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  1. Article ; Online: NIH/NIBIB Introduces New Center for Biomedical Engineering Technology Acceleration.

    Mertz, Leslie

    IEEE pulse

    2023  Volume 14, Issue 2, Page(s) 8–10

    Abstract: ... previously held appointments as professor, Wallace H. Coulter distinguished faculty fellow, and diversity ...

    Abstract In Late January 2023, the National Institute of Biomedical Imaging and Bioengineering (NIBIB) launched a new center designed to accelerate biomedical discovery and therapeutics, in part by pulling together expert, multidisciplinary teams from throughout the National Institutes of Health (NIH) to quickly respond when national or global health crises strike. The inaugural director of this Center for BME Technology Acceleration, or BETA Center, is biomedical engineer Manu Platt, Ph.D., (Figure 1) who is also taking on the role of NIBIB associate director for scientific diversity, equity, and inclusion. Platt previously held appointments as professor, Wallace H. Coulter distinguished faculty fellow, and diversity director of the Center on Emergent Behaviors of Integrated Cellular Systems and Cellular Manufacturing and Technologies at the Georgia Institute of Technology and Emory University.
    MeSH term(s) United States ; Humans ; Biomedical Engineering ; National Institute of Biomedical Imaging and Bioengineering (U.S.) ; National Institutes of Health (U.S.) ; Bioengineering ; Biomedical Technology
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2567191-1
    ISSN 2154-2317 ; 2154-2287
    ISSN (online) 2154-2317
    ISSN 2154-2287
    DOI 10.1109/MPULS.2023.3269743
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  2. Article: A. Kim, k.f. Anderson, j. Berliner, j. Hassan, j. Jensen, h.j. Mertz, h. Pietsch, a. Rao, R. Scherer, and a. Sutterfield.

    Kim, A / Anderson, K F / Berliner, J / Hassan, J / Jensen, J / Mertz, H J / Pietsch, H / Rao, A / Scherer, R / Sutterfield, A

    Stapp car crash journal

    2003  Volume 47, Page(s) 489–523

    Abstract: In this study, three dummies were evaluated on the component level and as a whole. Their responses were compared with available volunteer and embalmed Post Mortem Human Subject (PMHS) data obtained under similar test conditions to evaluate their ... ...

    Abstract In this study, three dummies were evaluated on the component level and as a whole. Their responses were compared with available volunteer and embalmed Post Mortem Human Subject (PMHS) data obtained under similar test conditions to evaluate their biofidelity. The volunteer and PMHS data, used as comparators in this study, were used previously to establish some of the biofidelity requirements of the Hybrid III. The BioRID II, the Hybrid III, and the RID2 were all subjected to rear impact HYGE sled tests with deltaVs of 17 and 28 km/hr to determine their biofidelity in these conditions. A static pull test, where a load was manually applied to the head of each dummy, was used to evaluate the static strength of their necks in flexion and extension. Finally, pendulum tests were conducted with the Hybrid III and RID2 to evaluate the dynamic characteristics of their necks in flexion and extension. The sled test results indicate that out of the three dummies, the overall flexibility of the Hybrid III is comparable to that of the volunteer anticipating the impact. The overall flexibilities of the BioRID II and the RID2 are greater than those of all the comparators used in this study (the tensed volunteer and the two embalmed PMHSs). The responses of the Hybrid III are closer to those of the tensed volunteer than those of the PMHSs. The responses of the BioRID II and the RID2 are closer to those of the PMHSs than to the tensed volunteer.
    Language English
    Publishing date 2003-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2037200-0
    ISSN 1532-8546 ; 0585-086X
    ISSN 1532-8546 ; 0585-086X
    DOI 10.4271/2003-22-0022
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  3. Article ; Online: Electronic Health Record Reform: An Alternative Response to Physician Burnout.

    Mertz, Howard

    The American journal of medicine

    2020  Volume 134, Issue 9, Page(s) e498

    MeSH term(s) Burnout, Professional/prevention & control ; Burnout, Psychological ; Electronic Health Records ; Humans ; Physicians
    Language English
    Publishing date 2020-10-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2021.04.022
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  4. Article: Relativistic effects and two-body currents in (H)((-->)e(')p)n using out-of-plane detection.

    Zhou, Z L / Chen, J / Soong, S B / Young, A / Jiang, X / Alarcon, R / Arenhövel, H / Bernstein, A / Bertozzi, W / Comfort, J / Dodson, G / Dolfini, S / Dooley, A / Dow, K / Farkhondeh, M / Gilad, S / Hicks, R / Hotta, A / Joo, K /
    Kaloskamis, N I / Karabarbounis, A / Kowalski, S / Kunz, C / Margaziotis, D J / Mertz, C / Miller, M / Miskimen, R / Miura, T / Miyase, H / Papanicolas, C N / Peterson, G / Ramirez, A / Rowntree, D / Sarty, A J / Shaw, J / Suda, T / Tamae, T / Tieger, D / Tjon, J A / Tschalaer, C / Tsentalovich, E / Turchinetz, W / Vellidis, C E / Warren, G A / Weinstein, L B / Williamson, S / Zhao, J / Zwart, T

    Physical review letters

    2001  Volume 87, Issue 17, Page(s) 172301

    Abstract: Measurements of the (2)H((-->)e,e(')p)n reaction were performed with the out-of-plane magnetic ...

    Abstract Measurements of the (2)H((-->)e,e(')p)n reaction were performed with the out-of-plane magnetic spectrometers (OOPS) at the MIT-Bates Linear Accelerator. The longitudinal-transverse, f(LT) and f(')(LT), and the transverse-transverse, f(TT), interference responses at a missing momentum of 210 MeV/c were simultaneously extracted in the dip region at Q2 = 0.15 (GeV/c)(2). In comparison to models of deuteron electrodisintegration, the data clearly reveal strong effects of relativity and final-state interactions and the importance of two-body meson-exchange currents and isobar configurations. We demonstrate that such effects can be disentangled by extracting these responses using the novel out-of-plane technique.
    Language English
    Publishing date 2001-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.87.172301
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  5. Article: Why Do I Choose an Animal Model or an Alternative Method in Basic and Preclinical Biomedical Research? A Spectrum of Ethically Relevant Reasons and Their Evaluation.

    Kahrass, Hannes / Pietschmann, Ines / Mertz, Marcel

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 4

    Abstract: Background: Research model selection decisions in basic and preclinical biomedical research have not yet been the subject of an ethical investigation. Therefore, this paper aims, (1) to identify a spectrum of reasons for choosing between animal and ... ...

    Abstract Background: Research model selection decisions in basic and preclinical biomedical research have not yet been the subject of an ethical investigation. Therefore, this paper aims, (1) to identify a spectrum of reasons for choosing between animal and alternative research models (e.g., based on in vitro or in silico models) and (2) provides an ethical analysis of the selected reasons.
    Methods: In total, 13 researchers were interviewed; the interviews were analyzed qualitatively. The ethical analysis was based on the principlism approach and a value judgement model.
    Results: This paper presents 66 reasons underlying the choice of researchers using animal (27 reasons) or alternative models (39). Most of the reasons were assigned to the work environment (29) and scientific standards (22). Other reasons were assigned to personal attitudes (11) and animal welfare (4). Qualitative relevant normative differences are presented in the ethical analysis. Even if few reasons can be rejected outright from an ethical point of view, there are good reasons to give some more weight than others.
    Conclusions: The spectrum of reasons and their ethical assessment provide a framework for reflection for researchers who may have to choose between animal models and (investing in) alternatives. This can help to reflect on and ethically justify decisions.
    Language English
    Publishing date 2024-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14040651
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  6. Article: Suppression of prostaglandin H synthase-2 induction in human monocytes by in vitro or in vivo administration of interleukin 4.

    Mertz, P M / Corcoran, M L / McCluskey, K M / Zhang, Y / Wong, H L / Lotze, M T / DeWitt, D L / Wahl, S M / Wahl, L M

    Cellular immunology

    1996  Volume 173, Issue 2, Page(s) 252–260

    Abstract: ... in vivo effects of IL-4 on monocyte prostaglandin H synthase-2 (PGHS-2) and its regulation by second ...

    Abstract IL-4 is a potent modulator of monocyte function. Our previous studies demonstrated that the suppression of monocyte matrix metalloproteinase production by IL-4 is a result of its inhibition of PGE2 synthesis, which was attributed to an effect on prostaglandin synthase. Here we report on the in vitro and in vivo effects of IL-4 on monocyte prostaglandin H synthase-2 (PGHS-2) and its regulation by second messengers. Stimulation of monocytes with either LPS or Con A resulted in the induction of PGHS-2 which was significantly inhibited by IL-4. Inhibition of PGHS-2 mRNA and protein was detected at 0.05 to 0.1 ng/ml of IL-4 with substantial suppression at 10 to 20 ng/ml. If added later than 2 hr after LPS, IL-4 failed to suppress PGHS-2, indicating that IL-4 acted early in the signaling cascade. Moreover, the ability of exogenously added PGE2 or Bt2cAMP to restore PGHS-2 production in IL-4-treated monocytes further suggested early disruption of the pathway. The early event inhibited by IL-4 did not involve suppression of phospholipase activity, because LPS-induced arachidonic acid release was relatively unaffected by IL-4. Unlike PGHS-2, PGHS-1, the constitutively expressed PGHS, was not modulated by IL-4. Thus, IL-4 appears to selectively block PGHS-2 synthesis, thereby blocking subsequent steps in the pathway leading to the production of matrix metalloproteinases. In an extension of these findings, we examined peripheral blood monocytes from cancer patients undergoing IL-4 therapy. In these cells the induction of PGHS-2 expression by LPS was significantly reduced compared to that of monocytes obtained prior to IL-4 therapy. Although perhaps not relevant as an antitumor mechanism, these findings have important implications in defining the potent anti-inflammatory activities of IL-4 in vitro and in vivo.
    MeSH term(s) Amino Acid Sequence ; Arachidonic Acid/metabolism ; Bucladesine/pharmacology ; Cells, Cultured ; Cyclooxygenase Inhibitors ; Dinoprostone/pharmacology ; Enzyme Induction ; Humans ; Interleukin-4/pharmacology ; Interleukin-4/therapeutic use ; Molecular Sequence Data ; Monocytes/enzymology ; Monocytes/immunology ; Prostaglandin-Endoperoxide Synthases/biosynthesis ; Prostaglandin-Endoperoxide Synthases/drug effects ; Time Factors
    Chemical Substances Cyclooxygenase Inhibitors ; Interleukin-4 (207137-56-2) ; Arachidonic Acid (27YG812J1I) ; Bucladesine (63X7MBT2LQ) ; Prostaglandin-Endoperoxide Synthases (EC 1.14.99.1) ; Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 1996-11-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1006/cimm.1996.0275
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    Zs.A 417: Show issues Location:
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  7. Article ; Online: Animal research ethics as interaction of research ethics, animal ethics, and (animal protection) law.

    Selter, Felicitas / Hetzel, Tatiana / Kahrass, Hannes / Mertz, Marcel

    ALTEX

    2023  Volume 40, Issue 3, Page(s) 541–544

    MeSH term(s) Animals ; Animal Experimentation ; Animal Testing Alternatives ; Ethics, Research ; Animal Welfare
    Language English
    Publishing date 2023-07-20
    Publishing country Germany
    Document type Editorial
    ZDB-ID 165707-0
    ISSN 1868-8551 ; 1018-4562 ; 0946-7785
    ISSN (online) 1868-8551
    ISSN 1018-4562 ; 0946-7785
    DOI 10.14573/altex.2301171
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  8. Article ; Online: Systematic review of nerves at risk at the wrist in common surgical approaches to the forearm: Anatomical variations and surgical implications.

    Bridgwater, Hannah / Mertz, Tamara / Brassett, Cecilia / Ashwood, Neil

    Clinical anatomy (New York, N.Y.)

    2023  Volume 37, Issue 4, Page(s) 425–439

    Abstract: Three commonly used approaches to the forearm in orthopedic surgery are Henry's, Thompson's, and the ulnar approach, each of which has the potential to cause injury to nerves around the wrist. Preserving these nerves is important to prevent complications ...

    Abstract Three commonly used approaches to the forearm in orthopedic surgery are Henry's, Thompson's, and the ulnar approach, each of which has the potential to cause injury to nerves around the wrist. Preserving these nerves is important to prevent complications such as neuroma formation and motor and sensory changes to the hand. We conducted a review of the literature to assess the nerves at risk and whether 'safe zones' exist to avoid these nerves. An independent reviewer conducted searches in Embase and MEDLINE of the literature from 2010 to 2020. A total of 68 papers were identified, with 18 articles being included in the review. Multiple nerves were identified as being at risk for each of the approaches described. In the anterior approach, the palmar cutaneous branch of the median nerve (PCBMN) is most at risk of injury. An incision immediately radial to the flexor carpi radialis (FCR) or directly over the FCR is most likely to avoid injury to both superficial branch of the radial nerve (SBRN) and PCBMN. With Thompson's approach, the safest zone for an incision is directly over or slightly radial to Lister's tubercle to avoid injury to SBRN and lateral cutaneous nerve of the forearm. For the ulnar approach, a safe zone was shown to be on the ulnar side of the wrist around the ulnar styloid (US) when the forearm was in supination or a neutral position to avoid injury to the dorsal branch of the ulna nerve (DBUN). Care must be taken around the US due to the density of nerves and the proximity of the last motor branch of the posterior interosseous nerve to the ulnar head. This review highlighted the proximity of nerves to the three most common surgical incisions used to access the forearm. In addition, anatomical variations may exist, and each of the nerves identified as being at risk has multiple branches. Both factors increase the potential of intraoperative damage if the anatomy is not properly understood. The surgeon must adhere carefully to the established approaches to the wrist and distal forearm to minimize damage to nerves and optimize surgical outcomes for the patient.
    MeSH term(s) Humans ; Forearm/innervation ; Wrist/anatomy & histology ; Wrist Joint/surgery ; Ulna ; Peripheral Nerves/anatomy & histology ; Cadaver
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 1025505-9
    ISSN 1098-2353 ; 0897-3806
    ISSN (online) 1098-2353
    ISSN 0897-3806
    DOI 10.1002/ca.24129
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    Zs.A 2592: Show issues Location:
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  9. Book ; Thesis: Immunologie der Yersinia-getriggerten reaktiven Arthritis

    Mertz, Andreas K. H.

    2002  

    Author's details vorgelegt von Andreas K. H. Mertz
    Language German ; English
    Size 44 Bl. [94] S., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Ulm, Univ., Habil.-Schr., 2002
    HBZ-ID HT013789154
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 E 2774 order to use in reading room Magazin

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  10. Article ; Online: Helicobacter pylori Treatment Regimen Selection and Eradication Rates Across Department of Defense Patients for Fiscal Years 2016-2018.

    Junga, Zachary C / Mertz, Andrew / Pak, Kevin / Singla, Manish

    Military medicine

    2023  

    Abstract: ... methods: This was a retrospective cross-sectional study of all adult DoD beneficiaries with H. pylori ... In total, 20,548 H. pylori diagnostic tests were performed over the study period. A total of 1,592 non ... active duty and 374 active duty patients were diagnosed with H. pylori, were treated, and had eradication ...

    Abstract Introduction: The objective of this study was to measure the number of treatment successes and failures of various Helicobacter pylori treatment regimens among DoD beneficiaries.
    Materials and methods: This was a retrospective cross-sectional study of all adult DoD beneficiaries with H. pylori diagnosis, treatment, and eradication testing from October 2015 to September 2018. All stool antigen testing, urea breath test, and immunoglobulin G serologies were identified. Patients were excluded if they did not have a positive test, did not have treatment, or did not have eradication testing.
    Results: In total, 20,548 H. pylori diagnostic tests were performed over the study period. A total of 1,592 non-active duty and 374 active duty patients were diagnosed with H. pylori, were treated, and had eradication testing. The best performing regimens were tetracycline-based bismuth quadruple therapy and tinidazole-based clarithromycin triple therapy with eradication rates of 85% and 82%, respectively. Clarithromycin triple therapy was the most prescribed (63.9% of all regimens included in analysis). Of the 1,592 non-active duty and 374 active duty patients, 75.5% (1,202) and 70.6% (264) cleared the infection with treatment, respectively (P = 0.0449). Although trends were identified in differences in geographic eradication rates, none of these achieved the threshold of significance.
    Conclusions: This is the largest and most geographically widespread H. pylori treatment efficacy study in the USA over 20 years. None of the treatment regimens (when used in over five patients) achieved an eradication rate greater than 90%, but tetracycline-based bismuth quadruple therapy performed best among all regimens and populations. Eradication rates were lower in the active duty populations, with no treatment regimen achieving an eradication rate greater than 80%.
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usac428
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