LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 223

Search options

  1. Article ; Online: Catalase as a regulator of reactive sulfur metabolism; a new interpretation beyond hydrogen peroxide

    Kevil, Christopher G

    Redox biology

    2017  Volume 12, Page(s) 528–529

    MeSH term(s) Catalase ; Hydrogen Peroxide ; Sulfides ; Sulfur
    Chemical Substances Sulfides ; Sulfur (70FD1KFU70) ; Hydrogen Peroxide (BBX060AN9V) ; Catalase (EC 1.11.1.6)
    Language English
    Publishing date 2017-03-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ISSN 2213-2317
    ISSN (online) 2213-2317
    DOI 10.1016/j.redox.2017.03.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Redox Signaling and Cardiovascular Disease: New Paradigms and discoveries.

    Chen, Yabing / Kevil, Christopher G

    Redox biology

    2020  Volume 37, Page(s) 101743

    MeSH term(s) Cardiovascular Diseases ; Humans ; Oxidation-Reduction ; Reactive Oxygen Species ; Signal Transduction
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2020-09-29
    Publishing country Netherlands
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2020.101743
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: It's a "Gut Feeling": Association of Microbiota, Trimethylamine N-Oxide and Cardiovascular Outcomes.

    Kolluru, Gopi K / Kevil, Christopher G

    Journal of the American Heart Association

    2020  Volume 9, Issue 10, Page(s) e016553

    MeSH term(s) Case-Control Studies ; Gastrointestinal Microbiome ; Humans ; Methylamines ; Microbiota ; Myocardial Infarction ; Patients
    Chemical Substances Methylamines ; trimethyloxamine (FLD0K1SJ1A)
    Language English
    Publishing date 2020-05-05
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.120.016553
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article: Caveolin-1 Scaffolding Domain Peptide Regulates Colon Endothelial Cell Survival through JNK Pathway.

    Fang, Kai / Kevil, Christopher G

    International journal of inflammation

    2020  Volume 2020, Page(s) 6150942

    Abstract: It has been reported that pathological angiogenesis contributes to both experimental colitis and inflammatory bowel disease. Recently, we demonstrated that endothelial caveolin-1 plays a key role in the pathological angiogenesis of dextran sodium sulfate ...

    Abstract It has been reported that pathological angiogenesis contributes to both experimental colitis and inflammatory bowel disease. Recently, we demonstrated that endothelial caveolin-1 plays a key role in the pathological angiogenesis of dextran sodium sulfate (DSS) colitis. However, the molecular mechanism of caveolin-1 regulation of endothelial function is unknown. In this study, we examined how the antennapedia- (AP-) conjugated caveolin-1 scaffolding domain (AP-Cav) modulates vascular endothelial growth factor- (VEGF-) dependent colon endothelial cell angiogenic responses, as seen during colitis. We used mouse colon endothelial cells and found that AP-Cav significantly inhibited VEGF-mediated bromodeoxyuridine (BrdU) incorporation into colon microvascular endothelial cells. AP-Cav significantly blunted VEGF-dependent extracellular signal-regulated kinase 1/2 (ERK 1/2) phosphorylation at 10 minutes and 2 hours after stimulation, compared with the AP control peptide. AP-Cav + VEGF-A treatment also significantly increased c-Jun N-terminal kinase (JNK) phosphorylation at 2 hours. AP-Cav + VEGF-A treatment significantly downregulated retinoblastoma (Rb) protein levels, upregulated cleaved caspase-3 protein levels at 4 hours, and induced apoptosis. Thus, our study suggests that disruption of endothelial caveolin-1 function via the AP-Cav diverts VEGF signaling responses away from endothelial cell proliferation and toward apoptosis through the inhibition of mitogen-activated protein (MAP) kinase signaling and the induction of JNK-associated apoptosis.
    Language English
    Publishing date 2020-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573900-1
    ISSN 2042-0099 ; 2090-8040
    ISSN (online) 2042-0099
    ISSN 2090-8040
    DOI 10.1155/2020/6150942
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Joint transformer architecture in brain 3D MRI classification: its application in Alzheimer's disease classification.

    Alp, Sait / Akan, Taymaz / Bhuiyan, Md Shenuarin / Disbrow, Elizabeth A / Conrad, Steven A / Vanchiere, John A / Kevil, Christopher G / Bhuiyan, Mohammad A N

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8996

    Abstract: Alzheimer's disease (AD), a neurodegenerative disease that mostly affects the elderly, slowly impairs memory, cognition, and daily tasks. AD has long been one of the most debilitating chronic neurological disorders, affecting mostly people over 65. In ... ...

    Abstract Alzheimer's disease (AD), a neurodegenerative disease that mostly affects the elderly, slowly impairs memory, cognition, and daily tasks. AD has long been one of the most debilitating chronic neurological disorders, affecting mostly people over 65. In this study, we investigated the use of Vision Transformer (ViT) for Magnetic Resonance Image processing in the context of AD diagnosis. ViT was utilized to extract features from MRIs, map them to a feature sequence, perform sequence modeling to maintain interdependencies, and classify features using a time series transformer. The proposed model was evaluated using ADNI T1-weighted MRIs for binary and multiclass classification. Two data collections, Complete 1Yr 1.5T and Complete 3Yr 3T, from the ADNI database were used for training and testing. A random split approach was used, allocating 60% for training and 20% for testing and validation, resulting in sample sizes of (211, 70, 70) and (1378, 458, 458), respectively. The performance of our proposed model was compared to various deep learning models, including CNN with BiL-STM and ViT with Bi-LSTM. The suggested technique diagnoses AD with high accuracy (99.048% for binary and 99.014% for multiclass classification), precision, recall, and F-score. Our proposed method offers researchers an approach to more efficient early clinical diagnosis and interventions.
    MeSH term(s) Humans ; Aged ; Alzheimer Disease/pathology ; Neurodegenerative Diseases/pathology ; Magnetic Resonance Imaging/methods ; Neuroimaging ; Brain/diagnostic imaging ; Brain/pathology
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59578-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Redox Signaling and Cardiovascular Disease

    Yabing Chen / Christopher G. Kevil

    Redox Biology, Vol 37, Iss , Pp 101743- (2020)

    New Paradigms and discoveries

    2020  

    Keywords Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: Neurogranin expression regulates mitochondrial function and redox balance in endothelial cells.

    Jorgensen, Ashton N / Rashdan, Nabil A / Rao, K N Shashanka / Delgadillo, Luisa F / Kolluru, Gopi K / Krzywanski, David M / Pattillo, Christopher B / Kevil, Christopher G / Nam, Hyung W

    Redox biology

    2024  Volume 70, Page(s) 103085

    Abstract: Endothelial dysfunction and endothelial activation are common early events in vascular diseases and can arise from mitochondrial dysfunction. Neurogranin (Ng) is a 17kD protein well known to regulate intracellular ... ...

    Abstract Endothelial dysfunction and endothelial activation are common early events in vascular diseases and can arise from mitochondrial dysfunction. Neurogranin (Ng) is a 17kD protein well known to regulate intracellular Ca
    MeSH term(s) Animals ; Humans ; Mice ; Endothelial Cells/metabolism ; Hydrogen Peroxide/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Diseases/metabolism ; Neurogranin/metabolism ; Nitric Oxide/metabolism ; Oxidation-Reduction ; Reactive Oxygen Species/metabolism
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Neurogranin (132654-77-4) ; Nitric Oxide (31C4KY9ESH) ; Reactive Oxygen Species
    Language English
    Publishing date 2024-02-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2024.103085
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: Bad Smells and Broken DNA: A Tale of Sulfur-Nucleic Acid Cooperation.

    Shackelford, Rodney E / Li, Yan / Ghali, Ghali E / Kevil, Christopher G

    Antioxidants (Basel, Switzerland)

    2021  Volume 10, Issue 11

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    Language English
    Publishing date 2021-11-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10111820
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Sulfide regulation of cardiovascular function in health and disease.

    Kolluru, Gopi K / Shackelford, Rodney E / Shen, Xinggui / Dominic, Paari / Kevil, Christopher G

    Nature reviews. Cardiology

    2022  Volume 20, Issue 2, Page(s) 109–125

    Abstract: Hydrogen sulfide ( ... ...

    Abstract Hydrogen sulfide (H
    MeSH term(s) Humans ; Sulfides ; Hydrogen Sulfide/metabolism ; Heart ; Myocardial Infarction ; Heart Failure
    Chemical Substances Sulfides ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-022-00741-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6019: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 98: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Catalase as a regulator of reactive sulfur metabolism; a new interpretation beyond hydrogen peroxide✩

    Christopher G. Kevil

    Redox Biology, Vol 12, Iss , Pp 528-

    2017  Volume 529

    Keywords Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2017-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top