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  1. Article ; Online: Ab initio molecular dynamics determination of competitive O₂ vs. N₂ adsorption at open metal sites of M₂(dobdc).

    Parkes, Marie V / Greathouse, Jeffery A / Hart, David B / Gallis, Dorina F Sava / Nenoff, Tina M

    Physical chemistry chemical physics : PCCP

    2016  Volume 18, Issue 16, Page(s) 11528–11538

    Abstract: ... and competitive gas adsorption of O2 and N2 in the M2(dobdc) (M = Cr, Mn, Fe) MOF series ...

    Abstract The separation of oxygen from nitrogen using metal-organic frameworks (MOFs) is of great interest for potential pressure-swing adsorption processes for the generation of purified O2 on industrial scales. This study uses ab initio molecular dynamics (AIMD) simulations to examine for the first time the pure-gas and competitive gas adsorption of O2 and N2 in the M2(dobdc) (M = Cr, Mn, Fe) MOF series with coordinatively unsaturated metal centers. Effects of metal, temperature, and gas composition are explored. This unique application of AIMD allows us to study in detail the adsorption/desorption processes and to visualize the process of multiple guests competitively binding to coordinatively unsaturated metal sites of a MOF.
    Language English
    Publishing date 2016-04-28
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/c6cp00768f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Targeting mitotic regulators in cancer as a strategy to enhance immune recognition.

    Gregorczyk, Mateusz / Parkes, Eileen E

    DNA repair

    2023  Volume 132, Page(s) 103583

    Abstract: Eukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory responses driven by the immunogenic nature of cytoplasmic DNA. Cyclic GMP-AMP Synthase (cGAS) is the cytoplasmic dsDNA sensor, which upon ... ...

    Abstract Eukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory responses driven by the immunogenic nature of cytoplasmic DNA. Cyclic GMP-AMP Synthase (cGAS) is the cytoplasmic dsDNA sensor, which upon activation of Stimulator of Interferon Genes (STING), mediates production of pro-inflammatory interferons (IFNs) and interferon stimulated genes (ISGs). However, although this pathway is crucial in detection of viral and microbial genetic material, cytoplasmic DNA is not always of foreign origin. It is now recognised that specifically in genomic instability, a hallmark of cancer, extranuclear material in the form of micronuclei (MN) can be generated as a result of unresolved DNA lesions during mitosis. Activation of cGAS-STING in cancer has been shown to regulate numerous tumour-immune interactions such as acquisition of 'immunologically hot' phenotype which stimulates immune-mediated elimination of transformed cells. Nonetheless, a significant percentage of poorly prognostic cancers is 'immunologically cold'. As this state has been linked with low proportion of tumour-infiltrating lymphocytes (TILs), improving immunogenicity of cold tumours could be clinically relevant by exhibiting synergy with immunotherapy. This review aims to present how inhibition of vital mitotic regulators could provoke cGAS-STING response in cancer and improve the efficacy of current immunotherapy regimens.
    MeSH term(s) Humans ; Neoplasms/pathology ; DNA/metabolism ; Cytoplasm/metabolism ; Interferons ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism
    Chemical Substances DNA (9007-49-2) ; Interferons (9008-11-1) ; Nucleotidyltransferases (EC 2.7.7.-)
    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2071608-4
    ISSN 1568-7856 ; 1568-7864
    ISSN (online) 1568-7856
    ISSN 1568-7864
    DOI 10.1016/j.dnarep.2023.103583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5555: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: IBD BioResource: an open-access platform of 25 000 patients to accelerate research in Crohn's and Colitis.

    Parkes, Miles

    Gut

    2019  Volume 68, Issue 9, Page(s) 1537–1540

    MeSH term(s) Colitis, Ulcerative/genetics ; Colitis, Ulcerative/therapy ; Crohn Disease/genetics ; Crohn Disease/therapy ; Databases, Factual ; Gastrointestinal Agents/therapeutic use ; Genetic Predisposition to Disease ; Humans ; Tissue Banks ; Translational Research, Biomedical/methods ; United Kingdom
    Chemical Substances Gastrointestinal Agents
    Language English
    Publishing date 2019-07-03
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2019-318835
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  4. Book ; Online: Opinion by written procedure - Response to a request from the European Commission on the use of trammel nets in waters less than 600 m depth by way of derogation from Regulation (EC) No 43/2009

    Casey, John / Abella, J. Alvaro / Andersen, Jesper Levring / Bailey, Nick / Balguerias, Eduardo / Cardinale, Massimiliano / Curtis, Hazel / Daures, Fabienne / Kirkegaard, Eskild / Kraak, Sarah B. M. / Kuikka, Sakari / Martin, Paloma / Parkes, G. / Polet, H. / Prellezzo, R. / Sabatella, Evelina / Somarakis, Stylianos / Stransky, Christoph / Vanhee, Willy /
    Hoof, Luc van

    2009  

    Language English
    Publisher Office for Official Publications of the European Communities
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: Opinion by written procedure - Response to a request from the European Commission on the use of trammel nets in waters less than 600 m depth by way of derogation from Regulation (EC) No 43/2009

    Casey, John / Abella, J. Alvaro / Andersen, Jesper Levring / Bailey, Nick / Balguerias, Eduardo / Cardinale, Massimiliano / Curtis, Hazel / Daures, Fabienne / Kirkegaard, Eskild / Kraak, Sarah B. M. / Kuikka, Sakari / Martin, Paloma / Parkes, G. / Polet, H. / Prellezzo, R. / Sabatella, Evelina / Somarakis, Stylianos / Stransky, Christoph / Vanhee, Willy /
    Hoof, Luc van

    2009  

    Keywords Text
    Language English
    Publisher Office for Official Publications of the European Communities
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Debate session: So what causes inflammatory bowel disease? It's all in the genes.

    Parkes, Miles

    Journal of gastroenterology and hepatology

    2018  Volume 33 Suppl 3, Page(s) 23

    MeSH term(s) Autophagy/genetics ; Autophagy-Related Proteins/genetics ; CARD Signaling Adaptor Proteins ; GTP-Binding Proteins/genetics ; Gene-Environment Interaction ; Genome-Wide Association Study ; HLA Antigens/genetics ; Humans ; Immunity, Innate ; Inflammatory Bowel Diseases/etiology ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/immunology ; Interleukins ; Mycobacterium/immunology ; Nod2 Signaling Adaptor Protein/genetics ; Polymorphism, Genetic ; Interleukin-22
    Chemical Substances ATG16L1 protein, human ; Autophagy-Related Proteins ; CARD Signaling Adaptor Proteins ; CARD9 protein, human ; HLA Antigens ; Interleukins ; NOD2 protein, human ; Nod2 Signaling Adaptor Protein ; GTP-Binding Proteins (EC 3.6.1.-) ; IRGM protein, human (EC 3.6.1.-)
    Language English
    Publishing date 2018-10-09
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.14428
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    Zs.A 2180: Show issues Location:
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    Zs.MO 299: Show issues

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  7. Article ; Online: Selectively targeting the gut in inflammatory bowel disease: Targeting integrins.

    Parkes, Miles

    Journal of gastroenterology and hepatology

    2018  Volume 33 Suppl 3, Page(s) 26

    MeSH term(s) Animals ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Cell Movement ; Humans ; Immunoglobulins ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/immunology ; Integrins/antagonists & inhibitors ; Intestines/immunology ; Lymphocytes/immunology ; Molecular Targeted Therapy ; Mucoproteins
    Chemical Substances Antibodies, Monoclonal, Humanized ; Immunoglobulins ; Integrins ; MADCAM1 protein, human ; Mucoproteins ; integrin alpha4beta7 ; vedolizumab (9RV78Q2002)
    Language English
    Publishing date 2018-09-30
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.14431
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    Zs.MO 299: Show issues

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  8. Article ; Online: On the threshold of personalized medicine in inflammatory bowel disease: Next generation genetic predictors.

    Parkes, Miles

    Journal of gastroenterology and hepatology

    2018  Volume 33 Suppl 3, Page(s) 5–6

    MeSH term(s) Azathioprine/administration & dosage ; CD8-Positive T-Lymphocytes ; Disease Progression ; Drug Therapy, Combination ; Genome-Wide Association Study ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/etiology ; Inflammatory Bowel Diseases/genetics ; Inflammatory Bowel Diseases/therapy ; Infliximab/administration & dosage ; Leukocytes ; Precision Medicine/trends ; Pyrophosphatases
    Chemical Substances Infliximab (B72HH48FLU) ; NUDT15 protein, human (EC 2.6.1.-) ; Pyrophosphatases (EC 3.6.1.-) ; Azathioprine (MRK240IY2L)
    Language English
    Publishing date 2018-09-06
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.14416
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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Assessing 'response' to the low-FODMAP diet in irritable bowel syndrome: Should we be reporting harder primary endpoints?

    Conley, Thomas Edward / Parkes, Miles / Moss, Stephen / Probert, Chris

    Clinical nutrition (Edinburgh, Scotland)

    2024  Volume 43, Issue 5, Page(s) 1079–1086

    Abstract: Background & aims: The low-FODMAP diet (LFD) has become almost synonymous with IBS care, yet the challenges associated with this rigorous therapeutic approach are often underacknowledged. Despite positive outcomes in RCTs, comparator groups frequently ... ...

    Abstract Background & aims: The low-FODMAP diet (LFD) has become almost synonymous with IBS care, yet the challenges associated with this rigorous therapeutic approach are often underacknowledged. Despite positive outcomes in RCTs, comparator groups frequently exhibit substantial response rates, raising questions about the definition of 'response'. Whilst the assessment of response in drug trials has evolved to utilize the more stringent FDA/EMA primary clinical endpoints, trials of the LFD have not yet followed. The aim of this article is to opine whether the current approach to the measurement of clinical response to the LFD in clinical trials should be reconsidered.
    Methods: A comprehensive literature review of LFD clinical trials from the past decade was conducted, focusing on recorded response metrics for primary clinical endpoints.
    Results: While response definitions vary, the 50-point IBS-SSS delta emerged as the predominant metric. Notably, no trials to date have adopted the more stringent primary clinical endpoints used in drug trials. Other response measures included binary response metrics (such as 'adequate clinical response'), changes in visual analogue scales or stool form/output, reductions in abdominal pain, as well as changes the magnitude of the IBS-SSS delta. Whether these metrics correspond to a clinically meaningful improvement for the patient is less clear, and as such aligning patient-clinician expectations can be challenging.
    Conclusions: A paradigm shift in the conceptualization of 'response' coupled with an emphasis on harder clinical endpoints in the context of clinical trials may serve to better justify the trade-off between symptom-improvement and the inherent challenges associated with this burdensome therapeutic approach.
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2024.03.017
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    Zs.A 1774: Show issues Location:
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  10. Article ; Online: Coming together as a whole: lessons from connecting across sectors, cultures, and contexts to elevate efforts for planetary health.

    Parkes, Margot / Kennedy, Angel / Reynolds, Tannis / Doyon, Jonathan / Kutzner, Diana

    The Lancet. Planetary health

    2024  Volume 8 Suppl 1, Page(s) S2

    Abstract: Background: Addressing complex and interconnected ecological, social, and health issues necessitates upstream, solutions-oriented, and whole-systems thinking. Specifically, exploring what it means to live in reciprocity with the planet and all living ... ...

    Abstract Background: Addressing complex and interconnected ecological, social, and health issues necessitates upstream, solutions-oriented, and whole-systems thinking. Specifically, exploring what it means to live in reciprocity with the planet and all living systems, now and for generations to come, can have a crucial role in advancing planetary health.
    Methods: In this presentation, we show findings from four gatherings that we co-designed and co-hosted to connect communities, lands, waters, climate, and health. We draw lessons from two events in the Cowichan watershed (co-hosted by Cowichan Tribes) and the Stellako and Nechako watersheds (co-hosted by Stellat'en First Nation) that were co-designed with the ECHO Network. These gatherings brought together youth, Indigenous leaders, researchers, and health, community, and environmental decision-makers across British Columbia to learn how to address connected health, environmental, and community concerns. We supplement these findings with insights from two co-hosted conversations, that connected five continents and more than 40 countries, each enabling 24 h of continuous dialogue on the theme of working together for a healthy, just, and sustainable planet.
    Findings: Gatherings took place between Oct 12, 2022, and Dec 1, 2023. These gatherings each provided lessons about how Indigenous-led, integrative approaches that connect the health of people to lands, waters, and ecosystems can elevate and enhance our work and scholarship to address ecological, social, and health issues. Specifically, initiatives co-designed in this way help overcome challenges that arise when addressing boundary-crossing, intersectional and intersectoral issues at the nexus of climate, public health, and planetary health. Our findings include insights into strengthening research and public health capacity for integrative approaches to complex issues that are relevant to place-based contexts and have implications and applications for planetary health.
    Interpretation: Our presentation summarises how these gatherings-each of which were fuelled by a sense of love for the planet, each other, and future generations-have progressed intersectoral, intergenerational, boundary-crossing, and transformative approaches to planetary health. These insights help guide future directions for planetary health research, practice, and policy.
    Funding: The Canadian Institute of Health Research Environment (IP4150712), Michael Smith Health Research BC (RA-2022-2872), and Vancouver Foundation (FOI19-1781).
    MeSH term(s) Adolescent ; Humans ; Ecosystem ; Canada ; Planets ; Public Health ; Health Status
    Language English
    Publishing date 2024-04-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2542-5196
    ISSN (online) 2542-5196
    DOI 10.1016/S2542-5196(24)00067-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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