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Article ; Online: Serum Antibody Responses against Carbapenem-Resistant Klebsiella pneumoniae in Infected Patients.

Banerjee, Kasturi / Motley, Michael P / Diago-Navarro, Elizabeth / Fries, Bettina C

mSphere

2021 Volume 6, Issue 2

Abstract: Capsular polysaccharide (CPS) heterogeneity within carbapenem- ... ...

Abstract	Capsular polysaccharide (CPS) heterogeneity within carbapenem-resistant
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents/pharmacology ; Antibodies, Bacterial/blood ; Bacterial Capsules/genetics ; Bacterial Capsules/immunology ; Carbapenem-Resistant Enterobacteriaceae/immunology ; Carbapenems/pharmacology ; Female ; Genotype ; Humans ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/genetics ; Klebsiella pneumoniae/immunology ; Male ; Middle Aged ; Polysaccharides, Bacterial/genetics ; Polysaccharides, Bacterial/immunology ; Serogroup ; Virulence ; Young Adult
Chemical Substances	Anti-Bacterial Agents ; Antibodies, Bacterial ; Carbapenems ; Polysaccharides, Bacterial
Language	English
Publishing date	2021-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ISSN	2379-5042
ISSN (online)	2379-5042
DOI	10.1128/mSphere.01335-20
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A New Take on an Old Remedy: Generating Antibodies against Multidrug-Resistant Gram-Negative Bacteria in a Postantibiotic World.

Motley, Michael P / Fries, Bettina C

mSphere

2017 Volume 2, Issue 5

Abstract: With the problem of multidrug-resistant Gram-negative pathogens becoming increasingly dire, new strategies are needed to protect and treat infected patients. Though abandoned in the past, monoclonal antibody therapy against Gram-negative bacteria remains ...

Abstract	With the problem of multidrug-resistant Gram-negative pathogens becoming increasingly dire, new strategies are needed to protect and treat infected patients. Though abandoned in the past, monoclonal antibody therapy against Gram-negative bacteria remains a potential solution and has potential advantages over the broad-spectrum antibiotics they were once replaced by. This Perspective reviews the prospect of utilizing monoclonal antibody therapy against these pathogens, as well as the challenges of doing so and the current therapy targets under investigation.
Language	English
Publishing date	2017-10-04
Publishing country	United States
Document type	Journal Article
ISSN	2379-5042
ISSN	2379-5042
DOI	10.1128/mSphere.00397-17
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Article ; Online: Monoclonal antibody-based therapies for bacterial infections.

Motley, Michael P / Banerjee, Kasturi / Fries, Bettina C

Current opinion in infectious diseases

2019 Volume 32, Issue 3, Page(s) 210–216

Abstract: Purpose of review: This review highlights recent developments in the development of monoclonal antibodies to treat bacterial disease, including preclinical advances and the status of current clinical trials.: Recent findings: Monoclonal antibody (mAb) ...

Abstract	Purpose of review: This review highlights recent developments in the development of monoclonal antibodies to treat bacterial disease, including preclinical advances and the status of current clinical trials. Recent findings: Monoclonal antibody (mAb) therapy is becoming increasingly promising in the infectious disease field. Though bacterial exotoxins continue to be a mainstay of mAb targets, searches for protein targets on the surface of bacteria have uncovered new mechanisms of antibody-mediated action against bacteria. Additionally, surveys of the polysaccharide serotype prevalence among antibiotic-resistant bacterial populations have yielded opportunities to leverage human selective pressures to our clinical advantage. Several mAb candidates are progressing through clinical development with great promise, especially those with structures altered to provide maximum benefit. Although other clinical trials have recently proved unsuccessful, these failures and lessons from immune profiling provide opportunities to understand how vulnerabilities of certain targets may change in different disease states. Summary: Despite the hurdles of identifying effective targets and understanding how mAbs provide protection within different infections, we show that the progress made in these fields is a positive indication of mAbs becoming more widely accepted as the future for treating bacterial infections.
MeSH term(s)	Animals ; Antibodies, Bacterial/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Bacterial Infections/therapy ; Clinical Trials as Topic ; Drug Evaluation, Preclinical ; Humans ; Immunotherapy/methods ; Immunotherapy/trends
Chemical Substances	Antibodies, Bacterial ; Antibodies, Monoclonal
Language	English
Publishing date	2019-05-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	645085-4
ISSN	1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
ISSN (online)	1473-6527 ; 1535-3877
ISSN	0951-7375 ; 1355-834X
DOI	10.1097/QCO.0000000000000539
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Patient-Derived Antibody Data Yields Development of Broadly Cross-Protective Monoclonal Antibody against ST258 Carbapenem-Resistant

Banerjee, Kasturi / Motley, Michael P / Boniche-Alfaro, Camila / Bhattacharya, Somanon / Shah, Raj / Ardizzone, Andrew / Fries, Bettina C

Microbiology spectrum

2022 Volume 10, Issue 4, Page(s) e0176022

Abstract: The most pressing challenge for the development of anti-capsular antibodies is maximizing coverage against the heterogenous capsular polysaccharide (CPS) of carbapenem-resistant Klebsiella pneumoniae (CR- ...

Abstract	The most pressing challenge for the development of anti-capsular antibodies is maximizing coverage against the heterogenous capsular polysaccharide (CPS) of carbapenem-resistant Klebsiella pneumoniae (CR-
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Klebsiella Infections/drug therapy ; Klebsiella Infections/prevention & control ; Klebsiella pneumoniae ; Macrophages ; Mice
Chemical Substances	Anti-Bacterial Agents ; Antibodies, Monoclonal ; Carbapenems
Language	English
Publishing date	2022-07-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.01760-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A new Cannabis genome assembly associates elevated cannabidiol (CBD) with hemp introgressed into marijuana.

Grassa, Christopher J / Weiblen, George D / Wenger, Jonathan P / Dabney, Clemon / Poplawski, Shane G / Timothy Motley, S / Michael, Todd P / Schwartz, C J

The New phytologist

2021 Volume 230, Issue 4, Page(s) 1665–1679

Abstract: Demand for cannabidiol (CBD), the predominant cannabinoid in hemp (Cannabis sativa), has favored cultivars producing unprecedented quantities of CBD. We investigated the ancestry of a new cultivar and cannabinoid synthase genes in relation to cannabinoid ...

Abstract	Demand for cannabidiol (CBD), the predominant cannabinoid in hemp (Cannabis sativa), has favored cultivars producing unprecedented quantities of CBD. We investigated the ancestry of a new cultivar and cannabinoid synthase genes in relation to cannabinoid inheritance. A nanopore-based assembly anchored to a high-resolution linkage map provided a chromosome-resolved genome for CBDRx, a potent CBD-type cultivar. We measured cannabinoid synthase expression by cDNA sequencing and conducted a population genetic analysis of diverse Cannabis accessions. Quantitative trait locus mapping of cannabinoids in a hemp × marijuana segregating population was also performed. Cannabinoid synthase paralogs are arranged in tandem arrays embedded in long terminal repeat retrotransposons on chromosome 7. Although CBDRx is predominantly of marijuana ancestry, the genome has cannabidiolic acid synthase (CBDAS) introgressed from hemp and lacks a complete sequence for tetrahydrocannabinolic acid synthase (THCAS). Three additional genomes, including one with complete THCAS, confirmed this genomic structure. Only cannabidiolic acid synthase (CBDAS) was expressed in CBD-type Cannabis, while both CBDAS and THCAS were expressed in a cultivar with an intermediate tetrahydrocannabinol (THC) : CBD ratio. Although variation among cannabinoid synthase loci might affect the THC : CBD ratio, variability among cultivars in overall cannabinoid content (potency) was also associated with other chromosomes.
MeSH term(s)	Cannabidiol ; Cannabinoids ; Cannabis/genetics ; Chromosome Mapping ; Dronabinol
Chemical Substances	Cannabinoids ; Cannabidiol (19GBJ60SN5) ; Dronabinol (7J8897W37S)
Language	English
Publishing date	2021-02-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	208885-x
ISSN	1469-8137 ; 0028-646X
ISSN (online)	1469-8137
ISSN	0028-646X
DOI	10.1111/nph.17243
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Z 868: Show issues

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Article ; Online: The Role of IgG Subclass in Antibody-Mediated Protection against Carbapenem-Resistant Klebsiella pneumoniae.

Motley, Michael P / Diago-Navarro, Elizabeth / Banerjee, Kasturi / Inzerillo, Sean / Fries, Bettina C

mBio

2020 Volume 11, Issue 5

Abstract: Monoclonal antibodies (MAbs) have the potential to assist in the battle against multidrug-resistant bacteria such as carbapenem- ... ...

Abstract	Monoclonal antibodies (MAbs) have the potential to assist in the battle against multidrug-resistant bacteria such as carbapenem-resistant
MeSH term(s)	Animals ; Anti-Bacterial Agents/pharmacology ; Antibodies, Bacterial/classification ; Antibodies, Bacterial/immunology ; Antibodies, Monoclonal/classification ; Antibodies, Monoclonal/genetics ; Antibodies, Monoclonal/immunology ; Binding Sites, Antibody ; Carbapenem-Resistant Enterobacteriaceae/immunology ; Carbapenems/pharmacology ; Immunoglobulin G/classification ; Immunoglobulin G/immunology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/immunology ; Macrophages/immunology ; Mice ; Mice, Inbred C57BL ; Neutropenia ; Phagocytosis ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/prevention & control
Chemical Substances	Anti-Bacterial Agents ; Antibodies, Bacterial ; Antibodies, Monoclonal ; Carbapenems ; Immunoglobulin G
Language	English
Publishing date	2020-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mBio.02059-20
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Review of Viral Testing (Polymerase Chain Reaction) and Antibody/Serology Testing for Severe Acute Respiratory Syndrome-Coronavirus-2 for the Intensivist.

Motley, Michael P / Bennett-Guerrero, Elliott / Fries, Bettina C / Spitzer, Eric D

Critical care explorations

2020 Volume 2, Issue 6, Page(s) e0154

Abstract: Objective: As the severe acute respiratory syndrome-coronavirus-2 pandemic develops, assays to detect the virus and infection caused by it are needed for diagnosis and management. To describe to clinicians how each assay is performed, what each assay ... ...

Abstract	Objective: As the severe acute respiratory syndrome-coronavirus-2 pandemic develops, assays to detect the virus and infection caused by it are needed for diagnosis and management. To describe to clinicians how each assay is performed, what each assay detects, and the benefits and limitations of each assay. Data sources: Published literature and internet. Study selection: As well done, relevant and recent as possible. Data extraction: Sources were read to extract data from them. Data synthesis: Was synthesized by all coauthors. Conclusions: Available assays test for current or previous severe acute respiratory syndrome-coronavirus-2 infection. Nucleic acid assays such as quantitative, or real-time, polymerase chain reaction and loop-mediated isothermal amplification are ideal for acute diagnosis with polymerase chain reaction testing remaining the "gold standard" to diagnose acute infection by severe acute respiratory syndrome-coronavirus-2, specifically the presence of viral RNA. Assays that detect serum antibodies can theoretically diagnose both acute and remote infection but require time for the patient to develop immunity and may detect nonspecific antibodies. Antibody assays that quantitatively measure neutralizing antibodies are needed to test efficacy of convalescent plasma therapy but are more specialized.
Keywords	covid19
Language	English
Publishing date	2020-06-15
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000154
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: EXPERIMENTAL MODELING OF WAVE FORCES AND HYDRODYNAMICS ON ELEVATED COASTAL STRUCTURES SUBJECT TO WAVES, SURGE OR TSUNAMIS: THE EFFECT OF BREAKING, SHIELDING AND DEBRIS.

Lomonaco, Pedro / Alam, Mohammad Shafiqual / Arduino, Pedro / Barbosa, Andre / Cox, Daniel T / Do, Trung / Eberhard, Marc / Motley, Michael / Shekhar, Krishnendu / Tomiczek, Tori / Park, Hyoungsu / van de Lindt, John W / Winter, Andrew

Coastal engineering : proceedings of the ... international conference. International Conference on Coastal Engineering

2023 Volume 1, Issue 36, Page(s) 58–74

Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2628774-2
ISSN	2156-1028 ; 2156-1028
ISSN (online)	2156-1028
ISSN	2156-1028
DOI	10.9753/icce.v36.waves.53
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Review of Viral Testing (Polymerase Chain Reaction) and Antibody/Serology Testing for Severe Acute Respiratory Syndrome-Coronavirus-2 for the Intensivist

Motley, Michael P. / Bennett-Guerrero, Elliott / Fries, Bettina C. / Spitzer, Eric D.

Critical Care Explorations

Abstract: Objective: As the severe acute respiratory syndrome-coronavirus-2 pandemic develops, assays to detect the virus and infection caused by it are needed for diagnosis and management To describe to clinicians how each assay is performed, what each assay ... ...

Abstract	Objective: As the severe acute respiratory syndrome-coronavirus-2 pandemic develops, assays to detect the virus and infection caused by it are needed for diagnosis and management To describe to clinicians how each assay is performed, what each assay detects, and the benefits and limitations of each assay Data Sources: Published literature and internet Study Selection: As well done, relevant and recent as possible Data Extraction: Sources were read to extract data from them Data Synthesis: Was synthesized by all coauthors Conclusions: Available assays test for current or previous severe acute respiratory syndrome-coronavirus-2 infection Nucleic acid assays such as quantitative, or real-time, polymerase chain reaction and loop-mediated isothermal amplification are ideal for acute diagnosis with polymerase chain reaction testing remaining the “gold standard” to diagnose acute infection by severe acute respiratory syndrome-coronavirus-2, specifically the presence of viral RNA Assays that detect serum antibodies can theoretically diagnose both acute and remote infection but require time for the patient to develop immunity and may detect nonspecific antibodies Antibody assays that quantitatively measure neutralizing antibodies are needed to test efficacy of convalescent plasma therapy but are more specialized
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #605847
Database	COVID19

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Article ; Online: High contiguity Arabidopsis thaliana genome assembly with a single nanopore flow cell.

Michael, Todd P / Jupe, Florian / Bemm, Felix / Motley, S Timothy / Sandoval, Justin P / Lanz, Christa / Loudet, Olivier / Weigel, Detlef / Ecker, Joseph R

Nature communications

2018 Volume 9, Issue 1, Page(s) 541

Abstract: The handheld Oxford Nanopore MinION sequencer generates ultra-long reads with minimal cost and time requirements, which makes sequencing genomes at the bench feasible. Here, we sequence the gold standard Arabidopsis thaliana genome (KBS-Mac-74 accession) ...

Abstract	The handheld Oxford Nanopore MinION sequencer generates ultra-long reads with minimal cost and time requirements, which makes sequencing genomes at the bench feasible. Here, we sequence the gold standard Arabidopsis thaliana genome (KBS-Mac-74 accession) on the bench with the MinION sequencer, and assemble the genome using typical consumer computing hardware (4 Cores, 16 Gb RAM) into chromosome arms (62 contigs with an N50 length of 12.3 Mb). We validate the contiguity and quality of the assembly with two independent single-molecule technologies, Bionano optical genome maps and Pacific Biosciences Sequel sequencing. The new A. thaliana KBS-Mac-74 genome enables resolution of a quantitative trait locus that had previously been recalcitrant to a Sanger-based BAC sequencing approach. In summary, we demonstrate that even when the purpose is to understand complex structural variation at a single region of the genome, complete genome assembly is becoming the simplest way to achieve this goal.
MeSH term(s)	Arabidopsis/genetics ; Arabidopsis Proteins/genetics ; Chromosomes, Plant/genetics ; Genome, Plant ; Genomics/instrumentation ; Genomics/methods ; High-Throughput Nucleotide Sequencing/methods
Chemical Substances	Arabidopsis Proteins
Language	English
Publishing date	2018-02-07
Publishing country	England
Document type	Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-018-03016-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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