Result 1 - 10 of total 33304
Medical examiner (Philadelphia, Pa.)
2023 Volume 5, Issue 28, Page(s) 437–439
| Language | English |
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| Publishing date | 2023-12-20 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Medical examiner (Philadelphia, Pa.)
2023 Volume 5, Issue 24, Page(s) 369–370
| Language | English |
|---|---|
| Publishing date | 2023-12-20 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Atlanta medical register
2022 Volume 1, Issue 5, Page(s) 257–263
| Language | English |
|---|---|
| Publishing date | 2022-07-11 |
| Publishing country | United States |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2021 Volume 11, Issue 1, Page(s) 10038
Abstract: ... without compromising antinociception. Here we report the effects of D-cystine diethyl ester (D-cystine diEE) or D ... cystine dimethyl ester (D-cystine diME) on morphine-induced changes in ventilation, arterial-blood gas ... of tidal volume, minute ventilation, peak inspiratory flow, and inspiratory drive). Subsequent injection of D ...
| Abstract | We have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of D-cystine diethyl ester (D-cystine diEE) or D-cystine dimethyl ester (D-cystine diME) on morphine-induced changes in ventilation, arterial-blood gas chemistry, A-a gradient (index of gas-exchange in the lungs) and antinociception in freely moving rats. Injection of morphine (10 mg/kg, IV) elicited negative effects on breathing (e.g., depression of tidal volume, minute ventilation, peak inspiratory flow, and inspiratory drive). Subsequent injection of D-cystine diEE (500 μmol/kg, IV) elicited an immediate and sustained reversal of these effects of morphine. Injection of morphine (10 mg/kg, IV) also elicited pronounced decreases in arterial blood pH, pO |
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| MeSH term(s) | Analgesics, Opioid/adverse effects ; Animals ; Blood Gas Analysis ; Carbon Dioxide/blood ; Cystine/analogs & derivatives ; Cystine/pharmacology ; Cystine/therapeutic use ; Drug Evaluation, Preclinical ; Hydrogen-Ion Concentration ; Male ; Morphine/adverse effects ; Oxygen/blood ; Pulmonary Ventilation/drug effects ; Rats, Sprague-Dawley ; Rats |
| Chemical Substances | Analgesics, Opioid ; Carbon Dioxide (142M471B3J) ; Cystine (48TCX9A1VT) ; Morphine (76I7G6D29C) ; Oxygen (S88TT14065) ; cystine dimethyl ester (VEO23D129R) |
| Language | English |
| Publishing date | 2021-05-11 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-021-89455-2 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Scientific Reports, Vol 11, Iss 1, Pp 1-
2021 Volume 14
Abstract: ... without compromising antinociception. Here we report the effects of d-cystine diethyl ester (d-cystine diEE) or d ... cystine dimethyl ester (d-cystine diME) on morphine-induced changes in ventilation, arterial-blood gas ... of tidal volume, minute ventilation, peak inspiratory flow, and inspiratory drive). Subsequent injection of d ...
| Abstract | Abstract We have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of d-cystine diethyl ester (d-cystine diEE) or d-cystine dimethyl ester (d-cystine diME) on morphine-induced changes in ventilation, arterial-blood gas chemistry, A-a gradient (index of gas-exchange in the lungs) and antinociception in freely moving rats. Injection of morphine (10 mg/kg, IV) elicited negative effects on breathing (e.g., depression of tidal volume, minute ventilation, peak inspiratory flow, and inspiratory drive). Subsequent injection of d-cystine diEE (500 μmol/kg, IV) elicited an immediate and sustained reversal of these effects of morphine. Injection of morphine (10 mg/kg, IV) also elicited pronounced decreases in arterial blood pH, pO2 and sO2 accompanied by pronounced increases in pCO2 (all indicative of a decrease in ventilatory drive) and A-a gradient (mismatch in ventilation-perfusion in the lungs). These effects of morphine were reversed in an immediate and sustained fashion by d-cystine diME (500 μmol/kg, IV). Finally, the duration of morphine (5 and 10 mg/kg, IV) antinociception was augmented by d-cystine diEE. d-cystine diEE and d-cystine diME may be clinically useful agents that can effectively reverse the negative effects of morphine on breathing and gas-exchange in the lungs while promoting antinociception. Our study suggests that the d-cystine thiolesters are able to differentially modulate the intracellular signaling cascades that mediate morphine-induced ventilatory depression as opposed to those that mediate morphine-induced antinociception and sedation. |
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| Keywords | Medicine ; R ; Science ; Q |
| Subject code | 630 |
| Language | English |
| Publishing date | 2021-05-01T00:00:00Z |
| Publisher | Nature Portfolio |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
1994 Volume 36, Issue 2, Page(s) 119–120
| MeSH term(s) | Alaska ; History, 20th Century ; Humans ; Public Health/history ; Tuberculosis/history |
|---|---|
| Language | English |
| Publishing date | 1994-04 |
| Publishing country | United States |
| Document type | Biography ; Historical Article ; Journal Article |
| ZDB-ID | 603495-0 |
| ISSN | 0002-4538 |
| ISSN | 0002-4538 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 489: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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1992 Volume 34, Issue 3, Page(s) 156, 160
| MeSH term(s) | Alaska ; History, 20th Century ; Neurology/history |
|---|---|
| Language | English |
| Publishing date | 1992-07 |
| Publishing country | United States |
| Document type | Biography ; Historical Article ; Journal Article |
| ZDB-ID | 603495-0 |
| ISSN | 0002-4538 |
| ISSN | 0002-4538 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 489: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2015 Volume 36, Issue 4, Page(s) 489–494
| MeSH term(s) | DNA/analysis ; Female ; Forensic Genetics/methods ; Humans ; Male ; Models, Genetic |
|---|---|
| Chemical Substances | DNA (9007-49-2) |
| Language | English |
| Publishing date | 2015-02 |
| Publishing country | Germany |
| Document type | Comment ; Letter |
| ZDB-ID | 619001-7 |
| ISSN | 1522-2683 ; 0173-0835 |
| ISSN (online) | 1522-2683 |
| ISSN | 0173-0835 |
| DOI | 10.1002/elps.201570044 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1868: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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American journal of physiology. Regulatory, integrative and comparative physiology
2006 Volume 291, Issue 6, Page(s) R1567–78
Abstract: ... University. Earning his M.D. from St. Louis University and assuming a faculty position there, Wheelon and ...
| Abstract | Since 1953, illustrations have been inserted as "tailpieces" at the ends of articles in The American Journal of Physiology and The Journal of Applied Physiology. The drawings were made by Homer Wheelon, a member of the American Physiological Society from 1919 until his death in 1960. Forty-five years after his death, Wheelon is unknown, but he contributed 32 publications to the medical literature and trained J. Earl Thomas, an important 20th century gastrointestinal physiologist. Wheelon was born into poverty in 1883 to itinerant Methodist preachers, circumstances that guided his education and career choices. Throughout his life, Wheelon exhibited a fondness and talent for art and photography and an unusual breadth of intellectual interests and knowledge. Wheelon received a bachelor's degree from the University of Washington, then studied at the University of Oregon, Northwestern University, and St. Louis University. Earning his M.D. from St. Louis University and assuming a faculty position there, Wheelon and his graduate student, Thomas, conducted widely recognized gastrointestinal research. Returning to Seattle in 1921, Wheelon became a highly respected physician and hospital administrator, but he also found time to indulge his interest in visual art and poetry. In 1933, inspired by observing a rabbit being used in a pregnancy test, Wheelon began to write and illustrate an epic, 322-page poem, Rabbit No. 202, illustrations from which became the journals' tailpieces. The present study traces Wheelon's personal life and scientific career in an attempt to understand this complex man and the origins of his unusual poem and its drawings. |
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| MeSH term(s) | Art/history ; History, 19th Century ; History, 20th Century ; Periodicals as Topic/history ; Physiology/history ; Poetry as Topic/history ; Societies, Medical/history ; United States |
| Language | English |
| Publishing date | 2006-08-03 |
| Publishing country | United States |
| Document type | Biography ; Historical Article ; Journal Article |
| ZDB-ID | 603839-6 |
| ISSN | 1522-1490 ; 0363-6119 |
| ISSN (online) | 1522-1490 |
| ISSN | 0363-6119 |
| DOI | 10.1152/ajpregu.00390.2006 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Uc I Zs.89: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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1992 Volume 34, Issue 4, Page(s) 194–195
| MeSH term(s) | Alaska ; Family Practice/history ; History, 20th Century |
|---|---|
| Language | English |
| Publishing date | 1992-10 |
| Publishing country | United States |
| Document type | Biography ; Historical Article ; Journal Article |
| ZDB-ID | 603495-0 |
| ISSN | 0002-4538 |
| ISSN | 0002-4538 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 489: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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