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Article ; Online: A biochemical description of postsynaptic plasticity-with timescales ranging from milliseconds to seconds.

Li, Guanchun / McLaughlin, David W / Peskin, Charles S

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 7, Page(s) e2311709121

Abstract: Synaptic plasticity [long-term potentiation/depression (LTP/D)], is a cellular mechanism underlying ... learning. Two distinct types of early LTP/D (E-LTP/D), acting on very different time scales, have been ... of the induction of E-LTP/D at a spine head of a synapse of a hippocampal pyramidal neuron is developed. The single ...

Abstract	Synaptic plasticity [long-term potentiation/depression (LTP/D)], is a cellular mechanism underlying learning. Two distinct types of early LTP/D (E-LTP/D), acting on very different time scales, have been observed experimentally-spike timing dependent plasticity (STDP), on time scales of tens of ms; and behavioral time scale synaptic plasticity (BTSP), on time scales of seconds. BTSP is a candidate for a mechanism underlying rapid learning of spatial location by place cells. Here, a computational model of the induction of E-LTP/D at a spine head of a synapse of a hippocampal pyramidal neuron is developed. The single-compartment model represents two interacting biochemical pathways for the activation (phosphorylation) of the kinase (CaMKII) with a phosphatase, with ion inflow through channels (NMDAR, CaV1,Na). The biochemical reactions are represented by a deterministic system of differential equations, with a detailed description of the activation of CaMKII that includes the opening of the compact state of CaMKII. This single model captures realistic responses (temporal profiles with the differing timescales) of STDP and BTSP and their asymmetries. The simulations distinguish several mechanisms underlying STDP vs. BTSP, including i) the flow of [Formula: see text] through NMDAR vs. CaV1 channels, and ii) the origin of several time scales in the activation of CaMKII. The model also realizes a priming mechanism for E-LTP that is induced by [Formula: see text] flow through CaV1.3 channels. Once in the spine head, this small additional [Formula: see text] opens the compact state of CaMKII, placing CaMKII ready for subsequent induction of LTP.
MeSH term(s)	Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Neuronal Plasticity/physiology ; Long-Term Potentiation/physiology ; Receptors, N-Methyl-D-Aspartate/metabolism ; Synapses/metabolism
Chemical Substances	Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Receptors, N-Methyl-D-Aspartate
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2311709121
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Zs.A 1148: Show issues

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Article ; Online: Medication fill duration in pediatric hypertension: adherence, blood pressure control, and disparities.

McLaughlin, Meghan M / Gleber, Conrad D / Wang, Hongyue / Halterman, Jill S / Lande, Marc B

Pediatric nephrology (Berlin, Germany)

2024

Abstract: Background: Medication nonadherence is a barrier to hypertension control. The Centers for Disease Control and Prevention recommends prescribing 90-day fills for maintenance medications yet antihypertensives are often dispensed as 30-day fills. Our ... ...

Abstract	Background: Medication nonadherence is a barrier to hypertension control. The Centers for Disease Control and Prevention recommends prescribing 90-day fills for maintenance medications yet antihypertensives are often dispensed as 30-day fills. Our objectives were to examine how often patients receive 30-day supplies of medication despite prescriptions for longer duration and to examine the effect of medication fill duration on adherence and hypertension control. Methods: We conducted a retrospective cohort study of pediatric patients with hypertension over a 3-year period. For each patient, days prescribed per fill were compared to days dispensed per fill using pharmacy reports and insurance claim data. Proportion of Days Covered (PDC) was calculated to estimate adherence. Hypertension control was determined by provider assessment of control and blood pressure measurement at the final visit. Results: Final cohort included 449 patients. A total of 70% had at least one prescription for ≥ 90 days but only 37% had at least one dispense for ≥ 90 days. There was no difference in the likelihood of being prescribed a 90-day fill by insurance type (public vs. private); however, patients with public insurance were less likely to be dispensed a 90-day fill (OR = 0.068, p < 0.001). Patients who received 90-day fills had better adherence (median PDC 77.5% vs. 58.1%, p < 0.001) and were more likely to have hypertension control based on provider assessment. Conclusions: Longer fill duration is associated with improved adherence and hypertension control. Patients with public insurance are markedly less likely to be dispensed 90-day fills, a modifiable barrier to improving adherence.
Language	English
Publishing date	2024-04-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-024-06363-z
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Article ; Online: A Narrative Review of Cervical Cancer Screening Utilization Among Haitian Immigrant Women in the U.S.: Health Beliefs, Perceptions, and Societal Barriers and Facilitators.

Romelus, Juana / McLaughlin, Carol / Ruggieri, Dominique / Morgan, Sherry

Journal of immigrant and minority health

2024

Abstract: Haitian immigrant women living in the U.S. have a higher rate of cervical cancer mortality ... of articles from PubMed, SCOPUS, Embase, CINAHL/Nursing, and Psych Info. Inclusion criteria: U.S. Haitian ...

Abstract	Haitian immigrant women living in the U.S. have a higher rate of cervical cancer mortality than any other ethnic group, primarily due to lower rates of screening test utilization. Therefore, it is important to understand the issues affecting their pap smear screening behaviors. We conducted a narrative review of articles from PubMed, SCOPUS, Embase, CINAHL/Nursing, and Psych Info. Inclusion criteria: U.S. Haitian immigrant, screening, cervical cancer, health beliefs/perceptions. Exclusion criteria: HPV-vaccine. Primary barriers: (1) lack of knowledge of cervical cancer, HPV, and pap smears; (2) lack of culturally appropriate dissemination of information; and (3) difficulty obtaining the test. Primary facilitators: (1) provider recommendations, (2) Haitian media to disseminate health information, and (3) having health insurance. This review highlights the points for intervention by health professionals and policy makers to address this group's low pap smear utilization.
Language	English
Publishing date	2024-02-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2220162-2
ISSN	1557-1920 ; 1557-1912
ISSN (online)	1557-1920
ISSN	1557-1912
DOI	10.1007/s10903-024-01581-x
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Article ; Online: Causal connectivity measures for pulse-output network reconstruction: Analysis and applications.

Tian, Zhong-Qi K / Chen, Kai / Li, Songting / McLaughlin, David W / Zhou, Douglas

Proceedings of the National Academy of Sciences of the United States of America

2024 Volume 121, Issue 14, Page(s) e2305297121

Abstract: The causal connectivity of a network is often inferred to understand network function. It is arguably acknowledged that the inferred causal connectivity relies on the causality measure one applies, and it may differ from the network's underlying ... ...

Abstract	The causal connectivity of a network is often inferred to understand network function. It is arguably acknowledged that the inferred causal connectivity relies on the causality measure one applies, and it may differ from the network's underlying structural connectivity. However, the interpretation of causal connectivity remains to be fully clarified, in particular, how causal connectivity depends on causality measures and how causal connectivity relates to structural connectivity. Here, we focus on nonlinear networks with pulse signals as measured output, e.g., neural networks with spike output, and address the above issues based on four commonly utilized causality measures, i.e., time-delayed correlation coefficient, time-delayed mutual information, Granger causality, and transfer entropy. We theoretically show how these causality measures are related to one another when applied to pulse signals. Taking a simulated Hodgkin-Huxley network and a real mouse brain network as two illustrative examples, we further verify the quantitative relations among the four causality measures and demonstrate that the causal connectivity inferred by any of the four well coincides with the underlying network structural connectivity, therefore illustrating a direct link between the causal and structural connectivity. We stress that the structural connectivity of pulse-output networks can be reconstructed pairwise without conditioning on the global information of all other nodes in a network, thus circumventing the curse of dimensionality. Our framework provides a practical and effective approach for pulse-output network reconstruction.
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2305297121
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Article ; Online: Routine ultrasound screening for hip dysplasia in children with clubfoot is not supported.

McLaughlin, Dell / De Salvo, Sara / Brewerton, Kathryn / Hui, Caitlyn / Bouchard, Maryse

International orthopaedics

2024

Abstract: Purpose: Despite the existence of guidelines for screening for developmental dysplasia of the hip (DDH), there remains controversy regarding the need for routine ultrasound screening for DDH in patients with clubfoot due to an unclear correlation ... ...

Abstract	Purpose: Despite the existence of guidelines for screening for developmental dysplasia of the hip (DDH), there remains controversy regarding the need for routine ultrasound screening for DDH in patients with clubfoot due to an unclear correlation between the two conditions. The purpose of this study is to determine whether ultrasound screening for DDH in this population improved the diagnostic accuracy of DDH over standard assessment for patient risk factors and physical exam. Methods: This is a retrospective cross-sectional review of infants diagnosed with idiopathic clubfoot who underwent hip ultrasounds to assess for DDH as identified by keyword search in an institutional radiological database at a tertiary care paediatric hospital. Patient demographics, risk factors for DDH, physical exam findings, and ultrasound results were recorded. Results: Of the 120 patients who met the inclusion criteria between 2003 and 2018, 8 had hip dysplasia confirmed on ultrasound (6.7%). All these patients either had known risk factors for hip dysplasia or had an abnormal physical exam finding suggestive of hip instability or dislocation as performed by an orthopaedic surgeon on their initial consultation. Conclusion: A detailed history to determine risk factors and a thorough physical exam are adequate to determine the need for hip ultrasound in infants with idiopathic clubfoot. Routine ultrasound screening of all patients with clubfoot is likely unnecessary and may pose a significant burden on the health care system.
Language	English
Publishing date	2024-04-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80384-4
ISSN	1432-5195 ; 0341-2695
ISSN (online)	1432-5195
ISSN	0341-2695
DOI	10.1007/s00264-024-06169-6
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Zs.A 1324: Show issues

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Article: Endobronchial Migration of a POD Packing Coil Following Embolization of a Pulmonary Artery Pseudoaneurysm.

McLaughlin, Joseph N / Lamus, Daniel / Hegde, Siddhi / Kalva, Sanjeeva P

Seminars in interventional radiology

2023 Volume 40, Issue 5, Page(s) 407–410

Abstract: The authors report a case of endobronchial migration of a POD packing coil following embolization of a pulmonary artery pseudoaneurysm in a patient with cavitary tuberculosis and its successful management by bronchoscopy-assisted removal of the coil. ... ...

Abstract	The authors report a case of endobronchial migration of a POD packing coil following embolization of a pulmonary artery pseudoaneurysm in a patient with cavitary tuberculosis and its successful management by bronchoscopy-assisted removal of the coil. Coil migration may be secondary to continued cough and persistence of a bronchial to pulmonary artery fistula from tuberculous infection and inflammation.
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	848341-3
ISSN	1098-8963 ; 0739-9529
ISSN (online)	1098-8963
ISSN	0739-9529
DOI	10.1055/s-0043-1774408
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Article ; Online: Salicylic acids and pathogenic bacteria: new perspectives on an old compound.

Sykes, Ellen M E / White, Dawn / McLaughlin, Sydney / Kumar, Ayush

Canadian journal of microbiology

2023 Volume 70, Issue 1, Page(s) 1–14

Abstract: Salicylic acids have been used in human and veterinary medicine for their anti-pyretic, anti-inflammatory, and analgesic properties for centuries. A key role of salicylic acid-immune modulation in response to microbial infection-was first recognized ... ...

Abstract	Salicylic acids have been used in human and veterinary medicine for their anti-pyretic, anti-inflammatory, and analgesic properties for centuries. A key role of salicylic acid-immune modulation in response to microbial infection-was first recognized during studies of their botanical origin. The effects of salicylic acid on bacterial physiology are diverse. In many cases, they impose selective pressures leading to development of cross-resistance to antimicrobial compounds. Initial characterization of these interactions was in
MeSH term(s)	Humans ; Escherichia coli Proteins/genetics ; Bacterial Proteins/genetics ; Escherichia coli ; Salicylic Acid/pharmacology ; Anti-Infective Agents/pharmacology ; Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests
Chemical Substances	Escherichia coli Proteins ; Bacterial Proteins ; Salicylic Acid (O414PZ4LPZ) ; Anti-Infective Agents ; Anti-Bacterial Agents
Language	English
Publishing date	2023-09-12
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	280534-0
ISSN	1480-3275 ; 0008-4166
ISSN (online)	1480-3275
ISSN	0008-4166
DOI	10.1139/cjm-2023-0123
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Article ; Online: Childhood socioeconomic status and the pace of structural neurodevelopment: accelerated, delayed, or simply different?

Rakesh, Divyangana / Whittle, Sarah / Sheridan, Margaret A / McLaughlin, Katie A

Trends in cognitive sciences

2023 Volume 27, Issue 9, Page(s) 833–851

Abstract: Socioeconomic status (SES) is associated with children's brain and behavioral development. Several theories propose that early experiences of adversity or low SES can alter the pace of neurodevelopment during childhood and adolescence. These theories ... ...

Abstract	Socioeconomic status (SES) is associated with children's brain and behavioral development. Several theories propose that early experiences of adversity or low SES can alter the pace of neurodevelopment during childhood and adolescence. These theories make contrasting predictions about whether adverse experiences and low SES are associated with accelerated or delayed neurodevelopment. We contextualize these predictions within the context of normative development of cortical and subcortical structure and review existing evidence on SES and structural brain development to adjudicate between competing hypotheses. Although none of these theories are fully consistent with observed SES-related differences in brain development, existing evidence suggests that low SES is associated with brain structure trajectories more consistent with a delayed or simply different developmental pattern than an acceleration in neurodevelopment.
MeSH term(s)	Child ; Adolescent ; Humans ; Social Class ; Brain
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2010989-1
ISSN	1879-307X ; 1364-6613
ISSN (online)	1879-307X
ISSN	1364-6613
DOI	10.1016/j.tics.2023.03.011
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Article ; Online: Fast Scalable Image Restoration Using Total Variation Priors and Expectation Propagation.

Yao, Dan / McLaughlin, Stephen / Altmann, Yoann

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

2022 Volume 31, Page(s) 5762–5773

Abstract: This paper presents a scalable approximate Bayesian method for image restoration using Total Variation (TV) priors, with the ability to offer uncertainty quantification. In contrast to most optimization methods based on maximum a posteriori estimation, ... ...

Abstract	This paper presents a scalable approximate Bayesian method for image restoration using Total Variation (TV) priors, with the ability to offer uncertainty quantification. In contrast to most optimization methods based on maximum a posteriori estimation, we use the Expectation Propagation (EP) framework to approximate minimum mean squared error (MMSE) estimates and marginal (pixel-wise) variances, without resorting to Monte Carlo sampling. For the classical anisotropic TV-based prior, we also propose an iterative scheme to automatically adjust the regularization parameter via Expectation Maximization (EM). Using Gaussian approximating densities with diagonal covariance matrices, the resulting method allows highly parallelizable steps and can scale to large images for denoising, deconvolution, and compressive sensing (CS) problems. The simulation results illustrate that such EP methods can provide a posteriori estimates on par with those obtained via sampling methods but at a fraction of the computational cost. Moreover, EP does not exhibit strong underestimation of posteriori variances, in contrast to variational Bayes alternatives.
Language	English
Publishing date	2022-09-09
Publishing country	United States
Document type	Journal Article
ISSN	1941-0042
ISSN (online)	1941-0042
DOI	10.1109/TIP.2022.3202092
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Article ; Online: Mortality reduction and cumulative excess incidence (CEI) in the prostate-specific antigen (PSA) screening era.

McLaughlin, Patrick W / Cousins, Matthew M / Tsodikov, Alex / Soni, Payal D / Crook, Juanita M

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5810

Abstract: ... for comparison. Factor(s) independent of CEI (potential effects of treatment advances) explained 14.6 ...

Abstract	The extent to which PSA screening is related to prostate cancer mortality reduction in the United States (US) is controversial. US Surveillance, Epidemiology, and End Results Program (SEER) data from 1980 to 2016 were examined to assess the relationship between prostate cancer mortality and cumulative excess incidence (CEI) in the PSA screening era and to clarify the impact of race on this relationship. CEI was considered as a surrogate for the intensity of prostate cancer screening with PSA testing and subsequent biopsy as appropriate. Data from 163,982,733 person-years diagnosed with 544,058 prostate cancers (9 registries, 9% of US population) were examined. Strong inverse linear relationships were noted between CEI and prostate cancer mortality, and 317,356 prostate cancer deaths were avoided. Eight regions of the US demonstrated prostate cancer mortality reduction of 46.0-63.7%. On a per population basis, the lives of more black men than white men were saved in three of four registries with sufficient black populations for comparison. Factor(s) independent of CEI (potential effects of treatment advances) explained 14.6% of the mortality benefit (p-value = 0.3357) while there was a significant main effect of CEI (effect = -0.0064; CI: [-0.0088, -0.0040]; p-value < 0.0001). Therefore, there is a strong relationship between CEI and prostate cancer mortality reduction that was not related to factors independent of screening utilization. Minority populations have experienced large mortality reductions in the context of PSA mass utilization.
MeSH term(s)	Male ; Humans ; United States/epidemiology ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/epidemiology ; Incidence ; Early Detection of Cancer ; Mass Screening/methods
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2024-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55859-z
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