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  1. Article ; Online: Femurfracturen door langdurig bisfosfonaatgebruik.

    Somford, Matthijs P / Thomassen, Bregje J W / Draijer, W Frits

    Nederlands tijdschrift voor geneeskunde

    2010  Volume 154, Page(s) A1218

    Abstract: There is increasingly more evidence to suggest that spontaneous femur fractures may be an adverse effect of long-term bisphosphonate use. Patients typically present with prodromal thigh pain, cortical thickening on conventional radiographs or present at ... ...

    Title translation Femur fractures caused by long-term bisphosphonate therapy.
    Abstract There is increasingly more evidence to suggest that spontaneous femur fractures may be an adverse effect of long-term bisphosphonate use. Patients typically present with prodromal thigh pain, cortical thickening on conventional radiographs or present at A&E with a spontaneous transverse subtrochanteric femur fracture with a medial spike. Discontinuation of bisphosphonate therapy is advisable in patients presenting with a spontaneous femur fracture with specific features while using bisphosphonates. The way in which bisphosphonates alter the mechanical properties of bone is as yet unknown.
    MeSH term(s) Bone Density Conservation Agents/adverse effects ; Bone Density Conservation Agents/therapeutic use ; Diphosphonates/adverse effects ; Diphosphonates/therapeutic use ; Femoral Fractures/chemically induced ; Humans ; Time Factors
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates
    Language Dutch
    Publishing date 2010
    Publishing country Netherlands
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Time domain algorithm for accelerated determination of the first order moment of photo current fluctuations in high speed laser Doppler perfusion imaging.

    Draijer, Matthijs / Hondebrink, Erwin / van Leeuwen, Ton / Steenbergen, Wiendelt

    Medical & biological engineering & computing

    2009  Volume 47, Issue 10, Page(s) 1103–1109

    Abstract: Advances in optical array sensor technology allow for the real time acquisition of dynamic laser speckle patterns generated by tissue perfusion, which, in principle,allows for real time laser Doppler perfusion imaging(LDPI). Exploitation of these ... ...

    Abstract Advances in optical array sensor technology allow for the real time acquisition of dynamic laser speckle patterns generated by tissue perfusion, which, in principle,allows for real time laser Doppler perfusion imaging(LDPI). Exploitation of these developments is enhanced with the introduction of faster algorithms to transform photo currents into perfusion estimates using the first moment of the power spectrum. A time domain (TD)algorithm is presented for determining the first-order spectral moment. Experiments are performed to compare this algorithm with the widely used Fast Fourier Transform(FFT). This study shows that the TD-algorithm is twice as fast as the FFT-algorithm without loss of accuracy.Compared to FFT, the TD-algorithm is efficient in terms of processor time, memory usage and data transport.
    MeSH term(s) Algorithms ; Humans ; Laser-Doppler Flowmetry/methods ; Regional Blood Flow ; Signal Processing, Computer-Assisted
    Language English
    Publishing date 2009-10-10
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 282327-5
    ISSN 1741-0444 ; 0025-696X ; 0140-0118
    ISSN (online) 1741-0444
    ISSN 0025-696X ; 0140-0118
    DOI 10.1007/s11517-009-0537-x
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  3. Article ; Online: Twente Optical Perfusion Camera: system overview and performance for video rate laser Doppler perfusion imaging.

    Draijer, Matthijs / Hondebrink, Erwin / van Leeuwen, Ton / Steenbergen, Wiendelt

    Optics express

    2009  Volume 17, Issue 5, Page(s) 3211–3225

    Abstract: We present the Twente Optical Perfusion Camera (TOPCam), a novel laser Doppler Perfusion Imager based on CMOS technology. The tissue under investigation is illuminated and the resulting dynamic speckle pattern is recorded with a high speed CMOS camera. ... ...

    Abstract We present the Twente Optical Perfusion Camera (TOPCam), a novel laser Doppler Perfusion Imager based on CMOS technology. The tissue under investigation is illuminated and the resulting dynamic speckle pattern is recorded with a high speed CMOS camera. Based on an overall analysis of the signal-to-noise ratio of CMOS cameras, we have selected the camera which best fits our requirements. We applied a pixel-by-pixel noise correction to minimize the influence of noise in the perfusion images. We can achieve a frame rate of 0.2 fps for a perfusion image of 128x128 pixels (imaged tissue area of 7x7 cm2) if the data is analyzed online. If the analysis of the data is performed offline, we can achieve a frame rate of 26 fps for a duration of 3.9 seconds. By reducing the imaging size to 128x16 pixels, this frame rate can be achieved for up to half a minute. We show the fast imaging capabilities of the system in order of increasing perfusion frame rate. First the increase of skin perfusion after application of capsicum cream, and the perfusion during an occlusion-reperfusion procedure at the fastest frame rate allowed with online analysis is shown. With the highest frame rate allowed with offline analysis, the skin perfusion revealing the heart beat and the perfusion during an occlusion-reperfusion procedure is presented. Hence we have achieved video rate laser Doppler perfusion imaging.
    MeSH term(s) Equipment Design ; Female ; Hand ; Humans ; Laser-Doppler Flowmetry/instrumentation ; Microscopy, Video/instrumentation ; Online Systems ; Optical Phenomena ; Skin/blood supply ; Skin/diagnostic imaging ; Ultrasonography ; Young Adult
    Language English
    Publishing date 2009-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/oe.17.003211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Review of laser speckle contrast techniques for visualizing tissue perfusion.

    Draijer, Matthijs / Hondebrink, Erwin / van Leeuwen, Ton / Steenbergen, Wiendelt

    Lasers in medical science

    2008  Volume 24, Issue 4, Page(s) 639–651

    Abstract: When a diffuse object is illuminated with coherent laser light, the backscattered light will form an interference pattern on the detector. This pattern of bright and dark areas is called a speckle pattern. When there is movement in the object, the ... ...

    Abstract When a diffuse object is illuminated with coherent laser light, the backscattered light will form an interference pattern on the detector. This pattern of bright and dark areas is called a speckle pattern. When there is movement in the object, the speckle pattern will change over time. Laser speckle contrast techniques use this change in speckle pattern to visualize tissue perfusion. We present and review the contribution of laser speckle contrast techniques to the field of perfusion visualization and discuss the development of the techniques.
    MeSH term(s) Animals ; Humans ; Laser-Doppler Flowmetry ; Lasers ; Pattern Recognition, Automated/methods ; Pattern Recognition, Automated/statistics & numerical data ; Photography ; Regional Blood Flow ; Scattering, Radiation ; Skin/blood supply
    Language English
    Publishing date 2008-12-03
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632808-8
    ISSN 1435-604X ; 0268-8921
    ISSN (online) 1435-604X
    ISSN 0268-8921
    DOI 10.1007/s10103-008-0626-3
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  5. Article ; Online: Relation between the contrast in time integrated dynamic speckle patterns an the power spectral density of their temporal intensity fluctuations.

    Draijer, Matthijs J / Hondebrink, Erwin / Larsson, Marcus / van Leeuwen, Ton G / Steenbergen, Wiendelt

    Optics express

    2010  Volume 18, Issue 21, Page(s) 21883–21891

    Abstract: Scattering fluid flux can be quantified with coherent light, either from the contrast of speckle patterns, or from the moments of the power spectrum of intensity fluctuations. We present a theory connecting these approaches for the general case of mixed ... ...

    Abstract Scattering fluid flux can be quantified with coherent light, either from the contrast of speckle patterns, or from the moments of the power spectrum of intensity fluctuations. We present a theory connecting these approaches for the general case of mixed static-dynamic patterns of boiling speckles without prior assumptions regarding the particle dynamics. An expression is derived and tested relating the speckle contrast to the intensity power spectrum. Our theory demonstrates that in speckle contrast the concentration of moving particles dominates over the contribution of speed to the particle flux. Our theory provides a basis for comparison of both approaches when used for studying tissue perfusion.
    MeSH term(s) Algorithms ; Diagnostic Imaging/methods ; Erythrocytes/pathology ; Humans ; Lasers ; Light ; Models, Statistical ; Optics and Photonics ; Physics/methods ; Rheology/methods ; Time Factors
    Language English
    Publishing date 2010-10-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.18.021883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Time domain algorithm for accelerated determination of the first order moment of photo current fluctuations in high speed laser Doppler perfusion imaging

    Draijer, Matthijs / Hondebrink, Erwin / van Leeuwen, Ton / Steenbergen, Wiendelt

    Medical & biological engineering & computing. 2009 Oct., v. 47, no. 10

    2009  

    Abstract: Advances in optical array sensor technology allow for the real time acquisition of dynamic laser speckle patterns generated by tissue perfusion, which, in principle, allows for real time laser Doppler perfusion imaging (LDPI). Exploitation of these ... ...

    Abstract Advances in optical array sensor technology allow for the real time acquisition of dynamic laser speckle patterns generated by tissue perfusion, which, in principle, allows for real time laser Doppler perfusion imaging (LDPI). Exploitation of these developments is enhanced with the introduction of faster algorithms to transform photo currents into perfusion estimates using the first moment of the power spectrum. A time domain (TD) algorithm is presented for determining the first-order spectral moment. Experiments are performed to compare this algorithm with the widely used Fast Fourier Transform (FFT). This study shows that the TD-algorithm is twice as fast as the FFT-algorithm without loss of accuracy. Compared to FFT, the TD-algorithm is efficient in terms of processor time, memory usage and data transport.
    Language English
    Dates of publication 2009-10
    Size p. 1103-1109.
    Publisher Springer-Verlag
    Publishing place Berlin/Heidelberg
    Document type Article
    ZDB-ID 282327-5
    ISSN 1741-0444 ; 0025-696X ; 0140-0118
    ISSN (online) 1741-0444
    ISSN 0025-696X ; 0140-0118
    DOI 10.1007/s11517-009-0537-x
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Burn imaging with a whole field laser Doppler perfusion imager based on a CMOS imaging array.

    van Herpt, Heleen / Draijer, Matthijs / Hondebrink, Erwin / Nieuwenhuis, Marianne / Beerthuizen, Gerard / van Leeuwen, Ton / Steenbergen, Wiendelt

    Burns : journal of the International Society for Burn Injuries

    2010  Volume 36, Issue 3, Page(s) 389–396

    Abstract: Laser Doppler perfusion imaging (LDPI) has been proven to be a useful tool in predicting the burn wound outcome in an early stage. A major disadvantage of scanning beam LDPI devices is their slow scanning speed, leading to patient discomfort and imaging ... ...

    Abstract Laser Doppler perfusion imaging (LDPI) has been proven to be a useful tool in predicting the burn wound outcome in an early stage. A major disadvantage of scanning beam LDPI devices is their slow scanning speed, leading to patient discomfort and imaging artifacts. We have developed the Twente Optical Perfusion Camera (TOPCam), a whole field laser Doppler perfusion imager based on a CMOS imaging array, which is two orders of magnitude faster than scanning beam LDPI systems. In this paper the first clinical results of the TOPCam in the setting of a burn centre are presented. The paper shows perfusion images of burns of various degrees. While our system encounters problems caused by blisters, tissue necrosis, surface reflection and curvature in a manner similar to scanning beam imagers, it poses a clear advantage in terms of procedure time. Image quality in terms of dynamic range and resolution appears to be sufficient for burn diagnosis. Hence, we made important steps in overcoming the limitations of LDPI in burn diagnosis imposed by the measurement speed.
    MeSH term(s) Adolescent ; Adult ; Aged ; Arm Injuries/diagnosis ; Arm Injuries/pathology ; Blister/diagnosis ; Burns/diagnosis ; Burns/pathology ; Equipment Design ; Female ; Humans ; Laser-Doppler Flowmetry/instrumentation ; Laser-Doppler Flowmetry/methods ; Male ; Middle Aged ; Necrosis ; Skin/pathology ; Young Adult
    Language English
    Publishing date 2010-05
    Publishing country Netherlands
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 197308-3
    ISSN 1879-1409 ; 0305-4179
    ISSN (online) 1879-1409
    ISSN 0305-4179
    DOI 10.1016/j.burns.2009.05.009
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  8. Article ; Online: Bilateral fractures of the femur diaphysis in a patient with rheumatoid arthritis on long-term treatment with alendronate: clues to the mechanism of increased bone fragility.

    Somford, Matthijs P / Draijer, Frits W / Thomassen, Bregje J W / Chavassieux, Pascale M / Boivin, Georges / Papapoulos, Socrates E

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2009  Volume 24, Issue 10, Page(s) 1736–1740

    Abstract: Unusual fractures of the femur diaphysis have been reported in patients treated with alendronate and, although no causal relationship has been established, excessive suppression of bone turnover and length of treatment with alendronate have been ... ...

    Abstract Unusual fractures of the femur diaphysis have been reported in patients treated with alendronate and, although no causal relationship has been established, excessive suppression of bone turnover and length of treatment with alendronate have been implicated in their pathogenesis. We report here clinical, biochemical, and radiological findings of a patient with rheumatoid arthritis and multiple risk factors for fractures who was treated with alendronate for 8 yr and developed spontaneous bilateral subtrochanteric/diaphyseal fractures. Bone biopsies obtained form the iliac crest and the femur showed decreased bone formation with histomorphometric evidence of markedly increased bone resorption at the femur. These results show for the first time that an imbalance between bone resorption and bone formation at the affected bone is associated with the occurrence of these atypical femur fractures. The cause of this imbalance is currently unknown, and further studies of the epidemiology and pathogenesis of diaphyseal femur fractures are warranted.
    MeSH term(s) Aged ; Alendronate/adverse effects ; Alendronate/pharmacology ; Alendronate/therapeutic use ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnostic imaging ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/physiopathology ; Biopsy ; Bone Density/drug effects ; Bone Density/physiology ; Bone Density Conservation Agents/adverse effects ; Bone Density Conservation Agents/pharmacology ; Bone Density Conservation Agents/therapeutic use ; Calcification, Physiologic/drug effects ; Diaphyses/diagnostic imaging ; Diaphyses/drug effects ; Female ; Femoral Fractures/chemically induced ; Femoral Fractures/complications ; Femoral Fractures/diagnostic imaging ; Femoral Fractures/physiopathology ; Femur/drug effects ; Femur/pathology ; Humans ; Osteoclasts/drug effects ; Osteoclasts/pathology ; Radiography ; Time Factors
    Chemical Substances Bone Density Conservation Agents ; Alendronate (X1J18R4W8P)
    Language English
    Publishing date 2009-10
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1359/jbmr.090408
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