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  1. Book ; Online: Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases

    Kwok, Hang Fai

    2021  

    Keywords Humanities ; Social interaction ; DAPK1 ; SUMO ; SENP ; protein degradation ; post-translational modification ; amphibian Bowman-Birk inhibitor ; Tat peptide ; molecular cloning ; antifungal ; drug design ; protease inhibitor ; natural-based compound ; anticancer therapy ; lung cancer ; survivin ; apoptosis ; STAT3 ; colorectal cancer ; orientin ; cell cycle arrest ; Bcl-2 family proteins ; Astragalus membranaceus ; insulin ; PI3K ; AKT ; PPARγ ; PDX-1 ; Petasites japonicus ; Asteraceae ; lignan ; anti-inflammation ; NO ; PGE2 ; iNOS ; COX-2 ; molecular docking ; peptides ; kynurenines ; binding affinity ; μ-opioid receptor ; pharmacophore ; G-protein activation ; fucoidan ; PLGA ; docetaxel ; drug delivery system ; anticancer therapy/cancer treatment ; hIAPP ; amyloidogenesis ; insulin granules ; endoplasmic reticulum ; anionic lipids ; F23R variant ; β-sheet transitions ; β-cell cytotoxicity ; unfolded protein response ; pomegranate ; punicalagin ; tannins ; gingiva ; fibroblasts ; antioxidant ; wound healing ; branched-chain fatty acids ; Conidiobolus heterosporus ; peroxisome proliferator-activated receptor α ; lipid metabolism ; fatty acid oxidation ; hepatocyte ; n/a
    Size 1 electronic resource (180 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021044692
    ISBN 9783036503875 ; 3036503870
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Proteases-From Basic Structure to Function to Drug Design as Targeted Therapy

    Kwok, Hang Fai / Shaw, Christopher / Walker, Brian

    2021  

    Keywords Research & information: general ; MMP ; MMP2 ; MMP9 ; MMP7 ; MMP14 ; matrix metalloproteases ; PDAC ; pancreatic cancer ; Bowman-Birk inhibitor ; ranacyclin ; trypsin inhibitor ; structure-activity relationship ; synergistic effect ; Gentamicin ; matrix metalloproteinase ; extracellular matrix ; nuclei ; cancer ; apoptosis ; immune response ; cysteine protease inhibitor ; stefin ; signal peptide ; parasite ; phylogenetic analysis ; diversification ; protein structure ; vascular endothelial growth factors (VEGFs) ; VEGF-A ; PlGF ; VEGF-B ; VEGF-C ; VEGF-D ; angiogenesis ; lymphangiogenesis ; CCBE1 ; proteases ; ADAMTS3 ; plasmin ; cathepsin D ; KLK3 ; prostate-specific antigen (PSA) ; thrombin ; wound healing ; metastasis ; proteolytic activation ; vascular biology ; lymphedema
    Size 1 electronic resource (93 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021289797
    ISBN 9783036525747 ; 3036525742
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Editorial: Regulating cell cycle-related activities: The right target for cancer therapy.

    Kwok, Hang Fai

    Seminars in cancer biology

    2024  Volume 98, Page(s) 64–65

    MeSH term(s) Humans ; Cell Cycle/genetics ; Neoplasms/drug therapy ; Neoplasms/genetics
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Editorial
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2024.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2922: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Book ; Online: Venom and Toxin as Targeted Therapy

    Kwok, Hang Fai (Henry)

    2019  

    Abstract: Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted ... ...

    Abstract Targeted therapy has developed significantly in the last one and half decades, prescribing specific medications for treatment of particular diseases, such as cancer, diabetes, and heart disease. One of the most exciting recent developments in targeted therapies was the isolation of disease-specific molecules from natural resources, such as animal venoms and plant metabolites/toxins, for use as templates for new drug motif designs. In addition, the study of venom proteins/peptides and toxins naturally targeted mammalian receptors and demonstrated high specificity and selectivity towards defined ion channels of cell membranes. Research has also focsed intensely on receptors. The focus of this Special Issue of Toxins addressed the most recent advances using animal venoms, such as frog secretions, bee/ant venoms and plant/fungi toxins, as medicinal therapy. Recent advances in venom/toxin/immunotoxins for targeted cancer therapy and immunotherapy, along with using novel disease-specific venom-based protein/peptide/toxin and currently available FDA-approved drugs for combinationtreatments will be discussed. Finally, we included an overview of select promising toad/snake venom-based peptides/toxins potentially able to address the forthcoming challenges in this field. Both research and review articles proposing novelties or overviews, respectively, were published in this Special Issue after rigorous evaluation and revision by expert peer reviewers
    Keywords Science (General) ; Biology (General)
    Size 1 electronic resource (180 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Document type Book ; Online
    Note eng ; Open Access
    HBZ-ID HT020324013
    ISBN 9783039211890 ; 9783039211906 ; 3039211897 ; 3039211900
    DOI 10.3390/books978-3-03921-190-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article: Editorial: New mechanistic insights into cancer precision medicine.

    Kwok, Hang Fai

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1159703

    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1159703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Editorial: Drug discovery from natural sources: Animal venoms, plants, bacteria and fungi.

    Kwok, Hang Fai

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 998676

    Language English
    Publishing date 2022-09-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.998676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The significance of advanced COVID-19 diagnostic testing in pandemic control measures.

    Kwok, Hang Fai

    International journal of biological sciences

    2022  Volume 18, Issue 12, Page(s) 4610–4617

    Abstract: During the 2 years since the start of the novel coronavirus disease 2019 (COVID-19) pandemic, the scientific world made an enormous effort to fight against this disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has ... ...

    Abstract During the 2 years since the start of the novel coronavirus disease 2019 (COVID-19) pandemic, the scientific world made an enormous effort to fight against this disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has high transmissibility. Advancements in vaccine and treatment strategies have reduced both the hospitalization and mortality rates. However, the virus has shown its ability to evolve and evade from our COVID-19 combating armamentaria by the most common evolution mechanism-mutation. Diagnostic testing has been the first line of defense following the identification of the causative agent. Ever since, the scientific community has developed nuclei acid-based, antigen-based, and antibody-based diagnostic tests, and these testing methodologies are still playing a central role in slowing down viral transmission. These testing methods have different sensitivity and specificity and could be optimally used in areas facing different challenges owing to different level and conditions of COVID-19 outbreak. In this review, we discuss these testing methodologies as well as the considerations on how to apply these diagnostic tests optimally in the community to cope with the ever-changing pandemic conditions.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Testing ; Humans ; Pandemics/prevention & control ; SARS-CoV-2 ; Sensitivity and Specificity
    Language English
    Publishing date 2022-07-11
    Publishing country Australia
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.72837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Editorial

    Hang Fai Kwok

    Frontiers in Molecular Biosciences, Vol

    Drug discovery from natural sources: Animal venoms, plants, bacteria and fungi

    2022  Volume 9

    Keywords natural bioactive compounds ; phytochemicals ; diseases ; diagnosis ; precision treatments ; targeted therapies ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article: Editorial: Insights in Protein Chemistry and Enzymology: 2021.

    Kwok, Hang Fai / Zhang, Qi

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 944975

    Language English
    Publishing date 2022-06-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.944975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Editorial: Exercise and cancer: From clinical association to mechanistic insights.

    Lin, Yao / Kwok, Hang Fai

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 1007228

    Language English
    Publishing date 2022-09-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.1007228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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