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  1. Article ; Online: The D

    Wimer, Lauren / Goncharova, Elena / Galkina, Sofiya / Nyangau, Edna / Shankaran, Mahalakshmi / Davis, Asia / Prado, Leandro / Munoz, Maria Castro / Epstein, Sharon / Patterson, Cavan / Shaum, Nicholas / Hellerstein, Mark / Evans, William / Melov, Simon

    Aging cell

    2023  Volume 22, Issue 8, Page(s) e13897

    Abstract: ... Recently, the D ...

    Abstract Developing accurate methods to quantify age-related muscle loss (sarcopenia) could greatly accelerate development of therapies to treat muscle loss in the elderly, as current methods are inaccurate or expensive. The current gold standard method for quantifying sarcopenia is dual-energy X-ray absorptiometry (DXA) but does not measure muscle directly-it is a composite measure quantifying "lean mass" (muscle) excluding fat and bone. In humans, DXA overestimates muscle mass, which has led to erroneous conclusions about the importance of skeletal muscle in human health and disease. In animal models, DXA is a popular method for measuring lean mass. However, instrumentation is expensive and is potentially limited by anesthesia concerns. Recently, the D
    MeSH term(s) Muscle, Skeletal ; Absorptiometry, Photon ; Body Composition ; Animals ; Mice ; Male ; Female ; Mice, Inbred C57BL ; Creatinine/urine ; Body Weights and Measures/methods
    Chemical Substances Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.13897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Vitamin D

    Epstein, Sol

    (Rheumatic disease clinics of North America ; 38,1)

    2012  

    Author's details guest ed. Sol Epstein
    Series title Rheumatic disease clinics of North America ; 38,1
    Collection
    Language English
    Size XIV, 242 S. : Ill., graph. Darst.
    Publisher Saunders an imprint of Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT017261125
    ISBN 978-1-4557-3931-8 ; 1-4557-3931-6
    Database Catalogue ZB MED Medicine, Health

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    Se 363 -38,1- verfügbar in Königswinter Königswinter

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  3. Book: Vitamin D

    Epstein, Sol

    (Endocrinology and metabolism clinics of North America ; 39,2)

    2010  

    Author's details guest ed. Sol Epstein
    Series title Endocrinology and metabolism clinics of North America ; 39,2
    Collection
    Language English
    Size XVIII S., S. 244 - 479 : Ill., graph. Darst.
    Publisher Saunders
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016451451
    ISBN 978-1-4377-1817-1 ; 1-4377-1817-5
    Database Catalogue ZB MED Medicine, Health

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    Se 148 -39,2- verfügbar in Königswinter Königswinter

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  4. Article ; Online: The Confounding Story of Vitamin D.

    Epstein, Howard

    Skinmed

    2021  Volume 19, Issue 1, Page(s) 49–50

    MeSH term(s) Humans ; Vitamin D ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Vitamins
    Chemical Substances Vitamins ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171125-2
    ISSN 1751-7125 ; 1540-9740
    ISSN (online) 1751-7125
    ISSN 1540-9740
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  5. Article ; Online: The constellation of vitamin D, the acute-phase response, and inflammation.

    Antonelli, Maria J / Kushner, Irving / Epstein, Murray

    Cleveland Clinic journal of medicine

    2023  Volume 90, Issue 2, Page(s) 85–89

    MeSH term(s) Humans ; Vitamin D ; Acute-Phase Reaction ; Inflammation
    Chemical Substances Vitamin D (1406-16-2)
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.90a.22048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Why 25-dehydroxyvitamin D is a negative acute-phase reactant.

    Antonelli, Maria J / Kushner, Irving / Epstein, Murray

    Cleveland Clinic journal of medicine

    2023  Volume 90, Issue 9, Page(s) 535

    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Letter
    ZDB-ID 639116-3
    ISSN 1939-2869 ; 0891-1150
    ISSN (online) 1939-2869
    ISSN 0891-1150
    DOI 10.3949/ccjm.90c.09001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Vitamin D

    Makarova, Anastasia / Wang, Grace / Dolorito, John A / Kc, Subheksha / Libove, Eileen / Epstein, Ervin H

    The Journal of investigative dermatology

    2017  Volume 137, Issue 12, Page(s) 2613–2619

    Abstract: ... inhibiting vitamin D ...

    Abstract The effect of UVR on human basal cell carcinoma (BCC) epidemiology is complex-the incidence rises until approximately 30,000 hours of lifetime sunlight exposure and then plateaus. We hypothesize that UVR has opposing effects on BCC carcinogenesis-stimulatory via mutagenesis and inhibitory via production of hedgehog-inhibiting vitamin D
    MeSH term(s) Administration, Topical ; Animals ; Carcinogenesis ; Carcinoma, Basal Cell/metabolism ; Cell Proliferation ; Cholecalciferol/metabolism ; Disease Progression ; Female ; Gene Deletion ; Genotype ; Keratinocytes/cytology ; Male ; Mice ; Mice, Transgenic ; Oxidoreductases Acting on CH-CH Group Donors/genetics ; Radiation, Ionizing ; Sex Factors ; Skin/metabolism ; Skin/radiation effects ; Skin Neoplasms/metabolism ; Ultraviolet Rays
    Chemical Substances lathosterol delta-5-dehydrogenase ; Cholecalciferol (1C6V77QF41) ; Oxidoreductases Acting on CH-CH Group Donors (EC 1.3.-)
    Language English
    Publishing date 2017-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2017.05.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Current use of D-dimer for the exclusion of venous thrombosis in hospitalized patients.

    Karny-Epstein, Nitzan / Abuhasira, Ran / Grossman, Alon

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 12376

    Abstract: D-dimer assay's utility for excluding venous thromboembolism (VTE) in hospitalized patients is ... debatable. We aimed to assess the current use of D-dimer as a diagnostic tool for excluding VTE ... in hospitalized patients and examine a mandatory age-adjusted D-dimer (AADD) threshold for diagnostic imaging ...

    Abstract D-dimer assay's utility for excluding venous thromboembolism (VTE) in hospitalized patients is debatable. We aimed to assess the current use of D-dimer as a diagnostic tool for excluding VTE in hospitalized patients and examine a mandatory age-adjusted D-dimer (AADD) threshold for diagnostic imaging. Retrospective cohort study between 2014 to 2019 that included patients from medical and surgical wards with a positive AADD result drawn during their hospitalization. The outcomes were determining a D-dimer threshold requiring further evaluation and assessing the prognostic value of D-dimer in predicting clinically relevant VTE in hospitalized patients. The cohort included 354 patients, 56% of them underwent definitive diagnostic imaging, and 7.6% were diagnosed with VTE after a positive AADD within 90 days of follow-up. Mortality rates were higher in patients diagnosed with VTE (33.3% vs. 15.9%, p = 0.03). Patients with pneumonia and other infectious etiologies were less likely to be further evaluated by definitive imaging (p = 0.001). Patients with a respiratory complaint (p = 0.02), chest pain (p < 0.001), or leg swelling (p = 0.01) were more likely to undergo diagnostic imaging. Patients with D-dimer levels > X2 the AADD were at increased risk of VTE [OR 3.87 (1.45-10.27)]. At 90 days of follow-up, no excess mortality was observed for patients without diagnostic evaluation following elevated AADD. D-dimer may be used in hospitalized patients to exclude VTE using the traditional AADD thresholds, with a high negative predictive value. D-dimer levels > X2 the AADD usually mandates further diagnostic imaging, while lower levels, probably do not require additional workup, with a sensitivity of almost 80% and no excess mortality.
    MeSH term(s) Fibrin Fibrinogen Degradation Products ; Humans ; Retrospective Studies ; Venous Thromboembolism/diagnosis ; Venous Thrombosis/diagnosis
    Chemical Substances Fibrin Fibrinogen Degradation Products ; fibrin fragment D
    Language English
    Publishing date 2022-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-16515-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Maladie d’Alzheimer, neuro-inflammation et virus herpétiques - Une piste qui trace son chemin.

    Epstein, Alberto L

    Medecine sciences : M/S

    2020  Volume 36, Issue 5, Page(s) 479–486

    Abstract: Infection of the brain with various types of pathogens, and the resulting inflammatory response, is becoming increasingly important in our understanding of the etiology of Alzheimer's disease (AD). The fact that several genes identified as risk factors ... ...

    Title translation Alzheimer's disease, neuro-inflammation, and herpes viruses, a path that traces its way.
    Abstract Infection of the brain with various types of pathogens, and the resulting inflammatory response, is becoming increasingly important in our understanding of the etiology of Alzheimer's disease (AD). The fact that several genes identified as risk factors are actually involved in the modulation of the immune response, as well as the very diversity of the infectious agents identified as possible actors in the evolution of this disease, argue in favor of the neuro-inflammatory hypothesis, as does the demonstration that the protein Aβ, one of the most important markers of AD, is an antimicrobial peptide. Among others, herpes viruses (mainly, but not only, HSV-1), which can establish latent infections in brain neurons, especially in the elder population, punctuated by episodes of reactivation following stress or immunosuppression, appear as very strong candidates to play an etiological role, if only as cofactors, of AD. Recent results show that, in human and rat neurons, infection with HSV-1 increases the formation of Aβ along the amyloidogenic pathway, as well as the phosphorylation of Tau proteins, another essential marker of AD. The growing evidence that chronic infections and defense mechanisms, including inflammatory processes, are at the heart of AD, warrants reviewing antiviral drugs such as acyclovir, and possibly vaccination, as potential avenues for AD control.
    MeSH term(s) Alzheimer Disease/etiology ; Alzheimer Disease/immunology ; Alzheimer Disease/therapy ; Alzheimer Disease/virology ; Animals ; Antiviral Agents/therapeutic use ; Herpesviridae/physiology ; Herpesviridae Infections/complications ; Herpesviridae Infections/immunology ; Herpesviridae Infections/pathology ; Humans ; Inflammation/complications ; Inflammation/pathology ; Inflammation/virology ; Neuroimmunomodulation/physiology ; Neurons/immunology ; Neurons/pathology ; Neurons/virology ; Rats ; Risk Factors ; Signal Transduction/physiology
    Chemical Substances Antiviral Agents
    Language French
    Publishing date 2020-05-26
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2020090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Educational Environments and Secondary School Outcomes Among Students Who Are D/deaf and Hard of Hearing in Special Education.

    Epstein, Sherise / Christianson, Erin / Ou, Henry C / Norton, Susan J / Sie, Kathleen C Y / Horn, David L

    Language, speech, and hearing services in schools

    2022  Volume 53, Issue 4, Page(s) 1161–1167

    Abstract: ... educational environments, and secondary school outcomes of students who are D/deaf and hard of hearing (D/HH ... to 2018, students who are D/HH receiving SpEd in the United States have spent increasingly more time ...

    Abstract Purpose: The purpose of this study is to provide updated national estimates on the annual number, educational environments, and secondary school outcomes of students who are D/deaf and hard of hearing (D/HH) receiving special education (SpEd) and related services in the United States.
    Method: We performed a retrospective cross-sectional descriptive analysis of Individuals with Disabilities Education Act, Part B, Section 618 data from 2012 to 2018. Participants included students 6-21 years old in SpEd with "hearing impairment" reported as their primary disability. The general population of students in secondary school served as a comparator, via Current Population Survey data. We described the annual number of students (a) overall, (b) by educational environment, and (c) by reason for exiting SpEd, including the proportion graduating from and dropping out of secondary school. We described variation over time.
    Results: The median annual number of students was 67,655, with minimal variation by year. The proportion in general education (GenEd) for ≥ 80% of the day increased by 4.2% over 6 years from 57.8% to 62.0%, whereas the proportions in GenEd for < 40% and 40%-79% of the day decreased by 1.6% and 1.3%, respectively. Proportions in the remainder of the environments changed < 1.0% each. Of exiters, 86.8% of students graduated, whereas 3.9% dropped out, compared to a dropout rate of 5.0% in the general population.
    Conclusion: From 2012 to 2018, students who are D/HH receiving SpEd in the United States have spent increasingly more time in GenEd, most graduated from high school, and few dropped out, with dropout patterns appearing similar to the general population.
    MeSH term(s) Adolescent ; Adult ; Child ; Cross-Sectional Studies ; Deafness ; Education, Special ; Hearing Loss ; Humans ; Persons With Hearing Impairments ; Retrospective Studies ; Schools ; Students ; United States/epidemiology ; Young Adult
    Language English
    Publishing date 2022-08-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2067619-0
    ISSN 1558-9129 ; 0161-1461
    ISSN (online) 1558-9129
    ISSN 0161-1461
    DOI 10.1044/2022_LSHSS-21-00148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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