable if new degrading enzymes are identified and require inclusion in the model.
    MeSH term(s) Infant, Newborn ; Humans ; Clostridium perfringens ; Bifidobacterium ; Mucins/analysis ; Oligosaccharides/analysis ; Milk, Human/chemistry ; Bifidobacterium bifidum ; Bacteria ; Glycoside Hydrolases/analysis ; Digestion
    Chemical Substances Mucins ; Oligosaccharides ; Glycoside Hydrolases (EC 3.2.1.-)
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-51012-4
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  4. Article ; Online: The impact of educational whiteboard videos on healthcare providers' self-efficacy to deprescribe.

    Turner, Justin P / Gagnon, Camille L / Khuong, Ninh B / McDonald, Emily G / Tannenbaum, Cara

    Journal of the American Geriatrics Society

    2023  Volume 71, Issue 5, Page(s) E15–E18

    MeSH term(s) Humans ; Deprescriptions ; Self Efficacy ; Health Personnel ; Educational Status ; Polypharmacy
    Language English
    Publishing date 2023-03-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18335
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.168: Show issues Location:
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  5. Article ; Online: Spectral analysis and kinetic modeling of radioluminescence in air and nitrogen.

    Jans, E R / Casey, T / Marshall, G J / Murzyn, C M / Harilal, S S / McDonald, B S / Harrison, R K

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 17, Page(s) 13316–13326

    Abstract: In this article we present a quantitative analysis of the second positive system of molecular nitrogen and the first negative system of the molecular nitrogen cation excited in the presence of ionizing radiation. Optical emission spectra of atmospheric ... ...

    Abstract In this article we present a quantitative analysis of the second positive system of molecular nitrogen and the first negative system of the molecular nitrogen cation excited in the presence of ionizing radiation. Optical emission spectra of atmospheric air and nitrogen surrounding
    Language English
    Publishing date 2024-05-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp06198a
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  6. Article: Evaluation of the Mechanical, Thermal and Rheological Properties of Hop, Hemp and Wood Fiber Plastic Composites.

    Talcott, Sierra / Uptmor, Benjamin / McDonald, Armando G

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 11

    Abstract: The aim of this study was to evaluate the use of waste natural fibers from milled hop bines and hemp stalks, without chemical treatment, and compare them to a commercial wood fiber for use in wood-plastic composite (WPC) materials. The fibers were ... ...

    Abstract The aim of this study was to evaluate the use of waste natural fibers from milled hop bines and hemp stalks, without chemical treatment, and compare them to a commercial wood fiber for use in wood-plastic composite (WPC) materials. The fibers were characterized (density, fiber size and chemical composition). WPCs were produced by the extrusion of a blend of fibers (50%), high-density polyethylene (HDPE) and coupling agent (2%). The WPCs were characterized for their mechanical, rheological, thermal, viscoelastic and water resistance properties. Pine fiber was about half the size of hemp and hop fibers and thus had a higher surface area. The pine WPC melts had a higher viscosity than the other two WPCs. Additionally, the tensile and flexural strengths of the pine WPC were higher than those of hop and hemp WPCs. The pine WPC was also shown to have the least water absorption followed by hop and hemp WPCs. This study highlights that different lignocellulosic fibers influence their WPC properties. The properties of the hop- and hemp-based WPCs were comparable to commercial WPCs and can be improved by further milling/screening the fibers to a smaller particle size (volumetric mean of ~88 μm) to increase their surface area, fiber-matrix interactions and improve stress-transfer.
    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16114187
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  7. Article ; Online: A Qualitative Analysis of Barriers to Accessing HIV Prevention Services During an HIV Outbreak among Persons who Inject Drugs in West Virginia.

    Hershow, Rebecca B / Worthington, Nancy / Adams, Monica / McDonald, Robert / Wilson, Suzanne / McBee, Shannon / Balleydier, Shawn / Curran, Kathryn G

    AIDS and behavior

    2024  Volume 28, Issue 2, Page(s) 669–681

    Abstract: In response to an increase in HIV diagnoses among persons who inject drugs (PWID) in Kanawha County, West Virginia, West Virginia Bureau for Public Health and CDC conducted a qualitative assessment in Kanawha County to inform HIV outbreak response ... ...

    Abstract In response to an increase in HIV diagnoses among persons who inject drugs (PWID) in Kanawha County, West Virginia, West Virginia Bureau for Public Health and CDC conducted a qualitative assessment in Kanawha County to inform HIV outbreak response activities. Interviews with 26 PWID and 45 community partners were completed. Transcribed interviews were analyzed to identify barriers to accessing HIV prevention services among PWID using the risk environment framework. Participants identified numerous political, physical, social, and economic community-level barriers that influenced access to HIV prevention services among PWID. Political factors included low community support for syringe services programs (SSPs); physical factors included low SSP coverage, low coverage of HIV testing outreach events, low HIV preexposure prophylaxis availability, and homelessness; social factors included stigma and discrimination; economic factors included community beliefs that SSPs negatively affect economic investments and limited resources for HIV screening in clinical settings. Individual-level barriers included co-occurring acute medical conditions and mental illness. Community-level interventions, such as low-barrier one-stop shop models, are needed to increase access to sterile syringes through comprehensive harm reduction services.
    MeSH term(s) Humans ; Substance Abuse, Intravenous/complications ; Substance Abuse, Intravenous/epidemiology ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; West Virginia/epidemiology ; Drug Users ; Disease Outbreaks ; Needle-Exchange Programs
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1339885-4
    ISSN 1573-3254 ; 1090-7165
    ISSN (online) 1573-3254
    ISSN 1090-7165
    DOI 10.1007/s10461-023-04254-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6451: Show issues Location:
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  8. Article ; Online: Caregivers' Perspectives on Use of and Need for Driving Resources for Their Autistic Adolescent.

    Sartin, Emma B / Webb, Margaret S / Labows, Christina G / Myers, Rachel K / Yerys, Benjamin E / McDonald, Catherine C / Curry, Allison E

    Autism in adulthood : challenges and management

    2024  Volume 6, Issue 1, Page(s) 86–94

    Abstract: Introduction: Autistic individuals who independently travel-or commute without companionship or supervision-report feeling more connected to social, education, and employment opportunities. Despite the potential for independent transportation to improve ...

    Abstract Introduction: Autistic individuals who independently travel-or commute without companionship or supervision-report feeling more connected to social, education, and employment opportunities. Despite the potential for independent transportation to improve quality of life, little is known about what transportation-related resources, specifically driving focused ones, exist for autistic individuals or how they and their families find and use them. The objectives of this study were to characterize: (1) where and how families in the United States find driving-related resources for their autistic adolescents; (2) families' perceived availability and utility of identified resources; and (3) resources families believe should be developed.
    Methods: We conducted semi-structured interviews with 33 caregivers of autistic adolescents aged 16-24 years without an intellectual disability. We used a directed-content approach to develop and implement codes; three trained coders analyzed all transcripts (inter-rater reliability ≥0.8 for all codes). Members of the research team reviewed coded data and created code summaries, which were then developed and discussed by the larger research team to determine final consensus.
    Results: Caregivers described a few existing resources that were helpful in guiding driving-related decisions. In addition, caregivers voiced that there were limited resources tailored to the unique needs that arise while teaching or learning how to drive, particularly ones that support their own and their adolescent's mental health. The limited resources and services identified as helpful-specifically support groups/perspectives of other families and specialized driving instructors-are seemingly difficult to find, costly, and/or perceived as having geographic- and time-related barriers.
    Conclusion: There is a critical need and opportunity for stakeholders of the autism community to both expand access to existing and develop novel driving-related resources for families with autistic adolescents, with a particular focus of supporting caregiver and adolescent mental health.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ISSN 2573-959X
    ISSN (online) 2573-959X
    DOI 10.1089/aut.2022.0055
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  9. Article: Global Initiative for Asthma 2019 Guidelines: New Changes to the Treatment of Mild Asthmatics 12 Years and Older.

    Stone, R G / McDonald, M / Elnazir, B

    Irish medical journal

    2020  Volume 113, Issue 5, Page(s) 69

    MeSH term(s) Administration, Inhalation ; Adolescent ; Adrenal Cortex Hormones/administration & dosage ; Adrenergic beta-2 Receptor Agonists/administration & dosage ; Adult ; Age Factors ; Albuterol/administration & dosage ; Albuterol/adverse effects ; Asthma/drug therapy ; Child ; Drug Therapy, Combination ; Female ; Formoterol Fumarate/administration & dosage ; Global Health ; Humans ; Maintenance Chemotherapy ; Male ; Middle Aged ; Practice Guidelines as Topic ; Risk Factors ; Severity of Illness Index ; Terbutaline/administration & dosage ; Terbutaline/adverse effects ; Young Adult
    Chemical Substances Adrenal Cortex Hormones ; Adrenergic beta-2 Receptor Agonists ; Terbutaline (N8ONU3L3PG) ; Albuterol (QF8SVZ843E) ; Formoterol Fumarate (W34SHF8J2K)
    Language English
    Publishing date 2020-05-07
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 193134-9
    ISSN 0332-3102 ; 0021-129X
    ISSN 0332-3102 ; 0021-129X
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 148: Show issues Location:
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  10. Article ; Online: Population-based outpatient antimicrobial use in Newfoundland and Labrador: a retrospective descriptive study.

    Edwards, Benjamin / Wilson, Robert / McDonald, Gerald / Daley, Peter

    CMAJ open

    2023  Volume 11, Issue 6, Page(s) E1109–E1117

    Abstract: Background: Data that have been reported on antimicrobial use in Newfoundland and Labrador (NL) do not appear to be representative of use at the population level. We sought to use pharmacy network data on prescriptions to describe outpatient ... ...

    Abstract Background: Data that have been reported on antimicrobial use in Newfoundland and Labrador (NL) do not appear to be representative of use at the population level. We sought to use pharmacy network data on prescriptions to describe outpatient antimicrobial use in NL.
    Methods: We analyzed all outpatient antimicrobial prescriptions dispensed between June 1, 2017, and June 8, 2021, from the provincial pharmacy network database and translated deidentified data into SPSS. We excluded prescriptions for parenteral and topical antimicrobials, antivirals and antifungals. We described antimicrobial use using the prescription rate and defined daily dose (DDD) rate.
    Results: Overall, we analyzed 1 586 534 prescriptions dispensed to 394 708 people by 3431 prescribers. The rate of antimicrobial use was 741 prescriptions per 1000 population per year (7161 DDD/1000 population/yr). The median duration of prescriptions was 7 (interquartile range 7-10) days. The prescription rate decreased from 867 to 546 per 1000 population per year (-37%) over the study period, and the mean DDD rate decreased from 8387 to 5356 DDD per 1000 population per year (-36.1%). Antimicrobials with the highest DDD rate were amoxicillin (1568 DDD/1000/yr), doxycycline (864 DDD/1000/yr) and ciprofloxacin (633 DDD/1000/yr). Prescribers wrote a mean of 102 (standard deviation 248) prescriptions per year; 3 prescribers wrote more than 2500 prescriptions per year. Overall, 9203 (2.3%) of the 394 708 people in the study population received 4 or more prescriptions per year.
    Interpretation: The rate of antimicrobial use in NL is lower than previously described in national surveillance data. Potential targets for stewardship intervention include prolonged duration of prescriptions, high-rate prescribers and high-rate patients, but further research is needed to assess the appropriateness of prescriptions according to diagnosis.
    Language English
    Publishing date 2023-11-28
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2701622-5
    ISSN 2291-0026 ; 2291-0026
    ISSN (online) 2291-0026
    ISSN 2291-0026
    DOI 10.9778/cmajo.20220221
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