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Article ; Online: Challenges and opportunities in mobile e-coaching.

van 't Klooster, Jan-Willem J R / Rabago Mayer, Lucia M / Klaassen, Bart / Kelders, Saskia M

Frontiers in digital health

2024 Volume 5, Page(s) 1304089

Abstract: Background: Mobile e-health technologies have proven to provide tailored assessment, intervention ... of design, realization, evaluation, and implementation of these e-health solutions is wicked and challenging ... interaction e-health solution that allows rapid prototyping, development, and evaluation of e-health ...

Abstract	Background: Mobile e-health technologies have proven to provide tailored assessment, intervention, and coaching capabilities for various usage scenarios. Thanks to their spread and adoption, smartphones are one of the most important carriers for such applications. Problem: However, the process of design, realization, evaluation, and implementation of these e-health solutions is wicked and challenging, requiring multiple stakeholders and expertise. Method: Here, we present a tailorable intervention and interaction e-health solution that allows rapid prototyping, development, and evaluation of e-health interventions at scale. This platform allows researchers and clinicians to develop ecological momentary assessment, just-in-time adaptive interventions, ecological momentary intervention, cohort studies, and e-coaching and personalized interventions quickly, with no-code, and in a scalable way. Result: The Twente Intervention and Interaction Instrument (TIIM) has been used by over 320 researchers in the last decade. We present the ecosystem and synthesize the main scientific output from clinical and research studies in different fields. Discussion: The importance of mobile e-coaching for prediction, management, and prevention of adverse health outcomes is increasing. A profound e-health development strategyand strategic, technical, and operational investments are needed to prototype, develop, implement, and evaluate e-health solutions. TIIM ecosystem has proven to support these processes. This paper ends with the main research opportunities in mobile coaching, including intervention mechanisms, fine-grained monitoring, and inclusion of objective biomarker data.
Language	English
Publishing date	2024-01-30
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-253X
ISSN (online)	2673-253X
DOI	10.3389/fdgth.2023.1304089
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Article: Amphotericin B-tartalmú orrspray posztoperatív alkalmazása orrpolyposissal járó krónikus rhinosinusitis eseteiben. Megelozheto-e a recidíva?

Gerlinger, Imre / Fittler, András / Mayer, Anna / Patzkó, Agnes / Fónay, Fruzsina / Pytel, József / Botz, Lajos

Orvosi hetilap

2008 Volume 149, Issue 37, Page(s) 1737–1746

Abstract: Unlabelled: Chronic rhinosinusitis affects 1-4% of the adult population. The aetiology of this multifactorial, chronic disease, which leads to a significant impairment of the quality of life, often accompanied by nasal polyposis, is not fully understood. ...

Title translation	Postoperative application of amphotericin B nasal spray in chronic rhinosinusitis with nasal polyposis. Can recidive polyposis be prevented?.
Abstract	Unlabelled: Chronic rhinosinusitis affects 1-4% of the adult population. The aetiology of this multifactorial, chronic disease, which leads to a significant impairment of the quality of life, often accompanied by nasal polyposis, is not fully understood. In the past decade it was presumed that the disease, which causes characteristic eosinophilic infiltration of the nasal mucosa, is triggered by an enhanced (but not classical allergic IgE type) immune response. Aim: If this supposition is correct, then it appears obvious that the administration of amphotericin B nasal spray in adequate concentration following endoscopic polypectomy should be advantageous for these patients, and might even reduce the number of recurrent cases. Methods: To check on this assumption, the authors conducted a prospective randomized placebo-controlled trial involving 33 patients, 30 of whom remained in the study throughout. Patients with nasal polyposis were operated on with an endoscopic technique between 1 November 2005 and 1 October 2006; one group of them (group A, 14 randomly selected patients) was treated with a nasal spray containing 5 mg/ml amphotericin B, while the placebo group (group B, 16 randomly selected patients) received a nasal spray lacking amphotericin B. The results were evaluated with the aid of a modified Lund-Mackay CT score, the SNAQ-11 test (which evaluates changes in the symptoms), the life-quality test and endoscopy. The SPSS 14.0 for Windows program was utilized to process the data of examinations performed preoperatively and one year postoperatively. Results: The CT scores of the group A patients exhibited wide scattering without signs of recovery one year after the operation. The CT scores of the group B patients indicated a slight improvement, though this did not prove significant in relation to group A. Both the SNAQ-11 test and the life-quality test revealed a significant improvement in each group, but the degrees of change in these tests did not significantly differ between the two groups of patients. The endoscopic findings indicated a slight improvement to the advantage of the amphotericin B-treated group 12 months after the operation. Conclusion: These results lead to the conclusion that the administration of amphotericin B nasal spray to patients operated on for nasal polyposis does not give rise to a significant alteration in CT scores, clinical symptoms, or quality of life. The more favourable clinical aspects observed in the amphotericin B-treated group during the endoscopic follow-up did not correspond to an improvement in the symptoms. In connection with the conclusions drawn from this study the authors discuss the available data on the fungal theory. They critically analyse the contradictory observations of 7 recent clinical studies.
MeSH term(s)	Adult ; Aerosols ; Aged ; Amphotericin B/administration & dosage ; Amphotericin B/therapeutic use ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Antifungal Agents/administration & dosage ; Antifungal Agents/therapeutic use ; Chronic Disease ; Endoscopy ; Female ; Humans ; Male ; Middle Aged ; Nasal Polyps/immunology ; Nasal Polyps/prevention & control ; Nasal Polyps/surgery ; Postoperative Period ; Prospective Studies ; Quality of Life ; Rhinitis/drug therapy ; Secondary Prevention ; Severity of Illness Index ; Sinusitis/drug therapy ; Surveys and Questionnaires ; Treatment Outcome
Chemical Substances	Aerosols ; Anti-Bacterial Agents ; Antifungal Agents ; Amphotericin B (7XU7A7DROE)
Language	Hungarian
Publishing date	2008-09-14
Publishing country	Hungary
Document type	English Abstract ; Journal Article ; Randomized Controlled Trial
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/OH.2008.28410
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Article ; Online: Linee guida ESC/ERS 2022 per la diagnosi e il trattamento dell’ipertensione polmonare.

Humbert, Marc / Kovacs, Gabor / Hoeper, Marius M / Badagliacca, Roberto / Berger, Rolf M F / Brida, Margarita / Carlsen, Jørn / Coats, Andrew J S / Escribano-Subias, Pilar / Ferrari, Pisana / Ferreira, Diogenes S / Ghofrani, Hossein Ardeschir / Giannakoulas, George / Kiely, David G / Mayer, Eckhard / Meszaros, Gergely / Nagavci, Blin / Olsson, Karen M / Pepke-Zaba, Joanna /

Quint, Jennifer K / Rådegran, Göran / Simonneau, Gerald / Sitbon, Olivier / Tonia, Thomy / Toshner, Mark / Vachiery, Jean-Luc / Vonk Noordegraaf, Anton / Delcroix, Marion / Rosenkranz, Stephan

Giornale italiano di cardiologia (2006)

2023 Volume 24, Issue 4 Suppl 1, Page(s) e1–e116

Title translation	2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension.
MeSH term(s)	Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/therapy ; Evidence-Based Medicine ; Algorithms
Language	Italian
Publishing date	2023-03-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2272414-X
ISSN	1972-6481 ; 1827-6806
ISSN (online)	1972-6481
ISSN	1827-6806
DOI	10.1714/4014.39906
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Article ; Online: Lungenschäden durch E‑Zigaretten.

Mayer, B / Nitschmann, S

Der Internist

2020 Volume 61, Issue 11, Page(s) 1204–1207

Title translation	Lung injury induced by e-cigarettes.
MeSH term(s)	Electronic Nicotine Delivery Systems ; Humans ; Lung Injury/chemically induced ; Nicotine/administration & dosage ; Nicotine/adverse effects ; Vaping/adverse effects
Chemical Substances	Nicotine (6M3C89ZY6R)
Language	German
Publishing date	2020-10-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2913-0
ISSN	1432-1289 ; 0020-9554
ISSN (online)	1432-1289
ISSN	0020-9554
DOI	10.1007/s00108-020-00879-w
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Article ; Online: Caffeine prevents prostaglandin E

Mitchell, L J / Mayer, C A / Mayer, A / Di Fiore, J M / Shein, S L / Raffay, T M / MacFarlane, P M

American journal of physiology. Regulatory, integrative and comparative physiology

2020 Volume 319, Issue 2, Page(s) R233–R242

Abstract: Continuous infusion of prostaglandin E1 ( ... ...

Abstract	Continuous infusion of prostaglandin E1 (PGE
MeSH term(s)	Alprostadil/pharmacology ; Animals ; Brain Stem/drug effects ; Brain Stem/metabolism ; Caffeine/pharmacology ; Microglia/drug effects ; Microglia/metabolism ; Nitric Oxide Synthase Type I/metabolism ; Plethysmography, Whole Body ; Proto-Oncogene Proteins c-sis/genetics ; Proto-Oncogene Proteins c-sis/metabolism ; Pulmonary Ventilation/drug effects ; Purinergic P1 Receptor Antagonists/pharmacology ; Rats ; Rats, Sprague-Dawley ; Respiration/drug effects
Chemical Substances	Proto-Oncogene Proteins c-sis ; Purinergic P1 Receptor Antagonists ; Caffeine (3G6A5W338E) ; Nitric Oxide Synthase Type I (EC 1.14.13.39) ; Alprostadil (F5TD010360)
Language	English
Publishing date	2020-06-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	603839-6
ISSN	1522-1490 ; 0363-6119
ISSN (online)	1522-1490
ISSN	0363-6119
DOI	10.1152/ajpregu.00316.2019
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Article ; Online: Reply to E. Grunfeld.

Halpern, Michael T / Viswanathan, Meera / Evans, Tammeka S / Birken, Sarah A / Basch, Ethan / Mayer, Deborah K

Journal of oncology practice

2015 Volume 11, Issue 4, Page(s) 347

MeSH term(s)	Humans ; Models, Theoretical ; Neoplasms/therapy ; Survivors
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	2236338-5
ISSN	1935-469X ; 1554-7477
ISSN (online)	1935-469X
ISSN	1554-7477
DOI	10.1200/JOP.2015.004754
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Article ; Online: In memoriam: Lauren E. Marsillio-Craney (1979-2020).

Weese-Mayer, Debra E / Leah Harris, Z / Paquette, Erin T / Sanchez-Pinto, L Nelson

Clinical autonomic research : official journal of the Clinical Autonomic Research Society

2021 Volume 31, Issue 4, Page(s) 589–590

Language	English
Publishing date	2021-05-30
Publishing country	Germany
Document type	News
ZDB-ID	1080007-4
ISSN	1619-1560 ; 0959-9851
ISSN (online)	1619-1560
ISSN	0959-9851
DOI	10.1007/s10286-021-00812-7
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Article ; Online: Vaporized Nicotine (E-Cigarette) and Tobacco Smoking Among People With HIV: Use Patterns and Associations With Depression and Panic Symptoms.

Journal of acquired immune deficiency syndromes (1999)

2022 Volume 92, Issue 3, Page(s) 197–203

Abstract: Background: Vaporized nicotine (VN) use is increasing among people with HIV (PWH). We examined demographics, patterns of use, depression, and panic symptoms associated with VN and combustible cigarette (CC) use among PWH.: Methods: We analyzed VN use ...

Abstract	Background: Vaporized nicotine (VN) use is increasing among people with HIV (PWH). We examined demographics, patterns of use, depression, and panic symptoms associated with VN and combustible cigarette (CC) use among PWH. Methods: We analyzed VN use among PWH in care at 7 US sites. PWH completed a set of patient-reported outcomes, including substance use and mental health. We categorized VN use as never vs. ever with the frequency of use (days/month) and CC use as never, former, or current. We used relative risk regression to associate VN and CC use, depression, and panic symptoms. Linear regression estimated each relationship with VN frequency. Models were adjusted for demographics. Results: Among 7431 PWH, 812 (11%) reported ever-using VN, and 264 (4%) reported daily use. Half (51%) of VN users concurrently used CC. VN users were more likely than those without use to be younger, to be White, and to report ever-using CC. PWH reporting former CC use reported ≥8.5 more days per month of VN use compared with never CC use [95% confidence interval (95% CI): 5.5 to 11.5 days/month] or current CC use (95% CI: 6.6 to 10.5 days/month). Depression (relative risk: 1.20 [95% CI: 1.02 to 1.42]) and panic disorder (1.71 [95% CI: 1.43 to 2.05]) were more common among PWH ever-using VN. Depression was common among PWH using VN (27%) and CC (22%), as was panic disorder (21% for VN and 16% for CC). Conclusion: Our study elucidated demographic associations with VN use among PWH, revealed the overlap of VN and CC use, and associations with depression/panic symptoms, suggesting roles of VN in self-medication and CC substitution, warranting further longitudinal/qualitative research.
MeSH term(s)	Humans ; Nicotine/adverse effects ; Electronic Nicotine Delivery Systems ; Depression/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy ; Tobacco Smoking
Chemical Substances	Nicotine (6M3C89ZY6R)
Language	English
Publishing date	2022-12-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000003132
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Article ; Online: A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host.

Harding, Christian M / Nasr, Mohamed A / Scott, Nichollas E / Goyette-Desjardins, Guillaume / Nothaft, Harald / Mayer, Anne E / Chavez, Sthefany M / Huynh, Jeremy P / Kinsella, Rachel L / Szymanski, Christine M / Stallings, Christina L / Segura, Mariela / Feldman, Mario F

Nature communications

2019 Volume 10, Issue 1, Page(s) 891

Abstract: ... protective and rapidly produced within E. coli using recombinant techniques. These proof-of-principle ...

Abstract	Chemical synthesis of conjugate vaccines, consisting of a polysaccharide linked to a protein, can be technically challenging, and in vivo bacterial conjugations (bioconjugations) have emerged as manufacturing alternatives. Bioconjugation relies upon an oligosaccharyltransferase to attach polysaccharides to proteins, but currently employed enzymes are not suitable for the generation of conjugate vaccines when the polysaccharides contain glucose at the reducing end, which is the case for ~75% of Streptococcus pneumoniae capsules. Here, we use an O-linking oligosaccharyltransferase to generate a polyvalent pneumococcal bioconjugate vaccine with polysaccharides containing glucose at their reducing end. In addition, we show that different vaccine carrier proteins can be glycosylated using this system. Pneumococcal bioconjugates are immunogenic, protective and rapidly produced within E. coli using recombinant techniques. These proof-of-principle experiments establish a platform to overcome limitations of other conjugating enzymes enabling the development of bioconjugate vaccines for many important human and animal pathogens.
MeSH term(s)	Animals ; Bacterial Capsules/genetics ; Bacterial Capsules/immunology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Genetic Engineering/methods ; Glycoproteins/genetics ; Glycoproteins/immunology ; Glycoproteins/isolation & purification ; Glycosylation ; Humans ; Pneumococcal Vaccines/genetics ; Pneumococcal Vaccines/isolation & purification ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/immunology ; Vaccines, Conjugate/genetics ; Vaccines, Conjugate/isolation & purification ; Vaccines, Synthetic/genetics ; Vaccines, Synthetic/isolation & purification
Chemical Substances	Glycoproteins ; Pneumococcal Vaccines ; Vaccines, Conjugate ; Vaccines, Synthetic
Language	English
Publishing date	2019-02-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-019-08869-9
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Article ; Online: E-learning in Plastic Surgery training in a developing country: Is it possible after the COVID-19 pandemic?

Coloccini, Alejandro / García Rodríguez, Breyner / Fichman, Matías / Mayer, Horacio F

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2023 Volume 88, Page(s) 119–121

MeSH term(s)	Humans ; COVID-19/epidemiology ; Surgery, Plastic/education ; Computer-Assisted Instruction ; Pandemics ; Developing Countries
Language	English
Publishing date	2023-10-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2023.10.128
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