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Article ; Online: Pathology of primary central nervous system lymphoma.

Commins, Deborah L

2006 Volume 21, Issue 5, Page(s) E2

Abstract: The understanding of primary central nervous system lymphoma (PCNSL) has lagged behind that of the much more common systemic, nodal lymphomas. Reasons for this include the relative rarity of PCNSL and the fact that these lesions differ in some ways from ... ...

Abstract	The understanding of primary central nervous system lymphoma (PCNSL) has lagged behind that of the much more common systemic, nodal lymphomas. Reasons for this include the relative rarity of PCNSL and the fact that these lesions differ in some ways from their histologically similar systemic counterparts. The purpose of this paper is twofold: first, the author provides concise descriptions of the pathological features of both common and uncommon types of PCNSL while discussing issues such as the confusion surrounding histological classification of PCNSLs, problems related to intraoperative diagnosis, and the appropriate diagnostic work up. Second, the author discusses a small number of molecular studies to demonstrate the great promise they offer. Such studies have already clarified some issues, including the category of lymphocyte from which the majority of PCNSLs are derived. Hopefully in the future these studies will help guide treatment decisions.
MeSH term(s)	Brain Neoplasms/classification ; Brain Neoplasms/pathology ; Humans ; Lymphoma/classification ; Lymphoma/pathology
Language	English
Publishing date	2006-11-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/foc.2006.21.5.3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Large solitary osteochondroma of the thoracic spine: Case report and review of the literature.

Pham, Martin H / Cohen, Justin / Tuchman, Alexander / Commins, Deborah / Acosta, Frank L

Surgical neurology international

2016 Volume 7, Issue Suppl 13, Page(s) S323–7

Abstract: Background: Spinal osteochondromas are typically benign tumors, but patients may present with myelopathy and neurologic deficits if there is tumor encroachment within the spinal canal.: Case description: We report here a case of a large solitary ... ...

Abstract	Background: Spinal osteochondromas are typically benign tumors, but patients may present with myelopathy and neurologic deficits if there is tumor encroachment within the spinal canal. Case description: We report here a case of a large solitary osteochondroma originating from the posterior vertebral body of T9 causing spinal cord compression and myelopathy. A 17-year-old man presented with 3 months of bilateral feet numbness and gait difficulty. Imaging demonstrated a large left-sided 5.9 cm × 5.0 cm × 5.4 cm osseous mass arising from the T9 vertebra consistent with an osteochondroma. He underwent bilateral costotransversectomies, and a left two-level lateral extracavitary approach for three partial corpectomies to both safely decompress the spinal canal as well as obtain a gross total resection of the tumor. Use of the O-arm intraoperative stereotactic computed tomographic navigation system assisted in delineating the osseous portions of the tumor for surgical removal. He experienced complete neurologic recovery after operative intervention. Conclusion: Careful surgical planning is needed to determine the best approach for spinal cord decompression and resection of this tumor, especially taking into account the bony elements from which it arises. We present this case, to highlight the feasibility of a single-stage posterior approach to the ventral thoracic spine for the resection of a large solitary thoracic osteochondroma causing cord compression.
Language	English
Publishing date	2016-05-17
Publishing country	United States
Document type	Case Reports
ISSN	2229-5097
ISSN	2229-5097
DOI	10.4103/2152-7806.182542
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Article: Cytologic Features of Hemangioblastoma

Commins, Deborah L. / Hinton, David R.

Acta Cytologica

2011 Volume 42, Issue 5, Page(s) 1104–1110

Institution	From the Department of Pathology, University of Southern California School of Medicine, Los Angeles, California, U.S.A
Keywords	hemangioblastoma ; meningioma ; astrocytoma ; carcinoma, renal cell
Language	English
Publishing date	2011-08-26
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Original Articles
ZDB-ID	80003-x
ISSN	1938-2650 ; 0001-5547
ISSN (online)	1938-2650
ISSN	0001-5547
DOI	10.1159/000332096
Database	Karger publisher's database

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Article ; Online: Large solitary osteochondroma of the thoracic spine

Martin H Pham / Justin Cohen / Alexander Tuchman / Deborah Commins / Frank L Acosta

Surgical Neurology International, Vol 7, Iss 14, Pp 323-

Case report and review of the literature

2016 Volume 327

Abstract: Background: Spinal osteochondromas are typically benign tumors, but patients may present with myelopathy and neurologic deficits if there is tumor encroachment within the spinal canal. Case Description: We report here a case of a large solitary ... ...

Abstract	Background: Spinal osteochondromas are typically benign tumors, but patients may present with myelopathy and neurologic deficits if there is tumor encroachment within the spinal canal. Case Description: We report here a case of a large solitary osteochondroma originating from the posterior vertebral body of T9 causing spinal cord compression and myelopathy. A 17-year-old man presented with 3 months of bilateral feet numbness and gait difficulty. Imaging demonstrated a large left-sided 5.9 cm × 5.0 cm × 5.4 cm osseous mass arising from the T9 vertebra consistent with an osteochondroma. He underwent bilateral costotransversectomies, and a left two-level lateral extracavitary approach for three partial corpectomies to both safely decompress the spinal canal as well as obtain a gross total resection of the tumor. Use of the O-arm intraoperative stereotactic computed tomographic navigation system assisted in delineating the osseous portions of the tumor for surgical removal. He experienced complete neurologic recovery after operative intervention. Conclusion: Careful surgical planning is needed to determine the best approach for spinal cord decompression and resection of this tumor, especially taking into account the bony elements from which it arises. We present this case, to highlight the feasibility of a single-stage posterior approach to the ventral thoracic spine for the resection of a large solitary thoracic osteochondroma causing cord compression.
Keywords	Costotransversectomy ; lateral extracavitary ; osteochondroma ; thoracic vertebrae ; Medicine ; R ; Surgery ; RD1-811 ; Internal medicine ; RC31-1245 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Neurology. Diseases of the nervous system ; RC346-429
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: HIV stroke risk: evidence and implications.

Singer, Elyse J / Valdes-Sueiras, Miguel / Commins, Deborah L / Yong, William / Carlson, Margrit

Therapeutic advances in chronic disease

2013 Volume 4, Issue 2, Page(s) 61–70

Abstract: An estimated 34 million men, women, and children are infected with human immunodeficiency virus type 1 (HIV-1), the virus that causes acquired immunodeficiency syndrome (AIDS). Current technology cannot eradicate HIV-1, and most patients with HIV-1- ... ...

Abstract	An estimated 34 million men, women, and children are infected with human immunodeficiency virus type 1 (HIV-1), the virus that causes acquired immunodeficiency syndrome (AIDS). Current technology cannot eradicate HIV-1, and most patients with HIV-1-infection (HIV+) will require lifelong treatment with combined antiretroviral therapy (cART). Stroke was recognized as a complication of HIV-1 infection since the early days of the epidemic. Potential causes of stroke in HIV-1 include opportunistic infections, tumors, atherosclerosis, diabetes, hypertension, autoimmunity, coagulopathies, cardiovascular disease, and direct HIV-1 infection of the arterial wall. Ischemic stroke has emerged as a particularly significant neurological complication of HIV-1 and its treatment due to the aging of the HIV+ population, chronic HIV-1 infection, inflammation, and prolonged exposure to cART. New prevention and treatment strategies tailored to the needs of the HIV+ population are needed to address this issue.
Language	English
Publishing date	2013-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2554816-5
ISSN	2040-6231 ; 2040-6223
ISSN (online)	2040-6231
ISSN	2040-6223
DOI	10.1177/2040622312471840
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Article ; Online: Review of meningioma histopathology.

Commins, Deborah L / Atkinson, Roscoe D / Burnett, Margaret E

Neurosurgical focus

2007 Volume 23, Issue 4, Page(s) E3

Abstract: The histological appearance of a meningioma is an important predictor of tumor behavior and is frequently a factor in decisions concerning therapy. The relationship between histological features and prognosis is formalized in grading schemes such as ... ...

Abstract	The histological appearance of a meningioma is an important predictor of tumor behavior and is frequently a factor in decisions concerning therapy. The relationship between histological features and prognosis is formalized in grading schemes such as those published by the World Health Organization (WHO), most recently in 2007. Although the latest edition is an improvement over previous grading schemes, the WHO scheme still fails to fully address a variety of important issues regarding the relationship between meningioma histological characteristics and behavior. In particular, routine histological examination fails to identify the subset of Grade I tumors that behave aggressively. Because of this, many additional prognostic markers that require immunohistochemical, cytogenetic, or molecular techniques to evaluate are under investigation. Only one, immunohistochemistry for the proliferation marker, Ki 67 (MIB-1), is used routinely and it has only limited utility. It is hoped that an understanding of the genetic changes that underlie tumor progression will improve healthcare professionals' ability to predict the behavior of meningiomas.
MeSH term(s)	Anaplasia/pathology ; Antibodies, Antinuclear/metabolism ; Antibodies, Monoclonal/metabolism ; Humans ; Meningeal Neoplasms/genetics ; Meningeal Neoplasms/metabolism ; Meningeal Neoplasms/pathology ; Meningioma/genetics ; Meningioma/metabolism ; Meningioma/pathology ; Neoplasm Invasiveness
Chemical Substances	Antibodies, Antinuclear ; Antibodies, Monoclonal ; MIB-1 antibody
Language	English
Publishing date	2007
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2026589-X
ISSN	1092-0684 ; 1092-0684
ISSN (online)	1092-0684
ISSN	1092-0684
DOI	10.3171/FOC-07/10/E3
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Article: Intracranial fusarium fungal abscess in an immunocompetent patient: case report and review of the literature.

Peterson, Asa / Pham, Martin H / Lee, Brian / Commins, Deborah / Cadden, Joseph / Giannotta, Steven L / Zada, Gabriel

Journal of neurological surgery reports

2014 Volume 75, Issue 2, Page(s) e241–5

Abstract: Introduction Fusarium spp is an omnipresent fungal species that may lead to fatal infections in immunocompromised populations. Spontaneous intracranial infection by Fusarium spp in immunocompetent individuals is exceedingly rare. Case Report An ... ...

Abstract	Introduction Fusarium spp is an omnipresent fungal species that may lead to fatal infections in immunocompromised populations. Spontaneous intracranial infection by Fusarium spp in immunocompetent individuals is exceedingly rare. Case Report An immunocompetent 33-year-old Hispanic woman presented with persistent headaches and was found to have a contrast-enhancing mass in the left petrous apex and prepontine cistern. She underwent a subsequent craniotomy for biopsy and partial resection that revealed a Fusarium abscess. She had a left transient partial oculomotor palsy following the operation that resolved over the next few weeks. She was treated with long-term intravenous antifungal therapy and remained at her neurologic baseline 18 months following the intervention. Discussion To our knowledge, this is the first reported case of Fusarium spp brain abscess in an immunocompetent patient. Treatment options include surgical intervention and various antifungal medications. Conclusion This case demonstrates the rare potential of intracranial Fusarium infection in the immunocompetent host, as well as its successful treatment with surgical aspiration and antifungal therapy.
Language	English
Publishing date	2014-11-12
Publishing country	Germany
Document type	Case Reports
ZDB-ID	2653397-2
ISSN	2193-6366 ; 2193-6358
ISSN (online)	2193-6366
ISSN	2193-6358
DOI	10.1055/s-0034-1387182
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Article ; Online: Atypical central neurocytoma with metastatic craniospinal dissemination: a case report.

Nayyar, Megha / Mayo, Mary Catherine / Shiroishi, Mark / Commins, Deborah / Liu, Charles Y / Go, John L / Kim, Paul E / Zee, Chi-Shing / Law, Meng / Lerner, Alexander

Clinical imaging

2016 Volume 40, Issue 6, Page(s) 1108–1111

Abstract: Central neurocytomas comprise nearly half of adult intraventricular neoplasms. The median age of onset is 34 years. It is typically a low-grade neoplasm (World Health Organization grade II), although some cases of malignant neurocytomas have been ... ...

Abstract	Central neurocytomas comprise nearly half of adult intraventricular neoplasms. The median age of onset is 34 years. It is typically a low-grade neoplasm (World Health Organization grade II), although some cases of malignant neurocytomas have been described. We present a rare case of an atypical central neurocytoma with craniospinal dissemination, including both imaging and pathologic findings.
MeSH term(s)	Cerebral Ventricle Neoplasms/pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neurocytoma/pathology ; Spinal Cord Neoplasms/etiology
Language	English
Publishing date	2016-11
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2016.06.004
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Article ; Online: A rare case of periosteal osteoblastoma located in the frontal cranial bone.

Lin, Yun Chyi / Commins, Deborah L / Fedenko, Alexander N / Pinsky, Gregory S

Archives of pathology & laboratory medicine

2005 Volume 129, Issue 6, Page(s) 787–789

Abstract: Periosteal osteoblastoma is an extremely rare bone-forming neoplasm located on the surface of cortical bone. Of the fewer than 30 cases of periosteal osteoblastomas found in the literature, 2 have been reported to be located in cranial bone, and these ... ...

Abstract	Periosteal osteoblastoma is an extremely rare bone-forming neoplasm located on the surface of cortical bone. Of the fewer than 30 cases of periosteal osteoblastomas found in the literature, 2 have been reported to be located in cranial bone, and these have not been documented in detail with clinical history, radiographic findings, macroscopic features, and microscopic findings. Although the differential diagnoses of periosteal lesions include parosteal and periosteal osteosarcoma, periosteal chondroma and chondrosarcoma, osteochondroma, osteoid osteoma, periostitis ossificans, and myositis ossificans, an important differential diagnosis both radiologically and pathologically of such a lesion in the cranium is meningioma. We report an unusual case of periosteal osteoblastoma located in the frontal cranial bone that was radiologically consistent with a meningioma. The differential diagnosis of metaplastic meningioma with differentiation toward bone is discussed.
MeSH term(s)	Adult ; Craniotomy ; Diagnosis, Differential ; Dura Mater/pathology ; Embolization, Therapeutic ; Female ; Frontal Bone/pathology ; Headache/etiology ; Humans ; Magnetic Resonance Imaging ; Meningeal Neoplasms/diagnosis ; Meningioma/diagnosis ; Osteoblastoma/complications ; Osteoblastoma/pathology ; Osteoblastoma/therapy ; Periosteum/pathology ; Skull Neoplasms/complications ; Skull Neoplasms/pathology ; Skull Neoplasms/therapy
Language	English
Publishing date	2005-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/2005-129-787-ARCOPO
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Article: Intracranial Fusarium Fungal Abscess in an Immunocompetent Patient: Case Report and Review of the Literature

Peterson, Asa / Pham, Martin H. / Lee, Brian / Commins, Deborah / Cadden, Joseph / Giannotta, Steven L. / Zada, Gabriel

Journal of Neurological Surgery Reports

2014 Volume 75, Issue 02, Page(s) e241–e245

Abstract: Introduction: Fusarium spp is an omnipresent fungal species that may lead to fatal infections in immunocompromised populations. Spontaneous intracranial infection by Fusarium spp in immunocompetent individuals is exceedingly rare.: Case Report: An ... ...

Abstract	Introduction: Fusarium spp is an omnipresent fungal species that may lead to fatal infections in immunocompromised populations. Spontaneous intracranial infection by Fusarium spp in immunocompetent individuals is exceedingly rare. Case Report: An immunocompetent 33-year-old Hispanic woman presented with persistent headaches and was found to have a contrast-enhancing mass in the left petrous apex and prepontine cistern. She underwent a subsequent craniotomy for biopsy and partial resection that revealed a Fusarium abscess. She had a left transient partial oculomotor palsy following the operation that resolved over the next few weeks. She was treated with long-term intravenous antifungal therapy and remained at her neurologic baseline 18 months following the intervention. Discussion: To our knowledge, this is the first reported case of Fusarium spp brain abscess in an immunocompetent patient. Treatment options include surgical intervention and various antifungal medications. Conclusion: This case demonstrates the rare potential of intracranial Fusarium infection in the immunocompetent host, as well as its successful treatment with surgical aspiration and antifungal therapy.
Keywords	intracranial abscess ; fungal infection
Language	English
Publishing date	2014-11-12
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2653397-2
ISSN	2193-6366 ; 2193-6358
ISSN (online)	2193-6366
ISSN	2193-6358
DOI	10.1055/s-0034-1387182
Database	Thieme publisher's database

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