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Article ; Online: Total protein concentration as a predictor of neoplastic peritoneal and pleural effusions of dogs.

Parsley, Ashley L / Schnelle, Amy N / Gruber, Erika J / Sander, William E / Barger, Anne M

2022 Volume 51, Issue 3, Page(s) 391–397

Abstract: Background: The diagnosis of neoplastic cavitary effusions requires the identification of neoplastic cells in effusions, yet the cytologic appearance of neoplastic effusions can be highly variable due to the varied mechanisms of formation. Additional ... ...

Abstract	Background: The diagnosis of neoplastic cavitary effusions requires the identification of neoplastic cells in effusions, yet the cytologic appearance of neoplastic effusions can be highly variable due to the varied mechanisms of formation. Additional parameters might aid in the interpretation of equivocal cytologic results. Objectives: Our goal was to evaluate whether total protein concentrations can be used to support the diagnosis of neoplasia in the peritoneal and pleural effusions of dogs with lower cellularities (≤5000 nucleated cells/μL). Methods: Pleural and peritoneal fluid analyses from dogs presented to the University of Illinois Veterinary Teaching Hospital between 2014 and 2019 were evaluated retrospectively. Effusions were categorized as neoplastic or non-neoplastic based on histology or cytology. Non-neoplastic effusions were subcategorized according to mechanism: decreased oncotic pressure, increased hydrostatic pressure, increased vascular permeability, leakage of urine, and leakage of lymph. The TP and blood albumin to fluid TP ratio (Alb Results: Twenty-seven neoplastic and 65 non-neoplastic cases were evaluated. TP was higher in the neoplastic group (P = .001) than in the non-neoplastic group. Neoplastic effusions had a lower Alb Conclusions: Fluid TP concentrations were significantly greater in neoplastic than non-neoplastic effusions; however, given the considerable overlap between groups, the diagnostic utility of this difference is low. A neoplastic etiology might be more likely in cases with an Alb
MeSH term(s)	Animals ; Ascitic Fluid/pathology ; Dog Diseases/diagnosis ; Dog Diseases/pathology ; Dogs ; Hospitals, Animal ; Hospitals, Teaching ; Pleural Effusion/diagnosis ; Pleural Effusion/etiology ; Pleural Effusion/veterinary ; Retrospective Studies
Language	English
Publishing date	2022-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2114702-4
ISSN	1939-165X ; 0275-6382
ISSN (online)	1939-165X
ISSN	0275-6382
DOI	10.1111/vcp.13122
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Article: Natural hair patterns.

Parsley, William M

Facial plastic surgery clinics of North America

2004 Volume 12, Issue 2, Page(s) 167–180

Abstract: Hair loss is complex and can be classified in many ways. This article has focused on the anatomic zones and their significance to hair restoration. Hair restoration surgeons must not only be aware of these patterns of loss but also their significance for ...

Abstract	Hair loss is complex and can be classified in many ways. This article has focused on the anatomic zones and their significance to hair restoration. Hair restoration surgeons must not only be aware of these patterns of loss but also their significance for the future.
MeSH term(s)	Alopecia/diagnosis ; Alopecia/surgery ; Esthetics ; Hair/anatomy & histology ; Hair/transplantation ; Humans ; Male ; Scalp ; Transplantation, Autologous
Language	English
Publishing date	2004-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1315178-2
ISSN	1558-1926 ; 1064-7406
ISSN (online)	1558-1926
ISSN	1064-7406
DOI	10.1016/j.fsc.2003.12.006
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Article ; Online: PepSAVI-MS Reveals a Proline-rich Antimicrobial Peptide in

Moyer, Tessa B / Heil, Lilian R / Kirkpatrick, Christine L / Goldfarb, Dennis / Lefever, William A / Parsley, Nicole C / Wommack, Andrew J / Hicks, Leslie M

Journal of natural products

2019 Volume 82, Issue 10, Page(s) 2744–2753

Abstract: Traditional medicinal plants are a rich source of antimicrobials; however, the bioactive peptide constituents of most ethnobotanical species remain largely unexplored. Herein, PepSAVI-MS, a mass spectrometry-based peptidomics pipeline, was implemented ... ...

Abstract	Traditional medicinal plants are a rich source of antimicrobials; however, the bioactive peptide constituents of most ethnobotanical species remain largely unexplored. Herein, PepSAVI-MS, a mass spectrometry-based peptidomics pipeline, was implemented for antimicrobial peptide (AMP) discovery in the medicinal plant
MeSH term(s)	Amaranthus/chemistry ; Antimicrobial Cationic Peptides/chemistry ; Antimicrobial Cationic Peptides/isolation & purification ; Antimicrobial Cationic Peptides/pharmacology ; Mass Spectrometry/methods ; Proline
Chemical Substances	Antimicrobial Cationic Peptides ; Proline (9DLQ4CIU6V)
Language	English
Publishing date	2019-09-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.9b00352
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Article ; Online: Review of factors affecting the growth and survival of follicular grafts.

Parsley, William M / Perez-Meza, David

Journal of cutaneous and aesthetic surgery

2010 Volume 3, Issue 2, Page(s) 69–75

Abstract: Great strides have been made in hair restoration over the past 20 years. A better understanding of natural balding and non-balding patterns along with more respect for ageing has helped guide proper hairline design. Additionally, the use of smaller ... ...

Abstract	Great strides have been made in hair restoration over the past 20 years. A better understanding of natural balding and non-balding patterns along with more respect for ageing has helped guide proper hairline design. Additionally, the use of smaller grafts has created a significantly improved natural appearance to the transplanted grafts. Inconsistent growth and survival of follicular grafts, however, has continued to be a problem that has perplexed hair restoration surgeons. This review attempts to explore the stresses affecting grafts during transplantation and some of the complexities involved in graft growth and survival. These authors reviewed the literature to determine the primary scope of aspects influencing growth and survival of follicular grafts. This scope includes patient selection, operating techniques, graft care, storage solutions and additives. The primary focus of the hair restoration surgeons should first be attention to the fundamentals of hair care, hydration, temperature, time out of body and gentle handling. Factors such as advanced storage solutions and additives can be helpful once the fundamentals have been addressed.
Language	English
Publishing date	2010-04-10
Publishing country	India
Document type	Journal Article
ZDB-ID	2461107-4
ISSN	0974-5157 ; 0974-2077
ISSN (online)	0974-5157
ISSN	0974-2077
DOI	10.4103/0974-2077.69014
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Article: PepSAVI-MS Reveals a Proline-rich Antimicrobial Peptide in Amaranthus tricolor

Moyer, Tessa B / Heil, Lilian R / Kirkpatrick, Christine L / Goldfarb, Dennis / Lefever, William A / Parsley, Nicole C / Wommack, Andrew J / Hicks, Leslie M

Journal of natural products. 2019 Sept. 26, v. 82, no. 10

2019

Abstract	Traditional medicinal plants are a rich source of antimicrobials; however, the bioactive peptide constituents of most ethnobotanical species remain largely unexplored. Herein, PepSAVI-MS, a mass spectrometry-based peptidomics pipeline, was implemented for antimicrobial peptide (AMP) discovery in the medicinal plant Amaranthus tricolor. This investigation revealed a novel 1.7 kDa AMP with strong activity against Escherichia coli ATCC 25922, deemed Atr-AMP1. Initial efforts to determine the sequence of Atr-AMP1 utilized chemical derivatization and enzymatic digestion to provide information about specific residues and post-translational modifications. EThcD (electron-transfer/higher-energy collision dissociation) produced extensive backbone fragmentation and facilitated de novo sequencing, the results of which were consistent with orthogonal characterization experiments. Additionally, multistage HCD (higher-energy collisional dissociation) facilitated discrimination between isobaric leucine and isoleucine. These results revealed a positively charged proline-rich peptide present in a heterogeneous population of multiple peptidoforms, possessing several post-translational modifications including a disulfide bond, methionine oxidation, and proline hydroxylation. Additional bioactivity screening of a simplified fraction containing Atr-AMP1 revealed activity against Staphylococcus aureus LAC, demonstrating activity against both a Gram-negative and a Gram-positive bacterial species unlike many known short chain proline-rich antimicrobial peptides.
Keywords	Amaranthus tricolor ; Escherichia coli ; Gram-positive bacteria ; Staphylococcus aureus ; anti-infective agents ; antimicrobial peptides ; bioactive properties ; derivatization ; dissociation ; disulfide bonds ; electron transfer ; ethnobotany ; hydroxylation ; isoleucine ; leucine ; mass spectrometry ; medicinal plants ; methionine ; oxidation ; post-translational modification ; proline ; screening
Language	English
Dates of publication	2019-0926
Size	p. 2744-2753.
Publishing place	American Chemical Society and American Society of Pharmacognosy
Document type	Article
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.9b00352
Database	NAL-Catalogue (AGRICOLA)

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Article: One size does not fit all: involve orthopaedic implant patients in deciding whether to use prophylactic antibiotics with dental procedures.

Jevsevar, David S / Cummins, Deborah S / Azar, Frederick M / Parsley, Brian S / Fehring, Thomas K / Lachiewicz, Paul F / Watters, William C

The Journal of the American Academy of Orthopaedic Surgeons

2015 Volume 23, Issue 3, Page(s) 141–142

MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Antibiotic Prophylaxis/methods ; Decision Making ; Dental Implants ; Dentistry, Operative ; Humans ; Orthopedic Procedures/methods ; Orthopedics ; Societies, Medical ; Surgical Wound Infection/prevention & control ; United States
Chemical Substances	Anti-Bacterial Agents ; Dental Implants
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Editorial
ZDB-ID	1200524-1
ISSN	1940-5480 ; 1067-151X
ISSN (online)	1940-5480
ISSN	1067-151X
DOI	10.5435/JAAOS-D-15-00045
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Zs.A 4048: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Review of factors affecting the growth and survival of follicular grafts

William M Parsley / David Perez-Meza

Journal of Cutaneous and Aesthetic Surgery , Vol 3, Iss 2, Pp 69-

2010 Volume 75

Abstract	Great strides have been made in hair restoration over the past 20 years. A better understanding of natural balding and non-balding patterns along with more respect for ageing has helped guide proper hairline design. Additionally, the use of smaller grafts has created a significantly improved natural appearance to the transplanted grafts. Inconsistent growth and survival of follicular grafts, however, has continued to be a problem that has perplexed hair restoration surgeons. This review attempts to explore the stresses affecting grafts during transplantation and some of the complexities involved in graft growth and survival. These authors reviewed the literature to determine the primary scope of aspects influencing growth and survival of follicular grafts. This scope includes patient selection, operating techniques, graft care, storage solutions and additives. The primary focus of the hair restoration surgeons should first be attention to the fundamentals of hair care, hydration, temperature, time out of body and gentle handling. Factors such as advanced storage solutions and additives can be helpful once the fundamentals have been addressed.
Keywords	Hair transplantation ; storage solutions ; ischemia reperfusion injury ; platelet-rich plasma ; Medicine (General) ; R5-920 ; Medicine ; R ; Surgery ; RD1-811
Language	English
Publishing date	2010-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Interprofessionalism

Joseph, Robert / Robinson, Richmond / Fleischer, Adam / Jaffe, Leland / Joseph, Alison / Baker, Isabel / Truong, Jacqueline / Nouvong, Aksone / Parsley, Nancy L / Becker, John H

Journal of the American Podiatric Medical Association

2019 Volume 108, Issue 6, Page(s) 560–563

Abstract: ... as the Dr. William M. Scholl College of Podiatric Medicine. It has been an integral part of Rosalind ...

Abstract	In 1912, the Illinois College of Chiropody and Orthopedics was founded, and is today known as the Dr. William M. Scholl College of Podiatric Medicine. It has been an integral part of Rosalind Franklin University of Medicine and Science in North Chicago, Illinois since 2001. Through the ensuing decades, Scholl College alumni have been instrumental in moving the profession forward.
MeSH term(s)	Chicago ; Curriculum ; Education, Medical/history ; History, 20th Century ; History, 21st Century ; Humans ; Interprofessional Relations ; Organizational Innovation ; Podiatry/education ; Podiatry/history ; Schools, Medical/organization & administration
Language	English
Publishing date	2019-02-11
Publishing country	United States
Document type	Historical Article ; Journal Article
ZDB-ID	632622-5
ISSN	1930-8264 ; 0003-0538 ; 8750-7315
ISSN (online)	1930-8264
ISSN	0003-0538 ; 8750-7315
DOI	10.7547/8750-7315-108.6.560
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Article: Displaced femoral neck fractures: is there a standard of care?

Macaulay, William / Yoon, Richard S / Parsley, Brian / Nellans, Kate W / Teeny, Steven M

Orthopedics

2007 Volume 30, Issue 9, Page(s) 748–749

Abstract: Many factors must be considered in treating displaced femoral neck fractures. For younger patients, ORIF is preferred, whereas arthroplasty is the better option for elderly patients. For institutionalized elderly patients with a low activity level or ... ...

Abstract	Many factors must be considered in treating displaced femoral neck fractures. For younger patients, ORIF is preferred, whereas arthroplasty is the better option for elderly patients. For institutionalized elderly patients with a low activity level or impaired mental status, the choice should be hemiarthroplasty (either unipolar or bipolar). For high-demand, active patients, evidence continues to mount toward THA as the favored treatment option. However, there is a need for larger clinical trials to demonstrate the most cost-effective way to treat sub-populations of an ever-growing number of patients with displaced femoral neck fractures.
MeSH term(s)	Arthroplasty, Replacement/standards ; Femoral Neck Fractures/surgery ; Humans ; Meta-Analysis as Topic ; Reoperation/statistics & numerical data ; Risk Factors ; Treatment Outcome
Language	English
Publishing date	2007-09-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	424447-3
ISSN	0147-7447
ISSN	0147-7447
DOI	10.3928/01477447-20070901-08
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Article ; Online: Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial.

Casella, James F / Barton, Bruce A / Kanter, Julie / Black, L Vandy / Majumdar, Suvankar / Inati, Adlette / Wali, Yasser / Drachtman, Richard A / Abboud, Miguel R / Kilinc, Yurdanur / Fuh, Beng R / Al-Khabori, Murtadha K / Takemoto, Clifford M / Salman, Emad / Sarnaik, Sharada A / Shah, Nirmish / Morris, Claudia R / Keates-Baleeiro, Jennifer / Raj, Ashok /

Alvarez, Ofelia A / Hsu, Lewis L / Thompson, Alexis A / Sisler, India Y / Pace, Betty S / Noronha, Suzie A / Lasky, Joseph L / de Julian, Elena Cela / Godder, Kamar / Thornburg, Courtney Dawn / Kamberos, Natalie L / Nuss, Rachelle / Marsh, Anne M / Owen, William C / Schaefer, Anne / Tebbi, Cameron K / Chantrain, Christophe F / Cohen, Debra E / Karakas, Zeynep / Piccone, Connie M / George, Alex / Fixler, Jason M / Singleton, Tammuella C / Moulton, Thomas / Quinn, Charles T / de Castro Lobo, Clarisse Lopes / Almomen, Abdulkareem M / Goyal-Khemka, Meenakshi / Maes, Philip / Emanuele, Marty / Gorney, Rebecca T / Padgett, Claire S / Parsley, Ed / Kronsberg, Shari S / Kato, Gregory J / Gladwin, Mark T

JAMA

2021 Volume 325, Issue 15, Page(s) 1513–1523

Abstract: Importance: Although effective agents are available to prevent painful vaso-occlusive episodes of sickle cell disease (SCD), there are no disease-modifying therapies for ongoing painful vaso-occlusive episodes; treatment remains supportive. A previous ... ...

Abstract	Importance: Although effective agents are available to prevent painful vaso-occlusive episodes of sickle cell disease (SCD), there are no disease-modifying therapies for ongoing painful vaso-occlusive episodes; treatment remains supportive. A previous phase 3 trial of poloxamer 188 reported shortened duration of painful vaso-occlusive episodes in SCD, particularly in children and participants treated with hydroxyurea. Objective: To reassess the efficacy of poloxamer 188 for vaso-occlusive episodes. Design, setting, and participants: Phase 3, randomized, double-blind, placebo-controlled, multicenter, international trial conducted from May 2013 to February 2016 that included 66 hospitals in 12 countries and 60 cities; 388 individuals with SCD (hemoglobin SS, SC, S-β0 thalassemia, or S-β+ thalassemia disease) aged 4 to 65 years with acute moderate to severe pain typical of painful vaso-occlusive episodes requiring hospitalization were included. Interventions: A 1-hour 100-mg/kg loading dose of poloxamer 188 intravenously followed by a 12-hour to 48-hour 30-mg/kg/h continuous infusion (n = 194) or placebo (n = 194). Main outcomes and measures: Time in hours from randomization to the last dose of parenteral opioids among all participants and among those younger than 16 years as a separate subgroup. Results: Of 437 participants assessed for eligibility, 388 were randomized (mean age, 15.2 years; 176 [45.4%] female), the primary outcome was available for 384 (99.0%), 15-day follow-up contacts were available for 357 (92.0%), and 30-day follow-up contacts were available for 368 (94.8%). There was no significant difference between the groups for the mean time to last dose of parenteral opioids (81.8 h for the poloxamer 188 group vs 77.8 h for the placebo group; difference, 4.0 h [95% CI, -7.8 to 15.7]; geometric mean ratio, 1.2 [95% CI, 1.0-1.5]; P = .09). Based on a significant interaction of age and treatment (P = .01), there was a treatment difference in time from randomization to last administration of parenteral opioids for participants younger than 16 years (88.7 h in the poloxamer 188 group vs 71.9 h in the placebo group; difference, 16.8 h [95% CI, 1.7-32.0]; geometric mean ratio, 1.4 [95% CI, 1.1-1.8]; P = .008). Adverse events that were more common in the poloxamer 188 group than the placebo group included hyperbilirubinemia (12.7% vs 5.2%); those more common in the placebo group included hypoxia (12.0% vs 5.3%). Conclusions and relevance: Among children and adults with SCD, poloxamer 188 did not significantly shorten time to last dose of parenteral opioids during vaso-occlusive episodes. These findings do not support the use of poloxamer 188 for vaso-occlusive episodes. Trial registration: ClinicalTrials.gov Identifier: NCT01737814.
MeSH term(s)	Adolescent ; Adult ; Analgesics, Opioid/therapeutic use ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/drug therapy ; Child ; Double-Blind Method ; Female ; Humans ; Male ; Pain/drug therapy ; Pain/etiology ; Placebos/adverse effects ; Placebos/therapeutic use ; Poloxamer/adverse effects ; Poloxamer/therapeutic use ; Vasodilator Agents/adverse effects ; Vasodilator Agents/therapeutic use ; Young Adult
Chemical Substances	Analgesics, Opioid ; Placebos ; Vasodilator Agents ; Poloxamer (106392-12-5)
Language	English
Publishing date	2021-04-20
Publishing country	United States
Document type	Clinical Trial, Phase III ; Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2021.3414
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