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Article ; Online: Semi-Automatic Graphical Tool for Measuring Coronary Artery Spatially Weighted Calcium Score from Gated Cardiac Computed Tomography Images.

Patel, Heli J / Kaufman, Audrey E / Pereañez, Marco / Soultanidis, Georgios / Ramachandran, Sarayu / Naidu, Sonum / Mani, Venkatesh / Fayad, Zahi A / Robson, Philip M

Journal of visualized experiments : JoVE

2023 , Issue 199

Abstract: The current standard for measuring coronary artery calcification to determine the extent of atherosclerosis is by calculating the Agatston score from computed tomography (CT). However, the Agatston score disregards pixel values less than 130 Hounsfield ... ...

Abstract	The current standard for measuring coronary artery calcification to determine the extent of atherosclerosis is by calculating the Agatston score from computed tomography (CT). However, the Agatston score disregards pixel values less than 130 Hounsfield Units (HU) and calcium regions less than 1 mm
MeSH term(s)	Humans ; Calcium ; Coronary Vessels/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Coronary Artery Disease/diagnostic imaging ; Calcinosis ; Reproducibility of Results ; Coronary Angiography/methods
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-09-22
Publishing country	United States
Document type	Journal Article ; Video-Audio Media ; Research Support, N.I.H., Extramural
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/65458
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pharyngeal Inflammation on Positron Emission Tomography/Magnetic Resonance Imaging Before and After Obstructive Sleep Apnea Treatment.

Cohen, Oren / Kaufman, Audrey E / Choi, Hyewon / Khan, Samira / Robson, Philip M / Suárez-Fariñas, Mayte / Mani, Venkatesh / Shah, Neomi A

Annals of the American Thoracic Society

2022 Volume 20, Issue 4, Page(s) 574–583

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Adult ; Humans ; Female ; Middle Aged ; Male ; Proteomics ; Sleep Apnea, Obstructive/diagnostic imaging ; Sleep Apnea, Obstructive/therapy ; Continuous Positive Airway Pressure/methods ; Magnetic Resonance Imaging ; Inflammation/diagnostic imaging ; Positron-Emission Tomography
Language	English
Publishing date	2022-12-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202207-594OC
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Article: Review of radiographic findings in COVID-19.

Kaufman, Audrey E / Naidu, Sonum / Ramachandran, Sarayu / Kaufman, Dalia S / Fayad, Zahi A / Mani, Venkatesh

World journal of radiology

2020 Volume 12, Issue 8, Page(s) 142–155

Abstract: The purpose of this study is to review the published literature for the range of radiographic findings present in patients suffering from coronavirus disease 2019 infection. This novel corona virus is currently the cause of a worldwide pandemic. ... ...

Abstract	The purpose of this study is to review the published literature for the range of radiographic findings present in patients suffering from coronavirus disease 2019 infection. This novel corona virus is currently the cause of a worldwide pandemic. Pulmonary symptoms and signs dominate the clinical picture and radiologists are called upon to evaluate chest radiographs (CXR) and computed tomography (CT) images to assess for infiltrates and to define their extent, distribution and progression. Multiple studies attempt to characterize the disease course by looking at the timing of imaging relative to the onset of symptoms. In general, plain CXR show bilateral disease with a tendency toward the lung periphery and have an appearance most consistent with viral pneumonia. Chest CT images are most notable for showing bilateral and peripheral ground glass and consolidated opacities and are marked by an absence of concomitant pulmonary nodules, cavitation, adenopathy and pleural effusions. Published literature mentioning organ systems aside from pulmonary manifestations are relatively less common, yet present and are addressed in this review. Similarly, publications focusing on imaging modalities aside from CXR and chest CT are sparse in this evolving crisis and are likewise addressed in this review. The role of imaging is examined as it is currently being debated in the medical community, which is not at all surprising considering the highly infectious nature of Severe Acute Respiratory Syndrome coronavirus 2.
Keywords	covid19
Language	English
Publishing date	2020-08-15
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2573705-3
ISSN	1949-8470
ISSN	1949-8470
DOI	10.4329/wjr.v12.i8.142
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Article: Human cytomegalovirus extensively re-organizes the human genome, diminishing TEAD1 transcription factor activity.

bioRxiv : the preprint server for biology

2024

Abstract: Human cytomegalovirus (HCMV) infects up to 80% of the world's population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 ... ...

Abstract	Human cytomegalovirus (HCMV) infects up to 80% of the world's population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 hours after infection. Integrative analyses reveal HCMV-induced perturbation of Hippo signaling through drastic reduction of TEAD1 transcription factor activity. We confirm extensive concordant loss of TEAD1 binding, active H3K27ac histone marks, and chromatin looping interactions upon infection. Our data position TEAD1 at the top of a hierarchy involving multiple altered important developmental pathways. HCMV infection reduces TEAD1 activity through four distinct mechanisms: closing of TEAD1-bound chromatin, reduction of YAP1 and phosphorylated YAP1 levels, reduction of TEAD1 transcript and protein levels, and alteration of
Language	English
Publishing date	2024-04-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.12.588762
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Article ; Online: Novel non-invasive assessment of upper airway inflammation in obstructive sleep apnea using positron emission tomography/magnetic resonance imaging.

Cohen, Oren / John, Mira M / Kaufman, Audrey E / Kundel, Vaishnavi / Burschtin, Omar / Khan, Samira / Fayad, Zahi / Mani, Venkatesh / Shah, Neomi A

Sleep & breathing = Schlaf & Atmung

2021 Volume 26, Issue 3, Page(s) 1087–1096

Abstract: Purpose: To develop a novel non-invasive technique to quantify upper airway inflammation using positron emission tomography/magnetic resonance imaging (PET/MRI) in patients with obstructive sleep apnea (OSA).: Methods: Patients with treatment naïve ... ...

Abstract	Purpose: To develop a novel non-invasive technique to quantify upper airway inflammation using positron emission tomography/magnetic resonance imaging (PET/MRI) in patients with obstructive sleep apnea (OSA). Methods: Patients with treatment naïve moderate-to-severe OSA underwent [18F]-fluoro-2-deoxy-D-glucose (FDG) PET/MRI. Three readers independently performed tracings of the pharyngeal soft tissue on MRI. Standardized uptake values (SUV) were generated from region of interest (ROI) tracings on corresponding PET images. Background SUV was measured from the sternocleidomastoid muscle. SUV and target-to-background (TBR) were compared across readers using intraclass correlation coefficient (ICC) analyses. SUV from individual image slices were compared between each reader using Bland-Altman plots and Pearson correlation coefficients. All tracings were repeated by one reader for assessment of intra-reader reliability. Results: Five participants completed our imaging protocol and analysis. Median age, body mass index, and apnea-hypopnea index were 41 years (IQR 40.5-68.5), 32.7 kg/m Conclusions: Our novel imaging technique demonstrated reliable quantification of upper airway FDG avidity. This technology has implications for future work exploring local airway inflammation in individuals with OSA and exposure to pollutants. It may also serve as an assessment tool for response to OSA therapies.
MeSH term(s)	Adult ; Aged ; Fluorodeoxyglucose F18 ; Humans ; Inflammation ; Magnetic Resonance Imaging ; Middle Aged ; Positron-Emission Tomography ; Reproducibility of Results ; Sleep Apnea, Obstructive
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2021-08-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1500381-4
ISSN	1522-1709 ; 1520-9512
ISSN (online)	1522-1709
ISSN	1520-9512
DOI	10.1007/s11325-021-02480-3
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Zs.A 5658: Show issues

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Article: Review of radiographic findings in COVID-19

Kaufman, Audrey E. / Naidu, Sonum / Ramachandran, Sarayu / Kaufman, Dalia S. / Fayad, Zahi A. / Mani, Venkatesh

World journal of radiology

Abstract: The purpose of this study is to review the published literature for the range of radiographic findings present in patients suffering from coronavirus disease 2019 infection This novel corona virus is currently the cause of a worldwide pandemic Pulmonary ... ...

Abstract	The purpose of this study is to review the published literature for the range of radiographic findings present in patients suffering from coronavirus disease 2019 infection This novel corona virus is currently the cause of a worldwide pandemic Pulmonary symptoms and signs dominate the clinical picture and radiologists are called upon to evaluate chest radiographs (CXR) and computed tomography (CT) images to assess for infiltrates and to define their extent, distribution and progression Multiple studies attempt to characterize the disease course by looking at the timing of imaging relative to the onset of symptoms In general, plain CXR show bilateral disease with a tendency toward the lung periphery and have an appearance most consistent with viral pneumonia Chest CT images are most notable for showing bilateral and peripheral ground glass and consolidated opacities and are marked by an absence of concomitant pulmonary nodules, cavitation, adenopathy and pleural effusions Published literature mentioning organ systems aside from pulmonary manifestations are relatively less common, yet present and are addressed in this review Similarly, publications focusing on imaging modalities aside from CXR and chest CT are sparse in this evolving crisis and are likewise addressed in this review The role of imaging is examined as it is currently being debated in the medical community, which is not at all surprising considering the highly infectious nature of Severe Acute Respiratory Syndrome coronavirus 2
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #761010
Database	COVID19

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Article: Imaging plaque inflammation in asymptomatic cocaine addicted individuals with simultaneous positron emission tomography/magnetic resonance imaging.

Bachi, Keren / Mani, Venkatesh / Kaufman, Audrey E / Alie, Nadia / Goldstein, Rita Z / Fayad, Zahi A / Alia-Klein, Nelly

World journal of radiology

2019 Volume 11, Issue 5, Page(s) 62–73

Abstract: Background: Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder ( ... ...

Abstract	Background: Chronic cocaine use is associated with stroke, coronary artery disease and myocardial infarction, resulting in severe impairments or sudden mortality. In the absence of clear cardiovascular symptoms, individuals with cocaine use disorder (iCUD) seeking addiction treatment receive mostly psychotherapy and psychiatric pharmacotherapy, with no attention to vascular disease ( Aim: To assess inflammation, plaque burden and plaque composition in iCUD aiming to detect markers of atherosclerosis and vascular disease. Methods: The bilateral carotid arteries were imaged with positron emission tomography/magnetic resonance imaging (PET/MRI) in iCUD asymptomatic for cardiovascular disease, healthy controls, and individuals with cardiovascular risk. PET with 18F-fluorodeoxyglucose ( Results: The majority of iCUD and controls had carotid FDG-PET signal greater than 1.6 but lower than 3, indicating the presence of mild to moderate inflammation. However, the MRI measure of wall structure was thicker in iCUD as compared to the controls and cardiovascular risk group, indicating greater carotid plaque burden. iCUD had larger wall area as compared to the healthy controls but not as compared to the cardiovascular risk group, indicating structural wall similarities between the non-control study groups. In iCUD, wall area correlated with greater cocaine withdrawal and craving. Conclusion: These preliminary results show markers of carotid artery disease burden in cardiovascular disease-asymptomatic iCUD. Broader trials are warranted to develop protocols for early detection of cardiovascular risk and preventive intervention in iCUD.
Language	English
Publishing date	2019-05-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573705-3
ISSN	1949-8470
ISSN	1949-8470
DOI	10.4329/wjr.v11.i5.62
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Article: Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification.

Kaufman, Audrey E / Pruzan, Alison N / Hsu, Ching / Ramachandran, Sarayu / Jacobi, Adam / Fayad, Zahi A / Mani, Venkatesh

World journal of radiology

2018 Volume 10, Issue 3, Page(s) 24–29

Abstract: Aim: To examine effects of computed tomography (CT) image acquisition/reconstruction parameters on clot volume quantification : Methods: This study was performed in conformance with HIPAA and IRB Regulations (March 2015-November 2016). A ten blood ... ...

Abstract	Aim: To examine effects of computed tomography (CT) image acquisition/reconstruction parameters on clot volume quantification Methods: This study was performed in conformance with HIPAA and IRB Regulations (March 2015-November 2016). A ten blood clot phantom was designed and scanned on a dual-energy CT scanner (SOMATOM Force, Siemens Healthcare GmBH, Erlangen, Germany) with varying pitch, iterative reconstruction, energy level and slice thickness. A range of clot and tube sizes were used in an attempt to replicate Results: On the acquisition side, the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification ( Conclusion: Aside from varying pitch, changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm.
Language	English
Publishing date	2018-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573705-3
ISSN	1949-8470
ISSN	1949-8470
DOI	10.4329/wjr.v10.i3.24
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Article: Feasibility of imaging superficial palmar arch using micro-ultrasound, 7T and 3T magnetic resonance imaging.

Pruzan, Alison N / Kaufman, Audrey E / Calcagno, Claudia / Zhou, Yu / Fayad, Zahi A / Mani, Venkatesh

World journal of radiology

2016 Volume 9, Issue 2, Page(s) 79–84

Abstract: Aim: To demonstrate feasibility of vessel wall imaging of the superficial palmar arch using high frequency micro-ultrasound, 7T and 3T magnetic resonance imaging (MRI).: Methods: Four subjects (ages 22-50 years) were scanned on a micro-ultrasound ... ...

Abstract	Aim: To demonstrate feasibility of vessel wall imaging of the superficial palmar arch using high frequency micro-ultrasound, 7T and 3T magnetic resonance imaging (MRI). Methods: Four subjects (ages 22-50 years) were scanned on a micro-ultrasound system with a 45-MHz transducer (Vevo 2100, VisualSonics). Subjects' hands were then imaged on a 3T clinical MR scanner (Siemens Biograph MMR) using an 8-channel special purpose phased array carotid coil. Lastly, subjects' hands were imaged on a 7T clinical MR scanner (Siemens Magnetom 7T Whole Body Scanner) using a custom built 8-channel transmit receive carotid coil. All three imaging modalities were subjectively analyzed for image quality and visualization of the vessel wall. Results: Results of this very preliminary study indicated that vessel wall imaging of the superficial palmar arch was feasible with a whole body 7T and 3T MRI in comparison with micro-ultrasound. Subjective analysis of image quality (1-5 scale, 1: poorest, 5: best) from B mode, ultrasound, 3T SPACE MRI and 7T SPACE MRI indicated that the image quality obtained at 7T was superior to both 3T MRI and micro-ultrasound. The 3D SPACE sequence at both 7T and 3T MRI with isotropic voxels allowed for multi-planar reformatting of images and allowed for less operator dependent results as compared to high frequency micro-ultrasound imaging. Although quantitative analysis revealed that there was no significant difference between the three methods, the 7T Tesla trended to have better visibility of the vessel and its wall. Conclusion: Imaging of smaller arteries at the 7T is feasible for evaluating atherosclerosis burden and may be of clinical relevance in multiple diseases.
Language	English
Publishing date	2016-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573705-3
ISSN	1949-8470
ISSN	1949-8470
DOI	10.4329/wjr.v9.i2.79
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Article ; Online: Cyclooxygenase products contribute to the exaggerated exercise pressor reflex evoked by static muscle contraction in male UCD-type 2 diabetes mellitus rats.

Samora, Milena / Huo, Yu / Stanhope, Kimber L / Havel, Peter J / Kaufman, Marc P / Harrison, Michelle L / Stone, Audrey J

Journal of applied physiology (Bethesda, Md. : 1985)

2024

Abstract: ... production of prostaglandin E ...

Abstract	Cyclooxygenase (COX) products of arachidonic acid metabolism, specifically prostaglandins, play a role in evoking and transmitting the exercise pressor reflex in health and disease. Individuals with type 2 diabetes mellitus (T2DM) have an exaggerated exercise pressor reflex; however, the mechanisms for this exaggerated reflex are not fully understood. We aimed to determine the role played by COX products in the exaggerated exercise pressor reflex in T2DM rats. The exercise pressor reflex was evoked by static muscle contraction in unanesthetized, decerebrate, male, adult UCD-T2DM (n=8) and healthy Sprague-Dawley (n=8) rats. Changes (∆) in peak mean arterial pressure (MAP) and heart rate (HR) during muscle contraction were compared before and after intra-arterial injection of indomethacin (1 mg/kg) into the contracting hindlimb. Data are presented as mean ± SD. Inhibition of COX activity attenuated the exaggerated peak MAP (Before: ∆32 ± 13 mmHg, After: ∆18 ± 8 mmHg; P=0.004) and blood pressor index (BPi) (Before: ∆683 ± 324 mmHg.s, After: ∆361 ± 222 mmHg.s; P=0.006), but not HR (Before: ∆23 ± 8 bpm, After ∆19 ± 10 bpm; P=0.452) responses to muscle contraction in T2DM rats. In healthy rats, COX activity inhibition did not affect MAP, HR or BPi responses to muscle contraction. Inhibition of COX activity significantly reduced local production of prostaglandin E
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	219139-8
ISSN	1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
ISSN (online)	1522-1601
ISSN	0021-8987 ; 0161-7567 ; 8750-7587
DOI	10.1152/japplphysiol.00879.2023
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